Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
USERS' SCORE
Good
Based on 12 Reviews
8.4
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**
Top Medical Research Studies
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
8
Quercetin shows promise for cholesterol
We explored how quercetin affects heart health in rats with high cholesterol. The study found that quercetin significantly improved lipid profiles and reduced oxidative stress linked to high-cholesterol diets.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
It also helped prevent diastolic dysfunction and cardiac cholesterol buildup, while supporting better energy metabolism in the heart. These positive effects suggest that quercetin could be beneficial for managing heart issues caused by high cholesterol and high sugar levels.
Read More
Most Useful Reviews
9
Cholesterol normalised
53 people found this helpful
Excellent! I bought it for my father, who has high blood pressure, high cholesterol, and various age-related concerns. He has tolerated it well; after just a month, the results were noticeable. His cholesterol levels gradually returned to normal, and his blood pressure has normalised as well. Quercetin is also being used to boost immunity.
Read More
9
Cholesterol decreased
3 people found this helpful
Very good! I have repurchased this multiple times as the quality is excellent, and the effects are remarkable. I recommend it! My cholesterol levels are high, and after taking this product, it significantly dropped.
Read More
9
Health improvements
1 people found this helpful
Best quercetin! I want to share my positive experience with Life Extension's optimised quercetin. The capsules are easy to swallow, and the dosage is well-considered. I take them according to the instructions and feel that I'm getting enough active ingredients for my health. The capsules have little to no smell or taste, which is important to me. I've noticed that my body operates more efficiently, and I feel much better since using this effective product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.8
- All Researches
9
We examined the effects of a berry extract from Lonicera caerulea, rich in polyphenols, on high cholesterol levels. In laboratory tests with Caco-2 cells and rats, the extract proved effective in reducing cholesterol levels and boosting antioxidant capacity.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
In rats fed a high cholesterol diet, supplementation with this berry extract significantly lowered total cholesterol and harmful LDL levels while raising beneficial HDL levels. We observed measurable improvements in cholesterol metabolism and antioxidant activity. Overall, Lonicera caerulea berry extract holds promise as a functional food for cholesterol management.
Read More
9
We investigated how onion peel extract, packed with quercetin, affects high cholesterol levels in mice. Divided into four groups, the mice were fed different diets for 12 weeks.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Those receiving the higher dose of onion peel extract showed significant reductions in serum and liver cholesterol levels, along with improved liver health markers compared to the group on a high cholesterol diet alone.
This suggests that quercetin may lower cholesterol by increasing its excretion.
Read More
8
We examined the effects of quercetin nanoemulsion (QT+NE) on cholesterol levels and muscle function in mice on a high-fat diet. Over 11 weeks, QT+NE showed a notable reduction in body weight gain and improved fat distribution when compared to a high-fat diet alone.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
Interestingly, QT+NE significantly boosted the activation of SIRT1, a gene linked to mitochondrial health, and maintained mitochondrial DNA levels. However, traditional quercetin failed to show these benefits. Our findings suggest that QT+NE could be a promising option for enhancing muscle health and managing cholesterol in high-fat dietary contexts.
Read More
8
We investigated how Massa Medicata Fermentata (MMF), which contains quercetin, impacts cholesterol and overall metabolic health. In our study, zebrafish were fed a high-cholesterol diet while receiving MMF for three weeks.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
The results showed that MMF helped reduce cholesterol accumulation and body mass index, indicating positive metabolic changes. Additionally, MMF demonstrated strong antioxidant effects, effectively inhibiting LDL oxidation and decreasing inflammation markers.
While we observed beneficial effects on cholesterol and inflammation, further research is needed to fully understand quercetin's role in these outcomes.
Read More
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cholesterol normalised
53 people found this helpful
Excellent! I bought it for my father, who has high blood pressure, high cholesterol, and various age-related concerns. He has tolerated it well; after just a month, the results were noticeable. His cholesterol levels gradually returned to normal, and his blood pressure has normalised as well. Quercetin is also being used to boost immunity.
Read More
9
Cholesterol decreased
3 people found this helpful
Very good! I have repurchased this multiple times as the quality is excellent, and the effects are remarkable. I recommend it! My cholesterol levels are high, and after taking this product, it significantly dropped.
Read More
9
Health improvements
1 people found this helpful
Best quercetin! I want to share my positive experience with Life Extension's optimised quercetin. The capsules are easy to swallow, and the dosage is well-considered. I take them according to the instructions and feel that I'm getting enough active ingredients for my health. The capsules have little to no smell or taste, which is important to me. I've noticed that my body operates more efficiently, and I feel much better since using this effective product.
Read More
9
Improved condition
1 people found this helpful
Very Cool Thing! The composition is superb! My condition improved significantly; my blood pressure normalised, my heart rate stabilised, and my cholesterol levels are nearly normal!
Read More
7.5
Overall health improvement
2 people found this helpful
Excellent! This is a fantastic product! I've been searching for a quality quercetin supplement, and this is precisely what I needed. Life Extension offers high-quality quercetin, combined with vitamin C for better absorption. I take one capsule daily with meals and feel much better, with an improved mood and fewer allergic reactions. The pack contains 60 capsules, which is convenient. I’m very satisfied and believe this is one of the best quercetin products available.
Read More
Frequently Asked Questions
9
Cholesterol normalised
53 people found this helpful
Excellent! I bought it for my father, who has high blood pressure, high cholesterol, and various age-related concerns. He has tolerated it well; after just a month, the results were noticeable. His cholesterol levels gradually returned to normal, and his blood pressure has normalised as well. Quercetin is also being used to boost immunity.
9
Cholesterol decreased
3 people found this helpful
Very good! I have repurchased this multiple times as the quality is excellent, and the effects are remarkable. I recommend it! My cholesterol levels are high, and after taking this product, it significantly dropped.
9
Effective product
The product has an unpleasant taste, yet it is very effective. I appreciated its high quality and certified raw materials. My child took it gladly. The ingredients are excellently chosen, and the tablet size is acceptable. The body absorbs it well. I liked the price and how effective it is; we noticed results within the first week. It has been beneficial for addressing my high cholesterol, and the improvements were maintained, although it did not impact my metabolism.
9
Improved condition
1 people found this helpful
Very Cool Thing! The composition is superb! My condition improved significantly; my blood pressure normalised, my heart rate stabilised, and my cholesterol levels are nearly normal!
7.5
Fights inflammation
1 people found this helpful
Quercetin in a good dosage, combined with bromelain, helps combat inflammation and improves immunity and vascular health. I am confident it will contribute to lowering my cholesterol levels!
7.5
Overall health improvement
2 people found this helpful
Excellent! This is a fantastic product! I've been searching for a quality quercetin supplement, and this is precisely what I needed. Life Extension offers high-quality quercetin, combined with vitamin C for better absorption. I take one capsule daily with meals and feel much better, with an improved mood and fewer allergic reactions. The pack contains 60 capsules, which is convenient. I’m very satisfied and believe this is one of the best quercetin products available.
7.5
Maintains cholesterol
The composition of quercetin aids in normalising blood sugar, supporting cardiovascular health, and effectively managing normal cholesterol levels. It also reduces the risk of stroke and boasts high antioxidant properties while helping to control inflammatory symptoms.
7
Supports heart health
1 people found this helpful
Optimised Quercetin is a bioflavonoid that supports cellular health and immune function. This Life Extension product contains 250 mg of quercetin and beneficial components like camu-camu berries and vitamin C. Quercetin strengthens the heart system and protects blood vessels, maintaining optimal cholesterol levels and balancing nitric oxide to alleviate pressure issues. Additionally, it reduces oxidative stress, promoting proper gene expression.
8
We observed the benefits of quercetin nanoemulsion (QN) in mice fed a high-cholesterol diet. Divided into groups, the mice were supplemented with different doses of QN for six weeks.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
Results showed improved serum and liver lipid profiles, suggesting that QN helped enhance cholesterol efflux by affecting specific pathways in the liver. Increased AMPK activity and reduced levels of certain microRNAs were also noted.
Overall, our findings indicate that QN could be beneficial for cholesterol regulation, at least in this animal model.
8
Quercetin potentially aids cholesterol management
We explored the impact of quercetin-3-glucoside on mice with high cholesterol diets. Over 12 weeks, mice were given either low or high cholesterol diets, some supplemented with quercetin.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
While there was no noticeable effect in those on a low cholesterol diet, quercetin did help reduce cholesterol and insulin levels in high cholesterol-diet mice. It increased important proteins that assist in cholesterol clearance but also seemed to promote insulin secretion in pancreatic cells.
Overall, quercetin may hold potential for managing cholesterol levels.
4
We investigated the effects of quercetin and rutin on cholesterol levels. In laboratory settings using liver cells, we found that both compounds significantly lowered cholesterol levels. They achieved this by boosting the expression of proteins involved in cholesterol metabolism.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
However, when tested in hamsters with high cholesterol, neither quercetin nor rutin led to significant reductions in plasma cholesterol after eight weeks. This suggests that while they might work well in cells, their benefits may not extend effectively to living organisms due to issues with how well they are absorbed.
7
We explored the impact of quercetin on high cholesterol in female Sprague Dawley rats subjected to unhealthy diets. The study involved different groups of rats, some receiving quercetin while others were given standard diets or fenofibrate.
While quercetin seemed to help reduce liver fat accumulation by about 50%, these effects weren't statistically significant. Hence, we can conclude that, currently, quercetin doesn't show substantial benefits in lowering cholesterol levels in this context. Nonetheless, its potential against liver complications is worth noting.
While quercetin seemed to help reduce liver fat accumulation by about 50%, these effects weren't statistically significant. Hence, we can conclude that, currently, quercetin doesn't show substantial benefits in lowering cholesterol levels in this context. Nonetheless, its potential against liver complications is worth noting.
References
- Lee MS, Doo M, Kim Y. Effects of quercetin nanoemulsion on SIRT1 activation and mitochondrial biogenesis in the skeletal muscle of high-fat diet-fed mice. Nutr Res Pract. 2024;18:806. doi:10.4162/nrp.2024.18.6.806
- Jung KM, Yu GR, Kim DH, Lim DW, Park WH. Massa Medicata Fermentata, a Functional Food for Improving the Metabolic Profile via Prominent Anti-Oxidative and Anti-Inflammatory Effects. Antioxidants (Basel). 2024;13. doi:10.3390/antiox13101271
- Lee MS, Kim Y. Effects of Quercetin Nanoemulsion on Cholesterol Efflux and MicroRNA-33/34a Expression in the Liver of Mice Fed with a High-Cholesterol Diet. Prev Nutr Food Sci. 2023;28:271. doi:10.3746/pnf.2023.28.3.271
- Yammine A, Auezova L, Lizard G, Greige-Gerges H. Activity of Na/K- and Ca-ATPases in human erythrocyte membranes: Protocol improvement, relation to cholesterol content, and effects of polyphenols. Biochimie. 2023;212:95. doi:10.1016/j.biochi.2023.04.010
- Liang N, Li YM, He Z, Hao W, Zhao Y, et al. Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration. Molecules. 2021;26. doi:10.3390/molecules26123766
- Oyetayo FL, Akomolafe SF, Ogundumi OA. Anti-hypercholesterolemic potential of diet supplemented with and tubers in high cholesterol fed rats. J Diabetes Metab Disord. 2020;19:1139. doi:10.1007/s40200-020-00615-z
- Donaldson J, Ngema M, Nkomozepi P, Erlwanger K. Quercetin administration post-weaning attenuates high-fructose, high-cholesterol diet-induced hepatic steatosis in growing, female, Sprague Dawley rat pups. J Sci Food Agric. 2019;99:6954. doi:10.1002/jsfa.9984
- Son HY, Lee MS, Chang E, Kim SY, Kang B, et al. Formulation and Characterization of Quercetin-loaded Oil in Water Nanoemulsion and Evaluation of Hypocholesterolemic Activity in Rats. Nutrients. 2019;11. doi:10.3390/nu11020244
- Liu S, You L, Zhao Y, Chang X. Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo. Food Res Int. 2018;107:73. doi:10.1016/j.foodres.2018.02.016
- Castillo RL, Herrera EA, Gonzalez-Candia A, Reyes-Farias M, de la Jara N, et al. Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats. Oxid Med Cell Longev. 2018;2018:7239123. doi:10.1155/2018/7239123
- Mbikay M, Mayne J, Sirois F, Fedoryak O, Raymond A, et al. Mice Fed a High-Cholesterol Diet Supplemented with Quercetin-3-Glucoside Show Attenuated Hyperlipidemia and Hyperinsulinemia Associated with Differential Regulation of PCSK9 and LDLR in their Liver and Pancreas. Mol Nutr Food Res. 2018;62:e1700729. doi:10.1002/mnfr.201700729
- Woo M, Kim M, Noh JS, Park CH, Song YO. Kimchi attenuates fatty streak formation in the aorta of low-density lipoprotein receptor knockout mice via inhibition of endoplasmic reticulum stress and apoptosis. Nutr Res Pract. 2017;11:445. doi:10.4162/nrp.2017.11.6.445
- Khamis AA, Salama AF, Kenawy ME, Mohamed TM. Regulation of hepatic hydroxy methyl glutarate - CoA reductase for controlling hypercholesterolemia in rats. Biomed Pharmacother. 2017;95:1242. doi:10.1016/j.biopha.2017.09.071
- Bhaskar S, Helen A. Quercetin modulates toll-like receptor-mediated protein kinase signaling pathways in oxLDL-challenged human PBMCs and regulates TLR-activated atherosclerotic inflammation in hypercholesterolemic rats. Mol Cell Biochem. 2016;423:53.
- Carrasco-Pozo C, Tan KN, Reyes-Farias M, De La Jara N, Ngo ST, et al. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic β-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol. 2016;9:229. doi:10.1016/j.redox.2016.08.007
- Kang HJ, Pichiah PBT, Abinaya RV, Sohn HS, Cha YS. Hypocholesterolemic effect of quercetin-rich onion peel extract in C57BL/6J mice fed with high cholesterol diet. Food Sci Biotechnol. 2016;25:855. doi:10.1007/s10068-016-0141-4
