Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc L-Methionine Sulfate)
15 mg
136%
Copper (as Gluconate)
1 mg
111%
Top Medical Research Studies
9.5
We evaluated the effectiveness of a nitric-zinc complex solution (NZCS) for treating palmoplantar and periungual warts in children. Over a series of sessions, we found that 83.9% of warts completely resolved, with 87.5% success in periungual cases. The treatment was painless and easy, requiring only biweekly applications.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Read More
9.5
We explored the use of a novel nitric-zinc complex (NZC) solution for treating external ano-genital warts, a common issue caused by the human papillomavirus. In this study, 100 patients underwent up to four treatments, showing a remarkable 92% cure rate after the sessions. The findings also indicated that patients with fewer warts achieved better results. While relapses occurred in some cases, most tolerated the treatment well. This study suggests that earlier diagnosis and treatment lead to a more favorable outcome against these warts.
Read More
9
Zinc treatment comparable to cryotherapy
We analyzed how effective a zinc-based solution (Nitrizinc® Complex) is compared to cryotherapy in treating anogenital warts. In our study, 120 participants received either treatment and were monitored for up to four sessions.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Read More
Most Useful Reviews
9
Plantars warts healed
These vitamins effectively helped me eliminate plantar warts without medical intervention. Now, my 6-year-old daughter has developed two warts, but after giving her the vitamins, I noticed they started to heal within a week. It feels miraculous! While I cannot guarantee similar results for others, I'm relieved we can avoid KVD sessions.
Read More
9
Significant wart removal
I believe this is the best zinc to take on an empty stomach. It successfully eliminated my husband's large plantar wart.
Read More
7.5
Warts decreased effectively
I had never considered zinc until I transitioned to a keto diet. I realised I could have been healthier and less ill. While I'm uncertain about the zinc and copper mix, its effects alongside vitamins C and D have greatly benefited my immunity; my warts are disappearing. Acne has resolved too, and I believe zinc supplements are worth noting. This element plays crucial roles in various bodily functions, including the production of digestive enzymes and boosting testosterone.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
We evaluated the effectiveness of a nitric-zinc complex solution (NZCS) for treating palmoplantar and periungual warts in children. Over a series of sessions, we found that 83.9% of warts completely resolved, with 87.5% success in periungual cases. The treatment was painless and easy, requiring only biweekly applications.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Additionally, the results were esthetically pleasing, with no significant side effects reported. This study highlights NZCS as a promising option for wart management in pediatric patients, making it easier for both children and their guardians.
Read More
9.5
We explored the use of a novel nitric-zinc complex (NZC) solution for treating external ano-genital warts, a common issue caused by the human papillomavirus. In this study, 100 patients underwent up to four treatments, showing a remarkable 92% cure rate after the sessions. The findings also indicated that patients with fewer warts achieved better results. While relapses occurred in some cases, most tolerated the treatment well. This study suggests that earlier diagnosis and treatment lead to a more favorable outcome against these warts.
Read More
9
Zinc treatment comparable to cryotherapy
We analyzed how effective a zinc-based solution (Nitrizinc® Complex) is compared to cryotherapy in treating anogenital warts. In our study, 120 participants received either treatment and were monitored for up to four sessions.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Our findings indicated that the zinc solution was as effective as cryotherapy for smaller warts and was generally more tolerable. Participants experienced a lower recurrence rate, making Nitrizinc a promising alternative to traditional cryotherapy for managing these warts.
Read More
9
We explored the effectiveness of a nitric-zinc complex solution (NZCS) in treating hard-to-handle warts caused by HPV. In a multicenter study involving 14 Italian dermatologists, 83 out of 106 responses reported using NZCS. Impressively, 84.1% of patients saw significant improvement with this treatment, much higher than the 44.8% success rate observed with past therapies. Not only did NZCS demonstrate superior efficacy, but it also provided better tolerability compared to previously used treatment methods.
Read More
8
We explored various intralesional treatments for plantar warts by analyzing 26 studies published between January 2012 and January 2021. Among the treatments assessed, zinc sulfate showed a decent median cure rate of 70%.
However, while it was better than some options, it didn't outperform intralesional vitamin D3, which had an impressive 80% cure rate. Overall, treatments like bleomycin and Candida antigen also showed effectiveness, but vitamin D3 stands as a promising first-line choice.
This study suggests ongoing consideration of different approaches for those struggling with stubborn plantar warts.
However, while it was better than some options, it didn't outperform intralesional vitamin D3, which had an impressive 80% cure rate. Overall, treatments like bleomycin and Candida antigen also showed effectiveness, but vitamin D3 stands as a promising first-line choice.
This study suggests ongoing consideration of different approaches for those struggling with stubborn plantar warts.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Plantars warts healed
These vitamins effectively helped me eliminate plantar warts without medical intervention. Now, my 6-year-old daughter has developed two warts, but after giving her the vitamins, I noticed they started to heal within a week. It feels miraculous! While I cannot guarantee similar results for others, I'm relieved we can avoid KVD sessions.
Read More
9
Significant wart removal
I believe this is the best zinc to take on an empty stomach. It successfully eliminated my husband's large plantar wart.
Read More
7.5
Warts decreased effectively
I had never considered zinc until I transitioned to a keto diet. I realised I could have been healthier and less ill. While I'm uncertain about the zinc and copper mix, its effects alongside vitamins C and D have greatly benefited my immunity; my warts are disappearing. Acne has resolved too, and I believe zinc supplements are worth noting. This element plays crucial roles in various bodily functions, including the production of digestive enzymes and boosting testosterone.
Read More
6
Wart reduction noted
8 people found this helpful
Super Dosage Zinc with an ideal copper ratio (15mg per 1mg) was taken with my husband for a month. I found that I became ill with the flu less frequently and when I did, it was for shorter durations. Notably, my wart has diminished in size. It is unfortunate we have stopped taking it as the jar is empty; perhaps my grey hair would have improved further. I intend to order more.
Read More
7.5
Warts avoided completely
This has been of great assistance in preventing warts from forming on my toes.
Read More
Frequently Asked Questions
9
Plantars warts healed
These vitamins effectively helped me eliminate plantar warts without medical intervention. Now, my 6-year-old daughter has developed two warts, but after giving her the vitamins, I noticed they started to heal within a week. It feels miraculous! While I cannot guarantee similar results for others, I'm relieved we can avoid KVD sessions.
6
Wart reduction noted
8 people found this helpful
Super Dosage Zinc with an ideal copper ratio (15mg per 1mg) was taken with my husband for a month. I found that I became ill with the flu less frequently and when I did, it was for shorter durations. Notably, my wart has diminished in size. It is unfortunate we have stopped taking it as the jar is empty; perhaps my grey hair would have improved further. I intend to order more.
7.5
Warts decreased effectively
I had never considered zinc until I transitioned to a keto diet. I realised I could have been healthier and less ill. While I'm uncertain about the zinc and copper mix, its effects alongside vitamins C and D have greatly benefited my immunity; my warts are disappearing. Acne has resolved too, and I believe zinc supplements are worth noting. This element plays crucial roles in various bodily functions, including the production of digestive enzymes and boosting testosterone.
7
We explored a new treatment approach for plantar warts using a nitric-zinc complex solution. In this study involving 72 patients, we aimed to observe how effective this solution is in achieving complete healing of warts.
The results were promising, showing a 59.2% cure rate after treatments. On average, patients received about 5.9 applications of the solution over a duration of around 9.4 weeks. Additionally, the recurrence rate was relatively low, noted at 6.7%.
Although we can’t isolate the specific contributions of zinc alone since it was part of a combined treatment with nitric acid, these findings suggest that the nitric-zinc complex could serve as a viable option for those suffering from plantar warts. This treatment may be considered among the first-line options for managing this common skin condition.
The results were promising, showing a 59.2% cure rate after treatments. On average, patients received about 5.9 applications of the solution over a duration of around 9.4 weeks. Additionally, the recurrence rate was relatively low, noted at 6.7%.
Although we can’t isolate the specific contributions of zinc alone since it was part of a combined treatment with nitric acid, these findings suggest that the nitric-zinc complex could serve as a viable option for those suffering from plantar warts. This treatment may be considered among the first-line options for managing this common skin condition.
7
Zinc treatment shows limited effect
We examined the effectiveness of a new treatment called nitric-zinc complex solution (NZCS) compared to the traditional cryotherapy for plantar warts. In our controlled study with 62 participants, we found that while cryotherapy had a cure rate of 65.5%, NZCS had a slightly lower rate of 56.6%.
Patients needed fewer treatment sessions with cryotherapy, averaging 3.6 sessions, versus 4.8 for those treated with NZCS. Despite its lower effectiveness, NZCS could still be considered a viable treatment option for those with plantar warts.
Patients needed fewer treatment sessions with cryotherapy, averaging 3.6 sessions, versus 4.8 for those treated with NZCS. Despite its lower effectiveness, NZCS could still be considered a viable treatment option for those with plantar warts.
4
We examined the effectiveness of intralesional zinc sulfate compared to intralesional Candida antigen in treating cutaneous warts. In a controlled trial with 105 patients, those treated with Candida antigen showed a remarkable 94.3% clearance rate, while zinc sulfate yielded only 74.2%. This indicates that while zinc treatment is an option, it isn't as successful as the Candida antigen approach. Ultimately, this study suggests that zinc isn't the most effective choice for wart treatment.
8
We conducted a randomized clinical trial to assess how effective intralesional zinc sulfate is in treating plantar warts, compared to vitamin D3 and saline. In total, 105 patients were enrolled and divided into three groups for a series of four treatment sessions.
At the study's conclusion, we found that 71.4% of patients given zinc sulfate saw a complete response, outperforming 62.9% in the vitamin D3 group and 40% in the saline group.
However, the treatment with zinc was associated with severe pain during injections in nearly half the patients. Despite its effectiveness, we have to consider this discomfort when evaluating treatment options.
At the study's conclusion, we found that 71.4% of patients given zinc sulfate saw a complete response, outperforming 62.9% in the vitamin D3 group and 40% in the saline group.
However, the treatment with zinc was associated with severe pain during injections in nearly half the patients. Despite its effectiveness, we have to consider this discomfort when evaluating treatment options.
References
- Rayo Pérez AM, Juárez Jiménez JM, Rayo Rosado R, García de la Peña R. The Effectiveness of Topical Treatment for Plantar Warts: A Retrospective Cohort Study. Infect Dis Rep. 2024;16:1108. 10.3390/idr16060090
- Garcia-Oreja S, Alvaro-Afonso FJ, Vigara-Aranda P, Paramio-Rodriguez G, Leon-Herce D, et al. Treatment of Plantar Warts with a Nitric-Zinc Complex Solution: A Review of 72 Cases. Viruses. 2024;16. 10.3390/v16081307
- García-Oreja S, Álvaro-Afonso FJ, García-Madrid M, López-Moral M, García-Álvarez Y, et al. Cryotherapy versus topical nitric-zinc complex solution for the treatment of plantar warts: A randomized controlled trial. J Med Virol. 2023;95:e29212. 10.1002/jmv.29212
- Youssef EMK, Eissa MAA, Bakr RM. Intralesional Candida albicans antigen versus intralesional zinc sulfate in treatment of cutaneous warts. Arch Dermatol Res. 2023;315:1305. 10.1007/s00403-022-02499-w
- Martin A, Thatiparthi A, Nourmohammadi N, Nguyen C, Sung C, et al. Emerging Intralesional Treatments for Plantar Warts: A Systematic Review. J Drugs Dermatol. 2022;21:1322. 10.36849/JDD.6735
- Awad A, Ismael AF, Sallam M, Abdelgaber S. Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation. J Cosmet Dermatol. 2022;21:4637. 10.1111/jocd.14876
- Song D, Pan L, Zhang M, Wang S. Clinical use of zinc in viral warts: a systematic review of the clinical trials. J Dermatolog Treat. 2022;33:1878. 10.1080/09546634.2021.1942420
- Pontini P, Mastorino L, Gaspari V, Granger C, Ramoni S, et al. A Multicentre, Randomised Clinical Trial to Compare a Topical Nitrizinc Complex Solution Versus Cryotherapy for the Treatment of Anogenital Warts. Dermatol Ther (Heidelb). 2020;10:1063. 10.1007/s13555-020-00430-7
- Nofal A, Albalat W, Ismail A, Khattab FM. Immunotherapeutic modalities for the treatment of recalcitrant plantar warts: a comparative study. J Dermatolog Treat. 2022;33:922. 10.1080/09546634.2020.1789540
- El Sayed MH, Sayed FS, Afify AA. Intralesional zinc sulfate 2% vs intralesional vitamin D in plantar warts: A clinicodermoscopic study. Dermatol Ther. 2020;33:e13308. 10.1111/dth.13308
- Songsantiphap C, Asawanonda P. Topical 15% Zinc Oxide Ointment Significantly Reduces the Size of Common Warts After Four Weeks: A Randomized, Triple-blinded, Placebo-controlled Trial. J Clin Aesthet Dermatol. 2019;12:26.
- Giacaman A, Granger C, Aladren S, Bauzá A, Alomar Torrens B, et al. Use of Topical Nitric-Zinc Complex Solution to Treat Palmoplantar and Periungual Warts in a Pediatric Population. Dermatol Ther (Heidelb). 2019;9:755. 10.1007/s13555-019-00330-5
- Abd El-Magid WM, Nada EEA, Mossa RA. Intralesional injection of vitamin D3 versus zinc sulfate 2% in treatment of plantar warts: a comparative study. J Dermatolog Treat. 2021;32:355. 10.1080/09546634.2019.1656326
- Ciccarese G, Drago F, Granger C, Parodi A. Efficacy Assessment of a Topically Applied Nitric-Zinc Complex Solution for the Treatment of External Ano-genital Warts in 100 Patients. Dermatol Ther (Heidelb). 2019;9:327. 10.1007/s13555-019-0300-7
- Puviani M, Manfredini M, Eisendle K. The SILVER study. Efficacy of topical nitric-zinc complex solution in the treatment of resistant warts: A postmarketing evaluation. Dermatol Ther. 2019;32:e12940. 10.1111/dth.12940
- El Taweel AA, Salem R, Allam A. Intralesional 2% zinc sulfate solution for plane warts: A case report. Dermatol Ther. 2019;32:e12761. 10.1111/dth.12761
