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SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
8
Folate intake decreases migraine severity
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Directly evaluates folate effects
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
7
Folate may reduce headache incidence
Association between serum folate levels and migraine or severe headaches: A nationwide cross-sectional study.
Relevant study on folate and headaches
We aimed to explore how serum folate levels might be connected to the occurrence of severe headaches and migraines. To do this, we analyzed data from the National Health and Nutrition Examination Survey, focusing on a large group of 13,351 participants. From this group, 2,742 individuals reported experiencing severe headaches or migraines in the past three months.
Our findings indicated that higher serum folate levels were associated with a lower likelihood of experiencing these types of headaches. Specifically, we calculated an odds ratio of 0.5, showing that as folate levels increased, the chances of suffering from migraines or severe headaches decreased. This pattern was particularly strong among women, people aged 20 to 50, and non-Hispanic White participants.
The results suggest that adequate folate levels could potentially play a role in reducing headache occurrences, though more research is needed to confirm these findings. Overall, our study points to the importance of serum folate not just as a nutritional measure, but also as a factor that might influence headache health.
Our findings indicated that higher serum folate levels were associated with a lower likelihood of experiencing these types of headaches. Specifically, we calculated an odds ratio of 0.5, showing that as folate levels increased, the chances of suffering from migraines or severe headaches decreased. This pattern was particularly strong among women, people aged 20 to 50, and non-Hispanic White participants.
The results suggest that adequate folate levels could potentially play a role in reducing headache occurrences, though more research is needed to confirm these findings. Overall, our study points to the importance of serum folate not just as a nutritional measure, but also as a factor that might influence headache health.
Read More
Most Useful Reviews
7.5
No more headaches
Best form of methylfolate. I started taking it when I discovered I was pregnant. Initially, I had headaches with the folate, but taking my vitamins at dinner helped my body adjust. No headaches have occurred for several months now, which is a relief.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.6
9
Migraine linked to folate genetics
[The role of genetic polymorphisms in folate metabolism genes in the manifestation of migraine in children].
Folate's role in headache relief
We examined the connection between genetic differences in folate metabolism and migraine experiences in children aged 7 to 18. The study involved 54 children with migraine symptoms and a control group of 115 others without neurological issues.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Focusing on four specific genetic variants linked to folate metabolism, we found that children with migraines were more likely to have a certain rare genetic variant that may increase plasma homocysteine levels, potentially indicating a hidden folate deficiency. In addition to genetic testing, we looked at vitamin B levels and the effectiveness of Cortexin, a treatment administered to the children.
After a 10-day course of Cortexin, many children reported significant improvements in their migraine symptoms, such as less headache pain, reduced fatigue, and better emotional stability. This suggests that while there’s a genetic connection to migraine, the treatment with Cortexin also plays a critical role in alleviating symptoms.
Read More
9
Folate intake may reduce headaches
Association between dietary folate intake and severe headache among adults in the USA: a cross-sectional survey.
Study directly examines folate effects
We examined the effects of dietary folate intake on severe headaches by analyzing data from a large national health survey. The study involved nearly 10,000 participants over the age of 20, where individuals self-reported their experiences with severe headaches.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Through sophisticated analysis methods, including multivariate logistic regression, we discovered that higher dietary folate intake appears to be associated with a lower likelihood of experiencing severe headaches. Specifically, participants who consumed more folate had significantly reduced odds of reporting severe headaches, with the most substantial impact seen in those with the highest intake levels.
Interestingly, we found that women aged 20 to 50 exhibited a non-linear association between folate and headache severity, suggesting that they might benefit from being more mindful of their folate consumption.
This research underscores the potential for dietary folate to play a protective role against severe headaches, encouraging individuals to consider increasing their folate intake for headache prevention.
Read More
9
Folate's unclear role in headaches
Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report.
Moderate relevance; mixed treatment effects
We explored the case of a 14-year-old girl who faced severe headaches and nausea due to cerebral venous thrombosis (CVT) and high levels of homocysteine. After thorough examinations, including brain imaging and genetic testing, she underwent treatment that included anticoagulants and supplementation with folate, as well as vitamins B12 and B6.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
The patient showed significant improvement in her condition within a month. She experienced relief from headaches, and her intracranial pressure decreased considerably. While the study indicates that folate was part of a comprehensive treatment approach, the specific contribution of folate alone to the relief of her headaches remains unclear due to the combined nature of the treatments.
This case highlights a unique instance of loss of heterozygosity at the methylenetetrahydrofolate reductase (MTHFR) gene and suggests that analyzing this genetic factor could be important in patients with CVT and hyperhomocysteinemia. However, we must interpret the efficacy of folate cautiously, as its isolated impact on headache resolution wasn't specifically tested.
Read More
8
Folate intake decreases migraine severity
Association between dietary folate intake and severe headache or migraine in adults: a cross-sectional study of the National Health and Nutrition Examination Survey.
Directly evaluates folate effects
We explored how dietary folate intake might be linked to severe headaches or migraines through a comprehensive analysis of data from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2004. By examining over 4,100 adults, we observed that around 17% reported experiencing severe headaches or migraines. Importantly, our study used advanced statistical methods to ensure accurate and meaningful results.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Our findings revealed a clear relationship: higher intake of dietary folate appeared to correlate with fewer headaches. Specifically, those with higher folate intake, measured in categorized segments, had significantly lower odds of experiencing severe headaches or migraines compared to those with lower intake levels. The results suggested that as folate intake increased, the likelihood of suffering from severe headaches decreased, supporting the idea of a beneficial relationship.
In summary, our study indicated a linear negative relationship between dietary folate and headache severity, suggesting that incorporating more folate-rich foods into our diets could potentially help reduce the occurrence of migraines. This research provides valuable insights into dietary interventions for managing headache symptoms.
Read More
8
Folate linked to migraine relief
Vitamin B and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004.
Study explores nutrient effects
We examined how folate and vitamin B can affect the occurrence of migraines, drawing from data collected in a large survey of adults in the United States. Our analysis focused on the dietary intake of these nutrients and their relationship with headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
The study involved over 7,000 participants, with about 1,350 reporting migraines. Interestingly, we found that higher intakes of both folate and vitamin B were associated with a reduced risk of experiencing severe headaches or migraines. Specifically, those who consumed sufficient amounts—2.39 mg/day of vitamin B and 502.01 µg/day of folate—enjoyed even more significant benefits.
Moreover, we observed a synergistic effect when both nutrients were consumed in higher amounts together, indicating they may work better as a team in preventing migraines. These findings suggest that ensuring adequate folate intake, along with vitamin B, could be a simple strategy for those who suffer from severe headaches.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
7.5
No more headaches
Best form of methylfolate. I started taking it when I discovered I was pregnant. Initially, I had headaches with the folate, but taking my vitamins at dinner helped my body adjust. No headaches have occurred for several months now, which is a relief.
