Last update
5/4/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle Seed 30:1 Extract(Silybum marianum) (Fruit/Seed) (80% [120 mg] Total Flavonoids)
150 mg
†
Top Medical Research Studies
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
8
We explored the impact of silymarin, a compound from Silybum marianum, on SPC212 human mesothelioma cells. Through a series of laboratory tests, we observed that silymarin exhibits a dose-dependent cytotoxic effect, with notable markers of apoptosis like cell shrinkage and nuclear changes. Although silymarin shows promise in inducing cell death in cancer cells, further research is needed to fully understand its potential as a cancer treatment.
Read More
7
We explored the effects of Silybum marianum on nerve damage caused by the chemotherapy drug cisplatin in cancer patients. In a double-blind study involving 60 participants, we divided them into two groups: one receiving Silybum and the other a placebo.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Read More
Most Useful Reviews
7
Improved quality of life
Great supplement. This extract ratio is very good. Apart from its known benefits, I recommend this to everyone battling Cancer! It reduces the side effects of chemotherapy and enhances quality of life.
Read More
7
Tumours decreased
My father uses this as part of the Dr Rath anti-Cancer protocol, taking about 7-10 pills daily (with 10g of C, 10g of L-lysine, NAC, and many other supplements, which are the most important). While we lack a counterfactual to prove it definitively, his tumours have decreased or even disappeared.
Read More
6
High quality product
Worth the price. I am not a doctor, but my first wife had an excellent nutritionist who collaborated with her Cancer doctor. I recall that Milk Thistle was advised to help support her liver function. I believe this Jarrow Milk Thistle product is of high quality and standardised. It seems to be an excellent product priced well from a manufacturer that receives high ratings from independent sources like consumer-labs.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.6
- All Researches
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
9
We investigated how grape seed procyanidin extract (GSE) and milk thistle silymarin extract (MTE) work together to combat lung cancer. Our study involved cell line experiments, along with testing on mice to see how these extracts affect tumor growth.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
Read More
8
We explored the impact of silymarin, a compound from Silybum marianum, on SPC212 human mesothelioma cells. Through a series of laboratory tests, we observed that silymarin exhibits a dose-dependent cytotoxic effect, with notable markers of apoptosis like cell shrinkage and nuclear changes. Although silymarin shows promise in inducing cell death in cancer cells, further research is needed to fully understand its potential as a cancer treatment.
Read More
8
We aimed to understand how the combination of silymarin, derived from the milk thistle plant, and cisplatin, a well-known chemotherapy drug, affects ovarian cancer cells. Our study involved treating A2780 cells with these substances, both separately and together.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
Read More
8
Milk thistle affects liver cancer cells
We examined how milk thistle, particularly its nano-micelle formulation, affects liver cancer cells. By testing these formulations on different cell lines, we discovered that the nano-milk thistle (N-MT) can effectively halt cell growth and induce cancer cell death.
This happens by altering key genes involved in the cell cycle and apoptosis pathways. Importantly, the treatment influenced the expression levels of specific genes like miR-155-3p, SOCS2, and PHLDA1, suggesting a targeted action of N-MT in combatting cancer in liver cells.
This happens by altering key genes involved in the cell cycle and apoptosis pathways. Importantly, the treatment influenced the expression levels of specific genes like miR-155-3p, SOCS2, and PHLDA1, suggesting a targeted action of N-MT in combatting cancer in liver cells.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7
Improved quality of life
Great supplement. This extract ratio is very good. Apart from its known benefits, I recommend this to everyone battling Cancer! It reduces the side effects of chemotherapy and enhances quality of life.
Read More
7
Tumours decreased
My father uses this as part of the Dr Rath anti-Cancer protocol, taking about 7-10 pills daily (with 10g of C, 10g of L-lysine, NAC, and many other supplements, which are the most important). While we lack a counterfactual to prove it definitively, his tumours have decreased or even disappeared.
Read More
6
High quality product
Worth the price. I am not a doctor, but my first wife had an excellent nutritionist who collaborated with her Cancer doctor. I recall that Milk Thistle was advised to help support her liver function. I believe this Jarrow Milk Thistle product is of high quality and standardised. It seems to be an excellent product priced well from a manufacturer that receives high ratings from independent sources like consumer-labs.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Karbasforooshan H, Rahimi H, Arasteh O, Allahyari A, Varmaghani M, et al. Evaluation of Oral Nano-Silymarin Formulation Efficacy in the Prevention of Hand-Foot Syndrome and Neuropathy Induced by XELOX or m-FOLFOX6 Regimens in Metastatic Colorectal Cancer: A Triple-Blinded, Randomized Clinical Trial. Iran J Pharm Res. 2024;23:e152364. 10.5812/ijpr-152364
- Tomsuk Ö, Kaçar S. Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells. Cell Biochem Biophys. 2025. 10.1007/s12013-024-01650-w
- Fatemi Shandiz A, Karimi G, Dayyani M, Hosseini S, Elyasi S. Evaluation of oral silymarin formulation efficacy in prevention of doxorubicin induced hepatotoxicity in patients with non-metastatic breast cancer. J Oncol Pharm Pract. 2024. 10.1177/10781552241268778
- Gholami AH, Ansari H, Dadkhah A. Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin. Adv Biomed Res. 2024;13:21. 10.4103/abr.abr_365_21
- Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. 10.3390/molecules29081901
- Verdura S, Encinar JA, Gratchev A, Llop-Hernández À, López J, et al. Silibinin is a suppressor of the metastasis-promoting transcription factor ID3. Phytomedicine. 2024;128:155493. 10.1016/j.phymed.2024.155493
- Karimzadeh MR, Masoudi Chelegahi A, Shahbazi S, Reiisi S. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Mol Biol Rep. 2024;51:118. 10.1007/s11033-023-09026-8
- Zhang X, Jiang Y, Guo N, Ding Y, Feng J, et al. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. J Pharm Biomed Anal. 2024;238:115816. 10.1016/j.jpba.2023.115816
- Rahnama S, Tehrankhah ZM, Mohajerani F, Mohammadi FS, Yeganeh ZY, et al. Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis. BMC Complement Med Ther. 2023;23:337. 10.1186/s12906-023-04168-5
- Gheybi F, Rajabian F, Tayarani-Najaran Z, Adibi AR, Alavizadeh SH, et al. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. J Trace Elem Med Biol. 2023;80:127291. 10.1016/j.jtemb.2023.127291
- Wu S, Chen G, Chen EY, Farshidpour LS, Zhang Q, et al. Core Structure-Activity Relationship Studies of 5,7,20--Trimethylsilybins in Prostate Cancer Cell Models. Pharmaceuticals (Basel). 2023;16. 10.3390/ph16040531
- Parsa L, Motafakkerazad R, Soheyli ST, Haratian A, Kosari-Nasab M, et al. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon. 2023;228:107127. 10.1016/j.toxicon.2023.107127
- Nawaz A, Zaib S, Khan I, Ahmed A, Shahzadi K, et al. : An Overview of its Phytochemistry and Pharmacological Activities with Emphasis on Potential Anticancer Properties. Anticancer Agents Med Chem. 2023;23:1519. 10.2174/1871520623666230412111152
- Faixová D, Ratvaj M, Maruščáková IC, Hrčková G, Karaffová V, et al. Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells. Life (Basel). 2023;13. 10.3390/life13020492
- Mao JT, Xue B, Lu QY, Lundmark L, Burns W, et al. Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer - The role of MiR-663a and FHIT. Life Sci. 2023;318:121492. 10.1016/j.lfs.2023.121492
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. 10.1007/s00228-022-03434-8
