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Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
The product is found useful for the following medical conditions
Allergies details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 9 Reviews
8.9
8
Vitamin D deficiency linked to allergies
Does vitamin D deficiency predispose to allergic proctocolitis?
Most Relevant Research
We investigated the potential connection between vitamin D deficiency and allergic proctocolitis (AP) in infants. Our study involved a careful comparison of vitamin D levels in infants diagnosed with AP against those of healthy infants. This meticulous, prospective approach allows us to draw insightful conclusions about how vitamin D might be influencing allergic conditions.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
We found that vitamin D levels were noticeably lower in infants suffering from AP compared to their healthy peers. Notably, a significant percentage of AP patients—34.7%—were found to be vitamin D deficient or insufficient. Furthermore, the study revealed that infants with vitamin D levels below 40.75 mcg/L were 3.5 times more likely to develop AP.
Our findings suggest an intriguing association between vitamin D deficiency and allergic proctocolitis, hinting that the rising rates of such allergies may be influenced by environmental factors. It appears crucial that we assess vitamin D levels in infants diagnosed with AP, as this could contribute to better understanding and management of the condition.
9.5
No allergies experienced
Most Useful Review
I consistently take this vitamin D, and I find the cost and quality to be optimal! There hasn’t been any intolerance, unlike other, cheaper supplements that caused allergies. My doctor recommended 2000 units, and I take this supplement every other day.
Bone Pain details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.7
USERS' SCORE
Good
Based on 10 Reviews
8.8
9
Vitamin D3 correction improves pain
Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty.
Most Relevant Research
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9.5
Improved bone density
Most Useful Review
D3 supports bone health and aids sleep. For four months, I've taken two D3 soft gels daily, totalling 10,000 I.U. My doctor initially prescribed only 2,000 I.U. to address low levels, but I found the results to be remarkable. I had chronic pain in my left knee for years, yet my bone density seems to be repairing, and inflammation has vanished. With added chiropractic adjustments about a month apart, I find I am healing without medication or surgery. I believe many doctors underestimate the required D3 dosage for treating bone loss.
Brain Tumor details
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.8
8
Vitamin D treatment shows promise
Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells.
Most Relevant Research
We investigated the effects of vitamin D, specifically its active form calcitriol, on glioblastoma, the most common type of primary brain cancer in adults. With very limited treatment options and a grim prognosis, glioblastoma poses a serious challenge due to its ability to develop resistance to therapies and acquire stem-like properties that fuel its growth.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
In our study, we treated glioblastoma stem-like cells in the lab with calcitriol and discovered some promising results. Among the more than 40 cell cultures we examined, approximately half showed sensitivity to the treatment. Notably, for a quarter of these cell lines, the response was classified as particularly strong.
We found that the effectiveness of calcitriol in reducing tumor growth and blocking stem-like traits could be linked to specific genetic variations in the vitamin D receptor. Importantly, the high responders displayed characteristics indicating reduced potential for both stemness and migration, which are key factors in tumor aggressiveness.
10
Migraine relief
Most Useful Review
I've suffered from migraines for over two decades, since my youth, to the extent that doctors suspected a brain tumour, leading to an MRI and spinal tap. A suggestion to try vitamin D initially met with scepticism from me, but after considerable persuasion, I gave it a shot. Remarkably, I have not experienced a migraine in TWO MONTHS. This is absolutely unprecedented for me. I am continually anticipating its return, yet it has not happened. It's an absolute life changer! I take 1,000 IU in the morning and 1,000 IU at night, though consulting your doctor for your specific needs is advisable. I'm incredibly thankful for this product!
Back Pain details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.7
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Vitamin D aids back pain recovery
An Unusual Mimic of Axial Spondyloarthritis: A Case Report.
Most Relevant Research
We observed a fascinating case involving a male in his 40s who experienced persistent inflammatory back pain for three months. Despite having a negative test for HLA-B27, a marker often associated with axial spondyloarthritis, clinical assessments suggested possible underlying issues.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
The clinical investigation led to an MRI, which confirmed bilateral symmetrical sacroiliitis. Interestingly, further tests showed he had very low vitamin D levels along with elevated parathyroid hormone—indicating a possible deficiency impacting his condition.
After starting treatment with vitamin D alongside nonsteroidal anti-inflammatory drugs (NSAIDs), he experienced notable relief from his symptoms. His condition improved significantly, and follow-up tests indicated that his vitamin D levels had normalized.
This case demonstrates the potential benefits of vitamin D in managing back pain, especially when classical markers are inconclusive. It highlights how a thorough diagnosis can reveal interconnected health issues and improve treatment outcomes.
9.5
Relieved back pain
Most Useful Review
One of the best capsules I have purchased; it greatly alleviated my back pain. The olive oil included helps with the absorption of Vitamin D, making it excellent quality. The pills are small and easy to swallow.
Chronic Fatigue Syndrome details
SCIENTIFIC SCORE
Questionable
Based on 3 Researches
5.8
USERS' SCORE
Good
Based on 5 Reviews
8.7
0
Vitamin D3 ineffective for CFS relief
Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome--a randomised controlled trial.
Most Relevant Research
We conducted a study to see if high-dose vitamin D3 could improve vascular health and reduce fatigue in individuals suffering from chronic fatigue syndrome (CFS). This was a well-structured trial involving 50 participants, all of whom met specific diagnostic criteria for CFS. Participants were divided into two groups: one received 100,000 units of vitamin D3 every two months, while the other received a placebo over a period of six months.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
Despite a noticeable increase of 22 nmol/L in vitamin D levels for those who received the treatment compared to the placebo group, we found no significant benefits. There was no change in arterial stiffness, a key vascular health indicator, nor improvements in overall fatigue as measured by the Piper Fatigue scale.
In essence, our findings indicate that high-dose oral vitamin D3 does not offer the hoped-for relief in vascular function or fatigue for patients with chronic fatigue syndrome. This suggests that other therapeutic options may need to be explored for individuals suffering from this condition.
8.8
Fatigue improvement
Most Useful Review
I received my order and started taking Vitamin D as I have a deficiency, despite living in the south. After two weeks, I noticed improvements; my fatigue has diminished and my sleep has improved significantly. I would recommend it to my friends and others.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Vitamin D supports depression management
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Most Relevant Research
We conducted a double-blind, randomized, placebo-controlled trial to explore how cholecalciferol, a form of vitamin D, influences depressive symptoms in individuals suffering from type 2 diabetes mellitus (T2DM). This clinical study lasted for 12 weeks and involved participants who were either given a daily dose of 4000 IU of cholecalciferol or a placebo.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
Throughout the study, we measured various factors, including the participants’ depression levels using the Beck Depression Inventory-II, as well as important biological markers like C-peptide, serotonin, and neurotrophin-3.
Our findings showed a significant reduction in depression scores among those taking cholecalciferol compared to the placebo group. Additionally, we observed a notable increase in C-peptide levels, which may indicate some metabolic benefits, although no significant changes were found in serotonin and neurotrophin-3 levels.
Ultimately, while cholecalciferol appears to alleviate mild to moderate depressive symptoms in T2DM patients through improved C-peptide levels, its impact on serotonin and neurotrophin-3 remains unclear. This highlights vitamin D as a potentially helpful option for managing depression alongside diabetes.
9.5
Energy boost
Most Useful Review
This supplement invigorates and significantly improves my mood! I experience heightened energy, a stable mood, and no autumn depression. It's more effective than D3 tablets for me!
Headache details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
8
Vitamin D reduces headache risk
New evidence that vitamin D prevents headache: a bidirectional two-sample Mendelian randomization analysis.
Most Relevant Research
We explored the potential connection between vitamin D levels and headaches through a thorough investigation using two-sample Mendelian randomization analysis. Our goal was to determine if there’s a causal relationship between high vitamin D levels and the risk of experiencing headaches.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
Our findings revealed that higher levels of vitamin D are linked to a lower risk of headaches. Specifically, we found that vitamin D may have a preventive effect, reducing the likelihood of headaches occurring. However, we also observed that there is no evidence to suggest that headaches cause changes in vitamin D levels.
This means while supplementing vitamin D may help keep headaches at bay, headaches themselves do not appear to affect vitamin D levels. This information contributes valuable insights into how maintaining sufficient vitamin D could play a role in headache management.
9.5
No more headaches
Most Useful Review
Good composition, fast delivery, and high-quality packaging. The capsules are a tad large but easy to swallow and taste citrusy. I've taken one daily for ten days, along with other supplements. I’ve noticed significant benefits; headaches have ceased, fatigue has reduced, and my mood has improved greatly. I highly recommend it for those interested in sports, fitness, or dieting, as omega-3 energises and replenishes the body effectively.
Leg Cramps details
SCIENTIFIC SCORE
Very Likely Ineffective
Based on 2 Researches
2
USERS' SCORE
Good
Based on 3 Reviews
8.7
4
We assessed the impact of vitamin D on leg cramps experienced during pregnancy, referring to data from various studies. One of the key findings was that vitamin D treatment showed little to no difference when it came to reducing the frequency of leg cramps.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
In a trial involving 84 women, participants who received vitamin D did not see significant changes in the frequency of leg cramps after three weeks or six weeks post-treatment. This suggests that, while vitamin D is often discussed in the context of health benefits, its effectiveness for leg cramps specifically might be quite limited.
Overall, the evidence we reviewed highlights the need for caution. The findings suggest that vitamin D may not be a viable treatment option for managing leg cramps during pregnancy, indicating a need for more robust research in this area.
9.5
Pain relief
Most Useful Review
My love! I adore vitamin D and take 5000ME regularly. It guarantees a state of cheer. At 60, I work mainly on my feet, and since I started taking vitamin D, the pain and heaviness in my legs have disappeared. I'm feeling great!
Osteoporosis details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.7
8
Vitamin D's impact on osteoporosis
The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis.
Most Relevant Research
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
9.5
Enhances bodily functions
Most Useful Review
Very important supplement at a reasonable price. People increasingly understand the importance of vitamin D, and my doctor states it enhances many bodily functions. I believe these supplements are becoming essential for those with osteoporosis.
Psoriasis details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
8
Vitamin D3 ethosomal gel for psoriasis
Synthesis of vitamin D3 loaded ethosomes gel to cure chronic immune-mediated inflammatory skin disease: physical characterization, in vitro and ex vivo studies.
Most Relevant Research
We explored the development of ethosomal gels infused with vitamin D3 to target psoriasis, a chronic skin condition driven by immune responses. Vitamin D3 has long been recognized for its vital role in skin health, particularly in promoting the growth and maturation of skin cells known as keratinocytes.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
Our research focused on creating a formulation that combines vitamin D3 with soya lecithin, propylene glycol, and ethanol. Through a series of tests, we assessed the size, shape, and encapsulation efficiency of the ethosomes, finding an impressive encapsulation rate of 96.25%.
The optimized ethosomes measured between 148 and 657 nanometers, with a manageable level of aggregation. We confirmed the formulation's safety and stability over six months, making it suitable for patient use. Additionally, our study demonstrated that this delivery system enabled effective permeation of the drug through membrane barriers.
As we delved into the physical characteristics and effectiveness of these gels, we observed that they could provide a novel and practical option for psoriasis sufferers seeking topical treatments.
9
Improved immunity
Most Useful Review
In general, the role of vitamin D in the body is significant. Vitamin D is essential for everyone, especially since sunlight alone does not prevent deficiency. It is swiftly excreted and involved in various metabolic processes. Vitamin D helps strengthen the immune system, aiding in the fight against Covid-19 and reducing the likelihood of autoimmune diseases. I believe it has contributed to my psoriasis improvement.
Anemia details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin D may reduce anemia risk
Serum Vitamin D Levels and Risk of Iron Deficiency Anemia in Adults: A Cross-Sectional Study and Mendelian Randomization Analysis.
Most Relevant Research
Our investigation centered on whether vitamin D levels play a significant role in iron deficiency anemia (IDA). We examined data from the National Health and Nutrition Examination Survey, which included over 3,700 participants, to explore the relationship between vitamin D and IDA.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
Our findings indicated that higher levels of serum vitamin D are linked to a lower risk of developing IDA. Specifically, those in the highest quartile of vitamin D levels had a significantly reduced risk compared to those in the lowest quartile. Interestingly, this protective effect appeared to be more pronounced in women.
We also found a non-linear relationship, suggesting that the effects of vitamin D on anemia become more complex at different levels. This was further supported by a Mendelian randomization analysis, which provided genetic evidence for a causal connection between vitamin D and IDA.
Overall, our results suggest that adequate vitamin D levels could be important for preventing anemia, especially among women. However, further research is certainly needed to confirm these findings and to investigate the potential for vitamin D treatment in managing IDA directly.
9.5
Improved health
Most Useful Review
Jarrow Formulas vitamin D3 has been a lifesaver for me. After my third child, I felt extremely unwell, experiencing cramps and paleness due to anemia. My doctor advised D3, and after three weeks, I noticed significant improvements—no more leg pain, a healthier complexion, and better energy levels. I take it with breakfast and dinner, and it absorbs well alongside fatty foods. The tablets are of excellent quality, and while the taste is unremarkable, the results speak for themselves.
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
High-dose vitamin D reduces anxiety
Effects of an 8-week high-dose vitamin D supplementation on fatigue and neuropsychiatric manifestations in post-COVID syndrome: A randomized controlled trial.
Most Relevant Research
We conducted a study to understand how high-dose vitamin D supplementation might impact anxiety levels, particularly in patients experiencing post-COVID symptoms. In our double-blind, randomized controlled trial, we enrolled 80 individuals dealing with fatigue or neuropsychiatric issues after COVID-19.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
Participants were split into two groups: one received a weekly dose of 60,000 IU of vitamin D, while the other group received a placebo. Over eight weeks, we evaluated various outcomes, including anxiety levels using the Depression, Anxiety, and Stress Scale (DASS-21).
The results were encouraging for the vitamin D group. We observed significant improvements in anxiety levels, with a notable reduction reported by participants. However, other measures related to sleep quality, depression, cognitive function, and inflammatory markers did not show similar significant changes.
Importantly, we found that the vitamin D group reported no serious adverse effects, indicating that this supplementation is generally safe. These findings suggest that high-dose vitamin D may offer substantial benefits for anxiety relief in patients recovering from COVID-19, albeit with limited effects on other symptoms.
9.5
Reduced anxiety
Most Useful Review
I trust the Jarrow brand and was satisfied with their vitamin D, which I take with my family at breakfast. Coupled with K2, we have fallen ill less often, and my feelings of anxiety have diminished. This product has truly benefited our health, and I highly recommend it.
Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.6
8
Vitamin D aids rheumatoid arthritis
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Most Relevant Research
We explored how vitamin D plays a role in managing rheumatoid arthritis (RA), a condition that causes joint inflammation and discomfort. It's been found that many people with RA often suffer from vitamin D deficiency, which may worsen their symptoms and overall disease severity.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
Our review indicates that vitamin D could help modulate immune responses and lower inflammation levels. Supplementing with vitamin D has shown potential in improving various disease activity markers, signaling that it could be a valuable addition to treatment strategies for RA.
Besides vitamin D, we also looked at other important vitamins like B12, C, and K. While vitamin D stands out for its immune benefits, B12 supports energy and neurological health, C helps with collagen production and inflammation reduction, and K contributes to bone health.
Together, these vitamins create a comprehensive approach to managing RA, emphasizing the need for further research to determine the best ways to use them effectively.
8.3
High-quality relief
Most Useful Review
During this challenging year due to COVID-19, I started taking vitamin D on my rheumatologist's advice. It works well against my rheumatoid arthritis and prevents colds and viruses. Having used other brands, I find Jarrow's quality outstanding. The delivery to Kazakhstan is also good, and everything is well packaged.
Bloating details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin D3 may reduce bloating
Calcium vitamin D3 supplementation in clinical practice: side effect and satisfaction.
Most Relevant Research
We aimed to assess how the supplement OsteoCalVitFort, which includes 500 mg of calcium and 400 I.U. of vitamin D3, affects bloating and overall satisfaction among users. In our study, 186 participants aged between 18 and 65 were invited to take two tablets daily—one after breakfast and one after dinner—over a period defined by the contents of a single pack.
After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.
With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.
After the supplement use, we discovered that symptoms like bloating and constipation showed a remarkable decline. Specifically, the reported cases of bloating decreased from 12.5% to just 0.6%. Similarly, occurrences of constipation dropped significantly, evidencing that the supplement not only supports bone health but also alleviates some common digestive concerns.
With a fantastic 94% satisfaction rate among users, it seems that OsteoCalVitFort stands out as a favorable option for those looking to enhance their calcium and vitamin D intake without experiencing the side effects often associated with similar supplements. Overall, this study gives us encouraging insights into the positive effects of vitamin D in reducing bloating.
9.5
No bloating
Most Useful Review
This is a fantastic product that my family loves. I truly appreciate this shop as it meets all my needs – I never expected to find everything in one place. My digestion has improved significantly, with no bloating or constipation since I started drinking this. The packaging is excellent, and the product's quality and taste are superb. I'll definitely buy again from this comprehensive shop with fast shipping.
Breast Cancer details
SCIENTIFIC SCORE
Questionable
Based on 16 Researches
6.3
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D and breast cancer link
Umbrella Review on the Relationship Between Vitamin D Intake and Cancer.
Most Relevant Research
We examined the relationship between vitamin D intake and breast cancer, delving into how this vitamin may play a role in prevention and management. The findings suggest that vitamin D may have a protective effect, potentially lowering the risk of developing breast cancer.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
While we found a notable connection, it’s important to recognize that most of the existing evidence comes from observational studies. This means we can identify associations but cannot definitively say that vitamin D causes these effects.
Additionally, there are several complexities in studying vitamin D, such as varying metabolism and differences in study designs, which make drawing firm conclusions challenging.
Although the research provides intriguing insights, more rigorous studies are necessary to truly clarify how vitamin D could be integrated into breast cancer care moving forward.
8.8
Immune function support
Most Useful Review
I prefer Jarrow Vitamin D3 for its effects on immune function, significantly enhancing my wellbeing. It's also suggested that maintaining vitamin D sufficiency may reduce the long-term risk of developing breast cancer and certain infections, including COVID-19.
Constipation details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
No constipation noted
Most Useful Review
I truly love this shop; it's a one-stop shop that has everything I need. I never thought I would find a place with all my requirements available. iHerb is superb, and I will certainly buy from this complete shop again! The shipment was incredibly fast, and my digestion improved greatly. There was no bloating or constipation after I started drinking this. I also appreciate the superb packaging and the quality of the product. The taste is delightful as well.
Frozen Shoulder details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Pain relief achieved
Most Useful Review
Using Vitamin D initially made me feel lethargic and fatigued for no apparent reason. Thankfully, all the pain in my joints and shoulders, particularly with my frozen shoulder, has vanished.
Influenza details
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.8
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D reduces influenza risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the link between vitamin D supplementation and its effectiveness in preventing influenza. In our analysis, we reviewed ten randomized controlled trials, which included a total of 4,859 participants. This rigorous investigation was thorough, pulling data from trusted sources such as PubMed, Cochrane Library, and Embase.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
Our findings showed that vitamin D supplementation was associated with a significant reduction in the risk of influenza infections. Specifically, we noted a 22% decrease in risk, with our calculations presenting a risk ratio of 0.78. Notably, there was little variability in outcomes among the included studies, suggesting that the results were quite consistent.
Additionally, our research indicated no signs of publication bias, adding credibility to our findings. This suggests that incorporating vitamin D supplementation into preventive strategies for influenza could be beneficial. Overall, vitamin D stands out as a promising option for reducing the risk of influenza infections, reinforcing the idea that it plays a crucial role in bolstering our immune defenses.
9.5
Maintains immunity
Most Useful Review
The dosage serves a prophylactic purpose; we take it during periods of ARVI and influenza to support our immunity.
Menopause details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.9
USERS' SCORE
Good
Based on 4 Reviews
8.6
8
Vitamin D supports bone health
Correlation between serum vitamin D levels and bone mass density evaluated by radiofrequency echographic multi-spectrometry technology (REMS) in menopausal women.
Most Relevant Research
We aimed to uncover the relationship between vitamin D levels and bone mineral density (BMD) in menopausal women, a group particularly vulnerable to osteoporosis due to hormonal changes. To achieve this, we conducted a thorough study involving 32 participants, all of whom were menopausal women without a history of hormone replacement therapy or vitamin D supplementation.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
Throughout our research, we measured the participants' serum vitamin D levels and evaluated their bone density using a technique called radiofrequency echographic multi-spectrometry (REMS). Our findings revealed a significant positive correlation between vitamin D levels and BMD—indicating that higher vitamin D levels were associated with better bone density.
This suggests that maintaining adequate vitamin D levels might be crucial for preserving bone health during menopause. Given the particular vulnerability of this demographic to osteoporosis, our study underscores the importance of monitoring and potentially supplementing vitamin D to support bone health in menopausal women.
Overall, we believe our findings contribute to the conversation around menopause management by highlighting the role of vitamin D in promoting healthier bones, and we suggest that REMS could serve as a valuable tool in assessing these changes in postmenopausal women.
9.5
Bone health support
Most Useful Review
This vitamin D3 is best absorbed in this form. It lowers the risk of cardiovascular diseases, osteoporosis, and assists with nutrient absorption during menopause. A deficiency hampers the body's ability to combat viruses and infections. It's crucial to take the right dose based on analysis.
Multiple Sclerosis details
SCIENTIFIC SCORE
Questionable
Based on 14 Researches
5.9
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
Vitamin D linked to MS activity
Vitamin D affects the risk of disease activity in multiple sclerosis.
Most Relevant Research
We explored how vitamin D (VitD) levels relate to the activity of multiple sclerosis (MS) in patients about to start treatment. By measuring serum levels of a specific form of VitD in 230 untreated individuals with relapsing-remitting MS, we aimed to see if higher VitD could reduce disease activity over the subsequent two years.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
Our findings revealed that lower VitD levels were linked to a greater likelihood of disease activity, specifically noting that patients with VitD levels below 20 ng/mL faced more than double the risk of experiencing such activity. Interestingly, we found that genetic factors also played a role; those with a genetic predisposition to higher VitD levels were more likely to have a delayed onset of MS and a better chance of maintaining a status known as No-Evidence of Disease Activity-3 (NEDA-3).
Through further analysis using Mendelian randomization, we confirmed that there is a causal relationship between VitD levels and disease activity in MS. This research highlights the potential benefits of monitoring and possibly supplementing VitD for patients, prompting a greater interest in lifestyle changes that could help manage the disease.
8.8
Vitamin D findings
Most Useful Review
I researched the link between D3 and multiple sclerosis and found a preliminary study contrasting high versus low daily doses. Those on 1000 IU of D3 experienced remarkably better outcomes, with nearly absent symptoms after a year. Although this study involved only 20 participants, it suggests that for those of us with MS, lesser doses may be more beneficial. I've now switched from 2000 IU to 1000 IU daily.
Sleep Apnea details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.6
7
Vitamin D's role in sleep apnea
Sleepiness and Vitamin D Levels in Patients with Obstructive Sleep Apnea.
Most Relevant Research
We aimed to explore the connection between Vitamin D levels and excessive daytime sleepiness in patients diagnosed with obstructive sleep apnea (OSA). In this study, we analyzed serum Vitamin D levels in a group of newly diagnosed OSA patients, dividing them into two categories: those who experienced excessive daytime sleepiness (EDS) and those who did not.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
Our findings indicated that patients with EDS had significantly lower levels of Vitamin D compared to their non-somnolent counterparts. The study showed that lower Vitamin D levels correlated with higher apnea-hypopnea indices (AHI) and lower oxyhemoglobin saturation during sleep. This suggests that sleep-related hypoxia may impact Vitamin D status and contribute to sleepiness.
Moreover, our analysis indicated that lower Vitamin D levels were independent predictors of EDS. This further emphasizes the potential role of Vitamin D in managing sleep quality for these patients. In summary, our study highlights an important association between Vitamin D levels and daytime sleepiness in people with sleep apnea, suggesting that improving Vitamin D status could be beneficial for managing EDS in these individuals.
9.5
Psoriasis improvement
Most Useful Review
I realised I was vitamin D deficient for some time. I've also been suffering from psoriasis and psoriatic arthritis for years. I started taking vitamin D during an insomnia episode, requiring one pill daily for a week. The psoriasis on my scalp has nearly disappeared, and I haven’t needed the topical steroids I relied on for five days. I also haven’t needed ibuprofen for my arthritis. If you’re vitamin D deficient and suffer from psoriasis, I recommend trying this.
Alzheimer details
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.4
USERS' SCORE
Good
Based on 1 Review
8.6
8
Vitamin D may aid Alzheimer treatment
Vitamin D Reduces GABA-Positive Astrocytes in the 5xFAD Mouse Model of Alzheimer's Disease.
Most Relevant Research
We aimed to understand how vitamin D influences the progression of Alzheimer’s disease (AD) by examining its effects on the brain. Our study involved male 5xFAD mice that underwent various dietary regimes and received vitamin D injections. This allowed us to investigate both vitamin D deficiency and supplementation in relation to AD symptoms.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
Through careful analysis of brain tissue, we looked for changes in amyloid-β (Aβ) plaques and the presence of reactive astrocytes—important cells that interact with neurons in the brain. Our findings demonstrated a noteworthy association between vitamin D levels and reductions in harmful Aβ pathways and reactive astrogliosis.
This is significant since it suggests that maintaining adequate vitamin D levels might be a promising strategy for preventing or treating Alzheimer’s disease. Overall, our study provides crucial insights into how vitamin D could potentially alter the course of AD, opening the door for new therapeutic approaches.
9.5
Supports Alzheimer's treatment
Most Useful Review
Jarrow is our trusted source for supplements. My wife takes this daily, as she has alzheimer's disease and suffers from vitamin D deficiency, which may influence its progression. A chiropractor recommended Jarrow when we sought a calcium supplement, and their BoneUp formulation reversed my wife's osteopenia.
Migraine details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.6
9
Vitamin D helps reduce migraines
Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies.
Most Relevant Research
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
10
Remarkable migraine improvement
Most Useful Review
I have had migraines for over twenty years, and after trying Vitamin D on a whim, I have not experienced a migraine in two months. This is unprecedented for me. I take 1,000 IU in the morning and another in the evening, and it has been life-changing. I encourage others to consult their doctor for the right dosage.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 10 Reviews
8.5
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Most Relevant Research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
8.8
Significant improvement
Most Useful Review
The quality is superb, as recommended by my doctor for health. I’m very pleased with its effects and look forward to ordering more.
Cancer details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 8 Reviews
8.5
5
Vitamin D's role in breast disease
Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study.
Most Relevant Research
We conducted an observational study to examine the levels of vitamin D in female patients with benign and malignant breast diseases. The research aimed to determine if there is a significant difference in vitamin D levels between those with non-cancerous conditions and those diagnosed with breast cancer.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
During the study, we analyzed adult female patients admitted to a surgical department. Importantly, we excluded those who had taken vitamin D supplements recently or who had prior vitamin D deficiencies. By measuring serum vitamin D levels through a specific testing method, we were able to gather meaningful data about their relationship to breast health.
Our findings indicated a notable difference in average vitamin D levels when comparing the two groups. This suggests that inadequate vitamin D could be linked to an increased risk of developing breast cancer. Therefore, we explored the potential benefits of vitamin D supplementation as a preventive measure against breast cancer—though we acknowledge that larger and more controlled studies are essential to draw firm conclusions.
At the same time, we recognize that vitamin D has effects beyond bone health, and it is crucial to consider these broader impacts when discussing its role in cancer risk.
9.5
Cancer cell inhibition
Most Useful Review
Vitamin D supports cell growth, restores immunity, and inhibits the growth of cancer cells, making it essential for overall health.
Hives details
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
9.5
Vitamin D may alleviate chronic hives
Vitamin D treatment for chronic urticaria: a case report.
Most Relevant Research
We explored the intriguing connection between vitamin D and chronic hives, also known as chronic urticaria. This condition involves recurring itchy welts that can be quite frustrating, especially when the triggers are often elusive. In this case, we observed a 14-year-old boy suffering from persistent hives that weren’t responding to conventional treatments. Thankfully, during his medical evaluation, we discovered he had a vitamin D deficiency.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
The boy underwent high-dose vitamin D replenishment, which led to a remarkable and swift improvement in his symptoms. This incident raises an important question about the potential role of vitamin D in both the development and treatment of chronic urticaria. While there’s some evidence suggesting a linked relationship, measuring vitamin D levels and providing supplementation aren’t standard practices in diagnosing or treating this condition yet.
Although our findings indicate that vitamin D might help some patients, we remain cautious about recommending routine screening for vitamin D deficiency in those with chronic urticaria. More research is needed to determine how cost-effective such screenings would be for this condition. Overall, this case sheds light on the possibility that vitamin D could play a significant role in managing chronic hives for certain individuals.
8.8
No hives experienced
Most Useful Review
I take various brands of vitamin D, and I like this one. It does not cause hives for me, and the dosage is ideal for my area.
Kidney Stones details
SCIENTIFIC SCORE
Questionable
Based on 6 Researches
5.5
USERS' SCORE
Good
Based on 1 Review
8.5
4
Vitamin D's limited effect on kidney stones
Effect of two vitamin D repletion protocols on 24-h urine calcium in patients with recurrent calcium kidney stones and vitamin D deficiency: a randomized clinical trial.
Most Relevant Research
We conducted a clinical trial to explore how different vitamin D treatment protocols affect kidney stones in patients who frequently experience them and have low vitamin D levels. We involved 62 participants, all with serum vitamin D levels between 10 to 20 ng/ml, and split them into two groups: one received 2000 IU of oral vitamin D daily for 12 weeks, while the other took 50,000 IU weekly for 8 weeks.
Our results showed that both treatment approaches led to a significant increase in 24-hour urine calcium. However, we observed no notable difference between the two therapies regarding this measure. Importantly, while there was an increase in 24-hour urine calcium, neither treatment affected the supersaturation levels of calcium oxalate or calcium phosphate, which are critical in the formation of kidney stones.
We also noted a significant rise in serum 25-hydroxyvitamin D levels, with the weekly regimen showing a greater increase. Alongside these changes, parathyroid hormone levels decreased in both groups. Ultimately, while vitamin D supplementation did elevate urine calcium levels, it did not enhance supersaturation factors that contribute to kidney stone formation, indicating that the benefits of vitamin D in this context may be limited.
Our results showed that both treatment approaches led to a significant increase in 24-hour urine calcium. However, we observed no notable difference between the two therapies regarding this measure. Importantly, while there was an increase in 24-hour urine calcium, neither treatment affected the supersaturation levels of calcium oxalate or calcium phosphate, which are critical in the formation of kidney stones.
We also noted a significant rise in serum 25-hydroxyvitamin D levels, with the weekly regimen showing a greater increase. Alongside these changes, parathyroid hormone levels decreased in both groups. Ultimately, while vitamin D supplementation did elevate urine calcium levels, it did not enhance supersaturation factors that contribute to kidney stone formation, indicating that the benefits of vitamin D in this context may be limited.
9
Improved well-being
Most Useful Review
This brand suited me better than others. I replaced the originally used 5000 ME with 2500 ME to prevent vitamin D deficiency, living in a very northern latitude. I noticed an improvement in my well-being with the Jarrow brand, especially initially. My sensitive kidneys have not hurt either. I did not experience the same benefits from other brands, and my kidneys had previously ached, possibly due to kidney stones.
Liver Disease details
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin D improves liver health
Effects of vitamin D supplementation on the glycaemic indices, lipid profile and liver function tests in patients with cirrhosis: a double-blind randomised controlled trial.
Most Relevant Research
We explored the effects of vitamin D supplementation in patients with liver cirrhosis—a progressive disease that often manifests alongside vitamin D deficiency. In a carefully designed study, we involved sixty patients who participated in a double-blind, randomized controlled trial. Each patient received either a weekly dose of 50,000 IU of vitamin D or a placebo over 12 weeks.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
Throughout the study, we assessed key health markers before and after supplementation, including liver function tests, lipid profiles, and glycaemic indices such as fasting blood glucose and insulin resistance. By the end of the trial, our findings indicated that vitamin D supplementation significantly improved fasting blood glucose levels and insulin resistance in the participants.
Specifically, we observed noteworthy increases in serum 25-hydroxy-vitamin D levels and reductions in fasting blood glucose and insulin resistance indicators. These results suggest that vitamin D might be an important player in improving metabolic health for those suffering from liver cirrhosis.
8.8
Reduced illness severity
Most Useful Review
Since beginning vitamin D supplementation, my levels improved significantly from 18 to 59. Although I'm unsure if this is rapid, I’ve noticed a reduction in aches and colds, which I often experienced with low levels. Recent discussions highlight the link between vitamin D levels and the severity of liver disease related to COVID-19; higher levels may correlate with milder disease. Stay healthy.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
6.5
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin D and nausea in gastroparesis
Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity.
Most Relevant Research
We delved into an intriguing question: how do low vitamin D levels affect nausea in people experiencing gastroparesis, a condition that slows gastric emptying? By measuring the vitamin D levels of patients from the Gastroparesis Clinical Consortium Registry, we aimed to uncover the relationships between vitamin D, nausea, and gastric function.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
Our findings revealed that over half of the patients had low vitamin D levels, specifically 56.1% of the 513 individuals studied. We observed a clear association between these low levels of vitamin D and increased experiences of nausea and vomiting. This was particularly notable in patients with delayed gastric emptying, where those with low vitamin D levels reported significantly more nausea.
While the study showed a correlation, it did not address whether supplementing with vitamin D could directly alleviate these symptoms. Instead, we found that lower vitamin D levels also related to a greater retention of food in the stomach after meals, which hints at a connection to gastric neuromuscular dysfunction. Overall, our study emphasized a noteworthy link between vitamin D and nausea but stopped short of confirming any direct treatment benefits.
8.8
No nausea experienced
Most Useful Review
Good quality. Vit D3 derived from extra virgin olive oil. I experienced no nausea. I have vitamin D deficiency and am taking 5000 IU as per my doctor's recommendation. The packaging is secure and it has helped enhance my immunity.
Vertigo details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.5
9
Vitamin D reduces vertigo recurrence
Vitamin D supplementation in preventing the recurrence of benign paroxysmal positional vertigo.
Most Relevant Research
We conducted a study to see how vitamin D affects the recurrence of benign paroxysmal positional vertigo (BPPV), a condition that can cause sudden bouts of dizziness. Our research was carefully designed as a randomized controlled trial, involving two groups: one received vitamin D supplements, while the other was given a placebo. We specifically focused on patients with low vitamin D levels, as previous evidence suggested they might benefit the most from supplementation.
Over the course of a year, the group receiving vitamin D supplements, at a dosage of 7000 IU weekly, showed significantly better results compared to the placebo group. At the six-month and one-year mark, the participants who took vitamin D not only had raised their vitamin D levels but also experienced fewer episodes of vertigo. The statistics revealed a marked decrease in recurrence rates for those taking vitamin D supplements, highlighting its potential role in preventing this frustrating condition.
In conclusion, our findings suggest that vitamin D supplementation could be an effective strategy for those prone to repetitive BPPV episodes, particularly if their initial vitamin D levels were on the low side.
Over the course of a year, the group receiving vitamin D supplements, at a dosage of 7000 IU weekly, showed significantly better results compared to the placebo group. At the six-month and one-year mark, the participants who took vitamin D not only had raised their vitamin D levels but also experienced fewer episodes of vertigo. The statistics revealed a marked decrease in recurrence rates for those taking vitamin D supplements, highlighting its potential role in preventing this frustrating condition.
In conclusion, our findings suggest that vitamin D supplementation could be an effective strategy for those prone to repetitive BPPV episodes, particularly if their initial vitamin D levels were on the low side.
8.8
Aids vertigo issues
Most Useful Review
Good D3, great quality and brand. It helps with my D3 deficiency, particularly when I experience vertigo.
Bronchitis details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin D links to bronchiolitis severity
The Relationship between Bronchiolitis Severity and Vitamin D Status.
Most Relevant Research
We explored the connection between vitamin D levels and the severity of acute bronchiolitis in infants, a condition primarily triggered by viral infections in children under the age of two. Our study involved 182 children with bronchiolitis, focusing on assessing disease severity using the Modified Tal Scoring System while also evaluating their serum vitamin D levels.
Our findings revealed that a significant number of infants, about 47.8%, had low vitamin D levels, indicating either deficiency or insufficiency. We observed that infants with lower vitamin D were more likely to experience severe cases of bronchiolitis. Additionally, those who required admission to the intensive care unit had an even higher frequency of vitamin D deficiencies.
This research suggests a strong link between vitamin D deficiency and severe bronchiolitis, emphasizing that checking vitamin D levels prior to the bronchiolitis season and providing adequate supplementation could potentially offer protective benefits for young children against this illness.
Our findings revealed that a significant number of infants, about 47.8%, had low vitamin D levels, indicating either deficiency or insufficiency. We observed that infants with lower vitamin D were more likely to experience severe cases of bronchiolitis. Additionally, those who required admission to the intensive care unit had an even higher frequency of vitamin D deficiencies.
This research suggests a strong link between vitamin D deficiency and severe bronchiolitis, emphasizing that checking vitamin D levels prior to the bronchiolitis season and providing adequate supplementation could potentially offer protective benefits for young children against this illness.
8.8
Never ill anymore
Most Useful Review
I’ve suffered from hay fever since childhood, enduring a month of sneezing each late spring. After experiencing acute bronchitis in January 2017, I realised I couldn't let that happen again. The NP prescribed me strong antibiotics, and while I recovered, I began taking this product soon after. Since then, I haven’t caught a cold or flu and don’t get flu shots. It’s July 2021, and I attribute my good health to this.
Flu details
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
8
Vitamin D reduces flu risk
Association Between Vitamin D and Influenza: Meta-Analysis and Systematic Review of Randomized Controlled Trials.
Most Relevant Research
We explored the potential benefits of vitamin D supplementation for reducing the risk of influenza infections. Through a comprehensive analysis of multiple Randomized Controlled Trials (RCTs), we aimed to clarify whether taking vitamin D can help prevent the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
Our investigation identified 10 relevant trials that included a total of 4,859 participants. These studies varied in their dosages and duration of vitamin D use, allowing us to assess overall effectiveness across different populations.
The findings were encouraging: our analysis demonstrated that vitamin D supplementation appears to significantly reduce the risk of getting influenza, suggesting that those who increase their vitamin D intake might be better protected during flu season.
Importantly, we did not find significant differences between the studies that could affect our result, and there was no hint of publication bias. Consequently, we can confidently suggest that including vitamin D in our health strategies could enhance our defenses against the flu.
8.8
No more hay fever
Most Useful Review
I have suffered from hay fever since childhood during late spring/early summer, but since taking these capsules, I no longer suffer. In January 2017, I had acute bronchitis after a flu episode and was near death. Since then, I've taken this product regularly and haven't been ill with a cold or flu since; I also don't get flu shots. Just ensure to take MK7 K2 alongside to avoid calcification of arteries.
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 10 Reviews
8.4
8
Vitamin D reduces cold severity
Influence of Vitamin D Supplementation by Simulated Sunlight or Oral D3 on Respiratory Infection during Military Training.
Most Relevant Research
We explored the connection between vitamin D levels and the frequency of upper respiratory tract infections (URTI) in physically active individuals throughout different seasons. In our research, we observed over 1,600 military recruits during their basic training, noting that only 21% were vitamin D sufficient during winter. Alarmingly, those who had sufficient vitamin D levels were found to be 40% less likely to experience URTIs compared to their deficient counterparts, suggesting that maintaining adequate vitamin D may be crucial for better respiratory health during demanding training periods.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
Building on these findings, we conducted a follow-up study with 250 recruits, where we implemented various vitamin D supplementation strategies. Participants received either a placebo, simulated sunlight exposure, or oral vitamin D3 supplementation. The results were promising: vitamin D helped alleviate the severity of URTI symptoms and significantly reduced the number of days experiencing a cold. Notably, both sunlight and dietary supplementation were equally effective in boosting vitamin D levels and improving outcomes.
Overall, achieving vitamin D sufficiency can markedly reduce the burden of URTIs, particularly in physically demanding scenarios such as military training.
8.3
Enhances strength
Most Useful Review
I take various vitamin D3 supplements to ensure diverse benefits. It truly supports me through the cold, dark season, enhancing my health and motivation during such times.
Heart Disease details
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.9
USERS' SCORE
Good
Based on 3 Reviews
8.4
7
Vitamin D's role in heart health
The Impact of Vitamin D Deficiency on Coronary Artery Disease Severity Based on Myocardial Perfusion Imaging: A Cross-Sectional Study.
Most Relevant Research
We examined how low levels of vitamin D (Vit D) could impact the severity of heart disease, specifically looking at myocardial ischemia. Our study involved two hundred patients who underwent myocardial perfusion imaging at Namazi Hospital in Shiraz, Iran, in 2019. We assessed both the severity of ischemia in patients and their vitamin D levels.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
The results revealed a clear pattern: when vitamin D levels dropped below 10 ng/mL, patients showed a significant increase in severe myocardial ischemia. Conversely, in patients with higher levels of vitamin D, we did not find any substantial association with abnormalities in heart imaging. This indicates that maintaining adequate vitamin D levels may play a role in reducing heart disease severity.
Overall, our findings suggest that vitamin D deficiency, especially levels below 10 ng/mL, could contribute to more severe heart conditions. This could prompt health care providers to consider monitoring and addressing vitamin D levels in patients at risk for heart disease.
8.8
Strengthens against heart disease
Most Useful Review
Vitamin D3 is essential for improving levels in the body, strengthening bones, and reducing chronic disease risks, including heart disease. It also enhances the immune system and promotes dental health. I’ve experienced positive effects from it.
Hypertension details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 1 Review
8.3
5.8
Supports hypertension treatment
Most Useful Review
Vitamin D3 primarily aids in the absorption of calcium and phosphorus, crucial for strong bones. Insufficient vitamin levels may lead to various health issues, including muscle pain, migraines, and hypertension. When sunlight is scarce, this supplement is beneficial for immunity. The packaging is convenient, and the softgel form allows easy consumption, even if you prefer to chew rather than swallow. I appreciate its effectiveness and the simple dosage of one tablet every other day, or daily if needed.
Insomnia details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.7
8
Vitamin D benefits for insomnia
Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial.
Most Relevant Research
We set out to explore the relationship between vitamin D and insomnia by examining how low-fat milk and yogurt fortified with 1,500 IU of nano-encapsulated vitamin D could improve sleep issues and overall quality of life.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
In our analysis, we included adults with abdominal obesity and a history of insomnia, identifying twenty-nine participants through insomnia severity questionnaires. They were split into four groups: one receiving fortified low-fat milk, another with unfortified milk, a third group consuming fortified yogurt, and a fourth with unfortified yogurt. Over a ten-week period, we tracked changes in insomnia symptoms and quality of life.
Our findings revealed that those drinking the vitamin D fortified milk experienced significant improvements in insomnia scores compared to those consuming regular milk. Additionally, quality of life assessments showed positive changes for both fortified and unfortified milk groups. However, the yogurt groups did not demonstrate significant benefits, indicating that while fortified dairy has potential, yogurt may not be as effective in this context.
In conclusion, incorporating fortified low-fat milk into our diets could help ease insomnia symptoms and enhance life satisfaction, although yogurt did not show the same promise.
9.5
No insomnia issue
Most Useful Review
Works brilliantly! Vitamin D is high quality, with an optimal dosage of 5000. I take it in the evening after dinner; I've found it’s better absorbed at night. There’s no effect on my sleep, no insomnia at all!
Eczema details
SCIENTIFIC SCORE
Questionable
Based on 13 Researches
6.9
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.5
8
Vitamin D reduces eczema severity
Vitamin D Supplementation for Treating Atopic Dermatitis in Children and Adults: A Systematic Review and Meta-Analysis.
Most Relevant Research
We focused on understanding the impact of vitamin D supplementation on atopic dermatitis, commonly known as eczema, in both children and adults. This systematic review analyzed data from eleven randomized controlled trials (RCTs), involving a total of 686 participants.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
Each study compared participants receiving vitamin D to those in control groups, measuring their eczema severity using established scoring systems. The results were compelling. We found that vitamin D supplementation led to a noteworthy reduction in eczema severity compared to those who did not receive this treatment.
Specifically, the analysis indicated a standardized mean difference of -0.41, suggesting significant benefits for individuals taking vitamin D. However, it’s essential to note that while the findings are promising, larger and longer-term studies are necessary to confirm these results.
5.8
Supports bone health
Most Useful Review
Vitamin D3 helps improve the absorption of calcium and phosphorus, essential for maintaining strong bones. It effectively supports immunity and is packaged well. The dosage is convenient, with one tablet taken every other day, although daily intake is possible. It has a soft shell, making it suitable for those who struggle to swallow.
