Last update
3/15/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
9
Thiamine enhances memory in hypothyroidism
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
8
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Read More
7
Vitamin B12 deficiency linked to hypothyroidism
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
Read More
Most Useful Reviews
2
No energy gained
5 people found this helpful
After taking these vitamins all week, I have experienced absolutely no increase in energy. As a menopausal woman with hypothyroidism, I require support against fatigue and lower moods. This product has not assisted with either issue, so I will return to the GNC Women’s multi-vitamin for energy and metabolism.
Read More
9
Highly recommended
3 people found this helpful
This supplement is excellent for anyone requiring a complex B vitamin, particularly those with hypothyroidism. It’s worth every penny I paid, and I take it on my doctor’s advice.
Read More
9
Correct dosage
This is not my first order for my hypothyroidism therapy. The composition and dosage are just right.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.8
- All Researches
9
Thiamine enhances memory in hypothyroidism
We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.
Read More
8
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Read More
7
Vitamin B12 deficiency linked to hypothyroidism
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
Read More
7
We examined the effects of Myo-inositol on autoimmune thyroiditis and hypothyroidism. Clinical studies indicated that combining Myo-inositol with seleniomethionine significantly reduced TSH levels in patients with subclinical hypothyroidism.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
2
No energy gained
5 people found this helpful
After taking these vitamins all week, I have experienced absolutely no increase in energy. As a menopausal woman with hypothyroidism, I require support against fatigue and lower moods. This product has not assisted with either issue, so I will return to the GNC Women’s multi-vitamin for energy and metabolism.
Read More
9
Highly recommended
3 people found this helpful
This supplement is excellent for anyone requiring a complex B vitamin, particularly those with hypothyroidism. It’s worth every penny I paid, and I take it on my doctor’s advice.
Read More
9
Correct dosage
This is not my first order for my hypothyroidism therapy. The composition and dosage are just right.
Read More
9
Improved energy levels
Ordered to assist my mother with mild hypothyroidism. She experienced low energy, fatigue, and muscle tremors. Since taking Vitamin D and CoQ10, her energy levels have significantly increased. This is one of the more effective B12 supplements available, especially when comparing ingredients and total vitamins. I highly recommend it.
Read More
6
Supports thyroid health
16 people found this helpful
I use a B-complex to support my thyroid gland, given my AIT and hypothyroidism. Alongside selenium and magnesium, my homocysteine levels have decreased and I continue to drink it regularly.
Read More
Frequently Asked Questions
6
Energy boost
I started taking this complex due to my numerous health issues, chiefly hypothyroidism and anemia. So far, there have been no side effects, and I feel an energy boost. Waking up is easier now, and I feel more balanced throughout the day. The drops are quite pleasant, with little taste or smell.
7.5
Calmed nervous system
This vitamin B complex is of good quality. With hypothyroidism, I take it in courses and definitely perceive the positive effects. My nervous system feels calmer, and since it’s a water-soluble vitamin, I find it beneficial.
6
Supports thyroid health
16 people found this helpful
I use a B-complex to support my thyroid gland, given my AIT and hypothyroidism. Alongside selenium and magnesium, my homocysteine levels have decreased and I continue to drink it regularly.
7.5
Doctor-prescribed
1 people found this helpful
I was prescribed this complex once my hypothyroidism was diagnosed. I take it alongside other cofactors for my thyroid. It’s best taken in a chelated form for better absorption.
9
Highly recommended
3 people found this helpful
This supplement is excellent for anyone requiring a complex B vitamin, particularly those with hypothyroidism. It’s worth every penny I paid, and I take it on my doctor’s advice.
7
Vitamin B12 deficiency linked to hypothyroidism
We explored the connection between vitamin B12 levels and hypothyroidism in a study involving 100 patients. A significant 68% of these patients were found to be vitamin B12 deficient, with a notable correlation to the presence of anti TPO and anti Thyroglobulin antibodies.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
This suggests that vitamin B12 may play a role in the symptoms experienced by hypothyroid individuals, especially since thyroid hormones influence the production of red blood cells. While supplementation could potentially help alleviate these symptoms, further research is essential to confirm its effectiveness in routine treatment.
8
We aimed to explore how B vitamins, including pyridoxine, betaine, folic acid, and cyanocobalamin, can correct homocysteine metabolism disrupted by hypothyroidism. By studying experimental rats treated for prolonged periods, we found that hypothyroidism severely reduced the activity of key enzymes involved in methylation, which in turn raised homocysteine levels—linked to heart disease risk.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
Our findings indicate that B vitamins have a promising potential to lower these harmful homocysteine levels and could help prevent complications like endothelial dysfunction in hypothyroid patients.
7
We examined the effects of Myo-inositol on autoimmune thyroiditis and hypothyroidism. Clinical studies indicated that combining Myo-inositol with seleniomethionine significantly reduced TSH levels in patients with subclinical hypothyroidism.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
This treatment not only lowered TSH but also reduced antithyroid autoantibodies, suggesting a positive immune-modulatory effect. However, further research with larger populations is needed to better understand how this treatment impacts overall quality of life and to investigate the underlying mechanisms involved.
References
- Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, et al. Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis. 2023;38:2603. 10.1007/s11011-023-01317-0
- Chatterjee T, Gupta R, Choudhary S. A Study on Vitamin B12 Levels in Hypothyroid Patients Presenting to a Tertiary Care Teaching Hospital. J Assoc Physicians India. 2023;71:1. PubMed
- Nechyporuk V, Korda M, Pentiuk L, Dmytrenko I, Bulko I. The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats. Pol Merkur Lekarski. 2020;48:55. PubMed
- Fallahi P, Ferrari SM, Elia G, Ragusa F, Paparo SR, et al. Myo-inositol in autoimmune thyroiditis, and hypothyroidism. Rev Endocr Metab Disord. 2018;19:349. 10.1007/s11154-018-9477-9
Data last updated:
