Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
USERS' SCORE
Good
Based on 14 Reviews
8.5
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Read More
8
Folic acid shows promise against depression
We evaluated how folic acid supplementation affects depression-related behaviors and brain health in a mouse model. Over eight weeks, mice received either a standard diet or one supplemented with folic acid.
Those on the folic acid diet showed improved behavior, including increased activity and reduced signs of despair in stress tests. Moreover, they exhibited better antioxidant levels and healthier brain structures.
Overall, the findings suggest that folic acid may help counteract depression and support cognitive function.
Those on the folic acid diet showed improved behavior, including increased activity and reduced signs of despair in stress tests. Moreover, they exhibited better antioxidant levels and healthier brain structures.
Overall, the findings suggest that folic acid may help counteract depression and support cognitive function.
Read More
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
Most Useful Reviews
9
Significant improvement
23 people found this helpful
The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey.
Read More
9
Improves condition
12 people found this helpful
I'm not a medic, and I rely on my sensations. I occasionally experience mild depression, which, if unchecked, could escalate. However, this medication helps prevent a downturn and even improves my state of depression, leading to complete relief. It’s also said to enhance heart function and the effectiveness of antidepressants, particularly in women, while normalising sleep and appetite—something I can attest to as it has notably aided me.
Read More
9
Fights depression
2 people found this helpful
Great! Helps combat depression. I received it promptly and well-packaged. I highly recommend it!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.1
- All Researches
9
We explored the effects of chlorzoxazone and folic acid on anxiety, depression, and memory using a mouse model of Spinocerebellar Ataxia type 3 (SCA3).
The combination of these treatments showed promising results, particularly in reducing signs of anxiety and depression while enhancing recognition memory in SCA3-84Q mice.
This suggests that a combined therapy might be beneficial for managing both motor and cognitive symptoms related to ataxia, highlighting the potential of folic acid in improving mood.
The combination of these treatments showed promising results, particularly in reducing signs of anxiety and depression while enhancing recognition memory in SCA3-84Q mice.
This suggests that a combined therapy might be beneficial for managing both motor and cognitive symptoms related to ataxia, highlighting the potential of folic acid in improving mood.
Read More
9
Folic acid mitigates depression symptoms
We examined how maternal vitamin D deficiency (VDD) impacts depression-like behaviors in offspring and the potential role of folic acid in this process.
Female mice were fed a VDD diet during pregnancy, leading to clear depression-like behaviors in their adult offspring.
However, when folic acid was given, it reversed certain negative changes, like DNA methylation, and reduced symptoms of depression.
This suggests that folic acid could be a significant factor in mitigating depression-related issues associated with maternal vitamin D deficiency.
Female mice were fed a VDD diet during pregnancy, leading to clear depression-like behaviors in their adult offspring.
However, when folic acid was given, it reversed certain negative changes, like DNA methylation, and reduced symptoms of depression.
This suggests that folic acid could be a significant factor in mitigating depression-related issues associated with maternal vitamin D deficiency.
Read More
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Read More
8
Multivitamins reduce depression symptoms
We conducted a double-blind, randomized controlled trial with 70 male patients undergoing Methadone Maintenance Treatment (MMT), to see how multivitamins affect anxiety and depression. Participants received either multivitamins or a placebo for 12 weeks. While we found no notable improvement in anxiety, there's encouraging news: the multivitamin group experienced significant reductions in depression levels. This suggests that certain vitamins, including folic acid, can positively influence mood among those in MMT.
Read More
8
This study focused on whether folic acid can help reduce depressive-like behaviors triggered by inflammation in mice.
We observed that folic acid significantly lowered immobility in tail suspension tests and improved behaviors affected by tumor necrosis factor (TNF-α).
Even at low doses, folic acid combined with common antidepressants showed positive effects. We found that it also influenced specific brain signaling pathways, possibly helping to balance mood by acting on certain neurotransmitter systems.
Overall, folic acid appears to be effective against inflammation-induced depression in this model.
We observed that folic acid significantly lowered immobility in tail suspension tests and improved behaviors affected by tumor necrosis factor (TNF-α).
Even at low doses, folic acid combined with common antidepressants showed positive effects. We found that it also influenced specific brain signaling pathways, possibly helping to balance mood by acting on certain neurotransmitter systems.
Overall, folic acid appears to be effective against inflammation-induced depression in this model.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant improvement
23 people found this helpful
The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey.
Read More
9
Improves condition
12 people found this helpful
I'm not a medic, and I rely on my sensations. I occasionally experience mild depression, which, if unchecked, could escalate. However, this medication helps prevent a downturn and even improves my state of depression, leading to complete relief. It’s also said to enhance heart function and the effectiveness of antidepressants, particularly in women, while normalising sleep and appetite—something I can attest to as it has notably aided me.
Read More
9
Fights depression
2 people found this helpful
Great! Helps combat depression. I received it promptly and well-packaged. I highly recommend it!
Read More
10
Improves mood
I take 5000mcg of methyl folic acid due to my MTHFR mutation. Since I began this supplement, I feel like a different person—no depression or tiredness. It has made a significant difference.
Read More
10
Mood uplifted
I've been taking this for over 100 days alongside B12 and B complex. I’ve noticed benefits for my skin, hair, and mood—my depression has disappeared, and my hair is becoming fuller, aiding in fighting baldness.
Read More
Frequently Asked Questions
7.5
Feeling better
4 people found this helpful
I absolutely adore shopping with you; delivery to Brazil is extraordinary! I've only been on this product for less than a month and have already noticed considerable improvements. My B vitamins and vitamin D were significantly low, causing cognitive issues, body aches, and ultimately depression and panic attacks. The folate has been essential for health and aiding in vitamin absorption, thank goodness I'm regaining my strength. I highly recommend making this purchase!
10
Mood uplifted
I've been taking this for over 100 days alongside B12 and B complex. I’ve noticed benefits for my skin, hair, and mood—my depression has disappeared, and my hair is becoming fuller, aiding in fighting baldness.
10
Improves mood
I take 5000mcg of methyl folic acid due to my MTHFR mutation. Since I began this supplement, I feel like a different person—no depression or tiredness. It has made a significant difference.
7.5
Mood normalization
4 people found this helpful
I chose this specific folate due to its high dosage and volume. I require folate to restore my methylation cycle impacted by stress and deficiencies, having previously discovered a B9 deficiency. I had never felt such depression before. After starting this folic acid, I noticed a remarkable improvement in my mood, which I hadn’t experienced before despite trying other options. This form of folate has been highly beneficial, especially when combined with my research on methylation processes.
9
Improves condition
12 people found this helpful
I'm not a medic, and I rely on my sensations. I occasionally experience mild depression, which, if unchecked, could escalate. However, this medication helps prevent a downturn and even improves my state of depression, leading to complete relief. It’s also said to enhance heart function and the effectiveness of antidepressants, particularly in women, while normalising sleep and appetite—something I can attest to as it has notably aided me.
9
Significant improvement
23 people found this helpful
The depression killer! I have experienced depression all my life. Methyl folate has significantly aided me in overcoming depression and mood swings. Its potency surpasses most other products, which is sufficient to do the job. Additionally, I take choline for better nerve transmission and exercise daily, yielding numerous benefits that I can't list fully here. My doctor was astonished by my progress. I hope this assists you in your journey.
8
Effective supplement
I’ve been taking this for my depression because a genetic test indicated I have issues converting folic acid. I highly recommend this product.
7.5
Essential cofactor
1 people found this helpful
Don’t run out of folate! Methyl folate is a vital cofactor for producing serotonin, dopamine, and norepinephrine, substances crucial for mood regulation. Low levels of these in the body are linked with depression.
7
We investigated how effective combining low-dose methylfolate with standard antidepressants is for treating depressive disorder.
In an open-label trial involving 44 patients, one group received traditional antidepressants while the other received the same medications along with methylfolate for four weeks.
We found that this combination therapy could be a safe and effective approach, potentially improving patient outcomes.
In an open-label trial involving 44 patients, one group received traditional antidepressants while the other received the same medications along with methylfolate for four weeks.
We found that this combination therapy could be a safe and effective approach, potentially improving patient outcomes.
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
References
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Guo Q, Wang Y, Guo L, Xu K, Shang S. Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study. Clin Nutr ESPEN. 2025;65:50. doi:10.1016/j.clnesp.2024.11.021
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. doi:10.1093/hmg/ddae079
- Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
- Tuo LJ, Song XY, Zhu YY, He HN, Song YP, et al. Gestational folic acid supplement prevents vitamin D deficiency-induced depression-like behavior by reversing cortical DNA hypomethylation in adult offspring. J Steroid Biochem Mol Biol. 2023;231:106313. doi:10.1016/j.jsbmb.2023.106313
- Pan LA, Segreti AM, Wrobleski J, Shaw A, Hyland K, et al. Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior. Psychol Med. 2023;53:6046. doi:10.1017/S0033291722003233
- Jin X, Cheng Z, Yu X, Tao Q, Huang R, et al. Continuous supplementation of folic acid in pregnancy and the risk of perinatal depression-A meta-analysis. J Affect Disord. 2022;302:258. doi:10.1016/j.jad.2022.01.080
- Lam NSK, Long XX, Li X, Saad M, Lim F, et al. The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review. Biomed Pharmacother. 2022;146:112541. doi:10.1016/j.biopha.2021.112541
- Maruf AA, Poweleit EA, Brown LC, Strawn JR, Bousman CA. Systematic Review and Meta-Analysis of L-Methylfolate Augmentation in Depressive Disorders. Pharmacopsychiatry. 2022;55:139. doi:10.1055/a-1681-2047
- Altaf R, Gonzalez I, Rubino K, Nemec EC. Folate as adjunct therapy to SSRI/SNRI for major depressive disorder: Systematic review & meta-analysis. Complement Ther Med. 2021;61:102770. doi:10.1016/j.ctim.2021.102770
- Budni J, Moretti M, Freitas AE, Neis VB, Ribeiro CM, et al. Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-α. Behav Brain Res. 2021;414:113512. doi:10.1016/j.bbr.2021.113512
- Saxena PP, Kyomen H. Leucovorin as an Antidepressant Adjunct in Elderly Inpatients With Treatment-resistant Depression. Prim Care Companion CNS Disord. 2021;23. doi:10.4088/PCC.20m02767
- Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, Mirzaei M, Vafa M. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92. doi:10.1016/j.jad.2021.03.055
- Falade J, Onaolapo AY, Onaolapo OJ. Evaluation of the Behavioural, Antioxidative and Histomorphological Effects of Folic Acid-supplemented Diet in Dexamethasone-induced Depression in Mice. Cent Nerv Syst Agents Med Chem. 2021;21:73. doi:10.2174/1871524921666210114125355
- Yang Y, Qi H, Zhang J, Jia J, Yang Y, et al. Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database. Front Nutr. 2025;12:1505700. doi:10.3389/fnut.2025.1505700
- Xiong Y, Zhou G, Zhou L, Guo M, Lu H. Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly. Heliyon. 2024;10:e36980. doi:10.1016/j.heliyon.2024.e36980
- Liu M, Wang G, Jiang C. Independent and combined effect of serum copper and folate on depression: cross-sectional data from the NHANES 2011-2016. Front Nutr. 2024;11:1389480. doi:10.3389/fnut.2024.1389480
- Gao S, Khalid A, Amini-Salehi E, Radkhah N, Jamilian P, et al. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses. Food Sci Nutr. 2024;12:3806. doi:10.1002/fsn3.4073
