Last update
4/7/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
Most Useful Reviews
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
Read More
10
Impressive blood results
2 people found this helpful
Life Extension offers such clean ingredients, which is why I prefer this brand. After my last blood test, my liver was in such good condition that my doctor was impressed by the Life Extension milk thistle. I wholeheartedly recommend it!
Read More
7.5
Decreased liver indices
2 people found this helpful
The effects of this product are remarkable. After two months of use, my blood and liver indices have significantly decreased.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
Read More
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
Read More
10
Impressive blood results
2 people found this helpful
Life Extension offers such clean ingredients, which is why I prefer this brand. After my last blood test, my liver was in such good condition that my doctor was impressed by the Life Extension milk thistle. I wholeheartedly recommend it!
Read More
7.5
Decreased liver indices
2 people found this helpful
The effects of this product are remarkable. After two months of use, my blood and liver indices have significantly decreased.
Read More
9
Effective detoxification
I adore this product! The quality is exceptional, and the natural ingredients provide numerous benefits. I initially purchased the standard formula but found that my liver pain subsided with this advanced version. The detox effect is palpable, and it has no taste, which is ideal. Milk thistle is a fantastic natural helper for liver detoxification, and I’ve seen improvements in my blood tests.
Read More
7.5
Grandmother's recovery
I bought this for my grandmother; her condition has improved significantly over the second course. Overall, her condition and blood markers have definitely improved over the past 3-4 months.
Read More
Frequently Asked Questions
7.5
Decreased liver indices
2 people found this helpful
The effects of this product are remarkable. After two months of use, my blood and liver indices have significantly decreased.
7.5
Grandmother's recovery
I bought this for my grandmother; her condition has improved significantly over the second course. Overall, her condition and blood markers have definitely improved over the past 3-4 months.
9
Liver function normalised
7 people found this helpful
I had fatty liver and was advised to exercise and maintain a healthy diet. Unfortunately, I struggled to follow through. I took these tablets for months, and my last blood test showed my liver has returned to normal. I continue to take them, hoping to maintain my liver function.
7.5
Reduced hangovers
3 people found this helpful
This product has significantly reduced my hangovers. I’ve taken it for about a year; I originally bought it for liver health without much thought. I noticed my fatigue has lessened, allowing me to wake up early feeling refreshed. Notably, my hangover symptoms have virtually disappeared, providing relief after nights out. Its long-term use seems to enhance these benefits.
8
We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.
7
Silibinin shows promise for COVID-19
We explored silibinin from Silybum marianum as a potential treatment against SARS-CoV-2, focusing on its anti-inflammatory and anticoagulant effects. Through in silico analysis, we found that silibinin effectively binds to key viral proteins, suggesting it could inhibit the virus's entry and replication.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
Our in vitro studies showed that silibinin also reduces expressions of proinflammatory genes linked to blood clotting. Overall, while silibinin shows promise, the need for more comprehensive clinical trials is crucial to fully understand its therapeutic potential against COVID-19.
References
- Speciale A, Muscarà C, Molonia MS, Cimino F, Saija A, et al. Silibinin as potential tool against SARS-Cov-2: In silico spike receptor-binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects. Phytother Res. 2021;35:4616. 10.1002/ptr.7107
- Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. 10.1186/s12906-017-1897-7
Data last updated:
