Jarrow Formulas L-Glutamine

I purchased these lozenges for myself and have been taking them regularly. Previously, I used zinc in the form of picolinate, but I decided to try the lozenges and I haven't regretted it for a moment, despite the fact that the zinc is in a different form. They have a very pleasant taste and help soothe my throat as they dissolve. Unlike other pharmaceutical preparations, I did not experience any nausea after taking these lozenges. Just a tip: if you do experience nausea, avoid taking them on an empty stomach. I can definitely see the effect; I take them every two hours at the onset of a sore throat, and they significantly relieve the discomfort. Highly recommend!

Anxiety details

Zhu J, Zhong Z, Shi L, Huang L, Lin C, et al. Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut. Gut Microbes. 2024;16:2401939. doi:10.1080/19490976.2024.2401939

Based on 4 Researches

l-glutamine's role in anxiety

Our exploration delves into how early life stress affects anxiety and social behavior, particularly through the role of l-glutamine. We found that maternal separation in mice led to reduced levels of amino acid transporters in the gut, which in turn caused lower glutamine levels in the bloodstream. This was significant since glutamine is vital for brain functions, including the production of key neurotransmitters that influence mood and behavior.

In our findings, we noted that these low glutamine levels were linked to synaptic dysfunction in the medial prefrontal cortex, which is crucial for regulating emotional responses. Importantly, we observed that when we supplemented the mice with l-glutamine, there was noticeable improvement in their social behaviors and reduced anxiety-like symptoms. This indicates that enhancing amino acid transport through l-glutamine could be a beneficial strategy to mitigate the adverse effects of early life stress on mental health.

Overall, our research highlights a promising relationship between l-glutamine supplementation and emotional behavior improvements, pointing to a potential pathway through which gut bacteria may influence anxiety and social interactions.

Significant improvement

Most Useful Review

141 people found this helpful

Simply the BEST supplement for IBS that I have ever taken! After suffering with IBS-C for over 10 years and undergoing numerous tests that returned normal results, the impact on my diet, sleep, anxiety, and travel enjoyment was profound. Following a bout of food poisoning, I became extremely sensitive to various foods. Despite trying many supplements, only L-glutamine made a significant difference for me. This product has alleviated my digestive issues and, unexpectedly, helped with my sleep and overall well-being. I began to feel better right away and I'm astonished that such a reasonably priced supplement could yield such remarkable results.

Autoimmune Disorder details

Promising treatment for rheumatoid arthritis

Based on 3 Researches

Wang S, Yin J, Liu Y, Jin M, Wang Q, et al. An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2. Biomed Pharmacother. 2024;170:116025. doi:10.1016/j.biopha.2023.116025

We investigated how a trace element solution combined with L-alanyl-L-glutamine (LG) affects rheumatoid arthritis (RA).

This solution, called LG-WLYS, showed impressive qualities, such as inhibiting harmful cell migration and inflammation.

Our results indicated a shift in macrophage types from M1 to M2, leading to a reduction in various inflammatory markers and improved antioxidant activity.

Overall, LG-WLYS demonstrated strong potential as a therapeutic option for RA, showing both preventive and treatment benefits.

7.5

Healing leaky gut

Most Useful Review

162 people found this helpful

Healing intestinal hyperpermeability i.e. "leaky gut". After being diagnosed with Hashimoto's autoimmune thyroiditis, I realised the connection with leaky gut. High-dose probiotics and digestive enzymes improved my gut health over weeks. L-glutamine has been crucial in healing my leaky gut and addressing malabsorption, and I recommend it highly to others with similar issues.

Back Pain details

87 people found this helpful

Great for arthritis, muscle pain, and inflammation due to leaky gut. My son and I both have Lyme Disease, leading to joint pain and swelling. His gluten intolerance causes further symptoms like joint pain and inflammation. After discovering that leaky gut was the cause, I focused on treatment. We started L-Glutamine, and within a week, my son's pain disappeared, allowing him to run freely. However, when we stopped taking it during summer, the muscle and joint pain returned. Each time I resume the supplement, pain relief follows swiftly. This product is cost-effective compared to pricier alternatives and has no adverse side effects.

Cardiovascular Disease details

Strengthened immune system

7 people found this helpful

Excellent value for money! I have ALS and take it in the morning alongside other supplements. Vitamins are vital for my immune system, and I feel stronger and more resilient against the disease. The progression of my ALS has slowed down, and I highly recommend it. If you found my comment helpful, please click yes!

Chronic Fatigue Syndrome details

Investigating L-glutamine in CFS

Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008;29:902.

We explored how natural anti-inflammatory and antioxidant substances like L-glutamine could affect chronic fatigue syndrome (CFS) in patients. Over a 10-14 month period, we measured immune responses and overall health in 41 CFS patients before and after treatment.

Our findings indicated that improving gut health through these substances might lead to better clinical outcomes. While the study emphasizes targeted treatments for leaky gut in CFS, we found that it’s a promising area for future research rather than a definitive cure.

7.5

Improved energy level

Most Useful Review

1 people found this helpful

My energy levels have improved, but without the morning capsule, I experience fatigue and general exhaustion.

Flu details

Significant improvement

13 people found this helpful

Relief for leaky gut and acid reflux. I was diagnosed with leaky gut and acid reflux, which tend to follow each other. I tried many supplements to improve these symptoms with little success. Then I read about L-Glutamine and its digestive benefits. This has been a Godsend; I’m seeing significant improvement. I take it on an empty stomach and wait about 40 minutes before eating. I take it upon waking, mid-afternoon, and right before bed for maximum effectiveness. I'm so grateful for the relief it has provided.

Heart Attack details

Improves heart function

33 people found this helpful

I use it after workouts to build muscle mass and enhance heart function. The volume is ample, and the tablets are medium-sized.

Leg Cramps details

1 people found this helpful

The doctor prescribed treatment for healing the intestinal walls, and I believe there is an effect, as my leg cramps and discomfort have disappeared. This was taken alongside other medications.

Cancer details

Targeted treatment for colon cancer

Moderately Effective

Based on 5 Researches

Sharma S, Kaur V, Duhan P, Singh R, Agnihotri N. Evaluation of Anticancer Activity of Novel and Tumor-Targeted Glutamine-Conjugated Organotin(IV) Compounds in Colorectal Cancer─An In Vitro and In Vivo Study. J Med Chem. 2025;68:2593. doi:10.1021/acs.jmedchem.4c01728

We focused on the potential of l-glutamine-conjugated organotin(IV) compounds as a targeted treatment for colorectal cancer. These compounds were tested in laboratory settings against human colon cancer cell lines, revealing marked cytotoxic effects.

Through our observations, we noted that these compounds were capable of inducing cell cycle arrest and promoting apoptosis, which are key processes in halting cancer cell growth. When applied in an experimental model of colon cancer, they effectively reduced tumor sizes and volume while selectively accumulating in the colon with minimal toxicity.

Importantly, our findings suggest that these glutamine-linked compounds not only exhibit strong anti-tumor activity but also address the issue of systemic toxicity often seen with traditional therapies. Overall, we believe these compounds could potentially serve as promising candidates in the fight against colon cancer.

7.5

Aids cancer prevention

Most Useful Review

193 people found this helpful

An important nutraceutical for health and healing. I prefer this brand of L-glutamine for its cost savings and pleasant taste. I take 6 grams daily on an empty stomach to promote digestive health, maintain muscle mass, and as a cancer preventive. L-glutamine is vital for athletes and those recovering from disease. Research shows that cancer cells consume L-glutamine, impacting healthy cells' survival. Supplementing helps counter the negative nitrogen balance that can occur in cancer patients, preventing cachexia, which often threatens those with cancer.

Chemotherapy details

Glutamine mouthwash reduces mucositis

Based on 4 Researches

Sankaran SS, Dewan P, Malhotra RK, Harit D, Kashyap B, et al. Glutamine Mouthwash for Preventing Methotrexate-Induced Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Cross-Over Trial. Indian Pediatr. 2025;62:269. doi:10.1007/s13312-025-00042-4

We assessed how glutamine mouthwash stacks up against standard oral hygiene practices in kids with acute lymphoblastic leukemia undergoing high-dose methotrexate treatment.

In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.

This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.

Useful for mucositis

Most Useful Review

1 people found this helpful

It is very useful to supplement during chemotherapy for family members, especially to treat mucositis.

Cold details

Immunity improved daily

I take it in the morning, after training, and before bed. Due to its effect on my immune system, I am no longer catching colds.

Eczema details

2 people found this helpful

The quality is good, and thankfully, my eczema has disappeared. I'm grateful for the quality ingredients, and the taste is delightful, even without glutamine.

Gastroesophageal Reflux Disease details

This product truly alleviates the discomfort caused by gastroesophageal reflux. I have noticed a significant reduction in symptoms.

Heartburn details

Excellent product! I appreciate the quality, composition, and ingredients. I have experienced health benefits, including relief from heartburn and back pain.

Irritable Bowel Syndrome details

Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, et al. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019;68:996. doi:10.1136/gutjnl-2017-315136

Based on 9 Researches

Glutamine reduces IBS-D symptoms

We examined the potential of l-glutamine as a treatment for postinfectious irritable bowel syndrome, specifically focusing on patients who experience diarrhea as a primary symptom. This study was a well-structured, randomized, double-blind, placebo-controlled trial that lasted for eight weeks.

Participants were divided into two groups, receiving either 5 grams of glutamine three times a day or a placebo. We aimed to track significant improvements in IBS symptoms, particularly looking for a reduction of at least 50 points on the Irritable Bowel Syndrome Severity Scoring System (IBS-SS).

Remarkably, we found that an impressive 79.6% of patients taking glutamine met this primary endpoint, compared to just 5.8% in the placebo group—which is a 14-fold difference! Alongside this, glutamine also positively impacted secondary outcomes like daily bowel movement frequency, stool consistency, and even normalized intestinal permeability.

The results suggest that oral dietary glutamine appears to be a safe and effective option for relieving IBS symptoms related to intestinal hyperpermeability following an infection. While the findings are promising, we recommend further large-scale trials to verify these benefits and explore underlying mechanisms.

Excellent digestive result

Most Useful Review

1 people found this helpful

I consumed the entire jar, and the results for digestion are excellent! I had issues with bowel movements, but L-glutamine has helped address them – my bowel function has improved!

Sleep Apnea details

1 people found this helpful

I previously bought the powder but have now switched to tablets for convenience. I use them to assist in treating intestinal leaks and occasionally take them with BCAAs. The price is reasonable. My sleep has noticeably improved; even when I go to bed late, I wake up refreshed and experience deep sleep, reminiscent of my childhood.

Swollen Lymph Nodes details

Works well! Although these come in a large pill, their shape makes them easy to swallow. L-glutamine is incredibly beneficial for my belly swelling and overall well-being. I have been taking this brand for years and feel an effect within an hour of consumption.

Allergies details

Glutamine enhances immune responses

Moderately Effective

Based on 2 Researches

Fan J, Wang X, Wang Y, Song J, Chen M, et al. Dietary glutamine supplementation improves both Th1 and Th17 responses via CARD11-mTORC1 pathway in murine model of atopic dermatitis. Int Immunopharmacol. 2024;143:113316. doi:10.1016/j.intimp.2024.113316

We investigated how dietary glutamine, a nutrient known to influence the immune system, impacts allergies, particularly in atopic dermatitis (AD). Our focus was on understanding the connection between glutamine and a specific protein called CARD11, which plays a crucial role in Th1 and Th17 immune responses.

In our study, we used mice that had been sensitized to house dust mites, a common trigger for allergic reactions. We found that these mice showed increased levels of certain immune markers, like interferon-gamma and interleukin-17, which are associated with allergic responses. However, when CARD11 was absent, these immune reactions were significantly diminished, highlighting CARD11's importance in managing allergic responses in AD.

Additionally, we looked at how blocking a signaling pathway linked to CARD11 influenced immune responses. Interestingly, when glutamine was added to the diet of mice lacking CARD11, we observed a restoration of those immune responses. This suggests that glutamine potentially enhances Th1 and Th17 responses through its action on the CARD11-mTORC1 pathway.

Overall, our findings suggest that glutamine supplementation could be a promising approach to improving immune responses in atopic dermatitis, opening the door for new dietary treatments for allergies.

Doctor-recommended drug

Most Useful Review

I've recently used this product, recommended by my doctor for restoring the intestinal mucosa. I appreciate that it does not provoke any allergies, and I plan to continue taking it.

Bacterial Infection details

Reversed stomach damage

Glutamine is the amino acid predominantly present in muscle tissue and can easily cross the blood-brain barrier, converting into glutamic acid within brain cells. It enhances gamma-aminobutyric acid levels, crucial for normal brain function, while also supporting acid-base balance and healthy gastrointestinal conditions. Importantly, research indicates that glutamine can prevent bacterial cell death, effectively reversing damage to stomach tissue associated with bacterial infection.

Bloating details