5/13/2025
Last update
5/13/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 13 Reviews
8.1
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Zinc (as OptiZinc® zinc monomethionine, zinc citrate)
50 mg
455%
Top Medical Research Studies
8
We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
Read More
9
We conducted a double-blind, placebo-controlled study in a long-term care facility in Italy to assess whether nightly supplementation of melatonin, magnesium, and zinc could help improve primary insomnia in elderly residents. A total of 43 participants, mostly in their late 70s, were divided into two groups: one received a combination of these supplements, while the other received a placebo for eight weeks.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
Read More
8
We tested the effectiveness of a unique nutraceutical product, ElleN®, aimed at alleviating postmenopausal symptoms, particularly sleeplessness due to anxiety and hot flushes. This product contains several natural ingredients, including zinc, but we acknowledge that its effects are evaluated in combination with others. In our study, women experiencing mild to moderate/severe menopausal symptoms took one tablet daily for three months.
Notably, we observed a significant reduction in the Kupperman Index, an indicator of menopausal discomfort, particularly related to insomnia and anxiety linked with hot flushes. While the product was well-tolerated and didn't lead to any side effects, we are unable to specify the isolated effects of zinc because the benefits were observed in conjunction with other ingredients.
Overall, the findings suggest that natural supplements like ElleN® can be beneficial for managing menopausal symptoms without resorting to hormone replacement therapy, but we must be cautious in attributing the outcomes to zinc alone, given the combination with other components.
Notably, we observed a significant reduction in the Kupperman Index, an indicator of menopausal discomfort, particularly related to insomnia and anxiety linked with hot flushes. While the product was well-tolerated and didn't lead to any side effects, we are unable to specify the isolated effects of zinc because the benefits were observed in conjunction with other ingredients.
Overall, the findings suggest that natural supplements like ElleN® can be beneficial for managing menopausal symptoms without resorting to hormone replacement therapy, but we must be cautious in attributing the outcomes to zinc alone, given the combination with other components.
Read More
Most Useful Reviews
9
Helps with insomnia
Zinc stabilises insomnia, depression, and autonomic dysfunction, especially during menopause and old age. The natural quality ingredients relieve stress, stimulate brain function, and enhance concentration while normalising sleep. GABA, as a neurotransmitter, boosts sleep quality, supporting growth hormone release at night. This effective formula mitigates stress factors for deeper and more restorative sleep, with optimal dosage.
Read More
9
Eases insomnia severity
Zinc citrate stabilises insomnia, depression, autonomic disorders, and conditions, particularly during menopause or in old age. Natural ingredients help relieve stress, stimulate brain function, and promote concentration while normalising sleep and mood. GABA improves sleep quality, with peak growth hormone release at night, ensuring deeper sleep and counteracting stress effectively. The dosage is optimal for best results.
Read More
9
Stabilises insomnia
Zinc immunity has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions like menopause or old age. The quality ingredients are natural, relieving excess stress, stimulating brain function, improving concentration, and enhancing performance while normalising sleep and mood. The capsules are medium-sized. GABA, a neurotransmitter of the central nervous system, enhances sleep quality, especially as the highest amount of growth hormone is released at night. This component also mitigates stress factors, providing significantly deeper and more effective sleep. The dosage is optimal.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
- All Researches
9
We conducted a double-blind, placebo-controlled study in a long-term care facility in Italy to assess whether nightly supplementation of melatonin, magnesium, and zinc could help improve primary insomnia in elderly residents. A total of 43 participants, mostly in their late 70s, were divided into two groups: one received a combination of these supplements, while the other received a placebo for eight weeks.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
Read More
8
We tested the effectiveness of a unique nutraceutical product, ElleN®, aimed at alleviating postmenopausal symptoms, particularly sleeplessness due to anxiety and hot flushes. This product contains several natural ingredients, including zinc, but we acknowledge that its effects are evaluated in combination with others. In our study, women experiencing mild to moderate/severe menopausal symptoms took one tablet daily for three months.
Notably, we observed a significant reduction in the Kupperman Index, an indicator of menopausal discomfort, particularly related to insomnia and anxiety linked with hot flushes. While the product was well-tolerated and didn't lead to any side effects, we are unable to specify the isolated effects of zinc because the benefits were observed in conjunction with other ingredients.
Overall, the findings suggest that natural supplements like ElleN® can be beneficial for managing menopausal symptoms without resorting to hormone replacement therapy, but we must be cautious in attributing the outcomes to zinc alone, given the combination with other components.
Notably, we observed a significant reduction in the Kupperman Index, an indicator of menopausal discomfort, particularly related to insomnia and anxiety linked with hot flushes. While the product was well-tolerated and didn't lead to any side effects, we are unable to specify the isolated effects of zinc because the benefits were observed in conjunction with other ingredients.
Overall, the findings suggest that natural supplements like ElleN® can be beneficial for managing menopausal symptoms without resorting to hormone replacement therapy, but we must be cautious in attributing the outcomes to zinc alone, given the combination with other components.
Read More
8
We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Helps with insomnia
Zinc stabilises insomnia, depression, and autonomic dysfunction, especially during menopause and old age. The natural quality ingredients relieve stress, stimulate brain function, and enhance concentration while normalising sleep. GABA, as a neurotransmitter, boosts sleep quality, supporting growth hormone release at night. This effective formula mitigates stress factors for deeper and more restorative sleep, with optimal dosage.
Read More
9
Eases insomnia severity
Zinc citrate stabilises insomnia, depression, autonomic disorders, and conditions, particularly during menopause or in old age. Natural ingredients help relieve stress, stimulate brain function, and promote concentration while normalising sleep and mood. GABA improves sleep quality, with peak growth hormone release at night, ensuring deeper sleep and counteracting stress effectively. The dosage is optimal for best results.
Read More
9
Stabilises insomnia
Zinc immunity has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions like menopause or old age. The quality ingredients are natural, relieving excess stress, stimulating brain function, improving concentration, and enhancing performance while normalising sleep and mood. The capsules are medium-sized. GABA, a neurotransmitter of the central nervous system, enhances sleep quality, especially as the highest amount of growth hormone is released at night. This component also mitigates stress factors, providing significantly deeper and more effective sleep. The dosage is optimal.
Read More
7.5
Effective for insomnia
1 people found this helpful
Zinc has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions, like menopause or old age. The quality of the natural ingredients relieves stress, stimulates brain function, improves concentration, boosts performance, and normalises sleep and mood. The capsules are medium-sized. GABA, a neurotransmitter, enhances sleep quality, with peak growth hormone release at night. This component mitigates stress factors and promotes significantly deeper and more effective sleep. The dosage is optimal.
Read More
7.5
Stabilises insomnia
Zinc has a stabilising effect on insomnia, depression, autonomic disorders, and other conditions, such as menopause or old age. The quality of natural ingredients helps relieve stress, stimulates brain function, improves concentration, boosts performance, and normalises sleep and mood. Medium-sized capsules of GABA, a central nervous system neurotransmitter, enhance sleep quality with the highest growth hormone release at night. This helps limit stress effects, ensuring deeper, more effective sleep.
Read More
Frequently Asked Questions
7.5
Helps insomnia recovery
Because it aids deep sleep, I gifted it to a friend suffering from insomnia, having heard that zinc and magnesium are beneficial for restful sleep. He mentioned he is responding well to it, so I remain hopeful it helps.
7.5
Improved mood
I always take it with magnesium and have noticed an improvement in my general mood, as well as a reduction in tiredness and insomnia.
9
Helps with insomnia
Zinc stabilises insomnia, depression, and autonomic dysfunction, especially during menopause and old age. The natural quality ingredients relieve stress, stimulate brain function, and enhance concentration while normalising sleep. GABA, as a neurotransmitter, boosts sleep quality, supporting growth hormone release at night. This effective formula mitigates stress factors for deeper and more restorative sleep, with optimal dosage.
7.5
Helpful for insomnia
For immunity, this product stabilises insomnia, depression, autonomic disorders, and other conditions, especially during menopause or old age. Quality natural ingredients relieve excess stress, stimulate brain function, improve concentration, and normalise sleep. GABA improves sleep quality and releases growth hormone at night. It effectively mitigates stress and promotes deeper, more effective sleep, and the dosage is optimal.
8
We explored the effects of zinc on sleep by looking at how it might help with insomnia. In our study, we gave mice a zinc-containing yeast extract and monitored their behavior and brain activity. The results were quite promising.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
We found that administering zinc at doses of 40 and 80 mg/kg led to a significant increase in non-rapid eye movement (NREM) sleep. This means that the mice were not only sleeping longer but also showed less activity, which is a good indicator of effective sleep. Interestingly, we did not observe any changes in rapid eye movement (REM) sleep, a crucial sleep phase for dreaming and deep rest.
Importantly, we didn’t see any negative side effects, such as rebound insomnia, within 24 hours after treating the mice. This suggests that zinc could be a safe option for those struggling with sleep issues, unlike other mineral extracts we tested, such as manganese, iron, and copper, which did not affect locomotor activity at all.
Overall, our findings provide the first evidence that zinc has a direct role in promoting sleep, opening up exciting possibilities for new sleep supplements featuring this essential mineral.
9
We conducted a double-blind, placebo-controlled study in a long-term care facility in Italy to assess whether nightly supplementation of melatonin, magnesium, and zinc could help improve primary insomnia in elderly residents. A total of 43 participants, mostly in their late 70s, were divided into two groups: one received a combination of these supplements, while the other received a placebo for eight weeks.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
Throughout the study, we focused on measuring sleep quality using several tools, including the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. After two months, we found that the group taking melatonin, magnesium, and zinc showed improvements in sleep quality and overall quality of life compared to the placebo group.
While the results are promising for the combination of these supplements, it's important to note that this study makes it challenging to determine the specific role that zinc alone may play in addressing insomnia. Nonetheless, the findings suggest that this combination could be beneficial for sleep in long-term care residents experiencing primary insomnia.
References
- Cappelli V, Morgante G, Di Sabatino A, Massaro MG, De Leo V. [Evaluation of the efficacy of a new nutraceutical product in the treatment of postmenopausal symptoms]. Minerva Ginecol. 2015;67:515.
- Cherasse Y, Saito H, Nagata N, Aritake K, Lazarus M, et al. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Mol Nutr Food Res. 2015;59:2087. 10.1002/mnfr.201500082
- Rondanelli M, Opizzi A, Monteferrario F, Antoniello N, Manni R, et al. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc. 2011;59:82. 10.1111/j.1532-5415.2010.03232.x
