' 
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Red Yeast Rice (Monascus purpureus)
1,200 mg
†
Coenzyme Q10 (Ubiquinone)
100 mg
†
Top Medical Research Studies
9
CoQ10 enhances cognitive function
Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause.
Directly addresses menopause cognition
We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
Read More
8
Coenzyme Q10 shows mixed efficacy
Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants.
Limited isolation of coenzyme Q10 effects
We explored the impact of coenzyme Q10 in a study aimed at managing dry eye disease in menopausal women undergoing antidepressant treatment. This was a thorough investigation involving sixty female participants with an average age of 63.25 years. In a double-blind, single-center setup, we compared eye drops containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E against a more traditional carmellose sodium formulation.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
Read More
4
Menopause, HRT, coenzyme Q10 study
Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants.
Limited isolated effect observed
We investigated how menopause and hormone replacement therapy (HRT) affect levels of coenzyme Q10 and other important antioxidants in women's bodies. Our study involved 50 premenopausal women, 33 healthy postmenopausal women, and 15 postmenopausal women undergoing HRT. We meticulously measured serum levels of coenzyme Q10, alpha-tocopherol, gamma-tocopherol, beta-carotene, and lycopene using high-pressure liquid chromatography.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Read More
Most Useful Reviews
8.8
LDH normalised
I don't consume alcohol but suspect familial hypercholesterolemia. After menopause, my LDH levels rose despite taking omega-3s and liver-supportive supplements. I had little expectation when trying this product, but after a blood test, my LDH was normal for the first time in over 10 years. There were no significant changes in my diet, and this was the only supplement I used since the last test. I'm curious if the red yeast rice or Q10 contributed to this result. I plan to continue using it and see what the next test shows.
Read More
8.8
LDL cholesterol reduction
Taking this to lower LDL cholesterol is recommended, particularly for women in menopause experiencing sudden increases in levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7
- All Researches
9
CoQ10 enhances cognitive function
Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause.
Directly addresses menopause cognition
We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.
We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.
Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.
Read More
8
Coenzyme Q10 shows mixed efficacy
Efficacy of 0.1% crosslinked hyaluronic acid, coenzyme Q10 and vitamin E in the management of dry eye disease in menopause patients receiving antidepressants.
Limited isolation of coenzyme Q10 effects
We explored the impact of coenzyme Q10 in a study aimed at managing dry eye disease in menopausal women undergoing antidepressant treatment. This was a thorough investigation involving sixty female participants with an average age of 63.25 years. In a double-blind, single-center setup, we compared eye drops containing crosslinked hyaluronic acid, coenzyme Q10, and vitamin E against a more traditional carmellose sodium formulation.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
After two months of treatment, we discovered that the coenzyme Q10 formulation, while demonstrating positive trends, could not be isolated from other ingredients in terms of effects specifically related to menopausal symptoms. The scores from the ocular surface disease index indicated favorable results for both formulations, but we didn’t find significant advantages that could confidently highlight the standalone benefits of coenzyme Q10.
While we observed improvements in tear stability and subjective dry eye symptoms with the lower total daily dose of crosslinked hyaluronic acid eye drops, we need to acknowledge that it remains challenging to draw conclusive benefits specifically associated with coenzyme Q10 in the context of menopause.
Read More
4
Menopause, HRT, coenzyme Q10 study
Effects of menopause and hormone replacement therapy on serum levels of coenzyme Q10 and other lipid-soluble antioxidants.
Limited isolated effect observed
We investigated how menopause and hormone replacement therapy (HRT) affect levels of coenzyme Q10 and other important antioxidants in women's bodies. Our study involved 50 premenopausal women, 33 healthy postmenopausal women, and 15 postmenopausal women undergoing HRT. We meticulously measured serum levels of coenzyme Q10, alpha-tocopherol, gamma-tocopherol, beta-carotene, and lycopene using high-pressure liquid chromatography.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Our findings revealed that postmenopausal women had higher levels of coenzyme Q10 and alpha-tocopherol compared to their premenopausal counterparts. However, interestingly, those on HRT experienced a significant drop in coenzyme Q10 and gamma-tocopherol, although their alpha-tocopherol levels increased. We also noted that beta-carotene, lycopene, and various lipid profiles were comparable across the groups, suggesting no significant impact from these treatments in those areas.
It appears that coenzyme Q10 could play a vital role in heart health due to its antioxidant properties and its function within the mitochondria. The decrease in coenzyme Q10 in women taking HRT raises concerns about potential increases in cardiovascular risk during menopause. Given these insights, further studies are needed to thoroughly explore the implications of HRT on antioxidant levels and cardiovascular health in postmenopausal women.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
LDH normalised
I don't consume alcohol but suspect familial hypercholesterolemia. After menopause, my LDH levels rose despite taking omega-3s and liver-supportive supplements. I had little expectation when trying this product, but after a blood test, my LDH was normal for the first time in over 10 years. There were no significant changes in my diet, and this was the only supplement I used since the last test. I'm curious if the red yeast rice or Q10 contributed to this result. I plan to continue using it and see what the next test shows.
Read More
8.8
LDL cholesterol reduction
Taking this to lower LDL cholesterol is recommended, particularly for women in menopause experiencing sudden increases in levels.
