5/18/2025
Last update
5/18/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.7
USERS' SCORE
Good
Based on 39 Reviews
8.3
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Read More
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
8
We delved into the impact of nano-selenium on hypothyroidism, particularly how it might alleviate related oxidative stress in the liver and kidneys. In the study, rats were divided into different groups, including a control group and those treated with propylthiouracil (PTU) to induce hypothyroidism. Some of the hypothyroid rats also received varying doses of nano-selenium to assess its effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Over a six-week period, we measured indicators of liver and kidney function, such as specific enzyme levels and markers for oxidative damage. Results showed that hypothyroidism significantly increased levels of harmful substances while decreasing beneficial ones. However, when nano-selenium was administered, we observed a noticeable improvement in these key indicators.
Overall, the presence of nano-selenium appeared to protect against the damaging effects of hypothyroidism, helping to restore balance in oxidative stress levels. This suggests that selenium may hold promise as a supportive treatment for liver and kidney health in individuals with thyroid disorders. Future research will help us understand the specific mechanisms behind these positive effects.
Read More
Most Useful Reviews
9
Reduced illness frequency
28 people found this helpful
Very good for those suffering from Hashimoto's disease or hypothyroidism. I was frequently unwell, but after using selenium, my health improved remarkably, leading to weight loss without needing thyroxine. This product truly made a difference for me.
Read More
9
Facilitates weight loss
23 people found this helpful
Advice from a brother: If you have hypothyroidism or Hashimoto's disease, take this without hesitation. I use it with thyroxine. After years of struggling to lose weight, I've noticed significant improvements after starting this product. The quality, ingredients, and packaging are excellent. If you don't see the benefit, you wouldn't rate the product.
Read More
7.5
Reduced thyroxine dosage
17 people found this helpful
I took this medication due to my lack of thyroid gland, and synthetic thyroxine isn't well absorbed in my body. After a couple of days on selenium, I experienced tachycardia, sweating, and pressure episodes, catching an overdose. Clearly, selenium worked, as it improved the deiodination process in my body, allowing me to reduce my thyroxine dosage. I continue to take selenium and feel well.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.7
- All Researches
9
We conducted a double-blinded, randomized controlled trial to investigate how selenium affects individuals with autoimmune hypothyroidism. In our study, we divided 144 patients into two groups, one receiving a combination of levothyroxine (a common thyroid treatment) and selenium, while the other group was given a placebo along with the same thyroid medication. This design allowed us to effectively measure the results and make a fair comparison between the two groups.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
After three months of treatment, we observed some interesting changes. The group that took selenium showed a significant reduction in anti-Tg antibodies—markers associated with thyroid autoimmunity—compared to the placebo group. We also found that their TSH levels decreased significantly, while their free T4 levels increased. This suggests that selenium not only helps lower immune system activity against the thyroid but also supports overall thyroid function.
Our findings suggest that incorporating selenium into the treatment plan for autoimmune hypothyroidism could be beneficial for patients. While this doesn't isolate selenium’s effects completely, as it was taken alongside levothyroxine, the results indicate its potential in managing thyroid health effectively.
Read More
9
Selenium aids subclinical hypothyroidism
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Read More
9
We explored the impact of vitamin E on liver and kidney health in rats affected by hypothyroidism. To conduct this research, we divided the rats into three groups: a control group, a group with induced hypothyroidism treated with propylthiouracil (PTU), and a third group with hypothyroidism that also received vitamin E injections.
Over the course of 42 days, we monitored various health markers in these groups. The hypothyroid rats showed a significant drop in important substances like serum thyroxin, which is critical for thyroid function. We also noted an increase in harmful compounds while protective enzyme activities plummeted in their liver and kidney tissues.
Interestingly, vitamin E appeared to reverse some of this damage. It raised the levels of important antioxidants and reduced harmful substances in the tissues of rats receiving it. Not only did we observe improvements in blood markers like alanine aminotransferase (ALT) and blood urea nitrogen (BUN), but albumin levels also increased, indicating a healthier state of the liver and kidneys.
Overall, our findings suggest that vitamin E has a protective role against liver and kidney damage in hypothyroid rats, potentially offering a beneficial adjunct therapy for thyroid-related health issues.
Over the course of 42 days, we monitored various health markers in these groups. The hypothyroid rats showed a significant drop in important substances like serum thyroxin, which is critical for thyroid function. We also noted an increase in harmful compounds while protective enzyme activities plummeted in their liver and kidney tissues.
Interestingly, vitamin E appeared to reverse some of this damage. It raised the levels of important antioxidants and reduced harmful substances in the tissues of rats receiving it. Not only did we observe improvements in blood markers like alanine aminotransferase (ALT) and blood urea nitrogen (BUN), but albumin levels also increased, indicating a healthier state of the liver and kidneys.
Overall, our findings suggest that vitamin E has a protective role against liver and kidney damage in hypothyroid rats, potentially offering a beneficial adjunct therapy for thyroid-related health issues.
Read More
8
Selenium and myo-inositol efficacy
We explored the impact of selenium supplementation on patients with autoimmune thyroiditis, particularly focusing on its effectiveness in restoring normal thyroid function. The study compared the effects of selenium alone against a combination therapy of selenium and myo-inositol (referred to as MI + Se).
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Through a systematic review of three studies involving 288 participants, we observed that the combined treatment of selenium and myo-inositol resulted in a notable decrease in thyroid-stimulating hormone (TSH) levels. This suggests that combining these two supplements may enhance the restoring of thyroid function better than selenium alone.
However, while we noted significant reductions in TSH and thyroglobulin antibodies, other measures like TPO antibodies, T3, and T4 levels showed minimal or no significant changes. This indicates that while the MI + Se treatment could help in some areas, more extensive research is necessary to fully understand its effectiveness and to perhaps confirm these findings with larger, long-term studies.
Read More
8
We investigated how selenium affects thyroid function in older Chinese adults, focusing particularly on its potential impact on hypothyroidism. Our study included participants aged 65 and older, who provided samples of their fingernails and whole blood for analysis. We specifically looked at hormone levels, including thyroid stimulating hormone (TSH) and various forms of thyroxine, to assess thyroid health.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Our findings revealed a strong positive association between selenium levels in the blood and fingernails, suggesting that higher selenium status is linked with lower TSH levels. We observed that participants in higher selenium quartiles had lower TSH, which is typically associated with less risk of hypothyroidism. For instance, those with the highest selenium levels showed a reduced odds ratio for hypothyroidism.
However, our results also highlighted a complex relationship; while higher selenium levels seemed to lower the risk of hypothyroidism, they were simultaneously linked with an increased risk of hyperthyroidism. This dual effect suggests that selenium status also plays a role in thyroid dysfunctions, with both positive and negative implications for thyroid health.
In summary, higher selenium levels are associated with lower TSH levels and may reduce the risk of hypothyroidism, but they also pose a higher risk for hyperthyroidism in this older population. This study emphasizes the intricate balance of nutrients like selenium in managing thyroid health, particularly among aging adults.
Read More
User Reviews
USERS' SCORE
Good
Based on 39 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced illness frequency
28 people found this helpful
Very good for those suffering from Hashimoto's disease or hypothyroidism. I was frequently unwell, but after using selenium, my health improved remarkably, leading to weight loss without needing thyroxine. This product truly made a difference for me.
Read More
9
Facilitates weight loss
23 people found this helpful
Advice from a brother: If you have hypothyroidism or Hashimoto's disease, take this without hesitation. I use it with thyroxine. After years of struggling to lose weight, I've noticed significant improvements after starting this product. The quality, ingredients, and packaging are excellent. If you don't see the benefit, you wouldn't rate the product.
Read More
7.5
Reduced thyroxine dosage
17 people found this helpful
I took this medication due to my lack of thyroid gland, and synthetic thyroxine isn't well absorbed in my body. After a couple of days on selenium, I experienced tachycardia, sweating, and pressure episodes, catching an overdose. Clearly, selenium worked, as it improved the deiodination process in my body, allowing me to reduce my thyroxine dosage. I continue to take selenium and feel well.
Read More
9
Improved health markers
9 people found this helpful
When hypothyroidism is present, this is necessary! In my opinion, this selenium is the best, with excellent dosage alongside Vit. E. My health and analysis results have improved significantly. I follow a schedule of two months of intake followed by one month off, after breakfast. Selenium is crucial for the thyroid gland, reproductive, and cardiovascular systems. The capsules are of a medium size and easy to swallow.
Read More
10
Supports thyroid function
4 people found this helpful
I recommend this! The quality is high, and the complex works well; the ingredients are well matched, and the composition is effective. Selenium is vital for the thyroid gland as it is part of an enzyme that activates the main thyroid hormone. It also enhances iodine absorption, crucial for thyroid health. Selenium protects the thyroid from damage, mitigating hypothyroidism effects. In combination with vitamin E, its absorption improves, making the complex effective for thyroid function, as evidenced by my experience.
Read More
Frequently Asked Questions
9
Increased energy levels
4 people found this helpful
The complex is working! I took it on the recommendation of a nutritionist to restore the functions of the thyroid gland. Hypothyroidism involves reduced volume of the thyroid gland and insufficient production of hormones, leading to fatigue, drowsiness, muscle weakness, an increased heart rate, hair loss, and more. Almost immediately after starting this complex, I felt much better, with increased energy, reduced hair loss, and improved heartbeat. I recommend it, as it’s an essential vitamin for your body’s excellent performance. I’m very pleased.
9
Normalised hormone levels
4 people found this helpful
I purchased this complex because of my hypothyroidism. After a two-month course, I added kelp to support my thyroid. I felt an increase in energy, and my TSH levels returned to normal (from 4.65 to 1.85); my hormone levels stabilised. I'm grateful to the manufacturer for this fantastic product!
10
Cured hypothyroidism
3 people found this helpful
An excellent product that aided my hypothyroidism resulting from iodine deficiency. Selenium is a cofactor for iodine absorption. Without selenium, iodine gets rapidly excreted. This supplement helped retain iodine in my body (to simplify). I recovered from hypothyroidism after a year of using this drug and iodine. Yes, it took time, but my thyroid levels now are exemplary!
9
Reduced illness frequency
28 people found this helpful
Very good for those suffering from Hashimoto's disease or hypothyroidism. I was frequently unwell, but after using selenium, my health improved remarkably, leading to weight loss without needing thyroxine. This product truly made a difference for me.
6
Facial swelling reduced
3 people found this helpful
I suffered from thyroiditis and symptoms of hypothyroidism. My facial swelling has significantly improved after taking these supplements every day. Although I have some tiring mornings, I avoid coffee and ensure I consume my thyroid supplements promptly.
7.5
Reduced thyroxine dosage
17 people found this helpful
I took this medication due to my lack of thyroid gland, and synthetic thyroxine isn't well absorbed in my body. After a couple of days on selenium, I experienced tachycardia, sweating, and pressure episodes, catching an overdose. Clearly, selenium worked, as it improved the deiodination process in my body, allowing me to reduce my thyroxine dosage. I continue to take selenium and feel well.
9
Improved health markers
9 people found this helpful
When hypothyroidism is present, this is necessary! In my opinion, this selenium is the best, with excellent dosage alongside Vit. E. My health and analysis results have improved significantly. I follow a schedule of two months of intake followed by one month off, after breakfast. Selenium is crucial for the thyroid gland, reproductive, and cardiovascular systems. The capsules are of a medium size and easy to swallow.
8
Reduce hypothyroid symptoms
1 people found this helpful
Selenium was prescribed by my endocrinologist to enhance thyroid function. The supplement is top-notch, with a significant reduction in hypothyroidism symptoms. I take it with terosin and magnesium, feeling revitalised. I'm very satisfied with the quality of this product and appreciate that it contains vitamin E, eliminating the need for separate orders.
7.5
Supports thyroid health
5 people found this helpful
I was advised by my endocrinologist to take this selenium in a chelated form with vitamin E to maintain the thyroid gland. I have hypothyroidism and nodes in both lobes. I take one capsule in the morning before meals. I was fortunate to get a 20% discount; it may be cheaper from other manufacturers, but not in this form with Vitamin E. I wish you all good health.
9
Selenium aids subclinical hypothyroidism
We approached the intriguing question of whether selenium, when combined with myo-inositol, could help those dealing with subclinical hypothyroidism. This study involved 148 women of reproductive age, who had their thyroid stimulating hormone (TSH) levels monitored over a six-month period while taking daily supplements.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
Throughout the study, we observed substantial improvements in TSH levels, as well as reductions in autoantibody titers, which are markers of thyroid autoimmune activity. Participants also reported better management of symptoms typically associated with hypothyroidism, including more regular menstrual cycles and lower cholesterol levels. Remarkably, these benefits appeared alongside the treatment quite consistently.
Overall, the findings suggest that incorporating selenium and myo-inositol into the treatment plan for subclinical hypothyroidism could be quite beneficial. This combination may not only help stabilize thyroid function but could also improve the quality of life for women affected by this condition. The study holds promise for those seeking alternative options to manage their thyroid health effectively.
8
We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.
Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.
However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.
3
We conducted a study to determine if selenium supplementation could enhance the quality of life (QoL) for patients suffering from autoimmune thyroiditis. In a robust clinical trial involving 412 participants who were already receiving levothyroxine treatment, we set up a double-blind, randomized control design. This means that neither the participants nor the researchers knew who was receiving selenium and who was on a placebo, ensuring that our observations were as unbiased as possible.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
Over 12 months, participants were given either 200 μg of selenium or a placebo daily. We assessed their quality of life multiple times using a questionnaire designed specifically for thyroid-related issues. While participants showed improvements in their QoL during the trial, we found no significant differences between the two groups after one year.
Interestingly, while selenium supplementation did lead to lower thyroid peroxidase antibody levels, it did not impact levothyroxine dosage or the balance of thyroid hormones in the body. Ultimately, both selenium and placebo groups experienced comparable improvements, indicating that selenium supplementation did not provide additional benefits beyond the placebo effect.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Zuhair V, Sheikh AT, Shafi N, Babar A, Khan A, et al. Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Clin Med Insights Endocrinol Diabetes. 2024;17:11795514241300998. 10.1177/11795514241300998
- Li F, Su L, Shao R, Luo J, Chen Y, et al. Selenium Status Associates with Thyroid Hormone and Thyroid Dysfunction in Older Chinese Adults. Biol Trace Elem Res. 2025;203:1413. 10.1007/s12011-024-04286-2
- AkbariRad M, Mazloum Khorasani Z, Beizae B, Ayatollahi H, Emadzadeh M, et al. Effect of selenium on anti-Tg antibody in patients with autoimmune hypothyroidism: A randomized controlled trial. Caspian J Intern Med. 2024;15:340. 10.22088/cjim.15.2.340
- Nagano K, Motomura Y, Bando H, Yamamoto M, Kanie K, et al. Thyroid dysfunction due to trace element deficiency-not only selenium but also zinc. Hormones (Athens). 2024;23:675. 10.1007/s42000-024-00550-1
- Wang S, Chen P, He Y, Wei J, Tian L, et al. A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments. BMC Endocr Disord. 2024;24:14. 10.1186/s12902-024-01536-1
- El-Shaer RAA, Ibrahim S, Hewady PM, Atef MM, El-Deeb OS, et al. Selenium protects against nesfatin-1 modulation of the hypothalamic-pituitary-testicular axis during hypothyroidism in male rats. Physiol Rep. 2024;12:e15923. 10.14814/phy2.15923
- Huwiler VV, Maissen-Abgottspon S, Stanga Z, Mühlebach S, Trepp R, et al. Selenium Supplementation in Patients with Hashimoto Thyroiditis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Thyroid. 2024;34:295. 10.1089/thy.2023.0556
- Larsen C, Winther KH, Cramon PK, Rasmussen ÅK, Feldt-Rasmusssen U, et al. Selenium supplementation and placebo are equally effective in improving quality of life in patients with hypothyroidism. Eur Thyroid J. 2024;13. 10.1530/ETJ-23-0175
- Kubiak K, Szmidt MK, Kaluza J, Zylka A, Sicinska E. Do Dietary Supplements Affect Inflammation, Oxidative Stress, and Antioxidant Status in Adults with Hypothyroidism or Hashimoto's Disease?-A Systematic Review of Controlled Trials. Antioxidants (Basel). 2023;12. 10.3390/antiox12101798
- Hosseini M, Behehsti F, Marefati N, Anaeigoudari A. Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats. Physiol Rep. 2023;11:e15682. 10.14814/phy2.15682
- Wróblewski M, Wróblewska J, Nuszkiewicz J, Pawłowska M, Wesołowski R, et al. The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases. Int J Mol Sci. 2023;24. 10.3390/ijms24054840
- Lu L, Huang Z, Wang X, Chen J. Interaction Between Dietary Selenium and Zinc Intakes on Hypothyroidism. Biol Trace Elem Res. 2023;201:4667. 10.1007/s12011-023-03563-w
- Payer J, Jackuliak P, Kužma M, Džupon M, Vaňuga P. Supplementation with myo-inositol and Selenium improves the clinical conditions and biochemical features of women with or at risk for subclinical hypothyroidism. Front Endocrinol (Lausanne). 2022;13:1067029. 10.3389/fendo.2022.1067029
- Hojjati Fard F, Sabzi F, Marefati N, Vafaee F, Beheshti F, et al. Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats. Metab Brain Dis. 2022;37:2719. 10.1007/s11011-022-01073-7
- Paparo SR, Ferrari SM, Patrizio A, Elia G, Ragusa F, et al. Myoinositol in Autoimmune Thyroiditis. Front Endocrinol (Lausanne). 2022;13:930756. 10.3389/fendo.2022.930756
- Berisha-Muharremi V, Tahirbegolli B, Phypers R, Hanna R. Efficacy of Combined Photobiomodulation Therapy with Supplements versus Supplements alone in Restoring Thyroid Gland Homeostasis in Hashimoto Thyroiditis: A Clinical Feasibility Parallel Trial with 6-Months Follow-Up. J Pers Med. 2023;13. 10.3390/jpm13081274
- Liu S, Lu C, He L, Shan Z, Teng W, et al. Vitamin E Intake and Prevalence Rates of Thyroid Dysfunction and Autoimmune Thyroiditis: A Cross-Sectional Analysis of NHANES Data. Thyroid. 2024;34:753. 10.1089/thy.2023.0561
- Kumar N, Das A, Kumari N, Singh G, Jain U, et al. Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism-Associated Ophthalmopathy. Mol Nutr Food Res. 2024;68:e2300589. 10.1002/mnfr.202300589
- Hedayati-Moghadam M, Baghcheghi Y, Beheshti F, Shabgah AG, Salmani H, et al. Vitamin E Prevented Hepatic and Renal Tissue Damage in Hypothyroid Rats. Adv Biomed Res. 2023;12:75. 10.4103/abr.abr_275_21
