Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.4
Supplement Facts
Serving Size: 2 Vegetarian Capsules
Amount Per Serving
%DV
Thiamine (vitamin B1) (as thiamine HCl)
100 mg
8333%
Riboflavin (vitamin B2) (as riboflavin and riboflavin 5'-phosphate)
75 mg
5769%
Niacin (as niacinamide and niacin)
100 mg•
625%
Vitamin B6 (as pyridoxine HCl and pyridoxal 5' phosphate)
100 mg
5882%
Folate (as L-5-methyltetrahydrofolate calcium salt)
680 mcg○
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12500%
Biotin
1000 mcg
3333%
Pantothenic acid (as D-calcium pantothenate)
500 mg
10000%
Calcium (as D-calcium pantothenate, dicalcium phosphate)
50 mg
4%
Inositol
100 mg
**
PABA (para-aminobenzoic acid)
50 mg
**
Top Medical Research Studies
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
Most Useful Reviews
9
Addresses exhaustion
2 people found this helpful
My experience with other brands included high doses of B12, which alleviated forgetfulness and bodily strain. I chose this B complex for my exhaustion due to insomnia from overtime work, and I found it effective. Melatonin didn’t work for me, but this helped me fall asleep quickly. The packaging quality and taste are commendable.
Read More
10
Cured insomnia
1 people found this helpful
Vitamin B complex is superb! I finally got rid of insomnia. This comprehensive set of B vitamins is crucial for the nervous system. After about a month of use, I found I could fall asleep without headphones and no longer woke multiple times during the night. I finally began to get adequate sleep, all thanks to this complex. I recommend it to anyone suffering from insomnia.
Read More
9
Reduced stress
Excellent product. It helped me eliminate insomnia and relieve stress at work, making me feel calmer. I fall asleep easily and wake up feeling refreshed. It’s not addictive, and the capsules are easy to swallow. Highly recommend.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 5 Researches
7.8
- All Researches
9
We examined a unique case of a 58-year-old woman with recurrent endometrial cancer who showed signs of severe depression and attempted suicide. Initially, her symptoms were believed to be linked to major depressive disorder.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
However, after administering intravenous thiamine due to her dietary deficiencies, we noticed remarkable changes. Her insomnia, palpitations, and other concerning symptoms improved dramatically within just an hour, and her suicidal thoughts completely vanished.
This case underlines the importance of recognizing thiamine deficiency as a potential reversible cause of psychiatric symptoms, rather than simply attributing them to depression alone.
Read More
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Read More
8
Vitamin B12 aids specific sleep disorders
We looked into the effects of Vitamin B12 on two patients with long-standing sleep-wake rhythm disorders.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
The first patient, a 15-year-old blind girl with a free-running sleep-wake cycle, saw her rhythm align with the environmental 24-hour cycle shortly after starting a daily dose of 1.5 mg of B12. Unfortunately, her sleep issues returned after stopping the B12 treatment.
The second patient, a 55-year-old man with delayed sleep phase syndrome, experienced improvement for over six months while on the same dosage.
While results were promising for these individuals, further research is necessary to better understand the broader effectiveness of Vitamin B12 for insomnia.
Read More
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
Read More
7
We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Addresses exhaustion
2 people found this helpful
My experience with other brands included high doses of B12, which alleviated forgetfulness and bodily strain. I chose this B complex for my exhaustion due to insomnia from overtime work, and I found it effective. Melatonin didn’t work for me, but this helped me fall asleep quickly. The packaging quality and taste are commendable.
Read More
10
Cured insomnia
1 people found this helpful
Vitamin B complex is superb! I finally got rid of insomnia. This comprehensive set of B vitamins is crucial for the nervous system. After about a month of use, I found I could fall asleep without headphones and no longer woke multiple times during the night. I finally began to get adequate sleep, all thanks to this complex. I recommend it to anyone suffering from insomnia.
Read More
9
Reduced stress
Excellent product. It helped me eliminate insomnia and relieve stress at work, making me feel calmer. I fall asleep easily and wake up feeling refreshed. It’s not addictive, and the capsules are easy to swallow. Highly recommend.
Read More
9
Sleep improved
Good composition! My husband has been taking it for two weeks, and he likes it! I used to suffer from insomnia, but now my sleep is fine.
Read More
9
Husband calmer
I ordered these vitamins for my husband, and the effects are noticeable. He has become calmer, his sleep has improved, and problems with insomnia have vanished. The tablets are small and easy to take, though there is a slight aftertaste that made him a bit uncomfortable.
Read More
Frequently Asked Questions
9
Sleep improved
Good composition! My husband has been taking it for two weeks, and he likes it! I used to suffer from insomnia, but now my sleep is fine.
10
Cured insomnia
1 people found this helpful
Vitamin B complex is superb! I finally got rid of insomnia. This comprehensive set of B vitamins is crucial for the nervous system. After about a month of use, I found I could fall asleep without headphones and no longer woke multiple times during the night. I finally began to get adequate sleep, all thanks to this complex. I recommend it to anyone suffering from insomnia.
7.5
Good for insomnia
Very effective for sleep and excellent for insomnia. My mother's digestive issues have also cleared up.
9
Reduced stress
Excellent product. It helped me eliminate insomnia and relieve stress at work, making me feel calmer. I fall asleep easily and wake up feeling refreshed. It’s not addictive, and the capsules are easy to swallow. Highly recommend.
7.5
Fights insomnia
Life Extension always meets my needs. With good ingredients and small capsules, it's easy to consume. I dealt with muscle weakness, fatigue, irritability, and insomnia, but B vitamins have really helped me combat these issues. I have experienced positive effects.
0
Severe anxiety response
Be cautious with these. This vitamin complex contains some methylated forms of B vitamins, which can adversely affect certain individuals, such as myself. After just a few days of use, I experienced severe anxiety, insomnia, and a loss of appetite. It's my fault for not reading the label!
9
Addresses exhaustion
2 people found this helpful
My experience with other brands included high doses of B12, which alleviated forgetfulness and bodily strain. I chose this B complex for my exhaustion due to insomnia from overtime work, and I found it effective. Melatonin didn’t work for me, but this helped me fall asleep quickly. The packaging quality and taste are commendable.
7.5
Improved sleep quality
Helped with depression, anxiety, and sleep during the day. I suggest trying it. Although it's not a cure-all, it has somewhat improved my mood (depression and anxiety), sleep quality (insomnia), and daytime lethargy caused by both. This product provides the best value regarding the level of ingredients for its cost compared to any b multi on iHerb or Chemist Warehouse (Australia). I also take an additional vitamin B12 tablet for my individual needs, which enhances my daytime energy, although not everyone may require it. I recommend this for anyone facing mental health concerns, sleep difficulties, or fatigue during the day.
0
Caused mood swings
Please be cautious and check the amounts before taking! This is a high-quality vitamin, but ensure you are truly deficient in B vitamins beforehand. I didn't realise how elevated the levels were—thousands of percentages above the daily value. This was my own error; however, when taken as directed, it resulted in insomnia and mood swings. Life Extension offers excellent quality products at an affordable price, and I trust their ingredients. The capsule size isn't overly large but could pose difficulties for those with trouble swallowing pills. They do have a somewhat peculiar taste, which I attribute to their potency.
7
We evaluated the effectiveness of a nutritional supplement, SPINOFF, on sleep quality and mental health in a pilot study involving 41 participants. Initially, participants reported significant sleep issues and psychological distress.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
After a 30-day treatment period, we observed significant reductions in both insomnia symptoms and sleep disturbances, with improved scores indicating better sleep quality and reduced psychological distress. For those who continued treatment, enhancements were even more pronounced.
Overall, our findings suggest that the SPINOFF supplement could be beneficial in tackling sleep difficulties and mental wellness.
8
In a 4-week open-label study involving 40 individuals with mild-to-moderate insomnia, we explored the effects of a combination formula containing melatonin and vitamin B6.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
Participants reported significant improvements in sleep quality, with average scores rising from 5.4 to 7.3 after two weeks.
Our findings also indicated enhancements in sleep onset latency and total sleep duration, all without serious side effects.
Overall, this combination treatment shows promise for those struggling with insomnia.
References
- De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. 10.3390/medsci12010002
- Ishida M, Sato S, Sato I, Yoshioka A, Uchida N, et al. What can cause cancer patients to attempt suicide? Thiamine deficiency mimicking the symptoms of major depressive disorder. Palliat Support Care. 2024;22:205. 10.1017/S1478951523001128
- Lemoine P, Bablon JC, Da Silva C. A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study. Complement Ther Med. 2019;45:104. 10.1016/j.ctim.2019.05.024
- Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.
- Okawa M, Mishima K, Nanami T, Shimizu T, Iijima S, et al. Vitamin B12 treatment for sleep-wake rhythm disorders. Sleep. 1990;13:15.
