Last update
3/27/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
Most Useful Reviews
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
9
Stress reduction
13 people found this helpful
I sought vitamins to promote hair growth and manage stress. The dosage is precise and impressive, and I’m experiencing more energy. My brain works better without unnecessary stress. The B vitamins are crucial for nerve support and overall health, and I’ve noticed a significant decrease in hair loss and a positive impact on my nervous system.
Read More
7.5
Brain function improved
3 people found this helpful
Your nervous system will be grateful for this complex of B vitamins, which is essential for the brain. It enhances brain function, reaction times, and reduces stress. The energy provided by these vitamins is vital for our daily productivity, mood, and behaviour. The combination of these B vitamins truly showcases their effectiveness, and I trust this brand for its proven quality.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Read More
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Read More
9
Stress reduction
13 people found this helpful
I sought vitamins to promote hair growth and manage stress. The dosage is precise and impressive, and I’m experiencing more energy. My brain works better without unnecessary stress. The B vitamins are crucial for nerve support and overall health, and I’ve noticed a significant decrease in hair loss and a positive impact on my nervous system.
Read More
7.5
Brain function improved
3 people found this helpful
Your nervous system will be grateful for this complex of B vitamins, which is essential for the brain. It enhances brain function, reaction times, and reduces stress. The energy provided by these vitamins is vital for our daily productivity, mood, and behaviour. The combination of these B vitamins truly showcases their effectiveness, and I trust this brand for its proven quality.
Read More
7.5
Cognitive improvement
1 people found this helpful
Excellent product! As a B vitamin complex, it is essential for improving issues like forgetfulness and fatigue, enhancing cognitive ability. It supports brain function while contributing to overall health and happiness.
Read More
7.5
Nerve issues resolved
1 people found this helpful
This product contains all types of vitamin B and is superb for nerve and brain health. I experienced numbness in my thigh, which dissipated after a week of usage.
Read More
Frequently Asked Questions
9
Relief and improvement
6 people found this helpful
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
9
Stress reduction
13 people found this helpful
I sought vitamins to promote hair growth and manage stress. The dosage is precise and impressive, and I’m experiencing more energy. My brain works better without unnecessary stress. The B vitamins are crucial for nerve support and overall health, and I’ve noticed a significant decrease in hair loss and a positive impact on my nervous system.
7.5
Cognitive improvement
1 people found this helpful
Excellent product! As a B vitamin complex, it is essential for improving issues like forgetfulness and fatigue, enhancing cognitive ability. It supports brain function while contributing to overall health and happiness.
7
We investigated how nicotinamide, a form of vitamin B3, impacts glioblastoma (GB) cells. Our findings reveal that it can induce a state of senescence, slowing down cell growth and altering their internal processes.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
While these senescent cells showed reduced tumor-forming capabilities, they maintained some level of tumor potential and proved to be reversible. This suggests nicotinamide could offer insights into managing GB, though its effects may vary and further research is essential.
8
Pyridoxine promotes glioblastoma cell death
We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.
References
- Narayanan A, Saurty-Seerunghen MS, Michieletto J, Delaunay V, Bruneel A, et al. Nicotinamide metabolism reprogramming drives reversible senescence of glioblastoma cells. Cell Mol Life Sci. 2025;82:126. 10.1007/s00018-025-05641-9
- Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. 10.1080/00207454.2023.2263815
