Overview

SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%

Top Medical Research Studies

We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
Read More
9
Zinc therapy shows promise for cough
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.

The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.

Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.
Read More
8
Zinc in mixed COVID treatment
We conducted a rigorous randomized controlled trial to evaluate the effectiveness of an innovative treatment involving a combination of two tablets: one with Aspirin and Promethazine, and another packed with essential micronutrients like vitamin D3, C, B3, zinc, and selenium. Our aim was to determine how this combination affects the symptoms of mild to moderate COVID-19, particularly cough.

Our study included 260 patients and followed a strict methodology, comparing this new treatment to the standard clinical management recommended by the Indian Council of Medical Research. Over a treatment period of 10 days, we observed notable improvements in symptoms, including cough, myalgia, headache, and anosmia, among those who received the APMV2020 treatment alongside standard care.

While zinc was included in the treatment, this study does not isolate its effect on cough specifically since it was part of a comprehensive combination. However, our findings indicated that APMV2020 treatment led to a significant reduction in cough symptoms and inflammatory markers. This positions APMV2020 as a promising candidate for inclusion in COVID-19 management protocols, not only for rapid recovery but also for its potential long-term benefits in reducing complications associated with the virus.
Read More

Most Useful Reviews

9
Effective cough remedy
We have been using it for quite some time, especially during colds; it helps with a cough very effectively.
Read More
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
Read More
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 3 Researches
6.3
  • All Researches
9
Zinc therapy shows promise for cough
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.

The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.

Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.
Read More
8
Zinc in mixed COVID treatment
We conducted a rigorous randomized controlled trial to evaluate the effectiveness of an innovative treatment involving a combination of two tablets: one with Aspirin and Promethazine, and another packed with essential micronutrients like vitamin D3, C, B3, zinc, and selenium. Our aim was to determine how this combination affects the symptoms of mild to moderate COVID-19, particularly cough.

Our study included 260 patients and followed a strict methodology, comparing this new treatment to the standard clinical management recommended by the Indian Council of Medical Research. Over a treatment period of 10 days, we observed notable improvements in symptoms, including cough, myalgia, headache, and anosmia, among those who received the APMV2020 treatment alongside standard care.

While zinc was included in the treatment, this study does not isolate its effect on cough specifically since it was part of a comprehensive combination. However, our findings indicated that APMV2020 treatment led to a significant reduction in cough symptoms and inflammatory markers. This positions APMV2020 as a promising candidate for inclusion in COVID-19 management protocols, not only for rapid recovery but also for its potential long-term benefits in reducing complications associated with the virus.
Read More
We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 18 Reviews
7.9
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Effective cough remedy
We have been using it for quite some time, especially during colds; it helps with a cough very effectively.
Read More
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
Read More
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
Read More
8
Helps fight cough
We take it during a cold; it helps to combat runny noses and cough effectively.
Read More
10
Strong preventive
Fine! An excellent form of zinc in an absorbable format and a preventive dosage! If I start to feel ill, I take two. I even give it to children if they begin to cough, and by morning everything is well again! I recommend it!
Read More

Frequently Asked Questions

7.5
Quick relief dosage
During colds, I don’t take it regularly, but I remember to use it when a cough disrupts my life. I double (or triple) the dosage, and after two days, everything is fine. It works; I just need to encourage my family and myself to take it daily.
9
Effective for cough
Excellent for use with the first symptoms of cold and cough.
7.5
Less frequent colds
Good! I have been taking this zinc for almost a year along with vitamin C, D, Omega and group B. I have significantly reduced the number of colds, previously suffering each month. If I felt slightly unwell, I would immediately develop a cough, a runny nose, or a temperature. Now, I can manage the onset of a cold swiftly, and I catch colds less often.
8
Helps fight cough
We take it during a cold; it helps to combat runny noses and cough effectively.
9
Effective cough solution
I recommend it for the immune system. I noticed a cough throughout the month. When I took it, the cough ceased. It worked well.
7.5
Family usage for cough
Excellent! This zinc is amazing. My entire family takes it, especially in winter when illnesses circulate. We increase our intake for coughs and other ailments.
2
Not suitable treatment
1 people found this helpful
Below average I gave two stars before the trial, and hopefully, if I see a good result, I will adjust my feedback afterwards. Unfortunately, it did not suit me. I have asthma. I took it one day, missed the next, following instructions, but noticed that on the days I took it, the cough persisted. Perhaps it may suit me better in the future, and I should not depend on others. Like, please, may God bless you from His vast grace.
9
No cough experience
Excellent! I take it with vitamins D and C, and I haven't had a cough.
7.5
Strong against cough
A very good formula, quite strong. I take it with NAC and vitamin C to fight colds and cough. This combination works wonders!
10
Strong preventive
Fine! An excellent form of zinc in an absorbable format and a preventive dosage! If I start to feel ill, I take two. I even give it to children if they begin to cough, and by morning everything is well again! I recommend it!
9
Coughing stopped
This supplement comes in convenient packaging, the capsules are small and easy to swallow. I take one daily, and it truly helped me; I stopped coughing (I likely have a zinc and copper deficiency).
7.5
Family remedy
It helps a lot with colds. When coughing, my whole family and I take it.
7.5
Supports cough relief
Zinc supports immune function and has an excellent effect on hair beauty. It notably helps with coughs.
We conducted a pilot trial to explore the effectiveness of zinc acetate in treating chronic refractory cough, a condition that causes significant discomfort for many people. In this study, we compared zinc acetate against a placebo over a period of six weeks, with the aim of measuring improvements in quality of life and cough symptoms using several established questionnaires.

Our group included 34 participants who were primarily white females suffering from moderate to severe cough. Throughout the trial, we noted that those taking zinc acetate did experience a rise in serum zinc levels, which indicates that the treatment was effective in that regard. However, when assessing the overall impact on cough symptoms and quality of life, both the zinc and placebo groups showed improvements, but those improvements were minimal.

Importantly, the treatment effects observed did not reach the clinically meaningful thresholds that would suggest zinc acetate significantly benefits cough management. Therefore, we concluded that there is no substantial advantage to using zinc therapy over placebo for people dealing with chronic cough, and suggest that larger trials are unnecessary at this time.
9
Zinc therapy shows promise for cough
We explored the effectiveness of Epipharyngeal Abrasive Therapy (EAT) in addressing chronic cough, particularly in the context of Long COVID. This treatment, prevalent in Japan, uses zinc chloride to reduce inflammation in the epipharyngeal mucosa. We followed a 21-year-old man whose chronic cough persisted for four months after a mild COVID-19 infection. Upon diagnosis, we identified chronic epipharyngitis as the culprit behind his ongoing cough.

The EAT involved weekly treatments for three months. We observed that this therapy not only cleared residual SARS-CoV-2 spike RNA from the epipharyngeal mucosa but also led to a decrease in inflammation and proinflammatory cytokines. While the application of zinc chloride was a significant part of the treatment, it was combined with other elements of EAT, making it challenging to isolate zinc's specific impact on cough relief.

Overall, we found that EAT could be a promising avenue for individuals suffering from chronic cough related to Long COVID, highlighting an innovative way to utilize zinc in managing this persistent symptom.

References

  1. Balasubramanian A, Holbrook JT, Canning BJ, Que LG, Castro M, et al. Efficacy and tolerability of zinc acetate for treatment of chronic refractory cough: pilot randomised futility trial. ERJ Open Res. 2023;9. doi:10.1183/23120541.00678-2022
  2. Nishi K, Yoshimoto S, Tanaka T, Kimura S, Shinchi Y, et al. A Potential Novel Treatment for Chronic Cough in Long COVID Patients: Clearance of Epipharyngeal Residual SARS-CoV-2 Spike RNA by Epipharyngeal Abrasive Therapy. Cureus. 2023;15:e33421. doi:10.7759/cureus.33421
  3. Kumar GS, Vadgaonkar A, Purunaik S, Shelatkar R, Vaidya VG, et al. Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial. Cureus. 2022;14:e25467. doi:10.7759/cureus.25467
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