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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetarian Tablet
Amount Per Serving
%DV
Folate [as (6S)-5-Methyltetrahydrofolate, Calcium salt]
1,700 mcg○
425%
Top Medical Research Studies
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Directly studies folic acid effects
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
9
Folate may aid hypothyroid treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Relevant but mixed findings
We aimed to discover how certain B vitamins, particularly folate, could influence homocysteine metabolism in rats suffering from hypothyroidism. Through our study, we created conditions that mimicked hyperthyroidism and hypothyroidism in the animals over a period of 21 days.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Read More
7
Folic acid may aid thyroid function
Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring.
Relevant but not definitive results.
We explored how different doses of lithium during pregnancy affected the neurodevelopment of offspring in rats, while evaluating if folic acid could provide any protective benefits. Pregnant rats were divided into various groups, including those exposed to high doses of lithium and others receiving folic acid alongside lithium treatment. More specifically, we examined how folic acid might lessen the negative effects associated with lithium administration, particularly concerning thyroid function.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Read More
Most Useful Reviews
6.3
No side effects
It's not a bad medication. I bought it for the protocol for correcting disorders related to hypothyroidism, and I haven't experienced any unpleasant side effects.
Read More
8
Suitable for pregnancy
I purchased this from TikTok. The quality is good and seems more suited for pregnant women. Currently, I don't think I need it, but I take it for my hypothyroidism.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
9
Folic acid aids hypothyroid cognition
Folic acid attenuated learning and memory impairment via inhibition of oxidative damage and acetylcholinesterase activity in hypothyroid rats.
Directly studies folic acid effects
Our study aimed to understand how folic acid (FA) impacts cognitive issues linked to hypothyroidism. We used a rat model, treating them with propylthiouracil (PTU) to induce hypothyroidism. After administering various doses of folic acid over several weeks, we monitored behavior through tests designed to assess learning and memory skills.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
We observed that the cognitive impairments caused by hypothyroidism were significantly reduced when folic acid was included in the diet, especially at higher doses. In the Morris water maze, rats treated with folic acid demonstrated quicker escape times and traveled shorter distances compared to those not receiving the treatment. Similarly, in the passive avoidance test, there was a marked increase in the latency for hypothyroid rats to explore dark areas when taking folic acid.
Additionally, we found that folic acid not only improved cognitive performance but also positively influenced brain chemistry. It reduced instances of oxidative stress markers and lowered acetylcholinesterase (AChE) activity while enhancing beneficial enzyme activities. This points to folic acid’s potential protective role in the brain, particularly through combatting oxidative damage and supporting cholinergic function.
In conclusion, our findings suggest that folic acid can effectively aid learning and memory in hypothyroid conditions, primarily through its regulatory effects on oxidative stress and essential enzymatic activities.
Read More
9
Folate may aid hypothyroid treatment
The impact of B vitamins on the functioning of methylation cycle in the liver and the kidneys of hyper- and hypothyroid rats.
Relevant but mixed findings
We aimed to discover how certain B vitamins, particularly folate, could influence homocysteine metabolism in rats suffering from hypothyroidism. Through our study, we created conditions that mimicked hyperthyroidism and hypothyroidism in the animals over a period of 21 days.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Our focus was on vitamins such as folic acid, pyridoxine, and betaine, assessing how they might help correct imbalances in homocysteine levels associated with thyroid dysfunction. We found that hypothyroid rats had significantly higher levels of homocysteine, which is often linked to increased risk of heart problems.
Notably, we discovered that administering folic acid, along with other B vitamins, led to a significant reduction in homocysteine levels in these rats. This finding suggests that folate could play an important role in potentially alleviating some of the negative effects of hypothyroidism, particularly regarding cardiovascular health.
Therefore, our observations indicate that B vitamins, especially folate, could be beneficial in managing homocysteine levels in hypothyroidism, contributing to reduced risks of endothelial dysfunction.
Read More
7
Folic acid may aid thyroid function
Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring.
Relevant but not definitive results.
We explored how different doses of lithium during pregnancy affected the neurodevelopment of offspring in rats, while evaluating if folic acid could provide any protective benefits. Pregnant rats were divided into various groups, including those exposed to high doses of lithium and others receiving folic acid alongside lithium treatment. More specifically, we examined how folic acid might lessen the negative effects associated with lithium administration, particularly concerning thyroid function.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Our observations revealed that high doses of lithium led to significant disruptions in both behavioral and biochemical markers linked to thyroid health. This included imbalances in thyroid hormones and evidence of oxidative stress. However, when we introduced folic acid at the highest dose, we found promising improvements. Folic acid appeared to reduce memory impairments and anxiety-like behaviors, along with improving antioxidant and anti-inflammatory indicators compared to groups receiving only lithium.
While our findings suggest that folic acid could offer protective effects during lithium treatment and hypothyroidism, we must also consider that lithium poses clear risks when prescribed to pregnant individuals. We emphasize that further research is necessary to fully understand the relationship between folic acid and thyroid function in such contexts.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
8
Suitable for pregnancy
I purchased this from TikTok. The quality is good and seems more suited for pregnant women. Currently, I don't think I need it, but I take it for my hypothyroidism.
6.3
No side effects
It's not a bad medication. I bought it for the protocol for correcting disorders related to hypothyroidism, and I haven't experienced any unpleasant side effects.
