Jarrow Formulas MSM

20 people found this helpful

Leg Cramps details

This fixed my muscle cramps in my legs, hands, and neck. I began developing severe cramps in my legs and hands that originated in my tendons and ligaments. After consulting several doctors and undergoing tests without answers, a friend recommended this, and I decided to try it. Since then, I haven't experienced any cramps. If I become dehydrated, this helps to hydrate my muscles and prevents tightness in my neck, alleviating headaches and TMJ flare-ups.

I took this due to pain in my thumb. Remarkably, the pain and swelling subsided within a day of taking it.

Swollen Lymph Nodes details

8 people found this helpful

Tendonitis details

I have been using Doctor's Best MSM 1000mg for years, but I found the large bottles sometimes cumbersome. I switched to a different brand that uses the same ingredients (OptiMSM) but comes in veggie capsules, which I find easier to swallow. My main reason for taking MSM was to alleviate pain in my Achilles tendons, which had persisted for years. I was astonished by how effectively it worked. I also take it when I feel discomfort in my knees and lower back, and it indeed helps.

1 people found this helpful

Athlete’s Foot details

Excellent MSM, a necessary supplement, particularly for athletes.

2 people found this helpful

Chronic Cough details

It’s essential for our family. I initially bought it for its effectiveness against allergies, and the chronic cough I’d had for six months disappeared. Since then, I’ve been using it regularly, and the symptom of slightly stiff fingers in the morning has nearly gone. I also take it with my child for his tics, and the eye tics have vanished too.

Cold details

Improved cold resistance

23 people found this helpful

Very useful for joints and more. I started taking MSM alongside collagen and vitamin C 900 mg soluble. I also tried dogrose tincture, and it really helped! My joints improved significantly – they no longer hurt and could manage heavy loads, plus I started catching fewer colds. Previously, if there was a draft or I got too cool, I would quickly come down with a cold or even herpes on my nose. I even experimented sitting by an open window in winter in shorts, and nothing happened! The capsules are convenient for those with little time who dislike the taste of MSM. Swallowing the capsules is quick and easy.

46 people found this helpful

Bloating details

Where to begin? After my husband used DMSO for his painful joints, we switched to MSM. It has nearly eradicated his joint pain, regulated his gut, and eliminated his IBS. I've also seen tremendous benefits: no more severe PMS pain, my belly bloating is gone, and I have normal energy levels. Even my asthma is gone! This supplement is fantastic, and my skin has cleared up too!

Bone Pain details

Stronger bones overall

54 people found this helpful

This MSM powder is a must for cellular, tissue, and bone healing. I've used it for decades post-knee injury, and after two years of minimal daily intake, my spurs and pain have vanished. At over 60 years old, I feel fantastic and believe in this product’s effectiveness for overall health and toxin elimination.

Cancer details

MSM anal cancer treatment feasibility

Questionable

Based on 3 Researches

Reynolds CW, Lieb W, Schecter A, Gaisa MM, McGill SK, et al. Piloting of a Screen‑Triage‑Treat Surgical Approach Model for Management of Anal Cancer in Liberia. Ann Glob Health. 2024;90:75. doi:10.5334/aogh.4576

We explored the challenges faced by men who have sex with men (MSM) regarding anal cancer treatment in Liberia. With limited access to screening and care for anal cancers, we aimed to investigate whether a screen-triage-treat approach could effectively help identify and manage anal high-grade squamous intraepithelial lesions (aHSIL) within this vulnerable population.

In our study, we collaborated with local organizations to gather data from MSM and transgender individuals. Participants were recruited and engaged in self-swabbing to test for high-risk human papillomavirus (HPV), alongside HIV testing. Those who tested positive for aHSIL were offered further evaluation and treatment using high-resolution anoscopy and infrared coagulation.

Among 110 participants, a significant number turned out to be living with HIV, and nearly half tested positive for high-risk HPV. This indicates a notable health concern. While 68% of those who tested positive opted for further procedures, we found that this model effectively presented a potential solution for identifying anal cancer risks and can work in a low-resource environment.

Overall, our findings suggest that implementing a screen-triage-treat model shows promise for reducing anal cancer incidence among MSM in Liberia. This approach, previously successful in cervical cancer management, might become a crucial tool in cancer prevention strategies for similar low- and middle-income countries.

Improves recovery and health

Most Useful Review

129 people found this helpful

Methylsulfonylmethane (MSM) is excellent for my ballet training as it supports my joints and aids recovery. The effects are tangible; it's best taken with silicon supplements. MSM not only helps with joint pain and cholesterol levels but also possesses anti-cancer properties, boosts immunity, detoxifies the liver, promotes normal blood levels, and enhances brain function.

Updated: Mar 2026

Gout details

MSM shows promise for gout treatment

Likely Very Effective

Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, et al. Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway. J Ethnopharmacol. 2024;318:116906. doi:10.1016/j.jep.2023.116906

This study aimed to explore how Modified Simiaowan (MSM), a traditional six-herb formula, can help treat gouty arthritis (GA). We examined its effects on macrophages in the lab, as well as in animal models with induced gout. Using various techniques, we analyzed the inflammation response and the underlying biological pathways affected by MSM.

Through our research, we observed that MSM has strong anti-inflammatory and antioxidant properties. It seems to alleviate the symptoms of gouty arthritis by interacting with specific signaling pathways in the body, particularly the Nrf2/HO-1/ROS/NLRP3 pathway. This means that MSM not only reduces inflammation but also helps the body combat oxidative stress, which is significant in managing gout.

Overall, our findings suggest that MSM could be a promising natural solution for those struggling with gouty arthritis, providing relief through a multi-faceted approach to treatment. The study bridges traditional herbal remedies with modern scientific understanding, highlighting the potential benefits of integrating such treatments into healthcare for gout.

Gout eliminated

Most Useful Review

Msm is a must-buy. My skin has been strengthened and inflammation is reduced. The gout has disappeared.

Updated: Apr 2025

Hair Loss details

MSM shows promise for hair loss

Likely Very Effective

Hummadi AA, Gany SN, Hadi NR. EVALUATION OF THE EFFECT OF TOPICALLY APPLIED METHYLSULFONYLMETHANE AND THEIR COMBINATION WITH MINOXIDIL SOLUTION FOR IMPROVEMENT OF HAIR GROWTH IN MALE MICE. Wiad Lek. 2022;75:2744. doi:10.36740/WLek202211206

We explored the potential of Methylsulfonylmethane (MSM) as a treatment to minimize hair loss. In our study, we used twenty male Wister Albino mice, carefully dividing them into four groups to test different treatments: a control group with distilled water, a group treated with Minoxidil, one with MSM, and a group receiving a combination of MSM and Minoxidil.

Over the course of the study, we observed that the mice given MSM experienced notable improvements compared to the control group. Specifically, hair growth increased, and hair follicle numbers were significantly higher in the groups treated with MSM, whether alone or in combination with Minoxidil.

Additionally, we found a reduction in tissue levels of 8-isoprostane—a marker of oxidative stress—in the medicated groups, pointing to MSM’s antioxidant properties. There was also an increase in vascular endothelial growth factor, suggesting enhanced blood supply to the hair follicles.

Our overall conclusion is that MSM shows promise in reducing hair loss through its remarkable antioxidant and anti-inflammatory effects in male mice. This research indicates that MSM could be a valuable ally in the fight against hair loss.

Hair recovery success

Most Useful Review

42 people found this helpful

I can't believe such a result! I've been taking these vitamins for only a month. I always had perfect hair (not dyed or styled), but its structure changed drastically in summer, leading to split ends and hair loss. I tried numerous shampoos and oils with no success! I decided to tackle the issue from within. Now my hair is better than ever—silky, shiny, soft, and growing quickly! I cut the ends every two weeks by 2-3 cm. I’m thrilled with my vibrant hair. Additionally, my nails have become strong and are growing quickly, saving me on frequent manicures! I highly recommend this to anyone struggling with unhealthy hair. If you find this comment helpful, please like it! Thank you!

Updated: Mar 2026

Blood Clot details

This high-quality supplement significantly reduced the creaking and pain in my knees, restoring blood flow to normal levels. I take it alongside calcium from the same manufacturer with no reported side effects. I highly recommend purchasing it!

5 people found this helpful

Chronic Fatigue Syndrome details

This product is good—I've experienced reduced fatigue and found it very effective. Due to MSM's nature, it's advisable to avoid taking it at dinner, as some people may face side effects like insomnia or nightmares.

Adenoiditis details

Eases throat discomfort

I purchased this for myself and have been taking it regularly. Previously, I used picolinate, but this time I opted for these lozenges and have no regrets, despite the different zinc form! They have a delightful taste and help soothe my throat while dissolving. Unlike some pharmaceutical preparations, these lozenges didn’t cause any nausea. If you do experience nausea, try not taking them on an empty stomach. I notice an effect when I start feeling a sore throat, taking them every two hours as instructed, which significantly alleviates the discomfort. Highly recommended!

Cardiovascular Disease details

Chronic pain alleviated

I take one pill daily. Since starting this, both my chronic shoulder and back pains have vanished. I intend to continue taking it for life.

Knee Pain details

MSM improves mild knee pain

Questionable

Based on 5 Researches

Toguchi A, Noguchi N, Kanno T, Yamada A. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023;15. doi:10.3390/nu15132995

We explored the effects of methylsulfonylmethane (MSM) on knee pain through a well-structured randomized, double-blind, placebo-controlled trial.

Involving 88 healthy participants, the study compared the outcomes of those taking MSM against a placebo over a 12-week period.

Results showed that MSM significantly improved knee health and overall well-being according to the Japanese Knee Osteoarthritis Measure, with a notable difference in scores between the two groups.

This suggests that MSM could be a helpful option for those dealing with mild knee pain.

Positive impact

Most Useful Review

28 people found this helpful

I find it beneficial and it doesn't harm. I purchased it for my father who suffers from knee pain. Please keep him in your prayers. The taste isn't pleasant, but the quality is satisfactory.

Updated: Mar 2026

Osteoporosis details

MSM enhances bone cell differentiation

Kim DN, Joung YH, Darvin P, Kang DY, Sp N, et al. Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells. Mol Med Rep. 2016;14:460. doi:10.3892/mmr.2016.5274

We investigated how methylsulfonylmethane (MSM) interacts with bone morphogenetic protein 2 (BMP-2) to potentially enhance the differentiation of mesenchymal stem cells (MSCs) into osteoblasts, which are crucial for bone health. The study revealed that both MSM and BMP-2, when combined, lead to increased levels of certain proteins that aid in this process.

Observing changes in cell structure and mineral deposits helped us see the effectiveness of these treatments. The researchers noted that using MSM alongside BMP-2 significantly boosted the differentiation of MSCs into osteoblasts compared to using either treatment on its own.

Moreover, the findings indicated that the combination treatment elevated the expression of genes related to osteoblast differentiation. This suggests that MSM could play a beneficial role in promoting bone formation when used with BMP-2. However, it is essential to consider that the study's focus on the combination makes it challenging to assess MSM's isolated impact on osteoporosis directly.

Menopause support

Most Useful Review

This is good for osteoporosis and essential during menopause.

Updated: Mar 2026

Arthritis details

MSM improves knee osteoarthritis symptoms

Possibly Effective

Based on 13 Researches

Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006;14:286.

We conducted a randomized, double-blind, placebo-controlled trial exploring the effects of methylsulfonylmethane (MSM) on knee osteoarthritis pain. Fifty adults aged 40 to 76 participated, taking either MSM or a placebo for 12 weeks.

While MSM did show improvements in pain and physical function, there was no significant effect on stiffness or overall symptom scores. This means that while MSM might help with certain aspects of osteoarthritis, the overall benefits and long-term safety need more research.

Significant pain relief

Most Useful Review

88 people found this helpful

I suffer from an undiagnosed condition producing daily musculoskeletal pain. After discovering that higher doses of MSM could provide relief, I began taking up to 16 capsules daily spaced out, which resulted in fantastic pain relief. Research suggests MSM is effective for knee arthritis. Now, I assess my pain level and adjust my MSM intake accordingly. This supplement is benign and very helpful, and I highly recommend it.

Updated: Mar 2026

Autoimmune Disorder details

KCNA2 autoimmunity diverse; immunotherapy beneficial

Arlt FA, Miske R, Machule ML, Broegger Christensen P, Mindorf S, et al. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain Behav Immun. 2024;117:399. doi:10.1016/j.bbi.2024.01.220

We analyzed data from 35 patients with KCNA2 IgG autoantibodies linked to various neuropsychiatric issues, including cognitive impairment and seizures. These autoantibodies were notably present in cerebrospinal fluid in some patients and showed different subclasses in serum.

Notably, four patients saw significant improvement with early immunotherapy, particularly those with autoimmune encephalitis. The findings suggest that KCNA2 autoimmunity is varied, indicating the need for more research to clarify its role and therapeutic approaches.

Reduced pain

Most Useful Review

8 people found this helpful

I endure cartilage tissue degeneration, experiencing severe joint pain from spinal hernias and protrusions. MSM has been tremendously helpful, enabling me to go without a corset, as directed by my doctors. I rarely rely on painkillers anymore, and I highly recommend this natural remedy to those in similar circumstances.

Updated: Mar 2026

Frozen Shoulder details

MSM is a dietary sulphur that is highly effective for joint pain, including shoulders, hips, and knees.

High Cholesterol details

Cartilage health booster

2 people found this helpful

This product is excellent for improving cartilage condition. I purchased it for my 30-year-old husband, who had knee pain due to cartilage issues. He noticed a definite improvement in his joints after taking it. The capsules are tasteless, and though the packaging is ordinary, the quality is remarkable. The presence of noticeable results assures me of its efficacy!

It's very effective for joint pain, but regrettably, I can't continue because of the pimples on my face. I think it's the best nutritional supplement for those who find it suits them well.

Common Cold details

11 people found this helpful

Acne details

I've been taking this with vitamin C and B6. My rough skin has improved remarkably, and I believe the sulphur significantly aids in skin smoothness.

46 people found this helpful

Constipation details

Must have, for probably everyone! My husband was recommended DMSO for his painful joints, which worked but caused bad breath. After some research, we began taking MSM, around 4000 to 6000 mg daily. We have noticed numerous benefits in just two months; my husband's joint pains have almost vanished, and he no longer suffers from IBS or sleep issues. I've seen significant improvements too: my PMS pain is much reduced, and I’ve regulated my gut which had previously experienced constipation. I no longer have chronic fatigue, and respiratory issues like asthma are gone. My overall energy is normal, and I even sleep soundly now. This stuff is quite miraculous, and we've experienced fewer colds too.

Liver Disease details

Promotes liver health

Excellent for maintaining liver health.

I am very satisfied. I continue taking it as it has significantly alleviated my father's knee cartilage pain. While dealing with Trichomonas vaginosis, I took Jarrow femdom dophilus lactobacillus and Candida Support alongside three MSM tablets for two days. All symptoms of Candidiasis related to Trichomonas have vanished. I strive to maintain a steady diet.

Candidiasis details

Diarrhea details