Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 25 Reviews
8.6
Supplement Facts
Serving Size: 2 capsules
Amount Per Serving
%DV
Aged Garlic Extract™†† Powder (bulb)
400 mg
**
Nattokinase (NSK-SD®)
70 mg
**
L-Theanine (Suntheanine®)
24 mg
**
Top Medical Research Studies
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
9
We aimed to understand how nattokinase affects hypertension by comparing its efficacy against its non-protease fragments in spontaneously hypertensive rats.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Most Useful Reviews
9
Progressive improvement
468 people found this helpful
After using this product for six weeks, my hypertension has shown consistent improvement. I was sceptical about pharmaceutical medications, given my family history. However, I've seen numbers drop significantly and plan to continue my regimen, which includes exercise and dietary changes.
7.5
Headaches eliminated
34 people found this helpful
I suffer from type II Vasculitis, resulting in high blood pressure and headaches. With this product, my hypertension headaches have vanished. While my blood pressure only slightly decreased, the elimination of headaches is a significant benefit, making it essential to my daily routine.
10
Consistently optimal readings
22 people found this helpful
I'm a believer! My blood pressure has been at pre-hypertension levels for a couple of years, ranging from 140/85 to 135/70. My father has high blood pressure, and medication frightens me. I work out three times a week and take four of these daily. The morning after my first dosage, my pressure was 113/70, consistently the same each morning. Love this product!
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
- All Researches
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
9
We aimed to understand how nattokinase affects hypertension by comparing its efficacy against its non-protease fragments in spontaneously hypertensive rats.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
Through a continuous oral administration test, we found that a higher dose of nattokinase significantly lowered systolic and diastolic blood pressure, alongside reducing plasma fibrinogen levels.
Interestingly, while the fragments also reduced blood pressure, they worked differently, lowering angiotensin II levels without affecting fibrinogen. Our findings suggest that nattokinase and its fragments interact with hypertension in distinct ways.
8
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
8
We evaluated how nattokinase affects blood pressure in people living with pre-hypertension or stage 1 hypertension. In this randomized, double-blind, placebo-controlled trial involving 86 participants, we found that those taking nattokinase showed a significant drop in both systolic and diastolic blood pressure after 8 weeks. Specifically, systolic blood pressure decreased by an average of 5.55 mmHg, while diastolic blood pressure fell by 2.84 mmHg. Our results suggest that nattokinase could be a beneficial option in managing hypertension.
7
Aged garlic extract lowers blood pressure
We examined the effects of aged garlic extract (AGE) on blood pressure in individuals with hypertension through a thorough review of randomized controlled trials (RCTs). Our analysis included data from various studies, ultimately bringing together results from nine trials that involved a total of 584 participants.
The findings indicated that supplementation with AGE tea could lead to reductions in both systolic and diastolic blood pressure. Specifically, we noted a decrease in systolic blood pressure by an average of 4.03 mmHg and a slight reduction in diastolic blood pressure by 1.44 mmHg. However, the most significant improvements were observed with daily doses exceeding 1200 mg.
Given that the overall data suggest positive outcomes for those with hypertension, particularly at higher dosages, we believe that AGE could be a beneficial addition to lifestyle and dietary strategies for managing high blood pressure. That said, further, well-designed clinical trials are necessary to validate these results and establish clearer recommendations.
The findings indicated that supplementation with AGE tea could lead to reductions in both systolic and diastolic blood pressure. Specifically, we noted a decrease in systolic blood pressure by an average of 4.03 mmHg and a slight reduction in diastolic blood pressure by 1.44 mmHg. However, the most significant improvements were observed with daily doses exceeding 1200 mg.
Given that the overall data suggest positive outcomes for those with hypertension, particularly at higher dosages, we believe that AGE could be a beneficial addition to lifestyle and dietary strategies for managing high blood pressure. That said, further, well-designed clinical trials are necessary to validate these results and establish clearer recommendations.
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Progressive improvement
468 people found this helpful
After using this product for six weeks, my hypertension has shown consistent improvement. I was sceptical about pharmaceutical medications, given my family history. However, I've seen numbers drop significantly and plan to continue my regimen, which includes exercise and dietary changes.
7.5
Headaches eliminated
34 people found this helpful
I suffer from type II Vasculitis, resulting in high blood pressure and headaches. With this product, my hypertension headaches have vanished. While my blood pressure only slightly decreased, the elimination of headaches is a significant benefit, making it essential to my daily routine.
10
Consistently optimal readings
22 people found this helpful
I'm a believer! My blood pressure has been at pre-hypertension levels for a couple of years, ranging from 140/85 to 135/70. My father has high blood pressure, and medication frightens me. I work out three times a week and take four of these daily. The morning after my first dosage, my pressure was 113/70, consistently the same each morning. Love this product!
9
Significantly lowered pressure
21 people found this helpful
This stuff works! I generally don't write reviews unless I'm impressed by my purchase. I've been on the borderline of hypertension for the past year and recently became serious about my health, which includes exercise and a healthier diet. When I checked my blood pressure, it was creeping up to 130/77. I purchased this product to lower my numbers. Low and behold, after just 5 days of taking these tablets twice daily alongside a shot of ACV, my pressure is now 110/84. This stuff is the real deal!
7.5
Recommended for lowering hypertension
21 people found this helpful
Very good product; I would definitely take it more often. I've struggled with hypertension for years, and medication wasn't helping much. I recommend this to everyone to lower their hypertension. It has dropped my blood pressure to good readings, closely monitored by my doctor, who is proud of my progress. Garlic, the key ingredient, is essential for maintaining healthy arteries and a sound cardiovascular system.
Frequently Asked Questions
9
Normalised blood pressure
2 people found this helpful
I ordered it for my mother, who has hypertension and experiences pressure spikes. Since taking the capsules for 17 days, her blood pressure has normalised. Thank you for an excellent product! Halyna
7.5
Stabilised blood pressure
7 people found this helpful
I used this for my mother, who has hypertension. Though it took some time, her blood pressure gradually stabilised. While she continues with her daily medications, the garlic extract complements her treatments effectively.
6
Reduced medication need
12 people found this helpful
I took it for an elderly person with high blood pressure. After beginning the supplement, the dose of his blood pressure medications was reduced. While this supplement won't completely eliminate the need for pharmaceuticals for someone who has dealt with hypertension for years, it effectively reduces the amount of chemical medication required.
6
Medication intake reduction
I combined this with my hypertension medication, and although I'm still monitoring its effect, it seems to be working. I'm gradually reducing my intake of blood pressure medicine.
9
Improved blood pressure
3 people found this helpful
Kyolic-aged-garlic-extract is beneficial for lowering blood pressure in patients with uncontrolled hypertension. Moreover, it may enhance arterial stiffness, inflammation, and the gut microbial profile.
9
Discontinued B/P meds
1 people found this helpful
This has truly helped my mother-in-law, who suffers from mild hypertension. Under her practitioner's supervision, she has stopped taking her blood pressure medications, and the practitioner was thrilled to hear she was using a natural product.
9
Immunity boost noted
Works brilliantly! Additionally, it's great for immunity. Garlic extract is excellent for hypertension.
7
Aged garlic extract lowers blood pressure
We examined the effects of aged garlic extract (AGE) on blood pressure in individuals with hypertension through a thorough review of randomized controlled trials (RCTs). Our analysis included data from various studies, ultimately bringing together results from nine trials that involved a total of 584 participants.
The findings indicated that supplementation with AGE tea could lead to reductions in both systolic and diastolic blood pressure. Specifically, we noted a decrease in systolic blood pressure by an average of 4.03 mmHg and a slight reduction in diastolic blood pressure by 1.44 mmHg. However, the most significant improvements were observed with daily doses exceeding 1200 mg.
Given that the overall data suggest positive outcomes for those with hypertension, particularly at higher dosages, we believe that AGE could be a beneficial addition to lifestyle and dietary strategies for managing high blood pressure. That said, further, well-designed clinical trials are necessary to validate these results and establish clearer recommendations.
The findings indicated that supplementation with AGE tea could lead to reductions in both systolic and diastolic blood pressure. Specifically, we noted a decrease in systolic blood pressure by an average of 4.03 mmHg and a slight reduction in diastolic blood pressure by 1.44 mmHg. However, the most significant improvements were observed with daily doses exceeding 1200 mg.
Given that the overall data suggest positive outcomes for those with hypertension, particularly at higher dosages, we believe that AGE could be a beneficial addition to lifestyle and dietary strategies for managing high blood pressure. That said, further, well-designed clinical trials are necessary to validate these results and establish clearer recommendations.
9
We explored the effectiveness of nattokinase, a fibrinolytic enzyme derived from fermented soybeans, in managing hypertension. This study involved a systematic review of six randomized controlled trials, encompassing 546 participants. Through a robust methodology, including data extraction and risk assessment, we aimed to determine how nattokinase supplementation could support cardiovascular health.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
Our findings indicated that nattokinase significantly reduced both systolic and diastolic blood pressure compared to a placebo. Specifically, we noted a decrease in systolic blood pressure by an average of 3.45 mm Hg and in diastolic blood pressure by 2.32 mm Hg. This suggests that nattokinase could be a beneficial adjunctive therapy for individuals struggling with high blood pressure.
However, it's important to highlight that while nattokinase may support blood pressure management, its effects on cholesterol levels were less encouraging. The study showed that lower doses of nattokinase could negatively impact total cholesterol and have no significant influence on triglyceride levels. Thus, while nattokinase appears promising for hypertension, the relationship between dosage and lipid levels warrants further investigation.
Overall, our research contributes to the understanding of nattokinase's role in hypertension treatment, highlighting its potential while pointing to areas that need more clarity regarding dosage and lipid interactions.
8
Our exploration centered on the effectiveness of nattokinase, an enzyme produced by Bacillus subtilis VITMS 2, in managing hypertension. We focused on how this enzyme might help in reducing blood pressure by inhibiting angiotensin-converting enzyme (ACE), which plays a significant role in regulating blood pressure levels.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
We discovered that nattokinase showed promising results in vitro, with a significant ACE inhibitory concentration of 0.06 mg/mL. Moreover, its fibrinolytic activity was impressive, indicating a high potential for tackling blood clotting issues that can arise alongside hypertension. The enzyme was highly stable at elevated temperatures and over varying pH levels, further suggesting its practical use in dietary applications.
Molecular docking studies supported our findings, showing strong binding affinity of nattokinase to the ACE, which aligns with its potential as an anti-hypertensive agent. With a specific activity of 2418.85 U/mg, this enzyme could indeed play a significant role in hypertension management through dietary supplementation or therapeutic use.
References
- Saadh MJ, Kariem M, Shukla M, Ballal S, Kumar A, et al. Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins Other Lipid Mediat. 2024;175:106914. doi:10.1016/j.prostaglandins.2024.106914
- Sleiman C, Daou RM, Al Hazzouri A, Hamdan Z, Ghadieh HE, et al. Garlic and Hypertension: Efficacy, Mechanism of Action, and Clinical Implications. Nutrients. 2024;16. doi:10.3390/nu16172895
- Li X, Long J, Gao Q, Pan M, Wang J, et al. Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Rev Cardiovasc Med. 2023;24:234. doi:10.31083/j.rcm2408234
- Qiao Y, Zhang K, Zhang Z, Zhang C, Sun Y, et al. Fermented soybean foods: A review of their functional components, mechanism of action and factors influencing their health benefits. Food Res Int. 2022;158:111575. doi:10.1016/j.foodres.2022.111575
- Keziah SM, Devi CS. Fibrinolytic and ACE Inhibitory Activity of Nattokinase Extracted from Bacillus subtilis VITMS 2: A Strain Isolated from Fermented Milk of Vigna unguiculata. Protein J. 2021;40:876. doi:10.1007/s10930-021-10023-8
- Fujita M, Ohnishi K, Takaoka S, Ogasawara K, Fukuyama R, et al. Antihypertensive effects of continuous oral administration of nattokinase and its fragments in spontaneously hypertensive rats. Biol Pharm Bull. 2011;34:1696.
- Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, et al. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008;31:1583. doi:10.1291/hypres.31.1583
