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Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
USERS' SCORE
Good
Based on 12 Reviews
8
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
Most Useful Reviews
7.5
Nervous system enhancement
3 people found this helpful
I found this product remarkable; it hasn't improved the pie at all ❤. It's one of the highest quality types. My father's condition, affected by diabetes, has worn him out; however, this has proved wonderful for his nervous system, and if he continues taking it, I believe his condition will significantly improve.
Read More
9
Protects nerve damage
1 people found this helpful
Excellent for me, as I have diabetes and it protects against nerve damage after Allah.
Read More
7.5
Improved overall health
16 people found this helpful
Since I started taking it, I've noticed a marked improvement in my health, especially as I have diabetes and have been experiencing severe hair loss and breakage. I've combined it with two biotin supplements from the same company, and I feel optimistic about the benefits.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.6
- All Researches
9
Thiamine treatment aids diabetes management
We examined a rare condition known as thiamine-responsive megaloblastic anaemia (TRMA) in a young man with type 1 diabetes and unexplained pancytopenia. After thorough testing revealed genetic factors, we found that daily thiamine supplementation effectively resolved his anemia.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
More importantly, this treatment not only improved his blood counts but also lowered his insulin needs. This highlights the significance of identifying genetic causes in young patients presenting with such symptoms.
Read More
9
We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.
Read More
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
Read More
8
We examined how ice plant extract and its active component, D-pinitol, influence insulin secretion and glucose levels in diabetic rats. The study found that both IPE and D-pinitol significantly boosted insulin secretion in rat insulin-secreting cells.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Additionally, these substances improved glucose tolerance and displayed positive effects on liver function and lipid profiles. Overall, the findings suggest that IPE and D-pinitol show promise as functional foods that could help manage diabetes.
Read More
8
Thiamine disulfide shows promise for diabetes
We investigated whether thiamine disulfide (TD) can lower blood sugar and improve insulin resistance in rats with type 1 diabetes. By assigning rats to different treatment groups, we used various tests to measure blood sugar, insulin sensitivity, and gene expression related to diabetes.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Results showed that TD effectively reduced blood glucose levels and improved several metabolic markers. However, it didn't affect the expression of the Glut4 gene, which plays a role in glucose uptake. Overall, TD demonstrated potential as a diabetes treatment, particularly in reducing insulin resistance.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Nervous system enhancement
3 people found this helpful
I found this product remarkable; it hasn't improved the pie at all ❤. It's one of the highest quality types. My father's condition, affected by diabetes, has worn him out; however, this has proved wonderful for his nervous system, and if he continues taking it, I believe his condition will significantly improve.
Read More
9
Protects nerve damage
1 people found this helpful
Excellent for me, as I have diabetes and it protects against nerve damage after Allah.
Read More
7.5
Improved overall health
16 people found this helpful
Since I started taking it, I've noticed a marked improvement in my health, especially as I have diabetes and have been experiencing severe hair loss and breakage. I've combined it with two biotin supplements from the same company, and I feel optimistic about the benefits.
Read More
7.5
B vitamins necessity
1 people found this helpful
I have bought this product more than once because most of the B vitamin doses are at 100, which are crucial for managing panic, depression, and obsessive behaviours, particularly for patients with type 2 diabetes who require high doses of these vitamins.
Read More
9
Better than previous
An excellent bioactive vitamin B complex. I use it every night with my diabetes medication; it’s much better than any others I have used before.
Read More
Frequently Asked Questions
7.5
Improved overall health
16 people found this helpful
Since I started taking it, I've noticed a marked improvement in my health, especially as I have diabetes and have been experiencing severe hair loss and breakage. I've combined it with two biotin supplements from the same company, and I feel optimistic about the benefits.
7.5
Nervous system enhancement
3 people found this helpful
I found this product remarkable; it hasn't improved the pie at all ❤. It's one of the highest quality types. My father's condition, affected by diabetes, has worn him out; however, this has proved wonderful for his nervous system, and if he continues taking it, I believe his condition will significantly improve.
9
Protects nerve damage
1 people found this helpful
Excellent for me, as I have diabetes and it protects against nerve damage after Allah.
7.5
Nervous system support
Very good complex. We took it for my mother, as she has diabetes and requires this vitamin. B vitamins are pivotal for energy synthesis, the proper functioning of the central nervous system and brain, and are crucial for the circulatory and cardiovascular systems. A deficiency in B vitamins often affects mood and mental health, leading to emotions such as irritability or depression. Additionally, signs like insomnia, fatigue, and poor hair and skin condition might indicate insufficient B vitamin levels.
9
Better than previous
An excellent bioactive vitamin B complex. I use it every night with my diabetes medication; it’s much better than any others I have used before.
7.5
Improves energy levels
The quality and ingredients are excellent. It contains a group of B vitamins and folic acid, improving energy and the product's effectiveness for the nervous system, particularly beneficial for those suffering from diabetes. The quantity and taste are acceptable, and the packaging is suitable.
7.5
B vitamins necessity
1 people found this helpful
I have bought this product more than once because most of the B vitamin doses are at 100, which are crucial for managing panic, depression, and obsessive behaviours, particularly for patients with type 2 diabetes who require high doses of these vitamins.
7
Annona muricata aids diabetes treatment
We explored the antidiabetic properties of Annona muricata leaf extract using a metabolomics approach on diabetes-induced rats. The study involved administering two doses of the extract to evaluate its impacts on metabolic profiles over four weeks.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
Remarkably, the lower dose showed significant benefits, lowering serum urea levels while exhibiting effects similar to metformin. We found that the extract positively influenced various metabolic pathways, confirming its traditional use for managing diabetes. Overall, the research highlights promising insights into how this natural treatment could aid in diabetes management.
8
We explored how nicotinamide riboside (NR), a vitamin precursor to NAD, influences bone loss in type 2 diabetic mice. By administering NR to mice with diabetes induced by a high-fat diet and streptozotocin, we observed impressive results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
NR not only improved insulin resistance, but also enhanced bone quality and microarchitecture. Plus, it helped reduce bone resorption and positively influenced crucial signaling pathways related to bone health.
Overall, our findings suggest that NR has potential as a treatment for diabetes-related bone issues, but further studies are needed to solidify these results.
7
We reviewed data from a 2009-2010 survey to understand how vitamin B6 influences the link between type 2 diabetes and periodontitis, a serious gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
Our findings revealed that individuals with diabetes have an increased risk of periodontitis. Importantly, higher levels of vitamin B6 appeared to reduce this risk.
This suggests that maintaining adequate vitamin B6 intake may benefit those with diabetes by potentially lowering their chances of developing gum disease.
7
We conducted a double-blind randomized trial focusing on the effects of pyridoxamine, a vitamin B6 metabolite, on bone health in older women with type 2 diabetes.
After a year of treatment with 200 mg of pyridoxamine twice daily, we saw a promising 23% increase in a bone formation marker compared to only 4% with a placebo.
Additionally, participants taking pyridoxamine experienced an improvement in bone density and a reduction in HbA1c levels, indicating better blood sugar control.
However, further research is necessary to fully understand pyridoxamine’s potential in protecting against fractures in this population.
After a year of treatment with 200 mg of pyridoxamine twice daily, we saw a promising 23% increase in a bone formation marker compared to only 4% with a placebo.
Additionally, participants taking pyridoxamine experienced an improvement in bone density and a reduction in HbA1c levels, indicating better blood sugar control.
However, further research is necessary to fully understand pyridoxamine’s potential in protecting against fractures in this population.
References
- Zubaidi SN, Wong PL, Qadi WSM, Dawoud EAD, Hamezah HS, et al. Deciphering the mechanism of Annona muricata leaf extract in alloxan-nicotinamide-induced diabetic rat model with H-NMR-based metabolomics approach. J Pharm Biomed Anal. 2025;260:116806. 10.1016/j.jpba.2025.116806
- Zhu J, Xu W, Wu S, Song D. Vitamin B6 status, type 2 diabetes mellitus, and periodontitis: evidence from the NHANES database 2009-2010. BMC Oral Health. 2025;25:299. 10.1186/s12903-025-05597-z
- Gao J, Meng X, Yang X, Xie C, Tian C, et al. The protection of nicotinamide riboside against diabetes mellitus-induced bone loss via OXPHOS. Bone. 2025;193:117411. 10.1016/j.bone.2025.117411
- Lee D, Kim SJ, Choi YJ, Rho YH, Kang TS, et al. The Glucose-Lowering Effect of and D-Pinitol: Studies on Insulin Secretion in INS-1 Cells and the Reduction of Blood Glucose in Diabetic Rats. Nutrients. 2025;17. 10.3390/nu17010193
- Brossfield AV, McMahon DJ, Fernando J, Omeragic B, Majeed R, et al. The Effects of the AGE Inhibitor Pyridoxamine on Bone in Older Women With Type 2 Diabetes: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2025;110:961. 10.1210/clinem/dgae700
- Pascoe MA, Hall AM, Gray A. Thiamine-responsive megaloblastic anaemia in a young adult with acute pancytopenia. BMJ Case Rep. 2024;17. 10.1136/bcr-2024-261435
- Didangelos T, Karlafti E, Kotzakioulafi E, Giannoulaki P, Kontoninas Z, et al. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Nutrients. 2024;16. 10.3390/nu16183045
- D'Haese S, Claes L, Jaeken E, Deluyker D, Evens L, et al. Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats. Int J Mol Sci. 2024;25. 10.3390/ijms25158508
- Rad MG, Sharifi M, Meamar R, Soltani N. Long term administration of thiamine disulfide improves FOXO1/PEPCK pathway in liver to reduce insulin resistance in type 1 diabetes rat model. Biomed Pharmacother. 2024;177:117053. 10.1016/j.biopha.2024.117053
- Zhu Y, Ying T, Xu M, Chen Q, Wu M, et al. Joint B Vitamin Intake and Type 2 Diabetes Risk: The Mediating Role of Inflammation in a Prospective Shanghai Cohort. Nutrients. 2024;16. 10.3390/nu16121901
- Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. 10.32725/jab.2024.009
