Last update
8/28/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
L-Glutamine
1,000 mg
†
Top Medical Research Studies
9
Glutamine mouthwash reduces mucositis
We assessed how glutamine mouthwash stacks up against standard oral hygiene practices in kids with acute lymphoblastic leukemia undergoing high-dose methotrexate treatment.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
Read More
7
We examined how glutamine impacts cancer treatment and the immune system. Glutamine, the most abundant amino acid in our blood, is vital for cancer cell growth. It fuels immune cell functions that can help combat cancer.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Read More
8
We observed the effects of amino acids, particularly glutamine, glycine, and serine, on chemotherapy sensitivity in gastric cancer cells. By studying 20 amino acids, we found that higher concentrations of these nutrients can improve how well these cancer cells respond to cisplatin—a common chemotherapy agent. This happens because these amino acids can help break down a protein called KDM4A, which otherwise helps cancer cells survive chemotherapy. Although promising, more research is needed to fully understand how nutrition therapy can help gastric cancer patients during treatment.
Read More
Most Useful Reviews
9
Supports immunity
1 people found this helpful
L-glutamine is crucial for immunomodulatory function, especially during chemotherapy. It aids in blood cell division, delivers nitrogen to cells, and maintains blood's acid-base balance. This amino acid protects intestinal mucosa from toxins and supports muscle building. Consuming foods rich in glutamine also helps with stress recovery.
Read More
9
Useful for mucositis
1 people found this helpful
It is very useful to supplement during chemotherapy for family members, especially to treat mucositis.
Read More
9
Improved energy
The chemotherapy caused side effects like damage to the oral mucosa and diarrhoea for a family member. However, following treatment, their symptoms significantly improved, leading to a better appetite and increased energy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Glutamine mouthwash reduces mucositis
We assessed how glutamine mouthwash stacks up against standard oral hygiene practices in kids with acute lymphoblastic leukemia undergoing high-dose methotrexate treatment.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
In a randomized cross-over trial involving 64 chemotherapy courses, children received either glutamine mouthwash or usual care. We found that while both groups experienced mucositis, the glutamine group showed a significantly lower rate of severe cases, shorter duration of discomfort, and less pain overall.
This suggests that glutamine mouthwash could be a beneficial addition to chemotherapy care for reducing the impact of painful mouth sores.
Read More
8
We observed the effects of amino acids, particularly glutamine, glycine, and serine, on chemotherapy sensitivity in gastric cancer cells. By studying 20 amino acids, we found that higher concentrations of these nutrients can improve how well these cancer cells respond to cisplatin—a common chemotherapy agent. This happens because these amino acids can help break down a protein called KDM4A, which otherwise helps cancer cells survive chemotherapy. Although promising, more research is needed to fully understand how nutrition therapy can help gastric cancer patients during treatment.
Read More
7
Targeting glutamine in colorectal cancer
We explored a phase I/II trial investigating how targeting glutamine metabolism alongside EGFR inhibition could influence treatment outcomes for metastatic colorectal cancer (mCRC). Our findings indicated that while the combination treatment was tolerable and showed some promising responses, including two patients achieving partial response, the study was halted early due to the termination of one drug's development.
Interestingly, the B-cell activation signature "B-score" surfaced as a potential biomarker for treatment response, prompting further investigations into enhancing therapies for tumors reliant on glutamine metabolism.
Interestingly, the B-cell activation signature "B-score" surfaced as a potential biomarker for treatment response, prompting further investigations into enhancing therapies for tumors reliant on glutamine metabolism.
Read More
7
We examined how glutamine impacts cancer treatment and the immune system. Glutamine, the most abundant amino acid in our blood, is vital for cancer cell growth. It fuels immune cell functions that can help combat cancer.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Interestingly, oral glutamine supplementation shows promise—potentially enhancing immune responses and improving chemotherapy outcomes. This suggests that glutamine could be a valuable ally in boosting cancer treatment effectiveness and patient prognosis. However, further research is needed to fully understand its mechanisms and benefits.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Supports immunity
1 people found this helpful
L-glutamine is crucial for immunomodulatory function, especially during chemotherapy. It aids in blood cell division, delivers nitrogen to cells, and maintains blood's acid-base balance. This amino acid protects intestinal mucosa from toxins and supports muscle building. Consuming foods rich in glutamine also helps with stress recovery.
Read More
9
Useful for mucositis
1 people found this helpful
It is very useful to supplement during chemotherapy for family members, especially to treat mucositis.
Read More
9
Improved energy
The chemotherapy caused side effects like damage to the oral mucosa and diarrhoea for a family member. However, following treatment, their symptoms significantly improved, leading to a better appetite and increased energy.
Read More
9
Improved side effects
Taking 10 capsules daily has significantly alleviated the side effects my family members experienced during chemotherapy, such as mucosal damage and neuralgia.
Read More
8
Improves well-being
3 people found this helpful
L-Glutamine positively affects heart and brain function, facilitates quick healing of wounds and burns. It prevents liver damage, stimulates growth hormone synthesis, and effectively eliminates metabolic waste. Moreover, it may reduce the secondary effects of chemotherapy, improving well-being for those with HIV and aiding the body in combating stress.
Read More
Frequently Asked Questions
9
Improved side effects
Taking 10 capsules daily has significantly alleviated the side effects my family members experienced during chemotherapy, such as mucosal damage and neuralgia.
9
Relieves oral ulcers
My family’s oral ulcers during chemotherapy have improved significantly. Tablets are more effective than powders. By improving oral conditions, we can better supplement other nutrients and recover quickly. I recommend it to others facing similar issues, wishing you all good health.
7.5
Essential for treatment
1 people found this helpful
Excellent! To reduce the side effects of chemotherapy, both chemotherapy and electrotherapy are indispensable.
9
Mucosa support
Family members undergoing chemotherapy can consume this, which greatly aids in repairing mucosal damage caused by chemotherapy drugs.
7.5
Mucous protection
My family uses it during chemotherapy to safeguard the mucous membranes effectively.
References
- Sankaran SS, Dewan P, Malhotra RK, Harit D, Kashyap B, et al. Glutamine Mouthwash for Preventing Methotrexate-Induced Mucositis in Children with Acute Lymphoblastic Leukemia: A Randomized Cross-Over Trial. Indian Pediatr. 2025;62:269. 10.1007/s13312-025-00042-4
- Ciombor KK, Bae SW, Whisenant JG, Ayers GD, Sheng Q, et al. Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer. Clin Cancer Res. 2025;31:1437. 10.1158/1078-0432.CCR-24-3133
- Nan D, Yao W, Huang L, Liu R, Chen X, et al. Glutamine and cancer: metabolism, immune microenvironment, and therapeutic targets. Cell Commun Signal. 2025;23:45. 10.1186/s12964-024-02018-6
- Fu J, Ni Y, Hu Y, Tang W, Fu J, et al. Glutamine, Serine and Glycine at Increasing Concentrations Regulate Cisplatin Sensitivity in Gastric Cancer by Posttranslational Modifications of KDM4A. Mol Carcinog. 2025;64:703. 10.1002/mc.23881
