Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
Read More
7
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Read More
9
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
Most Useful Reviews
9
Enhances bodily functions
4 people found this helpful
Very important supplement at a reasonable price. People increasingly understand the importance of vitamin D, and my doctor states it enhances many bodily functions. I believe these supplements are becoming essential for those with osteoporosis.
Read More
9
Childhood development
Vitamin D3 strengthens teeth and bones, supporting normal skeletal growth in children. It also enhances muscle strength and heart health, helping prevent illnesses like osteoporosis and rickets.
Read More
7.5
Bone health support
Jarrow Formulas Vitamin D3 is a high-potency supplement that supports bone health and the immune system. It contains cholecalciferol (D3), which is well absorbed by the body. I chose this supplement for its concentration of 125 mcg (5000 IU), ideal for treating vitamin D deficiency. After two weeks, I noticed improved energy and mood on cloudy days. It’s easy to digest, and I recommend checking vitamin D levels before starting.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.4
- All Researches
9
We explored how a specific probiotic strain, FSHHK13M1, affects vitamin D metabolism and osteoporosis in mice. Previous research pointed out that the gut microbiota plays a crucial role in vitamin D metabolism, which is especially relevant for older adults who tend to suffer from osteoporosis due to declining organ functions.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Our study demonstrated that treating the mice with FSHHK13M1 led to a significant increase in their serum levels of active vitamin D metabolites, particularly 1,25-dihydroxy vitamin D. This increase was linked to activation of important bone health pathways, helping to fortify bone structure and function.
Not only did we observe improvements in vitamin D levels, but the intervention also restored balance in the gut microbiota, which showed signs of imbalance in mice suffering from osteoporosis. The findings suggest that FSHHK13M1 could be a promising direction for improving bone health and reducing fracture risks in the elderly by enhancing vitamin D levels naturally.
Overall, this research highlights the potential of combining probiotics with vitamin D strategies for better management of osteoporosis, especially in older populations who often face challenges absorbing conventional treatments.
Read More
8
We explored the role of vitamin D (VD) supplementation in supporting cancer patients undergoing chemotherapy and radiotherapy, particularly regarding its effects on osteoporosis. The aim was to sift through scientific evidence to understand how vitamin D influences not just bone health but also alleviates the side effects of demanding cancer treatments.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
Read More
8
Vitamin D improves bone health
We investigated how vitamin D affects bone health, particularly focusing on individuals with celiac disease (CeD). Our study aimed to uncover the role of vitamin D alongside other key proteins in bone metabolism as patients transitioned to a gluten-free diet (GFD).
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
Read More
8
We examined the relationship between vitamin D levels and the risk of new vertebral fractures after patients underwent a specific spine procedure called percutaneous vertebral augmentation. Our focus was on postmenopausal women aged 50 and above, who often face an increased risk of fractures due to osteoporosis.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
Read More
8
We aimed to understand how vitamin D influences bone health and helps combat osteoporosis, a condition that weakens bones. In our study, we used various mouse models, including those that mimic a deficiency in active vitamin D. Through a range of advanced methods, we assessed how changes in vitamin D levels affected bone structure and metabolism.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
The research revealed that insufficient vitamin D led to a drop in Sirt1, a gene that plays a crucial role in maintaining bone density. This lack of Sirt1 resulted in increased bone loss. However, when we boosted Sirt1 levels in bone stem cells, we observed a reversal in bone loss. This improvement happened because higher Sirt1 levels reduced oxidative stress, slowed down aging processes in bone cells, and enhanced new bone formation while curbing bone resorption.
Additionally, our findings indicated that vitamin D directly stimulates Sirt1 expression in these stem cells, which is vital for bone health. We also explored the effects of resveratrol, a natural compound known for activating Sirt1, and found it helped alleviate osteoporosis symptoms linked to vitamin D deficiency by enhancing the relationship between Sirt1 and another protein called PGC1α, which supports bone formation and energy metabolism.
This research underscores the importance of the vitamin D-Sirt1/PGC1α axis in bone metabolism, providing insight into how vitamin D can serve as a target for osteoporosis prevention and treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Enhances bodily functions
4 people found this helpful
Very important supplement at a reasonable price. People increasingly understand the importance of vitamin D, and my doctor states it enhances many bodily functions. I believe these supplements are becoming essential for those with osteoporosis.
Read More
9
Childhood development
Vitamin D3 strengthens teeth and bones, supporting normal skeletal growth in children. It also enhances muscle strength and heart health, helping prevent illnesses like osteoporosis and rickets.
Read More
7.5
Bone health support
Jarrow Formulas Vitamin D3 is a high-potency supplement that supports bone health and the immune system. It contains cholecalciferol (D3), which is well absorbed by the body. I chose this supplement for its concentration of 125 mcg (5000 IU), ideal for treating vitamin D deficiency. After two weeks, I noticed improved energy and mood on cloudy days. It’s easy to digest, and I recommend checking vitamin D levels before starting.
Read More
7.5
Bone quality maintenance
Vitamin D3 is crucial for maintaining bone quality by aiding calcium absorption. It reduces the risk of osteoporosis and improves mood and energy levels. Without sufficient Vitamin D3, bone strength and health decline.
Read More
7.5
Preventing osteoporosis
I take Vitamin D every morning and evening as it seems beneficial for preventing osteoporosis. I plan to continue this.
Read More
Frequently Asked Questions
7.5
Bone health support
Jarrow Formulas Vitamin D3 is a high-potency supplement that supports bone health and the immune system. It contains cholecalciferol (D3), which is well absorbed by the body. I chose this supplement for its concentration of 125 mcg (5000 IU), ideal for treating vitamin D deficiency. After two weeks, I noticed improved energy and mood on cloudy days. It’s easy to digest, and I recommend checking vitamin D levels before starting.
7.5
Bone quality maintenance
Vitamin D3 is crucial for maintaining bone quality by aiding calcium absorption. It reduces the risk of osteoporosis and improves mood and energy levels. Without sufficient Vitamin D3, bone strength and health decline.
7.5
Reduced disease risk
This form of vitamin D is best absorbed and can help lower the risks of osteoporosis and other bone-related diseases. I believe it's essential to determine the correct dosage based on blood tests, as many self-prescribe incorrectly.
9
Childhood development
Vitamin D3 strengthens teeth and bones, supporting normal skeletal growth in children. It also enhances muscle strength and heart health, helping prevent illnesses like osteoporosis and rickets.
7.5
Osteoporosis protection
Maintaining optimal vitamin D levels is vital year-round, especially in northern regions prone to deficiency. My tests confirmed this. Following my doctor's advice, I chose this supplement as vitamin D promotes calcium absorption, helping prevent osteoporosis and inflammation while supporting cardiovascular health.
7.5
Preventing osteoporosis
I take Vitamin D every morning and evening as it seems beneficial for preventing osteoporosis. I plan to continue this.
8
We explored the role of vitamin D (VD) supplementation in supporting cancer patients undergoing chemotherapy and radiotherapy, particularly regarding its effects on osteoporosis. The aim was to sift through scientific evidence to understand how vitamin D influences not just bone health but also alleviates the side effects of demanding cancer treatments.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
Our findings indicated that adequate levels of VD are important for maintaining bone density in patients, especially those receiving preoperative chemoradiotherapy. Some studies showed that vitamin D supplementation could lessen certain severe side effects, like fatigue and nausea, often experienced during cancer treatments.
However, the evidence regarding the isolated effects of vitamin D on osteoporosis, specifically, was limited due to the varied designs of the included studies. Despite these challenges, it seems clear that vitamin D plays a valuable role in managing bone health and reducing treatment-related complications.
8
Vitamin D improves bone health
We investigated how vitamin D affects bone health, particularly focusing on individuals with celiac disease (CeD). Our study aimed to uncover the role of vitamin D alongside other key proteins in bone metabolism as patients transitioned to a gluten-free diet (GFD).
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
Through a careful examination, we observed notable changes in bone mineral density (BMD) among those who adhered to the GFD. Specifically, we found that patients after GFD treatment had improved serum levels of vitamin D, which correlated with healthier bone outcomes, including increased BMD and reduced markers of bone turnover.
Interestingly, even though the capacity for osteoclast formation—a type of cell responsible for bone resorption—remained elevated in these patients, their bone health still improved. This suggests that, while vitamin D plays a crucial role in bone strength, the connection between osteoclast activity and overall bone health might change with proper dietary management.
Our findings emphasized how vital vitamin D is for bone health, particularly in the context of managing celiac disease, where absorption can be compromised. Ultimately, we learned that a gluten-free lifestyle brings significant benefits for bone density, along with the supportive actions of vitamin D.
7
We explored the effects of vitamin D supplementation on osteoporosis, especially among individuals at risk for this condition. The Osteoporosis Research and Information Group (GRIO) highlighted the critical difference between daily and intermittent vitamin D dosing.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
Current literature indicates that taking high doses of vitamin D intermittently, such as 60,000 IU a month, can actually elevate the chances of falls, fractures, and even premature death in some groups. Conversely, daily supplementation of 800-1000 IU, particularly alongside calcium, has been shown to reduce falls and non-vertebral fractures in the elderly who have a vitamin D deficiency.
Before anyone starts supplementing, it is crucial to measure their vitamin D levels to achieve a target concentration of 30 to 60 ng/mL. For those needing a quick boost in vitamin D levels—like patients showing symptoms of osteomalacia or those with critically low vitamin D—a starting loading dose followed by daily maintenance is the preferred approach. If daily options aren’t available, of course, a smaller intermittent dose can be a temporary solution until better options are accessible.
7
Vitamin D's unclear effects on osteoporosis
We investigated the effectiveness of vitamin D treatment for osteoporosis in Duchenne Muscular Dystrophy (DMD). The study included research on the combination of vitamin D with calcium, which made it challenging to assess the isolated effects of vitamin D alone on bone health.
Although vitamin D is known for its role in bone mineralization, the specific impact on osteoporosis in individuals with DMD remains unclear. The evidence we found suggests that while vitamin D, together with calcium, showed some potential, it is difficult to draw strong conclusions about its effectiveness as a standalone treatment.
Overall, we saw limited insights into how vitamin D treatment might specifically benefit those with osteoporosis in DMD, indicating a need for further research to better understand its effects without the influence of additional supplements.
Although vitamin D is known for its role in bone mineralization, the specific impact on osteoporosis in individuals with DMD remains unclear. The evidence we found suggests that while vitamin D, together with calcium, showed some potential, it is difficult to draw strong conclusions about its effectiveness as a standalone treatment.
Overall, we saw limited insights into how vitamin D treatment might specifically benefit those with osteoporosis in DMD, indicating a need for further research to better understand its effects without the influence of additional supplements.
8
We explored how vitamin D levels impact mortality among patients diagnosed with either osteopenia or osteoporosis. This research drew on data from the National Health and Nutrition Examination Survey spanning from 2001 to 2018, focusing on a large group of 9,282 adults.
By using advanced statistical methods, we examined connections between serum 25-hydroxyvitamin D (25(OH)D) levels and various forms of mortality, including all-cause deaths, cardiovascular issues, and cancer. Our findings revealed that higher levels of serum 25(OH)D, specifically above 75.0 nmol/L, are significantly linked to a lower risk of death from all causes and cardiovascular conditions.
Nevertheless, we also noted that this relationship is not straightforward. It appears an L-shaped curve exists, indicating specific thresholds of 25(OH)D levels related to mortality risk. This suggests that while higher vitamin D levels improve outcomes, there is a minimum level that needs to be achieved for the benefits to take effect. Ultimately, our results highlight the importance of maintaining adequate vitamin D levels for patients with osteoporosis or osteopenia, suggesting that future studies could shed more light on how these mechanisms work.
By using advanced statistical methods, we examined connections between serum 25-hydroxyvitamin D (25(OH)D) levels and various forms of mortality, including all-cause deaths, cardiovascular issues, and cancer. Our findings revealed that higher levels of serum 25(OH)D, specifically above 75.0 nmol/L, are significantly linked to a lower risk of death from all causes and cardiovascular conditions.
Nevertheless, we also noted that this relationship is not straightforward. It appears an L-shaped curve exists, indicating specific thresholds of 25(OH)D levels related to mortality risk. This suggests that while higher vitamin D levels improve outcomes, there is a minimum level that needs to be achieved for the benefits to take effect. Ultimately, our results highlight the importance of maintaining adequate vitamin D levels for patients with osteoporosis or osteopenia, suggesting that future studies could shed more light on how these mechanisms work.
4
Vitamin D and osteoporosis treatment risks
We aimed to understand how vitamin D, when taken alongside calcium, affects individuals dealing with osteoporosis. This study involved 204 participants aged between 50 and 89 years, all receiving a specific daily dose of calcium carbonate and alfacalcidol for at least a year.
Our findings reveal an important aspect of this treatment: while calcium and vitamin D can be beneficial for bone health, there's a concerning association with kidney stone formation among users. Particularly, those with a history of recurrent kidney stones seemed to face an increased risk, which may be linked to higher urinary calcium excretion as a result of the supplements.
This highlights a dual-edged sword in osteoporosis treatment—while we seek to strengthen bones, we also have to consider potential harm. Thus, anyone considering or currently using these supplements should consult with their healthcare provider to carefully weigh the benefits against the risks, especially if they have a past of kidney stones.
Our findings reveal an important aspect of this treatment: while calcium and vitamin D can be beneficial for bone health, there's a concerning association with kidney stone formation among users. Particularly, those with a history of recurrent kidney stones seemed to face an increased risk, which may be linked to higher urinary calcium excretion as a result of the supplements.
This highlights a dual-edged sword in osteoporosis treatment—while we seek to strengthen bones, we also have to consider potential harm. Thus, anyone considering or currently using these supplements should consult with their healthcare provider to carefully weigh the benefits against the risks, especially if they have a past of kidney stones.
8
We examined the relationship between vitamin D levels and the risk of new vertebral fractures after patients underwent a specific spine procedure called percutaneous vertebral augmentation. Our focus was on postmenopausal women aged 50 and above, who often face an increased risk of fractures due to osteoporosis.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
In this retrospective study, we categorized patients into groups based on whether they experienced new osteoporotic vertebral fractures or not. Our analysis revealed that low levels of serum 25-hydroxyvitamin D are an independent risk factor for these new fractures.
This suggests that maintaining adequate vitamin D levels could be crucial for individuals recovering from this type of spinal surgery. By ensuring active vitamin D supplementation after the procedure, patients may significantly lower their chances of future osteoporotic vertebral fractures, promoting better recovery and overall health.
References
- Afonso ML, Capelas ML, Pimenta NM, Santos T, Mäkitie A, et al. A Systematic Review of Vitamin D Supplementation in Oncology: Chance of Science or Effectiveness?. Nutrients. 2025;17. doi:10.3390/nu17040634
- Wang H, Tian G, Pei Z, Yu X, Wang Y, et al. increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice. mSphere. 2025. doi:10.1128/msphere.01039-24
- Skubica P, Hoffmanova I, Dankova P. Chronically increased osteoclastogenesis in adult celiac disease patients does not hinder improvement in bone health induced by gluten-free diet: Role of vitamin D, OPG and IL-6. J Nutr Biochem. 2025. doi:10.1016/j.jnutbio.2025.109871
- Pickering ME, Souberbielle JC, Boutten A, Breuil V, Briot K, et al. Daily or intermittent vitamin D supplementation in patients with or at risk of osteoporosis: Position statement from the GRIO. Joint Bone Spine. 2025;92:105858. doi:10.1016/j.jbspin.2025.105858
- Shi L, Bao Y, Deng X, Xu X, Hu J. Association between calcium and vitamin D supplementation and increased risk of kidney stone formation in patients with osteoporosis in Southwest China: a cross-sectional study. BMJ Open. 2025;15:e092901. doi:10.1136/bmjopen-2024-092901
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
- Yang C, Chen L, Guo X, Sun H, Miao D. The Vitamin D-Sirt1/PGC1α Axis Regulates Bone Metabolism and Counteracts Osteoporosis. J Orthop Translat. 2025;50:211. doi:10.1016/j.jot.2024.10.011
- Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. doi:10.1248/bpb.b24-00536
- McCarrison S, Abdelrahman S, Quinlivan R, Keen R, Wong SC. Pharmacological and non-pharmacological therapies for prevention and treatment of osteoporosis in Duchenne Muscular Dystrophy: A systematic review. Bone. 2025;193:117410. doi:10.1016/j.bone.2025.117410
- Ma M, Zhang Y, Liu J, Tian C, Duan Z, et al. Associations of the serum 25-hydroxyvitamin D with mortality among patients in osteopenia or osteoporosis. Bone. 2025. doi:10.1016/j.bone.2025.117408
