' 
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Magnesium [as magnesium oxide, citrate, succinate)
500 mg
119%
Top Medical Research Studies
9
Magnesium shows neuroprotective promise
Neuroprotection on ischemic brain injury by Mg/H released from endovascular Mg implant.
Highly relevant to magnesium treatment
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
Read More
8
Magnesium reduces stroke risk
Causal Effect of Macronutrient and Micronutrient Intake on Stroke: A Two-Sample Mendelian Randomization Study.
Strong evidence of magnesium's effect
We explored how magnesium intake might influence the risk of stroke through a robust research design known as two-sample Mendelian randomization. This approach allows us to estimate the causal effects of nutrients on health outcomes, eliminating many confounding factors present in traditional observational studies.
Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.
This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.
Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
Our findings suggest that higher levels of magnesium are linked to a significantly lower risk of cardioembolic stroke, a type of stroke caused by blood clots that travel to the brain. Specifically, our results showed a striking reduction in risk, indicating that magnesium could play a protective role in stroke prevention.
This study also identified other beneficial nutrients, such as vitamin C and vitamin B9, further emphasizing the importance of diet in stroke management. However, we should exercise caution regarding vitamin B6, which showed a potential association with an increased risk of large-artery stroke, as this finding requires additional investigation.
Overall, this research highlights the importance of magnesium and certain vitamins in stroke prevention. These insights can help shape public health strategies aimed at reducing stroke risk through dietary recommendations.
Read More
8
Dietary magnesium inversely affects stroke
Association of Dietary Magnesium Intake with the Risk of Stroke among Adults.
Strong relevance to dietary magnesium
We examined the relationship between dietary magnesium intake and the risk of stroke using data from a large-scale health study involving nearly 30,000 American adults. By analyzing responses from self-reported questionnaires and dietary recalls over an 11-year period, we aimed to uncover how much magnesium from our diets might influence stroke occurrences.
Our findings revealed an interesting trend: higher magnesium intake appeared to lower the risk of stroke. Specifically, we discovered that individuals in the highest quartile of magnesium consumption had a 44% reduced odds of experiencing a stroke compared to those in the lowest quartile. Additionally, this protective effect was particularly strong among women and in adults aged 40 to 59.
It’s noteworthy that while we found a clear link between diet and stroke risk, the study did not differentiate the effects of magnesium supplementation or treatment in a clinical setting. Therefore, our observations highlight the potential benefits of incorporating magnesium-rich foods into our diets, emphasizing its significance in stroke prevention.
Our findings revealed an interesting trend: higher magnesium intake appeared to lower the risk of stroke. Specifically, we discovered that individuals in the highest quartile of magnesium consumption had a 44% reduced odds of experiencing a stroke compared to those in the lowest quartile. Additionally, this protective effect was particularly strong among women and in adults aged 40 to 59.
It’s noteworthy that while we found a clear link between diet and stroke risk, the study did not differentiate the effects of magnesium supplementation or treatment in a clinical setting. Therefore, our observations highlight the potential benefits of incorporating magnesium-rich foods into our diets, emphasizing its significance in stroke prevention.
Read More
Most Useful Reviews
7.5
Calming effect noted
I can feel the calming effect of magnesium, which is vital for normal bone structure. Low levels of magnesium are linked to various diseases, including osteoporosis, high blood pressure, heart disease, diabetes, and stroke. These pills are easy to take, and I felt the calming effects within 30 minutes. I opted for this after my last physical showed slightly elevated LDL levels, and I’ll post my next test results as an update.
Read More
8
Heart health support
Excellent magnesium supplement, but consult your doctor first. Magnesium is essential, impacting several bodily functions and helping manage chronic diseases like diabetes, cardiovascular issues, and stroke. While research shows magnesium aids bone health and may lower the risk of type 2 diabetes and cardiovascular diseases, more evidence is required for its widespread use in these areas. More studies are needed to definitively link magnesium supplementation with better heart health and reduced stroke risk.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.5
- All Researches
9
Magnesium's role in stroke recovery
MgSO as a novel hypothermia infusion solution promotes ischemic stroke recovery through Ca regulation of neurovascular units.
Moderate impact on stroke treatment
We explored the potential benefits of magnesium sulfate (MgSO) as a novel hypothermia infusion solution to aid recovery in patients experiencing acute ischemic stroke (AIS). In our investigation, we utilized rats that underwent a procedure mimicking stroke by occluding the middle cerebral artery. We compared the effectiveness of MgSO combined with hypothermia to traditional treatment methods.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
The results of our study indicated that the combination of MgSO and hypothermia far outperformed either treatment alone. This exciting discovery showed significant improvements in neurological abilities and reduced brain damage, as well as better maintenance of cerebral blood flow. We found that this protective effect was largely due to MgSO's ability to regulate calcium levels in various neurovascular unit (NVU) cells, which are crucial for brain health.
Our findings suggest that magnesium may offer a promising way to enhance recovery in stroke patients when used alongside hypothermia, potentially leading to better outcomes in their rehabilitation journey.
Read More
9
Magnesium enhances stroke therapy
Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke.
Moderate relevance to magnesium effects
We explored the effects of combining magnesium salts of salvianolic acid B and ginsenoside Rg1 as a potential treatment for ischemic stroke. The study used a well-structured approach, evaluating the impacts on infarct volume and neurological function in a model of middle cerebral artery occlusion.
Our findings revealed that the combination therapy was more effective than either treatment alone, significantly reducing the injured area of the brain and improving behavior in treated subjects. Specifically, the combined treatment not only resulted in a marked decrease in infarct volume but also supported better structural integrity of the brain tissue and an increase in neuron numbers.
We verified the synergistic benefits of this combination through thorough statistical analysis, showing that this approach could potentially enhance therapeutic outcomes for stroke patients. Notably, the mechanisms behind these improvements hinted towards mitigating cerebral metabolic disorders as a factor.
Overall, while the effect of magnesium alone is less clear, our results highlight the effectiveness of using it in combination with ginsenoside Rg1, paving the way for improved treatment strategies for those affected by stroke.
Our findings revealed that the combination therapy was more effective than either treatment alone, significantly reducing the injured area of the brain and improving behavior in treated subjects. Specifically, the combined treatment not only resulted in a marked decrease in infarct volume but also supported better structural integrity of the brain tissue and an increase in neuron numbers.
We verified the synergistic benefits of this combination through thorough statistical analysis, showing that this approach could potentially enhance therapeutic outcomes for stroke patients. Notably, the mechanisms behind these improvements hinted towards mitigating cerebral metabolic disorders as a factor.
Overall, while the effect of magnesium alone is less clear, our results highlight the effectiveness of using it in combination with ginsenoside Rg1, paving the way for improved treatment strategies for those affected by stroke.
Read More
9
Magnesium shows neuroprotective promise
Neuroprotection on ischemic brain injury by Mg/H released from endovascular Mg implant.
Highly relevant to magnesium treatment
We embarked on an intriguing exploration of how magnesium might help during cerebral ischemia, particularly after an acute stroke. The study set out to determine the potential benefits of a biodegradable neuroprotective stent that releases magnesium into the bloodstream, targeting areas impacted by reperfusion injury.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
To do this, we first looked at how pure magnesium affected neuron cells that had undergone oxygen-glucose deprivation and reoxygenation. Encouragingly, we found that the magnesium could indeed protect these cells from injury.
Building on this, we then tested out a magnesium wire in the carotid artery of rats, mimicking the human experience of stroke. The results indicated that this method successfully helped reduce behavioral issues, neural damage, and even blood-brain barrier disruption in the rats following a known stroke model.
In conclusion, magnesium-based implants may represent a promising local treatment option for alleviating the damage caused by strokes, bolstering support for using magnesium in neuroprotection.
Read More
9
Magnesium enhances stroke recovery
A Systematic Review and Meta-Analysis of Therapeutic Hypothermia and Pharmacological Cotherapies in Animal Models of Ischemic Stroke.
Moderate efficacy in combination therapy
We explored how magnesium, when combined with therapeutic hypothermia (TH), affects recovery from ischemic stroke. In our analysis, we examined various studies that specifically looked at this combination therapy alongside other cytoprotective medications. Our findings revealed that magnesium stands out as an effective agent, significantly enhancing the protective qualities of TH against brain injury and neurological impairment.
During the review, we noted that magnesium contributed positively to treatment outcomes across the board. It was particularly effective when coupled with TH, showing greater benefits in recovery compared to other drug combinations or no treatment at all. What’s fascinating is that using magnesium alongside TH presented the best overall results, making it a key player in future stroke therapies.
However, while magnesium's role is promising, it was primarily assessed in combination with other treatments. This means we still need to fully understand its isolated effects on stroke recovery. Overall, our analysis suggests that magnesium is a valuable addition to ischemic stroke treatment strategies, warranting further investigation to confirm its specific benefits.
During the review, we noted that magnesium contributed positively to treatment outcomes across the board. It was particularly effective when coupled with TH, showing greater benefits in recovery compared to other drug combinations or no treatment at all. What’s fascinating is that using magnesium alongside TH presented the best overall results, making it a key player in future stroke therapies.
However, while magnesium's role is promising, it was primarily assessed in combination with other treatments. This means we still need to fully understand its isolated effects on stroke recovery. Overall, our analysis suggests that magnesium is a valuable addition to ischemic stroke treatment strategies, warranting further investigation to confirm its specific benefits.
Read More
8
Magnesium-Heart Health Connection
Upper normal serum magnesium is associated with a reduction in incident death from fatal heart failure, coronary heart disease and stroke in non-dialysis patients with CKD stages 4 and 5.
Moderate relevance for stroke impact
We explored the connection between serum magnesium levels and the risk of stroke among non-dialysis patients with chronic kidney disease (CKD) stages 4 and 5. By analyzing data from a cohort of 1,271 patients over a ten-year period, we focused on how varying levels of magnesium could influence mortality rates related to fatal heart failure, coronary heart disease, and stroke.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
Our findings revealed that higher serum magnesium concentrations were associated with a significantly reduced risk of death from stroke and other cardiovascular events. This suggests that maintaining adequate magnesium levels could play a crucial role in improving outcomes for CKD patients who are at a higher risk for these serious conditions.
While the study did have its limitations, such as potential confounding factors, the association between higher magnesium levels and lower mortality rates is an important consideration in managing the health of CKD patients. As such, ensuring that these patients maintain optimal magnesium levels may be a beneficial strategy in reducing their risk of fatal stroke and enhancing overall health.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Calming effect noted
I can feel the calming effect of magnesium, which is vital for normal bone structure. Low levels of magnesium are linked to various diseases, including osteoporosis, high blood pressure, heart disease, diabetes, and stroke. These pills are easy to take, and I felt the calming effects within 30 minutes. I opted for this after my last physical showed slightly elevated LDL levels, and I’ll post my next test results as an update.
Read More
8
Heart health support
Excellent magnesium supplement, but consult your doctor first. Magnesium is essential, impacting several bodily functions and helping manage chronic diseases like diabetes, cardiovascular issues, and stroke. While research shows magnesium aids bone health and may lower the risk of type 2 diabetes and cardiovascular diseases, more evidence is required for its widespread use in these areas. More studies are needed to definitively link magnesium supplementation with better heart health and reduced stroke risk.
Read More
