Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
USERS' SCORE
Good
Based on 18 Reviews
8.5
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%
Top Medical Research Studies
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Read More
Most Useful Reviews
9
Improved well-being
312 people found this helpful
I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime!
Read More
7.5
Calming effects
257 people found this helpful
I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects.
Read More
9
Reduced irritability
217 people found this helpful
The vitamins inside the container look nice and have no taste, but they do have a smell. Unfortunately, the capsules are quite large and difficult to swallow. I’ve used them for a month now for nervous disorders caused by my stressful environment. With magnesium, I’ve combated sleepiness, headaches, irritability, and depression. My husband has also benefited greatly during this time.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.3
- All Researches
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
8
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
Read More
8
Magnesium deficiency correlates with depression
This study examined the relationship between magnesium deficiency, measured by the Magnesium Depletion Score (MDS), and depression among U.S. adults. We analyzed data from the National Health and Nutrition Examination Survey, focusing on those with moderate to severe depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Our findings revealed a significant link—higher MDS scores led to an increased risk of depression. Specifically, for each unit rise in MDS, the chance of developing depression increased by 13%. Interestingly, those with severe magnesium deficiency saw a staggering 58% rise in depression likelihood. This suggests that improving magnesium levels could be beneficial for both preventing and treating depression.
Read More
8
This study examined how magnesium deficiency relates to depression in adults aged 20 to 60. By using the National Health and Nutrition Examination Survey data from 2005 to 2018, we analyzed the magnesium depletion score (MDS) while assessing depression through the Patient Health Questionnaire-9.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Our findings reveal a positive association: as the MDS increases, so does the likelihood of depression. Each one-unit rise in MDS raises the odds of depression. However, results varied with different MDS levels. While these results are promising, further research is necessary to understand the underlying mechanisms better.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improved well-being
312 people found this helpful
I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime!
Read More
7.5
Calming effects
257 people found this helpful
I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects.
Read More
9
Reduced irritability
217 people found this helpful
The vitamins inside the container look nice and have no taste, but they do have a smell. Unfortunately, the capsules are quite large and difficult to swallow. I’ve used them for a month now for nervous disorders caused by my stressful environment. With magnesium, I’ve combated sleepiness, headaches, irritability, and depression. My husband has also benefited greatly during this time.
Read More
9
Mood enhancement
6 people found this helpful
I absolutely adore this product! Before using magnesium, I faced constant sleepiness, headaches, irritability, and depression. However, I have observed that it helps with the assimilation of vitamins, blood thinning, and joy hormone synthesis. It has significantly reduced my insomnia, migraines, and overall apathy. I feel great after just six hours of sleep and my brain function is much better. I wholeheartedly recommend it!
Read More
9
Sleep improvement
1 people found this helpful
Magnesium plays a crucial role in stabilising emotions. Over the past two months, I’ve noticed significant improvements, especially in my sleep. Previously, I struggled with insomnia and depression, but now I can sleep well, which feels like a true blessing.
Read More
Frequently Asked Questions
7.5
Calming effects
257 people found this helpful
I bought this for a girl who was experiencing a mild autumn depression. After a few days of use, she found that she was coping better with stress and felt much calmer overall. Her muscles relaxed, and her immune system seemed to be recovering. Importantly, she did not experience any side effects.
9
Reduced irritability
217 people found this helpful
The vitamins inside the container look nice and have no taste, but they do have a smell. Unfortunately, the capsules are quite large and difficult to swallow. I’ve used them for a month now for nervous disorders caused by my stressful environment. With magnesium, I’ve combated sleepiness, headaches, irritability, and depression. My husband has also benefited greatly during this time.
9
Improved well-being
312 people found this helpful
I had been experiencing constant sleepiness, headaches, irritability, and depression before starting magnesium. Using Magnesium Caps has helped me assimilate essential vitamins and minerals, thin my blood, and synthesise the hormone of joy. It effectively alleviated insomnia and my migraines, apathy and depression have vanished. I now feel refreshed after six hours of sleep and my mental clarity has improved significantly. I highly recommend it, especially when taken before bedtime!
7.5
Helps anxiety
Indira Magnesium has helped me with stress and depression following childbirth. It calmed me during a time when I was struggling with postpartum depression and insufficient sleep. I feel much more at ease now.
9
Less irritable
This magnesium has significantly reduced my irritability, anxiety, and depression after giving birth. I take one tablet before bed, and I feel much better now, without issues I previously faced.
7.5
Mood stabilisation
This supplement has significantly helped with fatigue, difficulties falling asleep, mood swings and depression. I use it because I experience high levels of mental and physical stress, and it has made a notable difference.
9
Sleep improvement
1 people found this helpful
Magnesium plays a crucial role in stabilising emotions. Over the past two months, I’ve noticed significant improvements, especially in my sleep. Previously, I struggled with insomnia and depression, but now I can sleep well, which feels like a true blessing.
7.5
Mind stabilisation
1 people found this helpful
Magnesium is beneficial for treating hay fever and alleviating depression and anxiety. A lack of magnesium can hinder serotonin synthesis, which stabilises the mind. It promotes blood circulation, supports hair growth, and improves skin moisture, making it easier to obtain essential minerals through supplements.
6
Questionable effects
I bought this to help with sleep and depression, but it didn’t significantly improve sleep for me. I'm uncertain of its impact on my depression, but it seems beneficial when taken consistently.
7
Magnesium complex shows antidepressant promise
We explored the antidepressant effects of a new imipramine-magnesium (IMI-Mg) complex in male mice. Using established behavioral tests like the forced swim and tail suspension tests, we found that this complex notably reduced immobility time, indicating potential antidepressant-like activity.
Importantly, the results were comparable to administering imipramine and magnesium individually. This promising finding suggests the IMI-Mg complex could pave the way for enhanced treatment approaches, improving safety and patient adherence in depression therapies.
Importantly, the results were comparable to administering imipramine and magnesium individually. This promising finding suggests the IMI-Mg complex could pave the way for enhanced treatment approaches, improving safety and patient adherence in depression therapies.
9
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
8
We examined the role of magnesium levels in relation to depressive symptoms through a comprehensive analysis of data from Taiwan's Nutrition and Health Survey. Involving 2,196 participants, we employed logistic and linear regression methods to assess these relationships.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
Our findings revealed that higher magnesium levels correlated with fewer depressive symptoms. Interestingly, this connection was stronger in individuals with elevated C-reactive protein (CRP) levels, suggesting that inflammation influences how magnesium affects mood.
Overall, maintaining adequate magnesium levels might be beneficial, especially for those dealing with inflammation.
References
- Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. doi:10.3390/molecules30030519
- Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. doi:10.1007/s00394-025-03597-x
- Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. doi:10.1684/mrh.2024.0535
- Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. doi:10.3389/fpubh.2024.1486434
- Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
- Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. doi:10.1016/j.jtemb.2024.127543
- Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
- Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056
- Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. doi:10.1177/21501319241252570
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. doi:10.3390/nu15071560
- Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. doi:10.3390/nu15030774
- Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
- Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
- Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. doi:10.1684/mrh.2022.0503
- Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. doi:10.1080/1028415X.2021.1945859
- Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. doi:10.1016/j.ajogmf.2021.100407
