Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Medium or Average
Based on 7 Reviews
6.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
MethylSulfonylMethane (MSM)
1,000 mg
†
Top Medical Research Studies
8
MSM risk behaviors linked to diarrhea
We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
Read More
9.5
Human intestinal spirochetosis linked to MSM
We explored the intriguing link between human intestinal spirochetosis (HIS) and chronic diarrhea, focusing on a group of six men who have sex with men (MSM). This condition significantly affects young MSM, particularly those living with HIV. During our review, we found that five of these six patients experienced diarrhea, which was often linked to their sexual practices, including condomless anal intercourse and oro-anal sex.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Read More
Most Useful Reviews
0
Stopped usage due to
I discontinued using this product because it caused abdominal discomfort and diarrhoea.
Read More
2
Diarrhea stopped
1 people found this helpful
During my first intake, stools passed easily with increased bowel movements—four times by the second day. On the third day, diarrhea started, and by the fourth, I took no more. Although the diarrhea ceased due to anti-diarrheal medication, I experienced stomach pain and fatigue. After taking no more on the fifth day, I felt less tired, but I still faced liver issues and continued diarrhea.
Read More
7.5
Initial diarrhoea experienced
After my initial intake, I experienced diarrhoea. However, as I became accustomed to it, the situation improved. The effects seem to be realised primarily with consistent use.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
Human intestinal spirochetosis linked to MSM
We explored the intriguing link between human intestinal spirochetosis (HIS) and chronic diarrhea, focusing on a group of six men who have sex with men (MSM). This condition significantly affects young MSM, particularly those living with HIV. During our review, we found that five of these six patients experienced diarrhea, which was often linked to their sexual practices, including condomless anal intercourse and oro-anal sex.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Read More
8
MSM risk behaviors linked to diarrhea
We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 7 Reviews
6.2
- All Reviews
- Positive Reviews
- Negative Reviews
0
Stopped usage due to
I discontinued using this product because it caused abdominal discomfort and diarrhoea.
Read More
2
Diarrhea stopped
1 people found this helpful
During my first intake, stools passed easily with increased bowel movements—four times by the second day. On the third day, diarrhea started, and by the fourth, I took no more. Although the diarrhea ceased due to anti-diarrheal medication, I experienced stomach pain and fatigue. After taking no more on the fifth day, I felt less tired, but I still faced liver issues and continued diarrhea.
Read More
7.5
Initial diarrhoea experienced
After my initial intake, I experienced diarrhoea. However, as I became accustomed to it, the situation improved. The effects seem to be realised primarily with consistent use.
Read More
0
Caused severe migraines
This product doesn’t agree with me. After trying several bottles from different brands, I find that even one pill causes severe migraines and diarrhoea.
Read More
4
Frequent bathroom visits
MSM is reputed to benefit joints. However, if I consume a bit too much, I experience swelling and diarrhoea, necessitating frequent visits to the bathroom. After some time, it becomes manageable.
Read More
Frequently Asked Questions
2
Diarrhea stopped
1 people found this helpful
During my first intake, stools passed easily with increased bowel movements—four times by the second day. On the third day, diarrhea started, and by the fourth, I took no more. Although the diarrhea ceased due to anti-diarrheal medication, I experienced stomach pain and fatigue. After taking no more on the fifth day, I felt less tired, but I still faced liver issues and continued diarrhea.
7.5
Initial diarrhoea experienced
After my initial intake, I experienced diarrhoea. However, as I became accustomed to it, the situation improved. The effects seem to be realised primarily with consistent use.
0
Stopped usage due to
I discontinued using this product because it caused abdominal discomfort and diarrhoea.
0
Caused severe migraines
This product doesn’t agree with me. After trying several bottles from different brands, I find that even one pill causes severe migraines and diarrhoea.
4
Adjust dosage advised
This product can help relieve pain, but I sometimes experience diarrhoea. Adjusting the dosage may be necessary for better tolerance.
2
Limited intake due to
I want to eat a lot, but if I overindulge, I get diarrhoea, which leads me to only take two pills daily. This is quite upsetting.
4
Frequent bathroom visits
MSM is reputed to benefit joints. However, if I consume a bit too much, I experience swelling and diarrhoea, necessitating frequent visits to the bathroom. After some time, it becomes manageable.
8
MSM risk behaviors linked to diarrhea
We explored the connections between human intestinal spirochetosis (HIS) and its symptoms, particularly diarrhea, in a group of individuals diagnosed at a tertiary hospital in Madrid. Our focus was on understanding how risky behaviors, especially among men who have sex with men (MSM), impact the prevalence of HIS and associated gastrointestinal issues.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
In our review of 165 patients diagnosed with HIS, we found that most were male, with a significant majority identifying as MSM. Notably, a substantial portion of these individuals reported engaging in chemsex and unprotected oral-anal intercourse. Overall, 81.1% of patients were symptomatic, and diarrhea, notably the most common complaint (68.3%), raised concerns about the link between HIS and severe gastrointestinal distress.
Our analysis revealed that younger patients, particularly those under 41, had a higher likelihood of experiencing symptoms. Despite this, a high percentage (92.7%) had normal colonoscopy results. Interestingly, many patients also had previous or concurrent sexually transmitted diseases, which can complicate the diagnosis and treatment.
We observed that for symptomatic patients who did not have other gastrointestinal infections, treatment with metronidazole or doxycycline led to improvements. This highlights the importance of considering HIS as a potential cause of chronic diarrhea in MSM, especially after ruling out other conditions. Hence, we recommend this treatment approach for those exhibiting symptoms linked to HIS.
9.5
Human intestinal spirochetosis linked to MSM
We explored the intriguing link between human intestinal spirochetosis (HIS) and chronic diarrhea, focusing on a group of six men who have sex with men (MSM). This condition significantly affects young MSM, particularly those living with HIV. During our review, we found that five of these six patients experienced diarrhea, which was often linked to their sexual practices, including condomless anal intercourse and oro-anal sex.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
Importantly, all diagnoses were confirmed through colon biopsies using a special staining technique. Treatment for these patients involved metronidazole for five of them and benzathine penicillin G for one. Remarkably, all patients responded successfully to their treatments.
Overall, our study suggests that HIS should be considered in MSM presenting with ongoing diarrhea, particularly when paired with risky sexual behaviors or concurrent sexually transmitted infections (STIs). This connection indicates that HIS might even be sexually transmitted, underscoring the importance of awareness in this community.
References
- Pérez-Tanoira R, Tamarit MDP, Montaña AMV, Carmena D, Köster P, et al. Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals. Trop Med Infect Dis. 2023;8. doi:10.3390/tropicalmed8050250
- Garcia-Hernandez D, Vall-Mayans M, Coll-Estrada S, Naranjo-Hans L, Armengol P, et al. Human intestinal spirochetosis, a sexually transmissible infection? Review of six cases from two sexually transmitted infection centres in Barcelona. Int J STD AIDS. 2021;32:52. doi:10.1177/0956462420958350
