Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
USERS' SCORE
Good
Based on 18 Reviews
8.5
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
We investigated how diphenyl diselenide, a synthetic selenium compound, affects cognitive performance in a rat model of menopause. Female rats underwent ovariectomy, mimicking hormone loss in postmenopausal women, and were treated with diphenyl diselenide daily for 30 days.
The results showed that this treatment improved cognitive abilities, as evidenced by better performance in behavioral tests and prevented the increase of acetylcholinesterase activity.
Overall, diphenyl diselenide appears to hold promise in mitigating cognitive decline linked to menopause.
The results showed that this treatment improved cognitive abilities, as evidenced by better performance in behavioral tests and prevented the increase of acetylcholinesterase activity.
Overall, diphenyl diselenide appears to hold promise in mitigating cognitive decline linked to menopause.
We conducted a rigorous study to assess how vitamin E affects menopausal symptoms, especially hot flashes. In this triple-blind, randomized controlled trial with 93 postmenopausal women, participants were divided into groups receiving curcumin, vitamin E, or a placebo for eight weeks.
While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.
While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.
8
We examined the effects of vitamin E suppositories on vaginal atrophy in postmenopausal women. In a clinical trial, 52 women were divided into two groups—one used vitamin E, while the other applied estrogen cream for 12 weeks.
We saw improvements in vaginal health measures in the vitamin E group, suggesting it could be a helpful option for those who prefer to avoid hormone therapy.
However, further research is essential to fully understand its effectiveness.
We saw improvements in vaginal health measures in the vitamin E group, suggesting it could be a helpful option for those who prefer to avoid hormone therapy.
However, further research is essential to fully understand its effectiveness.
Most Useful Reviews
9
Hot flashes relief
195 people found this helpful
I purchased selenium from iHerb on my friend's recommendation, as I heard centenarians have high levels of this mineral. Our Selenium Super Complex contains three forms of selenium and vitamin E, which I find important. At my age, menopause brings hot flashes. After taking this complex, my symptoms, including hot flashes, weakness, and dizziness, vanished. I realised this complex aids the body in combating oxidative damage. You need to take it just once a day; there are 100 capsules in a jar, which lasts for three months.
9
Restored hormone levels
102 people found this helpful
Brought my hormone levels back to normal. I take DHEA alongside my infertility hormone treatments. At 28, I was diagnosed with premature ovarian deficiency and was heading toward early menopause based on my hormone levels. After a few weeks of taking 75mg daily, my hormone levels returned to the normal range for my cycle! No bad side effects noted. While my sex drive decreased after starting other hormone injections, I’ve experienced no other adverse effects. The pills are small and easy to swallow, and they don't upset my stomach.
9
Effective for menopause
41 people found this helpful
Great product. Going through menopause—this product works great!
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.5
- All Researches
9
This study looked at how a combination of stable ozonides and vitamin E acetate, called Ozoile, helps relieve symptoms of genitourinary syndrome in menopausal women.
After 20 days of treatment, we observed a significant reduction in symptoms such as pain and dryness, with pain incidence decreasing from 16.7% to 11.8% and dryness dropping from 85.5% to 53.8%.
Although Ozoile demonstrated effectiveness in addressing these symptoms, more research is necessary to understand how it compares to other treatments for this condition.
After 20 days of treatment, we observed a significant reduction in symptoms such as pain and dryness, with pain incidence decreasing from 16.7% to 11.8% and dryness dropping from 85.5% to 53.8%.
Although Ozoile demonstrated effectiveness in addressing these symptoms, more research is necessary to understand how it compares to other treatments for this condition.
9
We aimed to explore the effects of annatto tocotrienol, especially when paired with a self-emulsifying drug delivery system (SEDDS), on bone loss in a rat model of postmenopause.
After conducting a comprehensive study, we found that the SEDDS formulation significantly boosted the levels of delta-tocotrienol and was effective in promoting bone strength and health.
While both SEDDS-formulated and unformulated tocotrienol improved bone structure, the SEDDS offered superior results in certain areas, such as trabecular microstructure.
Overall, this suggests a promising path for human trials to further investigate tocotrienol's impact on postmenopausal bone health.
After conducting a comprehensive study, we found that the SEDDS formulation significantly boosted the levels of delta-tocotrienol and was effective in promoting bone strength and health.
While both SEDDS-formulated and unformulated tocotrienol improved bone structure, the SEDDS offered superior results in certain areas, such as trabecular microstructure.
Overall, this suggests a promising path for human trials to further investigate tocotrienol's impact on postmenopausal bone health.
9
We aimed to understand the effectiveness of the pollen extract Sérélys, combined with vitamin E, in reducing menopausal symptoms in women. In a multicenter study, 104 menopausal women took the extract for three months. Their symptoms were assessed, revealing significant reductions: hot flashes decreased by 48.5%, sleep disturbances by 50.1%, and depressive moods by 51.2%. Overall, the extract demonstrated a noticeable improvement in various alarming menopausal symptoms with minimal side effects, suggesting it could be a safe alternative for women seeking relief.
8
We investigated whether selenium (Se) intake affects bone health in postmenopausal women. By analyzing data from women over 50, we found a significant relationship between higher dietary selenium consumption and improved bone mineral density (BMD).
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
8
We reviewed multiple studies to investigate how E-MHK-0103, a nutraceutical derived from Mytilus galloprovincialis, could help alleviate menopausal symptoms.
The findings suggest that it has positive effects on hot flashes, mood swings, and joint pain, thanks to its anti-inflammatory properties and rich nutrient content, including vitamins, minerals, and selenium.
Importantly, E-MHK-0103 appears to enhance bone health and provides antioxidants, making it an interesting option for women seeking natural relief during menopause.
The findings suggest that it has positive effects on hot flashes, mood swings, and joint pain, thanks to its anti-inflammatory properties and rich nutrient content, including vitamins, minerals, and selenium.
Importantly, E-MHK-0103 appears to enhance bone health and provides antioxidants, making it an interesting option for women seeking natural relief during menopause.
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Hot flashes relief
195 people found this helpful
I purchased selenium from iHerb on my friend's recommendation, as I heard centenarians have high levels of this mineral. Our Selenium Super Complex contains three forms of selenium and vitamin E, which I find important. At my age, menopause brings hot flashes. After taking this complex, my symptoms, including hot flashes, weakness, and dizziness, vanished. I realised this complex aids the body in combating oxidative damage. You need to take it just once a day; there are 100 capsules in a jar, which lasts for three months.
9
Restored hormone levels
102 people found this helpful
Brought my hormone levels back to normal. I take DHEA alongside my infertility hormone treatments. At 28, I was diagnosed with premature ovarian deficiency and was heading toward early menopause based on my hormone levels. After a few weeks of taking 75mg daily, my hormone levels returned to the normal range for my cycle! No bad side effects noted. While my sex drive decreased after starting other hormone injections, I’ve experienced no other adverse effects. The pills are small and easy to swallow, and they don't upset my stomach.
9
Effective for menopause
41 people found this helpful
Great product. Going through menopause—this product works great!
9
Menopause symptom relief
3 people found this helpful
I acquired selenium from iHerb as recommended by a friend, knowing centenarians possess high levels of selenium. Our Selenium Super Complex has three types of selenium and Vitamin E for health and longevity, essential for me. At my age, menopause has brought hot flashes, which disappeared after using this complex. I realised it helps combat oxidative damage. You must take it once daily, with 100 capsules per can, enough for three months. Remember, selenium cannot be absorbed with sweets, and vegetarians often lack it; garlic and this supplement can help.
9
Drastic improvement
3 people found this helpful
I've wanted to try this product for ages. I'm 58 years old, and menopause has lasted eight years with severe hot flashes every three hours. I've taken special medications that provide little relief. After adding this complex with vitamin E, I've almost eliminated hot flashes. My health has improved; I no longer wake up at night and feel much calmer.
Frequently Asked Questions
7.5
Increased energy
My thyroid loves this selenium! I became a fan of this brand after buying Glycine and now purchase selenium with vitamin E to support thyroid function during menopause. The capsules are small and easy to swallow, with 100 capsules per pack, lasting over three months. After a few weeks, I feel more energetic and stronger!
9
Drastic improvement
3 people found this helpful
I've wanted to try this product for ages. I'm 58 years old, and menopause has lasted eight years with severe hot flashes every three hours. I've taken special medications that provide little relief. After adding this complex with vitamin E, I've almost eliminated hot flashes. My health has improved; I no longer wake up at night and feel much calmer.
6
Essential menopause supplement
As a food supplement for my menopause, this is vital given hormonal and inflammatory changes. I take it alongside magnesium, omega 3, and biotin. Although the capsules are large, the benefits for my hair and overall wellbeing are undeniable.
6
Improves dry skin
Excellent! My dry skin has improved significantly, especially during perimenopause.
9
Manages menopause symptoms
This supplement is highly effective for my increased excitability due to hormone fluctuations from menopause. Selenium helps normalise my hormones, reducing anxiety. I feel the benefits and notice an improvement in calmness. I must take it regularly; the tablets are convenient and neutral in taste.
7.5
Boosts immune system
Selenium is a vital antioxidant that protects the immune system, enhancing resistance to infections. The recommended daily intake ranges from 70-100 mcg. It's particularly useful for hormonal imbalances, thyroid issues, and reproductive health.
8
We reviewed multiple studies to investigate how E-MHK-0103, a nutraceutical derived from Mytilus galloprovincialis, could help alleviate menopausal symptoms.
The findings suggest that it has positive effects on hot flashes, mood swings, and joint pain, thanks to its anti-inflammatory properties and rich nutrient content, including vitamins, minerals, and selenium.
Importantly, E-MHK-0103 appears to enhance bone health and provides antioxidants, making it an interesting option for women seeking natural relief during menopause.
The findings suggest that it has positive effects on hot flashes, mood swings, and joint pain, thanks to its anti-inflammatory properties and rich nutrient content, including vitamins, minerals, and selenium.
Importantly, E-MHK-0103 appears to enhance bone health and provides antioxidants, making it an interesting option for women seeking natural relief during menopause.
8
We investigated whether selenium (Se) intake affects bone health in postmenopausal women. By analyzing data from women over 50, we found a significant relationship between higher dietary selenium consumption and improved bone mineral density (BMD).
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
5
We assessed how vitamin E supplementation impacts menopausal symptoms in women, as many seek alternatives to hormone therapy. Our review analyzed 16 studies, including a range of menopausal symptoms such as hot flashes and vaginal changes.
While vitamin E did show some beneficial effects, such as reducing hot flashes and improving vascular profiles, it was found to be less effective than estrogen. We noted that it could be a supportive option for those unable to use hormones. However, more rigorous research is needed before we make definitive conclusions.
While vitamin E did show some beneficial effects, such as reducing hot flashes and improving vascular profiles, it was found to be less effective than estrogen. We noted that it could be a supportive option for those unable to use hormones. However, more rigorous research is needed before we make definitive conclusions.
References
- Grili PPDF, Vidigal CV, da Cruz GF, Albergaria BH, Marques-Rocha JL, et al. Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women. Front Nutr. 2022;9:997414. doi:10.3389/fnut.2022.997414
- Corzo L, Rodriguez S, Alejo R, Fernandez-Novoa L, Aliev G, et al. E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions. Curr Drug Metab. 2017;18:39. doi:10.2174/1389200217666161014151341
- Adriani M, Diarry VI, Abdulah R, Wirjatmadi B. Selenium Intake in Hypertensive and Normotensive Post-Menopausal Indonesian Women. J Nutr Sci Vitaminol (Tokyo). 2015;61:322. doi:10.3177/jnsv.61.322
- da Rocha JT, Pinton S, Mazzanti A, Mazzanti CM, Beckemann DV, et al. Diphenyl diselenide ameliorates cognitive deficits induced by a model of menopause in rats. Behav Pharmacol. 2012;23:98. doi:10.1097/FBP.0b013e32834ed849
- Ha EJ, Smith AM. Selenium-dependent glutathione peroxidase activity is increased in healthy post-menopausal women. Biol Trace Elem Res. 2009;131:90. doi:10.1007/s12011-009-8346-5
- Venditti N, Petronio Petronio G, Guarnieri A, Pietrangelo L, Spicciato A, et al. Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women. Diseases. 2024;12. doi:10.3390/diseases12100237
- Liang G, Kow ASF, Lee YZ, Yusof R, Tham CL, et al. Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice. Biochem Biophys Res Commun. 2024;734:150443. doi:10.1016/j.bbrc.2024.150443
- Ronsini C, Iavarone I, Lacerenza N, Andreoli G, Vastarella MG, et al. Stable Ozonides plus Vitamin E Acetate (Ozoile) for Treatment of Genitourinary Syndrome. Medicina (Kaunas). 2024;60. doi:10.3390/medicina60060880
- Na Takuathung M, Klinjan P, Sakuludomkan W, Dukaew N, Inpan R, et al. Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Clin Med. 2023;12. doi:10.3390/jcm12041326
- Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, et al. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022;15. doi:10.3390/nu15010160
- Farshbaf-Khalili A, Ostadrahimi A, Mirghafourvand M, Ataei-Almanghadim K, Dousti S, et al. Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial. J Nutr Metab. 2022;2022:6339715. doi:10.1155/2022/6339715
- Porterfield L, Wur N, Delgado ZS, Syed F, Song A, et al. Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials. J Menopausal Med. 2022;28:9. doi:10.6118/jmm.21028
- Mohamad NV, Ima-Nirwana S, Chin KY. Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio. Int J Med Sci. 2021;18:3665. doi:10.7150/ijms.64045
- Mohamad NV, Ima-Nirwana S, Chin KY. Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss. Biomed Pharmacother. 2021;137:111368. doi:10.1016/j.biopha.2021.111368
- Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M. The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complement Ther Med. 2020;48:102267. doi:10.1016/j.ctim.2019.102267
- Fait T, Sailer M, Regidor PA. Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys in the management of women with menopausal symptoms. Gynecol Endocrinol. 2019;35:360. doi:10.1080/09513590.2018.1538347
- Golmakani N, Parnan Emamverdikhan A, Zarifian A, Sajadi Tabassi SA, Hassanzadeh M. Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial. Int Urogynecol J. 2019;30:831. doi:10.1007/s00192-018-3698-z
- Pourafshar S, Johnson SA, Keshavarz B, Feresin RG, Khalil DA, et al. The effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency. Menopause. 2018;25:336. doi:10.1097/GME.0000000000001003
- Parnan Emamverdikhan A, Golmakani N, Tabassi SA, Hassanzadeh M, Sharifi N, et al. A survey of the therapeutic effects of Vitamin E suppositories on vaginal atrophy in postmenopausal women. Iran J Nurs Midwifery Res. 2016;21:475.
- Radzinskii VE, Kuznetsova IV, Uspenskaya YB, Repina NB, Gusak YK, et al. Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial. Gynecol Endocrinol. 2016;32:64.
