Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
USERS' SCORE
Good
Based on 13 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Read More
9
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
8
We explored the effects of folic acid supplementation on stroke prevention through an analysis of 21 randomized controlled trials involving over 115,000 participants. Overall, we observed that folic acid significantly reduced stroke risk by about 10%.
Interestingly, the benefits were most pronounced in regions without fortified grains and among those without a prior history of stroke. Our findings suggest that grain fortification and individual health history play important roles in how effective folic acid can be for preventing strokes.
Interestingly, the benefits were most pronounced in regions without fortified grains and among those without a prior history of stroke. Our findings suggest that grain fortification and individual health history play important roles in how effective folic acid can be for preventing strokes.
Read More
Most Useful Reviews
9
Reduced homocysteine levels
59 people found this helpful
Does it really work? I previously ordered a more expensive product, but I decided to try this one to lower my homocysteine levels. For those unaware, homocysteine can damage our vessels, leading to high blood pressure, strokes, and other serious issues. After taking this medication, my homocysteine dropped from 9.3 to 5.5, which is perfect. I’m delighted with the results and have recommended it to my husband and mother. It’s crucial to manage homocysteine levels, especially for women planning to conceive, although many doctors overlook this.
Read More
9
Effective supplement for strokes
14 people found this helpful
This is a fantastic supplement that effectively lowers homocysteine levels. High homocysteine increases the risk of thrombosis, strokes, and other cardiovascular diseases. I firmly believe it’s an essential addition to anyone's health regimen.
Read More
9
Improves health significantly
This is an excellent and effective drug! I have high homocysteine, which puts me at risk for cardiovascular diseases, strokes, and Alzheimer's. Since using this supplement, I've noticed a significant improvement in my health! I won’t go without it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.4
- All Researches
9.5
We explored the connection between platelet levels, genetic factors, and the effectiveness of folic acid in preventing strokes. Using data from over 11,000 hypertensive patients, we found that those with low platelet counts and specific genetic markers showed the highest stroke risks. However, they also experienced significant benefits from folic acid treatment, with notable reductions in stroke occurrence. This suggests that understanding an individual’s platelet function may help identify who can benefit most from folic acid therapy in stroke prevention efforts.
Read More
9
We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Read More
9
We explored the connection between dietary vitamin B6 intake and stroke risk, looking at data collected from the National Health and Nutrition Examination Survey (NHANES) over a span of several years. This analysis involved 24,214 participants, with 921 having been diagnosed with stroke, allowing us to evaluate how varying levels of vitamin B6 might influence the likelihood of experiencing a stroke.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Our findings reveal that individuals who consumed higher amounts of vitamin B6 had a significantly lower risk of stroke compared to those with lower intake levels. Specifically, we found that those in the highest quartile of vitamin B6 consumption had an odds ratio of 0.48 for stroke risk when fully adjusted, indicating a clear protective benefit. Additionally, those engaging in moderate-intensity physical activity experienced even more pronounced effects.
We also investigated the relationship between vitamin B6 intake and stroke using advanced modeling techniques which demonstrated a non-linear, L-shaped connection. This suggests that as vitamin B6 intake increases, the risk of stroke decreases—especially after a certain threshold of consumption.
Overall, our study suggests that boosting dietary intake of vitamin B6 might be an effective strategy for reducing stroke risk, underscoring the nutrient's importance in maintaining our health.
Read More
9
We explored the cost-effectiveness of different folic acid supplementation strategies aimed at preventing strokes in hypertensive individuals in China. By examining four policy options, we aimed to find the best approach to support stroke prevention while considering potential complications from undetected vitamin B12 deficiencies.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
Read More
9
We investigated how vitamin B12 impacts neuroinflammation and recovery after an ischemic stroke. Our findings revealed that vitamin B12 plays a crucial role in programming microglial cells—immune cells in the brain—helping them divide and activate effectively, which is vital during the healing process. This treatment appeared to improve the metabolism of these cells as well, promoting better functionality and reduced brain injury after a stroke.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Interestingly, we found that vitamin B12 significantly limited gene alterations associated with strokes in these microglia. Throughout the acute phase of an ischemic stroke, vitamin B12 altered the activities of different microglial subsets, leading to less brain damage and enhanced neurological recovery for the mice in our study. However, when we depleted microglia before administering the stroke, the beneficial effects of vitamin B12 disappeared, highlighting the importance of microglia in this process.
Overall, our research underscores the potential of vitamin B12 in mitigating neuroinflammation and aiding recovery for stroke victims. Through our preclinical studies, we've established that vitamin B12 may indeed offer a promising avenue for improving neurological outcomes post-stroke, meriting further exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced homocysteine levels
59 people found this helpful
Does it really work? I previously ordered a more expensive product, but I decided to try this one to lower my homocysteine levels. For those unaware, homocysteine can damage our vessels, leading to high blood pressure, strokes, and other serious issues. After taking this medication, my homocysteine dropped from 9.3 to 5.5, which is perfect. I’m delighted with the results and have recommended it to my husband and mother. It’s crucial to manage homocysteine levels, especially for women planning to conceive, although many doctors overlook this.
Read More
9
Effective supplement for strokes
14 people found this helpful
This is a fantastic supplement that effectively lowers homocysteine levels. High homocysteine increases the risk of thrombosis, strokes, and other cardiovascular diseases. I firmly believe it’s an essential addition to anyone's health regimen.
Read More
9
Improves health significantly
This is an excellent and effective drug! I have high homocysteine, which puts me at risk for cardiovascular diseases, strokes, and Alzheimer's. Since using this supplement, I've noticed a significant improvement in my health! I won’t go without it.
Read More
9
Essential for heart health
These vitamins B12 and folate are highly absorbable and in the right dosage. They effectively lower dangerous homocysteine levels, which are a major contributor to cardiovascular diseases, strokes, and heart attacks. I recommend these for anyone with a folate cycle mutation, plus they taste great!
Read More
9
Prevention of stroke
Excellent! Methylfolate contains folic acid, which is effectively absorbed by the body due to the ability of the component to cross the blood-brain barrier. Taking this vitamin supplement can help prevent: heart attack, stroke, cardiovascular diseases, thrombosis, mental disorders, and miscarriage. This vitamin complex is recommended for women wishing to conceive or those already pregnant, as it reduces the risk of developing a fetus with brain activity abnormalities.
Read More
Frequently Asked Questions
9
Reduced homocysteine levels
59 people found this helpful
Does it really work? I previously ordered a more expensive product, but I decided to try this one to lower my homocysteine levels. For those unaware, homocysteine can damage our vessels, leading to high blood pressure, strokes, and other serious issues. After taking this medication, my homocysteine dropped from 9.3 to 5.5, which is perfect. I’m delighted with the results and have recommended it to my husband and mother. It’s crucial to manage homocysteine levels, especially for women planning to conceive, although many doctors overlook this.
4
Nutritionally vital
A nutritionist recommended these vitamins to reduce homocysteine levels and replenish deficiencies in B vitamins. Excess homocysteine damages blood vessels, leading to clots and increased stroke risk. Regular intake is essential for cardiovascular health.
7.5
Lowering stroke risk
An excellent supplement for lowering homocysteine levels. Elevated homocysteine can lead to increased thrombosis and significantly raises the risk of stroke, along with other heart and blood vessel diseases.
9
Improves health significantly
This is an excellent and effective drug! I have high homocysteine, which puts me at risk for cardiovascular diseases, strokes, and Alzheimer's. Since using this supplement, I've noticed a significant improvement in my health! I won’t go without it.
9
Essential for heart health
These vitamins B12 and folate are highly absorbable and in the right dosage. They effectively lower dangerous homocysteine levels, which are a major contributor to cardiovascular diseases, strokes, and heart attacks. I recommend these for anyone with a folate cycle mutation, plus they taste great!
9
Prevention of stroke
Excellent! Methylfolate contains folic acid, which is effectively absorbed by the body due to the ability of the component to cross the blood-brain barrier. Taking this vitamin supplement can help prevent: heart attack, stroke, cardiovascular diseases, thrombosis, mental disorders, and miscarriage. This vitamin complex is recommended for women wishing to conceive or those already pregnant, as it reduces the risk of developing a fetus with brain activity abnormalities.
7.5
High stroke risk
81 people found this helpful
One cause of high homocysteine levels is a deficiency in vitamins B1, B6, B12 and folic acid (B9), along with lifestyle factors such as smoking and excessive alcohol. Homocysteine, a product of methionine metabolism, requires these B vitamins for processing. High levels lead to the damage of blood vessels and increased stroke risk. Regular testing of homocysteine levels is essential, and supplements like Methyl B-12 and Methyl Folate may be beneficial.
5
Maintains cardiovascular health
Many now suffer from vitamin B deficiencies, especially B12, which should be at an optimal level. This complex is necessary for those with raised homocysteine levels, which increase the risk of heart attacks and strokes. It contains effective forms of B6, B9, and B12.
8
We explored the effects of folic acid supplementation on stroke prevention through an analysis of 21 randomized controlled trials involving over 115,000 participants. Overall, we observed that folic acid significantly reduced stroke risk by about 10%.
Interestingly, the benefits were most pronounced in regions without fortified grains and among those without a prior history of stroke. Our findings suggest that grain fortification and individual health history play important roles in how effective folic acid can be for preventing strokes.
Interestingly, the benefits were most pronounced in regions without fortified grains and among those without a prior history of stroke. Our findings suggest that grain fortification and individual health history play important roles in how effective folic acid can be for preventing strokes.
8
We explored the connection between folate, homocysteine levels, and outcomes in over 3,500 patients who suffered ischemic strokes. Our analysis found that higher folate levels were associated with a 29% decrease in the risk of severe outcomes, like death or major disability, at three months post-stroke.
Conversely, increased homocysteine levels correlated with a 52% higher risk of such outcomes. Notably, about 25.5% of the positive effects of folate were influenced by homocysteine. Overall, boosting folate could be beneficial for stroke recovery.
Conversely, increased homocysteine levels correlated with a 52% higher risk of such outcomes. Notably, about 25.5% of the positive effects of folate were influenced by homocysteine. Overall, boosting folate could be beneficial for stroke recovery.
8
We examined the link between folate concentrations and the risk of stroke in a study involving over 4,900 participants from a Chinese community.
By tracking these individuals for nearly a decade, we observed that those with higher folate levels had a lower chance of experiencing strokes.
Notably, levels of homocysteine (Hcy) contributed to this relationship, mediating a significant portion of the effect. Furthermore, we found that the impact of folate on stroke risk varied depending on specific genetic factors.
Overall, low folate levels appeared to increase the risk of stroke over ten years, suggesting a potential role for folate in stroke prevention.
By tracking these individuals for nearly a decade, we observed that those with higher folate levels had a lower chance of experiencing strokes.
Notably, levels of homocysteine (Hcy) contributed to this relationship, mediating a significant portion of the effect. Furthermore, we found that the impact of folate on stroke risk varied depending on specific genetic factors.
Overall, low folate levels appeared to increase the risk of stroke over ten years, suggesting a potential role for folate in stroke prevention.
9
We investigated the impact of combined B-vitamin supplementation—specifically folic acid, vitamin B12, and vitamin B6—on stroke prevention. Through a thorough analysis of 14 randomized controlled trials, we found that these vitamins significantly reduced stroke risk, especially in areas lacking folic acid fortification.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
Dosages below 0.8 mg/day for folic acid and 0.4 mg/day for vitamin B12 appeared to be the most effective. However, no benefits were seen in areas where fortification was already implemented. This suggests that while B vitamins can be beneficial, their effectiveness relies heavily on dietary conditions.
7
We aimed to investigate how vitamin treatments, including the B-complex, influence the risk of stroke. Through a thorough analysis of various studies, we found that vitamins such as B-complex, along with A, C, D, and folate, show promising links to stroke prevention.
Despite these insightful connections, it's important to note that the definitive benefits of vitamin B-complex still require more rigorous clinical trials to establish solid guidelines. Our findings encourage further exploration in the quest to reduce stroke risk via vitamin supplementation.
Despite these insightful connections, it's important to note that the definitive benefits of vitamin B-complex still require more rigorous clinical trials to establish solid guidelines. Our findings encourage further exploration in the quest to reduce stroke risk via vitamin supplementation.
References
- Liang Z, Fan F, Liu B, Li K, Chen H, et al. Association Between Serum Folate Concentrations and 10-Year Stroke Risk in a Prospective Community Cohort: Mediation and Interaction Analyses. Nutrients. 2024;17. doi:10.3390/nu17010159
- Shi M, Zheng J, Liu Y, Mao X, Wu X, et al. Folate, Homocysteine, and Adverse Outcomes After Ischemic Stroke. J Am Heart Assoc. 2024;13:e036527. doi:10.1161/JAHA.124.036527
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Zhang N, Zhou Z, Chi X, Fan F, Li S, et al. Folic acid supplementation for stroke prevention: A systematic review and meta-analysis of 21 randomized clinical trials worldwide. Clin Nutr. 2024;43:1706. doi:10.1016/j.clnu.2024.05.034
- Martínez-Torres NI, Cárdenas-Bedoya J, Torres-Mendoza BM. Acute Combined Cerebrolysin and Nicotinamide Administration Promote Cognitive Recovery Through Neuronal Changes in the Hippocampus of Rats with Permanent Middle Cerebral Artery Occlusion. Neuroscience. 2024;549:76. doi:10.1016/j.neuroscience.2024.05.006
- Zhang X, Zhang Q, Zhang Q, Wang H, Yin Y, et al. Tetrahydrofolate Attenuates Cognitive Impairment after Hemorrhagic Stroke by Promoting Hippocampal Neurogenesis via PTEN Signaling. eNeuro. 2024;11. doi:10.1523/ENEURO.0021-24.2024
- Shi Y, Zhang Z, Wang B, Wang Y, Kong X, et al. Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention. Signal Transduct Target Ther. 2024;9:110. doi:10.1038/s41392-024-01817-0
- Zhang N, Wu Z, Bai X, Song Y, Li P, et al. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119:821. doi:10.1016/j.ajcnut.2023.12.021
- Tripathi S, Nath M, Misra S, Kumar P. From A to E: Uniting vitamins against stroke risk-A systematic review and network meta-analysis. Eur J Clin Invest. 2024;54:e14165. doi:10.1111/eci.14165
- Zhang M, Zhong J, Peng Y, Hao L, Xiao B. Pyridoxal 5'-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis. EPMA J. 2025;16:95. doi:10.1007/s13167-024-00392-2
- Dong G, Xu W, Xu L. Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16172818
- Wang C, Li B, Zhu Q, Zhang Q, Xie Z, et al. Dietary vitamin B6 intake and stroke are negatively associated in adults: A cross-sectional study from the NHANES. Heliyon. 2024;10:e31125. doi:10.1016/j.heliyon.2024.e31125
- Rafay A, Abdul Fatir C, Hiba HT, Jamil M, Talha Awan M. Hyperhomocysteinemia Presenting as Stroke in a Young Individual: A Case Report. Cureus. 2024;16:e52381. doi:10.7759/cureus.52381
- Li ZC, Huang M, Yao QY, Lin CH, Hong BC, et al. Association between Gene Polymorphisms and the Efficacy of Vitamin Therapy in lowering Homocysteine Levels among Stroke Patients with Hyperhomocysteinemia. J Integr Neurosci. 2024;23:3. doi:10.31083/j.jin2301003
- An X, Du X, Yang B, Zhai N, Cui L. Prognostic Impact of Serum Homocysteine-Lowering Therapy on Patients with Hemorrhagic Stroke and Its Influence on National Institutes of Health Stroke Scale and China Stroke Scale Scores. Altern Ther Health Med. 2024;30:381.
- Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141. doi:10.3389/fneur.2023.1184141
- Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19:97. doi:10.1186/s12916-021-01977-8
- Zhang Y, Wang L, Li X, Geng J. Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats. Exp Ther Med. 2021;21:483. doi:10.3892/etm.2021.9914
- Chen L, Li Q, Fang X, Wang X, Min J, et al. Dietary Intake of Homocysteine Metabolism-Related B-Vitamins and the Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2020;11:1510. doi:10.1093/advances/nmaa061
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Gonçalves-Pereira J, Mergulhão P, Froes F. Medications to Modify Aspiration Risk: Those That Add to Risk and Those That May Reduce Risk. Semin Respir Crit Care Med. 2024;45:694. doi:10.1055/s-0044-1791827
- Yaldiko A, Coonrod S, Marella P, Hurley L, Jadavji NM. Maternal dietary deficiencies in folic acid or choline reduce primary neuron viability after exposure to hypoxia through increased levels of apoptosis. Nutr Neurosci. 2024. doi:10.1080/1028415X.2024.2398365
- Yang J, Wang J, Li B, Zhang Y. Folic acid for the primary prevention of stroke: a systematic review and meta-analysis. Front Nutr. 2024;11:1288417. doi:10.3389/fnut.2024.1288417
- Zhou L, Wang J, Wu H, Yu P, He Z, et al. Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study. Nutr J. 2024;23:76. doi:10.1186/s12937-024-00977-7
- Moti Wala S, AlEdani EM, Samuel EA, Ahmad K, Manongi NJ, et al. Exploring the Nexus: A Systematic Review on the Interplay of the Methylenetetrahydrofolate Reductase (MTHFR) Gene C677T Genotype, Hyperhomocysteinemia, and Spontaneous Cervical/Vertebral Artery Dissection in Young Adults. Cureus. 2024;16:e60878. doi:10.7759/cureus.60878
- Hu X, Jiang Y. The impact of SLCO1B1 polymorphisms on homocysteine concentrations: evidence for a stronger association in men. Front Nephrol. 2024;4:1465380. doi:10.3389/fneph.2024.1465380
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Atam V, Srivastava S, Sharma A, Atam I, Tewari J, et al. Serum Vitamin B12 Levels as a Risk Factor and Prognostic Marker in Patients With Acute Ischemic Stroke at a Tertiary Care Center in Northern India: A Case-Control Study. Cureus. 2024;16:e70473. doi:10.7759/cureus.70473
- Ge Y, Yang C, Zadeh M, Sprague SM, Lin YD, et al. Functional regulation of microglia by vitamin B12 alleviates ischemic stroke-induced neuroinflammation in mice. iScience. 2024;27:109480. doi:10.1016/j.isci.2024.109480
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Park EJ. Association between vitamin B12 status and heart rate variability in patients with ischemic stroke. Medicine (Baltimore). 2023;102:e33428. doi:10.1097/MD.0000000000033428
- Rasyid A, Mesiano T, Kurniawan M, Hidayat R, Eddy Yunus R, et al. Comprehensive Management of Acute Ischemic Stroke in Psoriatic Patient. Case Rep Dermatol Med. 2023;2023:6580971. doi:10.1155/2023/6580971
