' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
USERS' SCORE
Good
Based on 18 Reviews
8.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Highly relevant vitamin D study
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
Read More
9.5
Cholecalciferol eases depression symptoms
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Highly relevant vitamin D3 study
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
Read More
8
Vitamin D3 lowers depression scores
Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial.
Direct link to depression treatment
We conducted a thoughtful study to investigate whether vitamin D3 supplementation could help improve depression scores among rural adolescents. Over three years, we ran a well-structured randomized controlled trial including a group of 150 participants who received either a higher dose of 2250 IU of vitamin D3 or a lower dose of 250 IU.
Before starting, we assessed both the vitamin D levels and depression symptoms of participants to create a solid baseline for comparison. Throughout the study, participants were regularly checked on by our pediatric team to monitor any side effects from the treatment.
Our findings aimed to shed light on the connection between vitamin D deficiency and mental health issues. Ultimately, we observed that those who received vitamin D3 supplementation showed a notable reduction in depression scores. This suggests that addressing nutritional deficits may offer a promising avenue for supporting mental health in young people, potentially enhancing their overall well-being.
Before starting, we assessed both the vitamin D levels and depression symptoms of participants to create a solid baseline for comparison. Throughout the study, participants were regularly checked on by our pediatric team to monitor any side effects from the treatment.
Our findings aimed to shed light on the connection between vitamin D deficiency and mental health issues. Ultimately, we observed that those who received vitamin D3 supplementation showed a notable reduction in depression scores. This suggests that addressing nutritional deficits may offer a promising avenue for supporting mental health in young people, potentially enhancing their overall well-being.
Read More
Most Useful Reviews
10
Depression relief
I ordered this for my mother, and she became more energetic in the mornings; her depression has subsided.
Read More
9.5
Fatigue alleviated
Fatigue and depression have faded, which is very important for me. I combine it with Omega and find it very effective.
Read More
9.5
Improved mood noted
After starting a vitamin D & K supplement, I was impressed with its benefits, particularly my overall health. I noticed reduced joint pain and increased energy, along with greater mental clarity. My mood improved as I became less anxious and depressed, and additional health check-ups showed improved cardiovascular health. I highly recommend this supplement for overall improvement.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.2
- All Researches
9.5
Cholecalciferol eases depression symptoms
Effects of cholecalciferol supplementation on depressive symptoms, C-peptide, serotonin, and neurotrophin-3 in type 2 diabetes mellitus: A double-blind, randomized, placebo-controlled trial.
Highly relevant vitamin D3 study
We conducted a thorough exploration of how vitamin D3, or cholecalciferol, affects depressive symptoms in patients with type 2 diabetes mellitus (T2DM). This double-blind, randomized, placebo-controlled trial involved 70 participants who experienced both T2DM and depression. For 12 weeks, one group received a daily dose of 4000 IU of cholecalciferol, while the other group received a placebo.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
By assessing depression levels using the Beck Depression Inventory-II before and after the study, we observed notable results. Not only did the cholecalciferol group report a significant reduction in depression scores, but we found a marked increase in C-peptide levels as well, which may be linked to improvements in mood.
However, we did not find significant changes in serotonin and neurotrophin-3 levels between the two groups, leaving us with some unanswered questions about these mechanisms. Overall, our findings suggest that supplementing with cholecalciferol could potentially relieve mild to moderate depressive symptoms for people managing T2DM, especially through enhanced C-peptide levels.
Read More
9
Calcitriol impacts depression positively
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway.
Relevant study on vitamin D3 effects
We explored how calcitriol, the active form of vitamin D3, impacts depression linked to neuroinflammation. Using a well-structured study with control and experimental groups, we examined the effects of calcitriol on mice exposed to lipopolysaccharide (LPS), a substance that induces depressive-like behavior and neuroinflammation.
During our experiments, we found that calcitriol not only reduced the inflammatory response in brain cells but also improved behavioral symptoms associated with depression. In particular, it lowered the levels of inflammation-related molecules while promoting anti-inflammatory ones in the brain's hippocampus, an area important for mood and memory.
We observed that calcitriol helped alleviate some of the negative behavioral effects triggered by LPS. The treatment also appeared to prevent the activation of microglia, the brain's immune cells, by interfering with a specific signaling pathway involved in inflammation.
Overall, our findings suggest that vitamin D3 could offer promising benefits as a treatment for depression by tackling neuroinflammation and protecting neuronal health.
During our experiments, we found that calcitriol not only reduced the inflammatory response in brain cells but also improved behavioral symptoms associated with depression. In particular, it lowered the levels of inflammation-related molecules while promoting anti-inflammatory ones in the brain's hippocampus, an area important for mood and memory.
We observed that calcitriol helped alleviate some of the negative behavioral effects triggered by LPS. The treatment also appeared to prevent the activation of microglia, the brain's immune cells, by interfering with a specific signaling pathway involved in inflammation.
Overall, our findings suggest that vitamin D3 could offer promising benefits as a treatment for depression by tackling neuroinflammation and protecting neuronal health.
Read More
9
Vitamin D3 shows antidepressant potential
Effect of Vitamin D3 on Depressive Behaviors of Rats Exposed to Chronic Unpredictable Mild Stress.
Direct link to depression treatment
We looked at how vitamin D3 could help combat depression, especially in the context of chronic stress. The study involved 40 male Wistar rats, divided into different groups to compare the effects of vitamin D3, the antidepressant fluoxetine, and a combination of both.
The rats underwent 21 days of mild but unpredictable stress, simulating conditions often linked to depression. To measure the effects, we conducted several behavioral tests and collected blood samples to assess hormonal changes.
Results showed that vitamin D3 had a positive impact similar to fluoxetine on the rats' depressive behaviors. Specifically, we found that vitamin D3 improved results in key behavioral tests, suggesting it can help protect against stress-induced anxiety and depression.
Notably, the levels of corticosterone, a stress hormone, were lower in rats that received vitamin D3, indicating a protective effect. Overall, this study emphasizes the potential of vitamin D3 in alleviating depressive symptoms resulting from chronic stress.
The rats underwent 21 days of mild but unpredictable stress, simulating conditions often linked to depression. To measure the effects, we conducted several behavioral tests and collected blood samples to assess hormonal changes.
Results showed that vitamin D3 had a positive impact similar to fluoxetine on the rats' depressive behaviors. Specifically, we found that vitamin D3 improved results in key behavioral tests, suggesting it can help protect against stress-induced anxiety and depression.
Notably, the levels of corticosterone, a stress hormone, were lower in rats that received vitamin D3, indicating a protective effect. Overall, this study emphasizes the potential of vitamin D3 in alleviating depressive symptoms resulting from chronic stress.
Read More
9
Vitamin D3 improves depressive symptoms
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial.
Highly relevant vitamin D study
We conducted a double-blind randomized clinical trial to explore the effects of vitamin D3 supplementation on depression. Our study involved 56 adults with mild to moderate depression, who were assigned to either a vitamin D group or a placebo group. Over the course of eight weeks, the vitamin D group received a high dose of 50,000 IU cholecalciferol every two weeks, while the control group received a placebo.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
After the treatment period, we observed that the participants who received the vitamin D3 experienced a significant reduction in depression severity, as measured by the Beck Depression Inventory-II. Interestingly, this improvement in mood occurred independently of any changes in inflammatory biomarkers like IL-1β, IL-6, and hs-CRP, which we also assessed during the study.
This indicates that while vitamin D supplementation may positively impact depressive symptoms, its effects are not directly linked to the inflammatory markers we evaluated. Our findings suggest that vitamin D3 could be a helpful addition to depression treatment strategies, particularly in individuals with low vitamin D levels.
Read More
8
Vitamin D3 lowers depression scores
Does Vitamin D3 Supplementation Improve Depression Scores among Rural Adolescents? A Randomized Controlled Trial.
Direct link to depression treatment
We conducted a thoughtful study to investigate whether vitamin D3 supplementation could help improve depression scores among rural adolescents. Over three years, we ran a well-structured randomized controlled trial including a group of 150 participants who received either a higher dose of 2250 IU of vitamin D3 or a lower dose of 250 IU.
Before starting, we assessed both the vitamin D levels and depression symptoms of participants to create a solid baseline for comparison. Throughout the study, participants were regularly checked on by our pediatric team to monitor any side effects from the treatment.
Our findings aimed to shed light on the connection between vitamin D deficiency and mental health issues. Ultimately, we observed that those who received vitamin D3 supplementation showed a notable reduction in depression scores. This suggests that addressing nutritional deficits may offer a promising avenue for supporting mental health in young people, potentially enhancing their overall well-being.
Before starting, we assessed both the vitamin D levels and depression symptoms of participants to create a solid baseline for comparison. Throughout the study, participants were regularly checked on by our pediatric team to monitor any side effects from the treatment.
Our findings aimed to shed light on the connection between vitamin D deficiency and mental health issues. Ultimately, we observed that those who received vitamin D3 supplementation showed a notable reduction in depression scores. This suggests that addressing nutritional deficits may offer a promising avenue for supporting mental health in young people, potentially enhancing their overall well-being.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Depression relief
I ordered this for my mother, and she became more energetic in the mornings; her depression has subsided.
9.5
Fatigue alleviated
Fatigue and depression have faded, which is very important for me. I combine it with Omega and find it very effective.
9.5
Improved mood noted
After starting a vitamin D & K supplement, I was impressed with its benefits, particularly my overall health. I noticed reduced joint pain and increased energy, along with greater mental clarity. My mood improved as I became less anxious and depressed, and additional health check-ups showed improved cardiovascular health. I highly recommend this supplement for overall improvement.
Read More
9.5
Mood enhancement
The best vitamin D I've had, small and easy to swallow with excellent quality. During autumn-winter, I experienced significant blues and signs of depression. After trying vitamin D, my mood improved dramatically, and my desire to live returned.
9.5
Melancholy lifted
I’ve been taking this for years. In a previous winter of darkness, I nearly succumbed to depression but found vitamin D3 removed my melancholy within days, and I’ve continued its use annually.
