Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.2
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%
Top Medical Research Studies
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
Most Useful Reviews
9
Effective heartburn relief
Excellent product! I take it at night, and it significantly helps with my heartburn. The magnesium is of high quality, and the package is relatively large.
Read More
9
Heartburn-free option
I love Life Extension Magnesium Caps; they are the only supplement that doesn't give me heartburn, and they are effective! I've recently discovered a liquid form from another brand that I adore. It’s much easier to take and tastes delightful!
Read More
7.5
Good absorption
I take magnesium before bed for better sleep quality. Previously, I experienced heartburn with other products, but this one is fine. The capsules contain soft powder, which I believe aids absorption.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.5
- All Researches
9
We explored the impact of a new treatment, Marial®, on patients suffering from gastroesophageal reflux disease (GERD). In a large survey involving 56 gastroenterological offices across Italy, patients were treated with either proton pump inhibitors (PPIs), a combination of PPIs and an additional remedy, or the Marial® formulation containing magnesium alginate. The results showed that both Marial® and the combination therapy significantly reduced heartburn symptoms, with Marial® proving to be more effective than the combination. Overall, patients reported a marked improvement in their GERD-related symptoms.
Read More
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Read More
7
Rapid relief, similar effectiveness observed
We conducted a study to see how well a fixed-dose combination of esomeprazole and magnesium hydroxide works for heartburn compared to enteric-coated esomeprazole. By using a crossover design, forty-nine healthy subjects received each treatment, allowing us to closely observe the effects.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Our findings showed that the combination drug reached maximum concentration faster and achieved gastric pH levels that suggest quicker acid suppression. Despite these advantages, the overall effectiveness in reducing gastric acidity was similar for both treatments. This indicates that while magnesium may enhance the speed of relief, it doesn't significantly outperform traditional esomeprazole.
Read More
7
We investigated how different types of mineral waters might assist in treating patients with gastroesophageal reflux disease (GERD). Ninety patients were split into three groups: a control group receiving standard treatment, one group drinking boric sodium bicarbonate water, and another consuming highly mineralized sodium-magnesium water.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
While basic treatment showed little effectiveness, the boric water alleviated some symptoms, and the magnesium water notably improved dyspepsia and liver function. Overall, our findings support the use of mineral waters as part of a comprehensive GERD treatment plan.
Read More
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective heartburn relief
Excellent product! I take it at night, and it significantly helps with my heartburn. The magnesium is of high quality, and the package is relatively large.
Read More
9
Heartburn-free option
I love Life Extension Magnesium Caps; they are the only supplement that doesn't give me heartburn, and they are effective! I've recently discovered a liquid form from another brand that I adore. It’s much easier to take and tastes delightful!
Read More
7.5
Good absorption
I take magnesium before bed for better sleep quality. Previously, I experienced heartburn with other products, but this one is fine. The capsules contain soft powder, which I believe aids absorption.
Read More
6
No heartburn
We take magnesium in courses. Initially, I found this magnesium normal. The key point for me is that it does not induce heartburn. Occasionally, I feel sick from other vitamins.
Read More
0
Increased heartburn
I've used Life Extension magnesium for over a year without issues. It aids muscle relaxation, sleep, and keeps me regular. However, this recent bottle seems different; it has been causing me awful heartburn, likely due to its acidity. I've also discovered it's mostly magnesium citrate instead of a good mix of magnesium types, which is disappointing.
Read More
Frequently Asked Questions
9
Effective heartburn relief
Excellent product! I take it at night, and it significantly helps with my heartburn. The magnesium is of high quality, and the package is relatively large.
6
No heartburn
We take magnesium in courses. Initially, I found this magnesium normal. The key point for me is that it does not induce heartburn. Occasionally, I feel sick from other vitamins.
4
Constipation relief
30 people found this helpful
I order this magnesium quite often. The dosage is good, though the shape of the capsules is not ideal. It serves as a helpful pain reliever for menstruation. I originally ordered magnesium citrate for my aunt who struggled with constipation. After starting it, her stools became loose, and she found it easier to go to the loo. However, after a month of taking it, she experienced some heartburn. Thus, I suggest magnesium chloride for those with stomach issues, but this magnesium could still be used. I recommend it.
9
Heartburn-free option
I love Life Extension Magnesium Caps; they are the only supplement that doesn't give me heartburn, and they are effective! I've recently discovered a liquid form from another brand that I adore. It’s much easier to take and tastes delightful!
7.5
Good absorption
I take magnesium before bed for better sleep quality. Previously, I experienced heartburn with other products, but this one is fine. The capsules contain soft powder, which I believe aids absorption.
0
Increased heartburn
I've used Life Extension magnesium for over a year without issues. It aids muscle relaxation, sleep, and keeps me regular. However, this recent bottle seems different; it has been causing me awful heartburn, likely due to its acidity. I've also discovered it's mostly magnesium citrate instead of a good mix of magnesium types, which is disappointing.
8
GutGard® shows promise for heartburn
In a well-designed phase III trial, we explored how GutGard®, a licorice extract, helps relieve heartburn related to gastroesophageal reflux. Over 28 days, participants were randomly assigned to receive either GutGard® or a placebo without knowing which one they had.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
Remarkably, those taking GutGard® reported quicker relief from their GER symptoms, particularly heartburn, compared to those on the placebo. This suggests that GutGard® may offer an effective, safe option for managing heartburn symptoms.
7
Our observational study focused on 40 patients suffering from gastroesophageal reflux disease (GERD) treated with a gel combining sodium hyaluronic acid and magnesium alginate. This gel works to hydrate and protect the mucosal tissues in the digestive tract.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
We split our patients into two groups: one receiving the gel and the other using conventional treatments alongside proton pump inhibitors. Throughout the follow-up, many reported a significant reduction in heartburn symptoms, with some patients finding relief in just five days.
While the results are encouraging, further research is needed to fully understand the extent of magnesium’s benefits in treating GERD.
7
We investigated the effectiveness of dietary changes and natural remedies in treating gastrointestinal symptoms in a 73-year-old woman with newly diagnosed Parkinson's disease. The patient faced constipation and acid reflux after starting medication. By increasing her vegetable intake, fiber, protein, and hydration while reducing sugars, she saw improvements in her symptoms. Notably, integrating apple cider vinegar, deglycyrrhizinated licorice, probiotics, and magnesium citrate helped alleviate her acid reflux significantly—50% improvement within just five days. Ultimately, she achieved complete symptom resolution in one month, highlighting the promise of diet and natural treatments.
References
- Raj JP, Saxena U, Belhekar MN, Mamde A, Darak H, et al. Efficacy and Safety of GutGard® in Managing Gastroesophageal Reflux-Related Symptoms: A Phase III, Single-Centre, Double-Blind, Randomized Placebo-Controlled Trial. Complement Med Res. 2025;32:26. 10.1159/000543367
- Kim Y, Bae S, Jeon I, Kwon J, Hong SH, et al. Pharmacokinetics and Pharmacodynamics of a Fixed-Dose Combination of Esomeprazole and Magnesium Hydroxide Compared to the Enteric-Coated Esomeprazole. Clin Ther. 2024;46:870. 10.1016/j.clinthera.2024.08.006
- Dragomiretska NV, Babov KD, Gushcha SG, Zabolotna IB, Plakida AL, et al. Application of mineral waters in the complex treatment of patients with gastroesophageal reflux disease. Minerva Gastroenterol Dietol. 2020;66:225. 10.23736/S1121-421X.20.02601-X
- Neiworth-Petshow EM, Baldwin-Sayre C. Naturopathic Treatment of Gastrointestinal Dysfunction in the Setting of Parkinson's Disease. Integr Med (Encinitas). 2018;17:44.
- Bianchetti M, Peralta S, Nicita R, Aragona SE, Ciprandi G. Emerging from gastroesophageal reflux (EMERGE): An Italian survey - II the viewpoint of the patient. J Biol Regul Homeost Agents. 2018;32:983.
- Aragona SE, Mereghetti G, Bianchetti M, Mangiavillano B, Zurlo T, et al. Regenerative medicine in the treatment of gastro-esophageal reflux disease and laryngo-pharyngeal reflux. From research to cure. J Biol Regul Homeost Agents. 2017;31:207.
