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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Biotin (as d-Biotin)
330 mcg
1,100%
Alpha Lipoic Acid (Thioctic Acid)
300 mg
†
Top Medical Research Studies
9.5
Alpha-Lipoic Acid Shows Stroke Potential
Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke.
High relevance for stroke treatment
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
Read More
9
Investigating AA-9 for stroke
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study.
Direct focus on neuroprotective effects
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
Read More
7
ALA's potential in stroke treatment
A comprehensive review on alpha-lipoic acid delivery by nanoparticles.
Moderate relevance to stroke effects
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
Read More
Most Useful Reviews
8
Reduced stroke damage
Fantastic benefits. This supplement has numerous health advantages and was recommended by my holistic doctor. Lipoic acid is known to reduce oxidative stress and enhance insulin sensitivity, improve lipids, and reduce the risk of stroke, among other benefits. It not only helps in improving metabolic syndrome but also aids in visual function and protects against conditions like cataracts.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.5
9.5
Alpha-Lipoic Acid Shows Stroke Potential
Ischemic Microenvironment-Targeted Bioinspired Lipoprotein Sequentially Penetrates Cerebral Ischemic Lesions to Rescue Ischemic Stroke.
High relevance for stroke treatment
We examined how alpha-lipoic acid (ALA) impacts stroke recovery, particularly through a newly developed delivery system designed to target ischemic brain lesions. This system uses bioinspired lipoproteins to carry ALA, allowing it to reach the areas most affected by stroke more effectively than standard methods.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
In experiments with mice experiencing a transient middle cerebral artery occlusion (a model for stroke), we observed that the ALA-loaded lipoprotein system accumulated significantly in the ischemic brain tissue—2.29 times more than a nontargeted version. This increased delivery resulted in several positive outcomes, such as restoring neurological function, reducing brain cell death, and lessening inflammation, which is key for healing after a stroke.
Overall, our findings suggest that ALA, when delivered effectively to the right brain areas, has considerable potential to improve recovery from ischemic strokes. This innovative approach opens new avenues for treating strokes and enhancing patient outcomes.
Read More
9
Investigating AA-9 for stroke
Discovery of neuroprotective Agents: Potent, brain Penetrating, lipoic acid derivatives for the potential treatment of ischemic stroke by regulating oxidative stress and inflammation - a Preliminary study.
Direct focus on neuroprotective effects
In our exploration of neuroprotective agents for treating ischemic stroke, we focused on lipoic acid, a naturally occurring compound that shows promise in this area. However, we noticed that standard lipoic acid has limitations, including low efficacy and instability, which hinder its direct use in treatments.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
To address these issues, we synthesized 37 lipoic acid derivatives, with compound AA-9 emerging as the standout performer. Through in vitro experiments using tert-butyl hydroperoxide to mimic oxidative damage, we found that AA-9 demonstrated excellent therapeutic potential and an impressive safety profile.
Our subsequent studies using a rat model of ischemic stroke revealed that AA-9 significantly reduces the impact of stroke. This beneficial effect seems to stem from its antioxidant and anti-inflammatory properties, specifically by activating key cellular pathways that help protect the brain. Additionally, AA-9 outperformed regular alpha-lipoic acid in terms of stability and bioavailability, making it an exciting candidate for further research.
Overall, we believe AA-9 holds great promise as a neuroprotective agent for ischemic stroke and warrants further investigation to unlock its full potential.
Read More
7
ALA's potential in stroke treatment
A comprehensive review on alpha-lipoic acid delivery by nanoparticles.
Moderate relevance to stroke effects
We investigated the potential of alpha-lipoic acid (ALA) in treating cerebral ischemia, a condition often associated with strokes. The idea behind using ALA is its antioxidant properties, which might help mitigate damage caused during a stroke.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
One of the notable findings from the review is the promising application of ALA encapsulated within niosomes for this purpose. Niosomes can enhance the delivery of ALA to the brain, potentially improving cell protection during ischemic events.
However, it's essential to note that while there are indications of ALA's benefits, the study did not conclusively determine its effectiveness in treating stroke independently. This makes it crucial for us to exercise caution when interpreting the results and considering ALA as a therapeutic option for stroke treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8
Reduced stroke damage
Fantastic benefits. This supplement has numerous health advantages and was recommended by my holistic doctor. Lipoic acid is known to reduce oxidative stress and enhance insulin sensitivity, improve lipids, and reduce the risk of stroke, among other benefits. It not only helps in improving metabolic syndrome but also aids in visual function and protects against conditions like cataracts.
Read More
