We explored the long-term effects of monthly calcifediol, a form of vitamin D, on postmenopausal women who were found to be vitamin D insufficient, specifically those with levels below 30 ng/mL. Over a period of 24 months, we monitored 45 women, assessing their vitamin D levels and other health indicators at several checkpoints.
As we observed, the treatment effectively raised and maintained vitamin D levels in these women. After 24 months, there was a noticeable improvement, with average vitamin D levels increasing from 20.5 ng/mL at the start to 36.7 ng/mL. Impressively, only one participant registered a level below 20 ng/mL by the end of the study.
However, we also noted that while the levels initially rose, there wasn't a significant difference between the values at 12 months and those at 24 months. Moreover, no serious side effects were reported, and measures of calcium and kidney function remained stable.
Overall, our findings suggest that regular vitamin D supplementation can help maintain adequate levels in postmenopausal women, though it does not appear to offer specific benefits for relieving menopausal symptoms directly. Thus, while the administration of calcifediol has its merits, further research could be required to examine its influence on other menopausal aspects.