Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism.
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
Read More
4
Magnesium shows promise in thyroid recovery
Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation.
We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.
Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.
However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
Read More
9
Magnesium improves hypothyroid inflammation
Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism.
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Read More
Most Useful Reviews
9
Effective supplement
After being diagnosed with hypothyroidism and trying hormonal therapy with no improvement, I decided to try magnesium. I've been taking it for less than a week, and I already feel better—no more freezing limbs or constipation. This supplement genuinely works!
Read More
9
Excellent improvement
Excellent for hypothyroidism and those experiencing thyroid issues and lymphedema.
Read More
7.5
Useful magnesium benefits
The quality and ingredients are excellent. I ordered this magnesium alongside thyroid support capsules for my hypothyroidism. It’s useful for relaxation, sleep, and muscle recovery. The packaging is attractive and protects the capsules from light. I look forward to purchasing it again.
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
Read More
8
Magnesium shows potential benefits
Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism.
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
Read More
7
Magnesium's role in hypothyroidism
The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.
We explored how magnesium, as part of a broader supplementation strategy, influences thyroid function and overall well-being in patients with hypothyroidism. In a well-structured study, 104 individuals receiving traditional treatment with levothyroxine and vitamin D were randomly divided into two groups. One group received a combination of essential micronutrients, including magnesium, while the other received placebos over an 8-week period.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
Read More
7
Minerals affect thyroid dysfunction risk
Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey.
We delved into how different minerals might influence thyroid dysfunction, particularly focusing on hypothyroidism. Analyzing data from nearly 7,800 people, we utilized advanced statistical methods to explore the impact of mineral intake on thyroid hormones.
While we found that higher intakes of minerals like magnesium and calcium were linked to lower rates of hyperthyroidism, the study did not show significant benefits of magnesium specifically for hypothyroidism. The results suggest that a balanced intake of various minerals may support thyroid health overall.
Read More
4
Magnesium shows promise in thyroid recovery
Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation.
We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.
Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.
However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
All Reviews
Positive Reviews
Negative Reviews
9
Effective supplement
After being diagnosed with hypothyroidism and trying hormonal therapy with no improvement, I decided to try magnesium. I've been taking it for less than a week, and I already feel better—no more freezing limbs or constipation. This supplement genuinely works!
Read More
9
Excellent improvement
Excellent for hypothyroidism and those experiencing thyroid issues and lymphedema.
Read More
7.5
Useful magnesium benefits
The quality and ingredients are excellent. I ordered this magnesium alongside thyroid support capsules for my hypothyroidism. It’s useful for relaxation, sleep, and muscle recovery. The packaging is attractive and protects the capsules from light. I look forward to purchasing it again.
Read More
7.5
Supports recovery
This dosage is wonderful for my hypothyroidism, aiding inflammation and muscle recovery from my rigorous training. I highly recommend it.
Read More
7.5
Regular intake
I take this for my hypothyroidism treatment. It has a good dosage, and I consume it regularly.
Read More
Frequently Asked Questions
Hypothyroidism is a medical condition that occurs when the thyroid gland, a small butterfly-shaped gland located at the base of the neck, does not produce enough thyroid hormones. These hormones, mainly thyroxine (T4) and triiodothyronine (T3), play a critical role in regulating various bodily functions, including metabolism, energy production, and overall growth and development. When hormone levels drop, it can lead to a slow metabolism, weight gain, fatigue, depression, and a host of other symptoms that can significantly affect quality of life.
The condition can be caused by a variety of factors, including autoimmune diseases like Hashimoto's thyroiditis, certain medications, radiation treatment, or iodine deficiency. Diagnosis typically involves blood tests to check levels of thyroid-stimulating hormone (TSH) and thyroid hormones. Treatment primarily includes hormone replacement therapy, with synthetic thyroid hormones such as levothyroxine being the most common form of treatment. With proper management, individuals with hypothyroidism can lead normal, healthy lives by ensuring they receive the necessary hormones their bodies need to function optimally.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in many bodily functions, including thyroid health. Research suggests that magnesium deficiency may negatively impact thyroid function, as this mineral is essential for converting the inactive thyroid hormone thyroxine (T4) into the active hormone tri-iodothyronine (T3). This conversion is vital for maintaining metabolic processes, and adequate magnesium levels can support overall thyroid health. Some studies indicate that ensuring sufficient magnesium intake may ease symptoms associated with hypothyroidism and contribute to better metabolic balance.
However, it's important to note that while magnesium can support thyroid function, it is not a replacement for thyroid hormone replacement therapy for those diagnosed with hypothyroidism. If you're considering magnesium supplementation or are curious about your magnesium levels in relation to thyroid health, it’s a good idea to consult with a healthcare professional. They can provide personalized recommendations based on your individual health needs, including appropriate dosages and dietary sources of magnesium.
Based on user reviews, the time it takes to see results from this supplement for hypothyroidism can vary. Several users report feeling improvements in as little as a week after starting the supplement. One reviewer mentioned they experienced relief from symptoms like freezing limbs and constipation within less than a week of use Read Review. Other users have expressed satisfaction with the supplement's efficacy and its role in aiding inflammation and muscle recovery, suggesting that benefits may be felt relatively quickly, although specific timelines were not provided Read Review.
Overall, while individual experiences may vary, early observations and feedback indicate that some users notice positive changes shortly after they begin taking the supplement. However, it is important to continue monitoring your symptoms and consult with a healthcare professional for personalized advice and timelines regarding your treatment.
Based on recent research, the use of magnesium as a supplement in managing hypothyroidism shows some potential but lacks conclusive evidence. A study involving 104 patients found that while micronutrient supplementation, which included magnesium, may have improved quality of life, it did not definitively demonstrate a significant improvement in thyroid function on its own [1]. Similarly, another study indicated that magnesium, when used alongside levothyroxine, reduced inflammation in hypothyroid rats, suggesting a potential benefit in inflammatory management rather than direct thyroid enhancement [2].
Moreover, while magnesium appeared to contribute positively to thyroid health in a small group of patients and was linked to improved thyroid hormone levels in another trial, it is important to note that results were not uniform across all individuals [3], [5]. Furthermore, a larger analysis suggested there might be no significant benefit from magnesium specifically regarding hypothyroidism outcomes [4]. Therefore, while magnesium may play a supportive role in thyroid health, more targeted clinical trials are necessary to establish its efficacy as a standalone treatment for hypothyroidism.
Users have reported various improvements in symptoms related to hypothyroidism after incorporating magnesium supplements into their routines. Many have noted significant benefits, such as relief from common symptoms like freezing limbs and constipation within just a week of starting the supplement Read Review. Additionally, there are anecdotal accounts from users highlighting how magnesium has aided not only in managing thyroid-related issues but also in promoting better sleep, relaxation, and muscle recovery, making it a versatile addition to their health regimen Read Review.
Furthermore, some users have emphasized that magnesium effectively supports their overall wellness journey, particularly for those dealing with thyroid dysfunction and conditions like lymphedema Read Review. While individual results can vary, the collective feedback suggests that many have experienced a positive shift in their symptoms, particularly in terms of inflammation and recovery from physical exertion Read Review. As always, it’s essential to consult with a healthcare professional to tailor any supplement approach to your unique needs.
Users report positive experiences when combining magnesium with other supplements for managing hypothyroidism. One reviewer specifically mentioned taking magnesium alongside thyroid support capsules, noting its benefits for relaxation, sleep, and muscle recovery, which enhances their overall approach to thyroid health Read Review. This combination appears to create a synergistic effect, helping to alleviate symptoms more effectively than magnesium alone.
Moreover, other users have highlighted the overall utility of magnesium in addressing thyroid health issues, indicating that it can complement other treatments and supplements Read Review. The collective feedback suggests that those dealing with hypothyroidism might find magnesium an excellent supportive addition to their health regimen, especially when used in conjunction with other targeted supplements Read Review. As always, consulting with a healthcare professional is recommended to ensure the best combination for individual needs.
Users report a generally positive response to magnesium supplements in the context of managing hypothyroidism, suggesting that they can provide relief from various symptoms. One user, who began taking magnesium after struggling with hormonal therapy, noted improvements in symptoms like freezing limbs and constipation within a week of starting supplementation Read Review. Furthermore, another user highlighted that the dosage they were taking was beneficial for handling inflammation and aiding muscle recovery from intense workouts Read Review.
Although specific dosages are not mentioned in the reviews, users commented on the effectiveness of their chosen supplement, with one stating that it has a "good dosage," indicating a sense of satisfaction with the amount they were taking Read Review. This suggests that magnesium may play a supportive role for those with hypothyroidism, particularly in conjunction with other thyroid support supplements Read Review. Overall, while users affirm the benefits of magnesium, it's important to note that personal experiences can vary.
9
Effective supplement
After being diagnosed with hypothyroidism and trying hormonal therapy with no improvement, I decided to try magnesium. I've been taking it for less than a week, and I already feel better—no more freezing limbs or constipation. This supplement genuinely works!
7.5
Supports recovery
This dosage is wonderful for my hypothyroidism, aiding inflammation and muscle recovery from my rigorous training. I highly recommend it.
7.5
Useful magnesium benefits
The quality and ingredients are excellent. I ordered this magnesium alongside thyroid support capsules for my hypothyroidism. It’s useful for relaxation, sleep, and muscle recovery. The packaging is attractive and protects the capsules from light. I look forward to purchasing it again.
9
Excellent improvement
Excellent for hypothyroidism and those experiencing thyroid issues and lymphedema.
7.5
Regular intake
I take this for my hypothyroidism treatment. It has a good dosage, and I consume it regularly.
7
Magnesium's role in hypothyroidism
The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial.
We explored how magnesium, as part of a broader supplementation strategy, influences thyroid function and overall well-being in patients with hypothyroidism. In a well-structured study, 104 individuals receiving traditional treatment with levothyroxine and vitamin D were randomly divided into two groups. One group received a combination of essential micronutrients, including magnesium, while the other received placebos over an 8-week period.
Our observations highlighted changes in insulin resistance and quality of life after the intervention, suggesting that micronutrient supplementation could have a bearing on these aspects of health. However, the specifics regarding magnesium's isolated effect on thyroid function were less clear due to the multi-nutritional approach taken in this trial.
While we acknowledge promising results related to quality of life, we must clarify that the study does not provide concrete evidence that magnesium alone significantly improves thyroid function. Further, more focused clinical trials are necessary to ascertain the role of magnesium, allowing for a better understanding of its potential benefits in hypothyroid patients.
9
Magnesium improves hypothyroid inflammation
Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism.
We explored the interaction between magnesium sulfate and levothyroxine in managing inflammation related to hypothyroidism. In this study, we used 60 male rats, dividing them into six different groups. These included normals, those given magnesium, hypothyroid rats, and various combinations of treatments with levothyroxine and magnesium.
Our findings showed that hypothyroidism led to an increase in inflammatory markers such as C-reactive protein and interleukin-6, while decreasing vital thyroid hormones. When we treated hypothyroid rats with either levothyroxine or magnesium, these inflammatory markers significantly decreased.
Notably, the rats that received a combination of both treatments experienced the most significant reduction in inflammation. This suggests that chronic low-grade inflammation in hypothyroid conditions might elevate the risk of cardiovascular diseases. Overall, using magnesium and levothyroxine together seems to be more effective in reducing inflammation compared to either treatment alone.
4
Magnesium shows promise in thyroid recovery
Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation.
We set out to investigate how magnesium, along with selenium and coenzyme Q10, could influence hypothyroidism in patients with benign thyroid diseases. Our approach included a small group of eight patients—five with hyperthyroidism and three with hypothyroidism—who received additional treatment aimed at addressing both their thyroid condition and related physical and psychological stresses.
Over a period of 2 to 4 years, we observed some significant changes. Initially, we focused on correcting musculoskeletal issues, followed by addressing stress. As a result, we noted that thyroid morphology normalized in many cases, which was confirmed through ultrasound examinations. Interestingly, we also saw a reduction in thyroid antibody levels for most patients.
However, we must be transparent about our findings. While magnesium and the other supplements showed promise, there were two cases of chronic thyroiditis that did not respond positively to treatment, possibly due to long-standing fibrosis. This indicates that while magnesium may play a role in thyroid health, its effectiveness can vary significantly based on individual circumstances and the duration of the thyroid condition.
8
Magnesium shows potential benefits
Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism.
We conducted a randomized double-blind study to see how supplementation with zinc, magnesium, and vitamin A might affect hypothyroidism.
In our trial with 86 participants, those receiving the supplements showed improved thyroid function, indicated by a significant increase in serum FT4 levels.
However, no noteworthy changes were observed in the control group regarding thyroid hormones.
Overall, while the supplementation shows promise for some thyroid improvement, it's not a guaranteed solution for everyone.
7
Minerals affect thyroid dysfunction risk
Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey.
We delved into how different minerals might influence thyroid dysfunction, particularly focusing on hypothyroidism. Analyzing data from nearly 7,800 people, we utilized advanced statistical methods to explore the impact of mineral intake on thyroid hormones.
While we found that higher intakes of minerals like magnesium and calcium were linked to lower rates of hyperthyroidism, the study did not show significant benefits of magnesium specifically for hypothyroidism. The results suggest that a balanced intake of various minerals may support thyroid health overall.
References
Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
Abbas AM, Sakr HF. Effect of magnesium sulfate and thyroxine on inflammatory markers in a rat model of hypothyroidism. Can J Physiol Pharmacol. 2016;94:426. 10.1139/cjpp-2015-0247
Moncayo R, Moncayo H. Proof of concept of the WOMED model of benign thyroid disease: Restitution of thyroid morphology after correction of physical and psychological stressors and magnesium supplementation. BBA Clin. 2015;3:113. 10.1016/j.bbacli.2014.12.005
Liu S, Huang W, Lin Y, Wang Y, Li H, et al. Machine learning-based exploration of the associations between multiple minerals' intake and thyroid dysfunction: data from the National Health and Nutrition Examination Survey. Front Nutr. 2025;12:1522232. 10.3389/fnut.2025.1522232
Rabbani E, Golgiri F, Janani L, Moradi N, Fallah S, et al. Randomized Study of the Effects of Zinc, Vitamin A, and Magnesium Co-supplementation on Thyroid Function, Oxidative Stress, and hs-CRP in Patients with Hypothyroidism. Biol Trace Elem Res. 2021;199:4074. 10.1007/s12011-020-02548-3