Last update
3/22/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%
Top Medical Research Studies
8
The study focused on understanding how dietary copper affects physiological issues tied to reduced levels of peptidylglycine alpha-amidating monooxygenase (PAM), especially regarding hypothyroidism.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
Read More
7
Zinc's uncertain role in hypothyroidism
We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
Read More
Most Useful Reviews
9
Affordable quality
This high-quality zinc and copper supplement is affordable. It’s the perfect option for managing hypothyroidism. Easy to take, with no taste or odour, I trust Jarrow Formulas and have consistently been satisfied with their products.
Read More
9
Essential supplement
The value for money is excellent! Zinc is crucial for my hypothyroidism, and I can’t recommend it highly enough.
Read More
9
Mineral synergy
I recommend this zinc and copper complex! It’s essential for my hypothyroidism. This high-quality supplement, along with selenium, magnesium, and vitamin D, has improved my tests and overall immunity. The capsules are easy to swallow.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
The study focused on understanding how dietary copper affects physiological issues tied to reduced levels of peptidylglycine alpha-amidating monooxygenase (PAM), especially regarding hypothyroidism.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
Read More
7
Zinc's uncertain role in hypothyroidism
We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Affordable quality
This high-quality zinc and copper supplement is affordable. It’s the perfect option for managing hypothyroidism. Easy to take, with no taste or odour, I trust Jarrow Formulas and have consistently been satisfied with their products.
Read More
9
Essential supplement
The value for money is excellent! Zinc is crucial for my hypothyroidism, and I can’t recommend it highly enough.
Read More
9
Mineral synergy
I recommend this zinc and copper complex! It’s essential for my hypothyroidism. This high-quality supplement, along with selenium, magnesium, and vitamin D, has improved my tests and overall immunity. The capsules are easy to swallow.
Read More
9
Energy restoration
An excellent supplement! Prescribed for my hypothyroidism and to improve thyroid function, I'm noticing heightened vitality and a significant lift in my spirits after a month of use.
Read More
7.5
Effective formulation
This zinc and copper combination is fantastic. It’s suitable for long-term use as part of my treatment for hypothyroidism.
Read More
Frequently Asked Questions
9
Energy restoration
An excellent supplement! Prescribed for my hypothyroidism and to improve thyroid function, I'm noticing heightened vitality and a significant lift in my spirits after a month of use.
9
Mineral synergy
I recommend this zinc and copper complex! It’s essential for my hypothyroidism. This high-quality supplement, along with selenium, magnesium, and vitamin D, has improved my tests and overall immunity. The capsules are easy to swallow.
7.5
Recommended dosage
1 people found this helpful
I take one capsule daily after meals, as prescribed by my endocrinologist for my hypothyroidism. The dosage is effective and beneficial.
7
Zinc's uncertain role in hypothyroidism
We conducted a study to investigate the effects of micronutrient supplementation, including zinc, on thyroid function and overall quality of life in patients with hypothyroidism. Our trial involved 104 participants who were receiving levothyroxine and vitamin D. They were randomly assigned to either a group that received a mix of essential nutrients or a placebo group over eight weeks.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
We measured various health markers before and after this period, including thyroid hormone levels, cholesterol, insulin resistance, and blood pressure. Our findings suggested that the group receiving the micronutrient supplement experienced improvements in insulin resistance and overall quality of life. However, it’s important to note that the specific effects of zinc alone are somewhat difficult to isolate, as it was part of a combination of nutrients being tested.
Ultimately, while the study indicates potential benefits of micronutrient supplementation for thyroid function in hypothyroid patients, further trials are necessary to clearly define the role of zinc and other nutrients in this context.
8
The study focused on understanding how dietary copper affects physiological issues tied to reduced levels of peptidylglycine alpha-amidating monooxygenase (PAM), especially regarding hypothyroidism.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
We evaluated the impact of PAM deficiencies in mice and found that those with reduced PAM levels struggled with thyroid regulation and body temperature, particularly when they were hypothyroid due to dietary restrictions. Interestingly, while these mice showed normal hormone response to cold, they couldn't maintain their body temperature effectively as compared to their healthy counterparts in colder environments.
However, when we introduced additional dietary copper, these PAM-deficient mice were able to stabilize their body temperature just as effectively as the normal mice. It appeared that copper supplementation helped restore some of the physiological functions that were impaired by low PAM levels.
Overall, our findings indicate that low dietary copper might exacerbate the challenges faced by those with PAM deficiencies, suggesting that copper intake could be an important factor in managing related hypothyroidism symptoms.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, et al. Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology. 2009;150:1739. 10.1210/en.2008-1202
Data last updated:
