5/11/2025
Last update
5/11/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
8
We investigated how vitamin D levels in the body are related to the risk of experiencing migraines. Using a method called Mendelian randomization, we carefully examined data from a large group of over 400,000 individuals to identify genetic factors linked to vitamin D levels. We found a total of 184 genetic instruments to analyze the potential relationship.
The findings were intriguing: as vitamin D levels increase, the risk of migraines appears to decrease. This association was confirmed through multiple datasets, showing that higher vitamin D is associated with a reduced likelihood of having migraines. The results were consistent not just for general migraine types but also for specific subtypes, such as migraines with and without aura.
Interestingly, while we checked for potential mediators like serum calcium, the contribution of calcium to this relationship was minimal. Our research suggests that low vitamin D levels could be a concern for migraine sufferers, and it highlighted the need for further well-designed studies. We recommend that future research explore the effects of vitamin D supplementation, especially for those who may be deficient in this important nutrient.
The findings were intriguing: as vitamin D levels increase, the risk of migraines appears to decrease. This association was confirmed through multiple datasets, showing that higher vitamin D is associated with a reduced likelihood of having migraines. The results were consistent not just for general migraine types but also for specific subtypes, such as migraines with and without aura.
Interestingly, while we checked for potential mediators like serum calcium, the contribution of calcium to this relationship was minimal. Our research suggests that low vitamin D levels could be a concern for migraine sufferers, and it highlighted the need for further well-designed studies. We recommend that future research explore the effects of vitamin D supplementation, especially for those who may be deficient in this important nutrient.
Read More
Most Useful Reviews
10
Remarkable migraine improvement
40 people found this helpful
I have had migraines for over twenty years, and after trying Vitamin D on a whim, I have not experienced a migraine in two months. This is unprecedented for me. I take 1,000 IU in the morning and another in the evening, and it has been life-changing. I encourage others to consult their doctor for the right dosage.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.5
- All Researches
9
We aimed to understand how vitamin D impacts migraine headaches in children. Through a thorough review of existing literature, we explored the significant association between serum vitamin D levels and the frequency and duration of migraine episodes in the pediatric population.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Our findings suggest that children with migraines might benefit from vitamin D supplementation. By potentially reducing the number and intensity of migraine episodes, vitamin D could improve the overall quality of life for these young patients.
It's important to note that this connection primarily focuses on children, as most studies have looked at adults. With vitamin D deficiency being a growing public health concern, our research highlights how addressing this deficiency may serve as a helpful strategy in managing pediatric migraines.
Read More
9
We conducted a study to investigate whether adding vitamin D supplements to topiramate therapy would improve migraine outcomes in children aged 5 to 14. In our double-blinded clinical trial, we randomly assigned participants to receive either topiramate with a daily 5000-IU vitamin D supplement or topiramate with a placebo for four months. By evaluating changes in headache frequency, severity, disability, and overall response to treatment, we aimed to see if vitamin D could provide additional benefits.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Our findings were quite promising. The children receiving the vitamin D supplement had a significant reduction in the number of headaches they experienced each month compared to those on placebo. Additionally, the vitamin D group reported less disability due to migraines and a higher percentage of positive treatment responses. Specifically, about 76% of children in the vitamin D group showed a good response, compared to just over 53% in the placebo group.
Safety was assessed as well, with side effects occurring in 13.3% of the vitamin D group and 20% in the placebo group, indicating that vitamin D was well-tolerated. Overall, we believe that combining vitamin D with topiramate represents a safe and potentially effective approach to managing pediatric migraines.
Read More
9
We explored the potential benefits of vitamin D supplementation for treating migraines. Our analysis focused on several randomized controlled trials (RCTs) to examine how effective vitamin D could be in alleviating migraine symptoms.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Through our review, we included six RCTs involving 301 patients. The results were quite promising. Vitamin D supplementation significantly reduced the number of headache attacks per month and the number of headache days experienced by patients. Additionally, it improved the MIDAS score, which measures the impact of migraines on daily life.
However, it's important to note that vitamin D did not show a significant effect on how long migraine attacks lasted or the severity of the headaches. Overall, our findings suggest that while vitamin D might be beneficial for reducing certain migraine-related symptoms, it isn’t a miracle cure for everyone.
Read More
9
We explored how vitamin D may impact migraines through a systematic review and meta-analysis of randomized controlled trials.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Analyzing data from five trials, we found that vitamin D significantly reduced the number of headache days, frequency of attacks, severity of headaches, and overall migraine-related disability compared to placebo.
This suggests that vitamin D treatment can effectively help alleviate migraine symptoms for many individuals.
Read More
8
Vitamin D and probiotics benefit migraines
We conducted a rigorous study to understand how vitamin D, combined with probiotics, can affect migraine headaches. In a randomized, triple-blinded, placebo-controlled trial, we enrolled adult patients aged 18 to 55 diagnosed with migraines. These individuals were divided into two groups: one receiving vitamin D and probiotics and the other receiving a placebo for 12 weeks.
Throughout the study, we assessed various factors, including the frequency and severity of migraines, mental health outcomes, and inflammation levels. Participants completed questionnaires and maintained a daily headache diary to track their symptoms.
After 12 weeks, we observed that the combination of vitamin D and probiotics had positive effects on the characteristics of migraines. However, while there were improvements noted, further research is needed to fully confirm these results. It's important to consider that we cannot isolate the effect of vitamin D alone due to its combination with probiotics in this study.
Throughout the study, we assessed various factors, including the frequency and severity of migraines, mental health outcomes, and inflammation levels. Participants completed questionnaires and maintained a daily headache diary to track their symptoms.
After 12 weeks, we observed that the combination of vitamin D and probiotics had positive effects on the characteristics of migraines. However, while there were improvements noted, further research is needed to fully confirm these results. It's important to consider that we cannot isolate the effect of vitamin D alone due to its combination with probiotics in this study.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Remarkable migraine improvement
40 people found this helpful
I have had migraines for over twenty years, and after trying Vitamin D on a whim, I have not experienced a migraine in two months. This is unprecedented for me. I take 1,000 IU in the morning and another in the evening, and it has been life-changing. I encourage others to consult their doctor for the right dosage.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Akif Özdemir FM, Çelik H. Assessment of Micronutrient Levels in Pediatric Migraine Patients. J Child Neurol. 2025. 10.1177/08830738241304868
- Hao S, Qian R, Chen Y, Liu J, Xu X, et al. Association between serum vitamin D and severe headache or migraine: A population-based analysis. PLoS One. 2025;20:e0313082. 10.1371/journal.pone.0313082
- Talandashti MK, Shahinfar H, Delgarm P, Jazayeri S. Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials. Neurol Sci. 2025;46:651. 10.1007/s10072-024-07794-0
- Tirani SA, Khorvash F, Saneei P, Moradmand Z, Askari G. Effects of probiotic and vitamin D co-supplementation on clinical symptoms, mental health, and inflammation in adult patients with migraine headache: a randomized, triple-blinded, placebo-controlled trial. BMC Med. 2024;22:457. 10.1186/s12916-024-03684-6
- Papasavva M, Vikelis M, Siokas V, Katsarou MS, Dermitzakis EV, et al. Genetic Variability in Vitamin D Receptor and Migraine Susceptibility: A Southeastern European Case-Control Study. Neurol Int. 2023;15:1117. 10.3390/neurolint15030069
- Ioannidou E, Tsakiris C, Goulis DG, Christoforidis A, Zafeiriou D. The association of serum vitamin D concentrations in paediatric migraine. Eur J Paediatr Neurol. 2023;47:60. 10.1016/j.ejpn.2023.09.007
- Das S, Roy A, Behera SK, Selvarajan S, Kamalanathan S, et al. Effects of Vitamin D on Migraine: A Meta-Analysis. Neurol India. 2023;71:655. 10.4103/0028-3886.383862
- Alipouri M, Amiri E, Hoseini R, Hezarkhani LA. Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: A randomized controlled clinical trial. J Affect Disord. 2023;334:12. 10.1016/j.jad.2023.04.108
- Niu PP, Wang X, Xu YM. Higher Circulating Vitamin D Levels Are Associated With Decreased Migraine Risk: A Mendelian Randomization Study. Front Nutr. 2022;9:907789. 10.3389/fnut.2022.907789
- Kotb Elmala M, Suliman HA, Al-Shokary AH, Ibrahim AO, Kamal NM, et al. The Impact of Vitamin D Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis. J Child Neurol. 2022;37:833. 10.1177/08830738221092882
- Ariyanfar S, Razeghi Jahromi S, Togha M, Ghorbani Z. Review on Headache Related to Dietary Supplements. Curr Pain Headache Rep. 2022;26:193. 10.1007/s11916-022-01019-9
- Canpolat M, Topcu A, Kardas F, Ipekten F, Per H, et al. An assessment of the relation between vitamin D levels and electroencephalogram (EEG) changes in migraine patients. Bratisl Lek Listy. 2022;123:92. 10.4149/BLL_2022_014
- Bahrampour N, Mirzababaei A, Yarizadeh H, Barekzai AM, Khorsha F, et al. The relationship between dietary nutrients patterns and intensity and duration of migraine headaches. Br J Nutr. 2022. 10.1017/S0007114522000046
- Hu C, Fan Y, Wu S, Zou Y, Qu X. Vitamin D supplementation for the treatment of migraine: A meta-analysis of randomized controlled studies. Am J Emerg Med. 2021;50:784. 10.1016/j.ajem.2021.07.062
- Sun S, Liu C, Jia Y, Wu J, Li H, et al. Association Between Migraine Complicated With Restless Legs Syndrome and Vitamin D. Front Neurol. 2021;12:777721. 10.3389/fneur.2021.777721
- Ghorbani Z, Rafiee P, Haghighi S, Razeghi Jahromi S, Djalali M, et al. The effects of vitamin D3 supplementation on TGF-β and IL-17 serum levels in migraineurs: post hoc analysis of a randomized clinical trial. J Pharm Health Care Sci. 2021;7:9. 10.1186/s40780-021-00192-0
- Bhuya MSI, Saiduzzaman M, Linckon K, Moniruzzaman AHM, Hossain MS, et al. Association of Serum Vitamin D Level in Patients with Migraine. Mymensingh Med J. 2025;34:312.
- Zhang YF, Xu ZQ, Zhou HJ, Liu YZ, Jiang XJ. The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies. Clin Neuropharmacol. 2021;44:5. 10.1097/WNF.0000000000000419
- Ghorbani Z, Rafiee P, Fotouhi A, Haghighi S, Rasekh Magham R, et al. The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. J Headache Pain. 2020;21:22. 10.1186/s10194-020-01090-w
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D3 might improve headache characteristics and protect against inflammation in migraine: a randomized clinical trial. Neurol Sci. 2020;41:1183. 10.1007/s10072-019-04220-8
- Ghorbani Z, Togha M, Rafiee P, Ahmadi ZS, Rasekh Magham R, et al. Vitamin D in migraine headache: a comprehensive review on literature. Neurol Sci. 2019;40:2459. 10.1007/s10072-019-04021-z
