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SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 28 Reviews
8.9
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin (as d-Biotin)
330 mcg
1,100%
Alpha Lipoic Acid (Thioctic Acid)
300 mg
†
Top Medical Research Studies
8
Alpha-lipoic acid enhances wound healing
Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.
Directly addresses diabetes treatment
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
7
Alpha-Lipoic Acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on diabetes treatment
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Read More
8
Alpha-lipoic acid enhances wound healing
Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections.
Combines LA with peptide treatment.
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
Read More
Most Useful Reviews
9.5
Weight loss aid
Works well for glucose control. Being menopausal and hypoglycaemic has made it challenging to lose weight. I now follow a keto lifestyle and take these pills at mealtimes twice daily, complemented by Berberine, Keto BHB, and Forskolin. This combination, along with my diet, has enabled me to lose 20lbs and over 25 inches while maintaining healthy blood sugar levels. The pills are a bit large but manageable. As noted on the bottle, consult your endocrinologist or PCP if you are treated for diabetes or glucose control!
Read More
10
Lifesaving product
I love this stuff! I've been taking it for twenty years due to diabetes. I'm not sure I would be alive without it. I take two tablets daily and can take them on an empty stomach. Although I've tried other brands, I consistently return to this one.
Read More
9
Stable sugar metabolism
Alpha-lipoic acid + biotin. I have been a dedicated alpha-lipoic acid fan for years with my doctor's approval. It offers many benefits as an antioxidant, particularly for pre-diabetes and vision. This formulation appeals to me as it includes biotin, which aids hair loss caused by asthma steroids. While claims about ALA's benefits exist, I can confirm my sugar metabolism stabilises when I take it. As a pre-diabetic due to long steroid use, my A1C remains below the diabetic threshold with this product. When I stopped it for a month prior to blood work, my A1C increased, but returned to normal after resuming for three months without changes to my diet or exercise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
8
Alpha-lipoic acid enhances wound healing
Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.
Directly addresses diabetes treatment
We aimed to understand how alpha-lipoic acid (LA) affects wound healing in diabetic conditions. The study involved five groups of mice: healthy controls, wounded healthy mice, wounded diabetic mice, and two groups of wounded diabetic mice treated with different doses of LA for 14 days.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Our findings indicated that LA plays a significant role in improving the healing process. It works by balancing the levels of anti-inflammatory and pro-inflammatory factors that are essential for wound recovery. Specifically, we saw effects on various immune cell types that are vital for healing, indicating that LA may help to enhance recovery in diabetic wounds.
This study highlights the potential of LA as a supportive treatment option for wound healing in diabetic patients, ultimately aiming to reduce the risk of infections and improve overall recovery from injuries.
Read More
8
Alpha-lipoic acid enhances wound healing
Multifunctional hyaluronic acid microneedle patch enhances diabetic wound healing in diabetic infections.
Combines LA with peptide treatment.
We set out to explore how alpha-lipoic acid (LA) could help in the healing of diabetic wounds, which often struggle to heal due to a mix of factors like high blood sugar and infections. In our investigation, we combined LA with a specialized peptide using a unique self-assembly process that didn’t require extra help from outside sources.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
This new combination was then placed into a microneedle patch made from hyaluronic acid (HA), allowing for a steady release of LA. We found that this patch was effective in fighting off harmful bacteria such as S. aureus and E. coli, which are common culprits in infections.
Furthermore, we observed that the sustained release of LA not only reduced harmful reactive oxygen species but also encouraged helpful immune responses and new blood vessel formation. This indicates a considerable improvement in tissue regeneration for wounds in diabetic patients. Overall, our findings suggest this multifunctional microneedle approach could significantly enhance healing in diabetic skin infections and showcases the considerable potential of combining LA in innovative treatment strategies.
Read More
7
Alpha-Lipoic Acid reduces AGEs
Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation Products in Type 2 Diabetes Patients with Neuropathy.
Direct effect on diabetes treatment
We explored the potential benefits of alpha-lipoic acid (ALA) for those with type 2 diabetes (T2DM) and nerve complications, known as neuropathy. In our study, we focused on how ALA affects advanced end glycation products (AGEs), which are harmful compounds that can worsen the condition by damaging blood vessels and nerve tissues.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Our six-month intervention involved 54 T2DM patients with neuropathy who continued their prescribed medications while taking 600 mg of ALA daily. We contrasted their results with a control group of 24 matched patients without neuropathy.
We observed that ALA treatment significantly reduced the levels of AGEs, demonstrating its efficacy in lowering these harmful substances in individuals with diabetes (from 11.89 to 10.95 AU/μg). However, we noted that ALA did not influence other markers like soluble AGE receptor (sRAGE) levels or the AGEs/sRAGE ratio.
Additionally, we found correlations indicating that as AGEs decreased, improvements were noted in nerve function and other health markers. Overall, results suggest that ALA could be a beneficial treatment option for improving diabetic neuropathy and enhancing endothelial function, although it doesn't isolate its benefits from other existing diabetes medications.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.9
10
Lifesaving product
I love this stuff! I've been taking it for twenty years due to diabetes. I'm not sure I would be alive without it. I take two tablets daily and can take them on an empty stomach. Although I've tried other brands, I consistently return to this one.
9.5
Reduces neuropathy pain
My husband has type 2 diabetes and experiences painful neuropathy. After two months of taking ALA, the pain lessened and his A1C dropped. With biotin added, it’s convenient, and we both feel good about the results.
9.5
Lowers blood sugars
My husband has been taking Alpha Lipoic Sustain for years, after reading Dr. Bernstein's book. It effectively lowers his blood sugars alongside Evening Primrose Oil. When we stopped these, his blood sugars increased. We will continue using them due to the excellent results.
9.5
Eases peripheral neuropathy
I’ve taken this for peripheral neuropathy for years, and it significantly alleviates foot pain. Missing a dose highlights its effectiveness; I double my dosage if I forget. Prescription meds were ineffective, but this was recommended for diabetes patients.
9.5
Prevents diabetic complications
Alpha-lipoic acid is a unique antioxidant that aids glucose metabolism and promotes energy production. I take it regularly for diabetes, and it’s vital for preventing complications. The addition of biotin enhances its effectiveness.
