We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.
Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.
Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
Read More
9
Zinc therapy shows promise for cough
A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy.
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.
The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.
Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.
Read More
8
Zinc in mixed COVID treatment
Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial.
We conducted a rigorous randomized controlled trial to evaluate the effectiveness of an innovative treatment involving a combination of two tablets: one with Aspirin and Promethazine, and another packed with essential micronutrients like vitamin D3, C, B3, zinc, and selenium. Our aim was to determine how this combination affects the symptoms of mild to moderate COVID-19, particularly cough.
Our study included 260 patients and followed a strict methodology, comparing this new treatment to the standard clinical management recommended by the Indian Council of Medical Research. Over a treatment period of 10 days, we observed notable improvements in symptoms, including cough, myalgia, headache, and anosmia, among those who received the APMV2020 treatment alongside standard care.
While zinc was included in the treatment, this study does not isolate its effect on cough specifically since it was part of a comprehensive combination. However, our findings indicated that APMV2020 treatment led to a significant reduction in cough symptoms and inflammatory markers. This positions APMV2020 as a promising candidate for inclusion in COVID-19 management protocols, not only for rapid recovery but also for its potential long-term benefits in reducing complications associated with the virus.
Read More
Most Useful Reviews
9
Effective cough remedy
We have been using it for quite some time, especially during colds; it helps with a cough very effectively.
Read More
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
Read More
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy.
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.
The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.
Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.
Read More
8
Zinc in mixed COVID treatment
Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial.
We conducted a rigorous randomized controlled trial to evaluate the effectiveness of an innovative treatment involving a combination of two tablets: one with Aspirin and Promethazine, and another packed with essential micronutrients like vitamin D3, C, B3, zinc, and selenium. Our aim was to determine how this combination affects the symptoms of mild to moderate COVID-19, particularly cough.
Our study included 260 patients and followed a strict methodology, comparing this new treatment to the standard clinical management recommended by the Indian Council of Medical Research. Over a treatment period of 10 days, we observed notable improvements in symptoms, including cough, myalgia, headache, and anosmia, among those who received the APMV2020 treatment alongside standard care.
While zinc was included in the treatment, this study does not isolate its effect on cough specifically since it was part of a comprehensive combination. However, our findings indicated that APMV2020 treatment led to a significant reduction in cough symptoms and inflammatory markers. This positions APMV2020 as a promising candidate for inclusion in COVID-19 management protocols, not only for rapid recovery but also for its potential long-term benefits in reducing complications associated with the virus.
Read More
2
Zinc acetate ineffective for cough
Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.
We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.
Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.
Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
All Reviews
Positive Reviews
Negative Reviews
9
Effective cough remedy
We have been using it for quite some time, especially during colds; it helps with a cough very effectively.
Read More
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
Read More
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
Read More
8
Helps fight cough
We take it during a cold; it helps to combat runny noses and cough effectively.
Read More
10
Strong preventive
Fine! An excellent form of zinc in an absorbable format and a preventive dosage! If I start to feel ill, I take two. I even give it to children if they begin to cough, and by morning everything is well again! I recommend it!
Coughing is a reflex action that helps clear the airways of mucus, irritants, or foreign particles. It is a natural mechanism the body uses to protect itself and can be triggered by various factors, including infections, allergies, or environmental irritants. There are two main types of coughs: acute coughs, which typically last less than three weeks and often result from a cold or respiratory infection, and chronic coughs, which persist for more than eight weeks and may indicate a more serious underlying condition.
Coughs can also be classified as dry or productive. A dry cough does not produce mucus, while a productive cough does. Treatment options depend on the underlying cause; over-the-counter medications, home remedies, or medical intervention may be recommended based on the severity and duration of the cough. If a cough is persistent, accompanied by other symptoms like fever, shortness of breath, or chest pain, it’s advisable to seek medical advice for a proper diagnosis and treatment plan.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc has garnered attention for its potential role in reducing the duration and severity of colds, which often include symptoms like cough. Some studies suggest that zinc may help by modulating the immune response and reducing inflammation in the throat and respiratory tract. While there are mixed results regarding its efficacy specifically for cough relief, it is commonly found in over-the-counter cold remedies. It’s important to note that more research is needed to confirm these benefits conclusively.
Based on user reviews, the timeframe for observing results when taking this supplement for coughs can vary, but many users report seeing improvement relatively quickly. For instance, one user noted that after doubling or tripling their dosage, they experienced relief within two days of taking the supplement when a cough disrupted their life Read Review. Others mention ongoing use during colds and have found it effective in combatting coughs immediately as symptoms begin to appear Read Review.
Several users highlighted a more preventive approach, wherein regular intake of the supplement led to a noticeable reduction in cough frequency over time Read Review. Reviewers indicated that starting the supplement at the first sign of a cough or cold yielded the best results, suggesting that the best practice is to begin taking it as soon as symptoms arise for quicker outcomes Read Review.
The use of zinc supplements, particularly zinc acetate, in the treatment of cough has garnered mixed results in scientific research. A pilot study focusing on zinc acetate for chronic refractory cough found that while participants did experience increased zinc levels in their serum, the overall benefits on cough symptoms and quality of life were minimal and did not reach clinically meaningful thresholds. This led the researchers to conclude that zinc therapy does not significantly improve cough management compared to a placebo [1].
Additionally, in a recent study exploring the effects of zinc chloride as part of a broader treatment protocol for chronic cough following COVID-19, researchers noted improvements when combined with other therapeutic methods. However, the combination made it difficult to assess the specific contribution of zinc to cough relief [2]. Thus, while zinc may play a role in cough treatment under certain conditions, the direct evidence supporting its efficacy as a standalone remedy remains inconclusive based on current research.
Users have shared positive experiences regarding the improvement of cough symptoms after using this supplement. Many remarked that taking it at the initial signs of a cold or cough led to effective results. For instance, one user noted that their family uses it during colds, particularly emphasizing its efficacy in managing coughs and runny noses Read Review. Another reviewer experienced a cessation of their persistent cough after starting the supplement, highlighting its benefits for their immune system Read Review.
Ongoing use of the supplement has also been reported to lead to fewer health issues overall; some users mentioned a notable decrease in the frequency of both coughs and colds since they began taking it regularly alongside other vitamins Read Review. Multiple reviewers stated that increasing their dosage during times of illness, particularly winter, resulted in faster recovery from coughs Read Review. However, it's important to remember that individual results can vary, and while many found success, a few users did not experience the same positive outcomes Read Review.
Based on user reviews, many individuals have successfully combined this supplement with other vitamins and supplements to enhance its effectiveness in managing cough symptoms. For instance, several users reported positive outcomes when taking it alongside vitamins D and C, noting that such combinations kept coughs at bay and supported overall immune health Read Review. Another user mentioned pairing the supplement with NAC and vitamin C specifically to fight colds and coughs, achieving remarkable results Read Review.
Reviewers also highlighted the importance of adjusting dosages during periods of illness, often increasing their intake to overcome coughs quickly. For example, one user noted that they would double or triple the dosage when a cough disrupted their life, reporting improvements within a couple of days Read Review. While overall experiences were positive, it's important to note that some users with specific conditions, like asthma, did not find the same benefits, indicating variability in results depending on individual health circumstances Read Review.
Users reporting on the right dose of Zinc for treating cough often mention varying dosages, emphasizing their effectiveness when used proactively. For instance, one user takes two capsules when they start feeling unwell, particularly if coughing begins, claiming quick relief by the next morning Read Review. Another user doubles or even triples their dosage when faced with disruptive coughs, experiencing results within two days Read Review. Many users also appreciate taking Zinc regularly, with some opting for a daily single capsule as a preventive measure against illness Read Review.
Overall, users suggest that Zinc works best when doubled or taken alongside vitamins like C and D when the first signs of a cold or cough appear. This strategic upping of the dose seems to facilitate quicker recovery from coughs and colds Read ReviewRead Review. While individual responses can vary, regular intake—often in a dose of one capsule daily—coupled with an increase during cold symptoms appears to be a commonly endorsed approach among users.
7.5
Quick relief dosage
During colds, I don’t take it regularly, but I remember to use it when a cough disrupts my life. I double (or triple) the dosage, and after two days, everything is fine. It works; I just need to encourage my family and myself to take it daily.
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
7.5
Less frequent colds
Good! I have been taking this zinc for almost a year along with vitamin C, D, Omega and group B. I have significantly reduced the number of colds, previously suffering each month. If I felt slightly unwell, I would immediately develop a cough, a runny nose, or a temperature. Now, I can manage the onset of a cold swiftly, and I catch colds less often.
8
Helps fight cough
We take it during a cold; it helps to combat runny noses and cough effectively.
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
7.5
Family usage for cough
Excellent! This zinc is amazing. My entire family takes it, especially in winter when illnesses circulate. We increase our intake for coughs and other ailments.
2
Not suitable treatment
1 people found this helpful
Below average I gave two stars before the trial, and hopefully, if I see a good result, I will adjust my feedback afterwards. Unfortunately, it did not suit me. I have asthma. I took it one day, missed the next, following instructions, but noticed that on the days I took it, the cough persisted. Perhaps it may suit me better in the future, and I should not depend on others. Like, please, may God bless you from His vast grace.
9
No cough experience
Excellent! I take it with vitamins D and C, and I haven't had a cough.
7.5
Strong against cough
A very good formula, quite strong. I take it with NAC and vitamin C to fight colds and cough. This combination works wonders!
10
Strong preventive
Fine! An excellent form of zinc in an absorbable format and a preventive dosage! If I start to feel ill, I take two. I even give it to children if they begin to cough, and by morning everything is well again! I recommend it!
9
Coughing stopped
This supplement comes in convenient packaging, the capsules are small and easy to swallow. I take one daily, and it truly helped me; I stopped coughing (I likely have a zinc and copper deficiency).
7.5
Family remedy
It helps a lot with colds. When coughing, my whole family and I take it.
7.5
Supports cough relief
Zinc supports immune function and has an excellent effect on hair beauty. It notably helps with coughs.
2
Zinc acetate ineffective for cough
Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial.
We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.
Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.
Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
9
Zinc therapy shows promise for cough
A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy.
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.
The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.
Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.
References
Balasubramanian A, Holbrook JT, Canning BJ, Que LG, Castro M, et al. Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial. ERJ Open Res. 2023;9. doi:10.1183/23120541.00678-2022
Nishi K, Yoshimoto S, Tanaka T, Kimura S, Shinchi Y, et al. A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy. Cureus. 2023;15:e33421. doi:10.7759/cureus.33421
Kumar GS, Vadgaonkar A, Purunaik S, Shelatkar R, Vaidya VG, et al. Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial. Cureus. 2022;14:e25467. doi:10.7759/cureus.25467