Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Milk Thistle Seed 30:1 Extract(Silybum marianum) (Fruit/Seed) (80% [120 mg] Total Flavonoids)
150 mg
†
Top Medical Research Studies
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
Read More
9
Effective silymarin delivery improves diabetes
We investigated how silymarin, derived from Silybum marianum, can potentially help manage type 2 diabetes. By using nanostructured lipid carriers (NLCs), we aimed to enhance silymarin's absorption since it usually has poor bioavailability.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Read More
8
We explored the effects of silibinin, an active compound from milk thistle, on type 2 diabetes in rats. Using a controlled study design, diabetic rats were treated with silibinin after exposure to diesel exhaust particles.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
Read More
Most Useful Reviews
7.5
Antioxidant benefits
Milk thistle is excellent for liver support. Being an antioxidant with anti-inflammatory properties, I recommend it for diabetes to aid the liver. I found the Jarrow brand to be effective and of good quality.
Read More
7.5
Detox and cleansing
2 people found this helpful
I recommend milk thistle, as it is effective for food poisoning, chronic intoxication, pregnancy-related toxicosis, obesity, and diabetes. It cleanses the liver and body of toxins, especially after chemotherapy or radiation therapy, reducing the risk of cardiovascular diseases and promoting overall health.
Read More
6
Effective for early diabetes
I purchased it because it showed effectiveness in my early diabetes.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
Read More
9
We observed significant improvements in blood sugar and lipid levels in diabetic rats treated with a polyherbal formulation named F6-SMONSECCE. This blend, made from various plant extracts, was tested against a known diabetic agent.
The results indicated substantial reductions in glucose and harmful cholesterol levels, alongside enhancements in insulin and beneficial HDL levels. Notably, there was also evidence of tissue healing in the pancreas and kidneys.
This suggests that F6-SMONSECCE could serve as a supportive treatment for diabetes, enhancing overall health alongside conventional medicines.
The results indicated substantial reductions in glucose and harmful cholesterol levels, alongside enhancements in insulin and beneficial HDL levels. Notably, there was also evidence of tissue healing in the pancreas and kidneys.
This suggests that F6-SMONSECCE could serve as a supportive treatment for diabetes, enhancing overall health alongside conventional medicines.
Read More
9
Effective silymarin delivery improves diabetes
We investigated how silymarin, derived from Silybum marianum, can potentially help manage type 2 diabetes. By using nanostructured lipid carriers (NLCs), we aimed to enhance silymarin's absorption since it usually has poor bioavailability.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Our study revealed that animals treated with NLCs showed significant reductions in blood glucose and triglyceride levels compared to those administered free silymarin. Additionally, there were notable protective effects on the liver and a reduction in nerve pain. Overall, these findings indicate that enhanced delivery methods could make silymarin a more effective treatment in diabetes management.
Read More
8
We explored the effects of silibinin, an active compound from milk thistle, on type 2 diabetes in rats. Using a controlled study design, diabetic rats were treated with silibinin after exposure to diesel exhaust particles.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
The results showed that silibinin positively influenced key insulin-related genes and reduced inflammation and oxidative stress. This suggests that silibinin may help regulate blood sugar levels and counteract some harmful effects of diabetes.
However, while promising, these findings require further investigation before we can fully endorse silibinin as a treatment option.
Read More
8
We investigated the effects of silibinin, a flavonoid from milk thistle, on diabetes in an animal model. Using healthy and diabetic rats, we examined how silibinin influenced insulin secretion, anxiety, and memory over 21 days.
Our findings showed that silibinin helped preserve insulin levels and decreased blood sugar. Additionally, it improved learning abilities in the rats. However, we did not evaluate the long-term effects or human applicability of these results. Overall, silibinin appears promising for diabetes management but needs further exploration.
Our findings showed that silibinin helped preserve insulin levels and decreased blood sugar. Additionally, it improved learning abilities in the rats. However, we did not evaluate the long-term effects or human applicability of these results. Overall, silibinin appears promising for diabetes management but needs further exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Antioxidant benefits
Milk thistle is excellent for liver support. Being an antioxidant with anti-inflammatory properties, I recommend it for diabetes to aid the liver. I found the Jarrow brand to be effective and of good quality.
Read More
7.5
Detox and cleansing
2 people found this helpful
I recommend milk thistle, as it is effective for food poisoning, chronic intoxication, pregnancy-related toxicosis, obesity, and diabetes. It cleanses the liver and body of toxins, especially after chemotherapy or radiation therapy, reducing the risk of cardiovascular diseases and promoting overall health.
Read More
6
Effective for early diabetes
I purchased it because it showed effectiveness in my early diabetes.
Read More
Frequently Asked Questions
6
Effective for early diabetes
I purchased it because it showed effectiveness in my early diabetes.
7.5
Antioxidant benefits
Milk thistle is excellent for liver support. Being an antioxidant with anti-inflammatory properties, I recommend it for diabetes to aid the liver. I found the Jarrow brand to be effective and of good quality.
7.5
Detox and cleansing
2 people found this helpful
I recommend milk thistle, as it is effective for food poisoning, chronic intoxication, pregnancy-related toxicosis, obesity, and diabetes. It cleanses the liver and body of toxins, especially after chemotherapy or radiation therapy, reducing the risk of cardiovascular diseases and promoting overall health.
9
Silibinin shows potential for diabetes
We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.
4
We reviewed several studies to understand how silymarin, a natural supplement, affects insulin resistance and sensitivity in individuals with diabetes. Our analysis showed that while silymarin can improve HOMA-IR levels slightly in type 2 diabetes patients, it did not significantly alter fasting insulin levels.
Interestingly, those with alcoholic cirrhosis experienced some benefits, but individuals with non-alcoholic fatty liver disease saw none. Overall, it appears that silymarin’s effects are limited, indicating a need for more robust research in this area.
Interestingly, those with alcoholic cirrhosis experienced some benefits, but individuals with non-alcoholic fatty liver disease saw none. Overall, it appears that silymarin’s effects are limited, indicating a need for more robust research in this area.
4
We investigated how silymarin (SMN) affects diabetic rats, specifically looking at metabolic and redox status. Over 30 days, diabetic rats were given either 50 or 100 mg/kg of SMN.
We noticed improvements in behaviors related to eating and drinking, as well as better kidney function. SMN also provided protective effects on the liver and pancreas.
However, it's important to note that silymarin did not manage blood sugar levels or improve pancreatic function in these diabetic animals.
We noticed improvements in behaviors related to eating and drinking, as well as better kidney function. SMN also provided protective effects on the liver and pancreas.
However, it's important to note that silymarin did not manage blood sugar levels or improve pancreatic function in these diabetic animals.
References
- Yin S, Zhu F, Liu Y, Chen Q. Effects of silymarin on insulin resistance and sensitivity: A systematic review and meta-analysis of randomized controlled trials. Diabetes Res Clin Pract. 2025;220:112008. doi:10.1016/j.diabres.2025.112008
- Awolaja OO. Protective potentials of extracted compound SILIBININ from milk thistle on type-2 diabetes mellitus and diesel exhaust particle (DEP) toxicity in experimental rats. J Nutr Biochem. 2025;137:109836. doi:10.1016/j.jnutbio.2024.109836
- Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x
- Dagli Gul AS, Boyuk Ozcan G, Arihan O. Silibinin as a promising treatment for diabetes: Insights into behavioral and metabolic changes in an animal model. Food Sci Nutr. 2024;12:3336. doi:10.1002/fsn3.3999
- Awla NJ, Naqishbandi AM, Baqi Y. Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome. ACS Pharmacol Transl Sci. 2023;6:1715. doi:10.1021/acsptsci.3c00171
- Akhtar MT, Almas T, Safdar S, Saadia M, Qadir R, et al. Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats. ACS Omega. 2023;8:21642. doi:10.1021/acsomega.3c01027
- Borymska W, Zych M, Dudek S, Kaczmarczyk-Sedlak I. Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats. Nutrients. 2022;14. doi:10.3390/nu14071450
- Santamarina AB, Moraes RCM, Nehmi Filho V, Murata GM, de Freitas JA, et al. The Symbiotic Effect of a New Nutraceutical with Yeast β-Glucan, Prebiotics, Minerals, and (Silymarin) for Recovering Metabolic Homeostasis via , , and Gene Expression in a Type-2 Diabetes Obesity Model. Antioxidants (Basel). 2022;11. doi:10.3390/antiox11030447
- Doostkam A, Fathalipour M, Anbardar MH, Purkhosrow A, Mirkhani H. Therapeutic Effects of Milk Thistle ( L.) and Artichoke ( L.) on Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Rats. Can J Gastroenterol Hepatol. 2022;2022:2868904. doi:10.1155/2022/2868904
- Colletta C, Colletta A, Placentino G. Lifestyle and silymarin: a fight against liver damage in NAFLD associated - prediabetic disease. J Diabetes Metab Disord. 2020;19:883. doi:10.1007/s40200-020-00576-3
- Miranda LMO, Agostini LDC, Lima WG, Camini FC, Costa DC. Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model. Biomed Environ Sci. 2020;33:690. doi:10.3967/bes2020.090
- Shen HH, Alex R, Bellner L, Raffaele M, Licari M, et al. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J Food Biochem. 2020;44:e13522. doi:10.1111/jfbc.13522
- Shah M, Nawaz S, Jan H, Uddin N, Ali A, et al. Synthesis of bio-mediated silver nanoparticles from Silybum marianum and their biological and clinical activities. Mater Sci Eng C Mater Biol Appl. 2020;112:110889. doi:10.1016/j.msec.2020.110889
- Mehrzadi S, Mirzaei R, Heydari M, Sasani M, Yaqoobvand B, et al. Efficacy and Safety of a Traditional Herbal Combination in Patients with Type II Diabetes Mellitus: A Randomized Controlled Trial. J Diet Suppl. 2021;18:31. doi:10.1080/19390211.2020.1727076
- Piazzini V, Micheli L, Luceri C, D'Ambrosio M, Cinci L, et al. Nanostructured lipid carriers for oral delivery of silymarin: Improving its absorption and in vivo efficacy in type 2 diabetes and metabolic syndrome model. Int J Pharm. 2019;572:118838. doi:10.1016/j.ijpharm.2019.118838
- Sun Y, Yang J, Liu W, Yao G, Xu F, et al. Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha. Mol Cell Biochem. 2019;460:81. doi:10.1007/s11010-019-03572-1
