We explored how garlic-derived polysaccharides could help relieve constipation while also enhancing gut health. In this study, we administered different doses of garlic polysaccharides (GPs) and a positive control, inulin, to Kunming mice. We paid close attention to their effects on various intestinal barriers and how they might alleviate constipation symptoms spurred by loperamide.
Our findings indicated that GPs not only improved the expression of vital proteins and mucins in the small intestine but also had a positive effect on gut bacteria. The garlic polysaccharides increased beneficial compounds like butyric acid, promoted the growth of healthy gut bacteria, and helped balance gut microbiota. Notably, GPs also showed promise in easing loperamide-induced constipation by improving bowel movement frequency and stool consistency.
This study highlights the potential of garlic polysaccharides in supporting intestinal health and alleviating constipation, suggesting they may serve as beneficial prebiotics. Overall, we found that incorporating garlic into the diet could enhance gut function and promote comfort in those struggling with constipation.
Read More