Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
Most Useful Reviews
9
Essential for menopause
Zinc is vital for women during menopause. It regulates hormone production, combats viruses, and restores muscle function, making a significant difference for me. It's crucial to take it correctly—preferably in the morning after a meal—and ideally alongside vitamin D for better absorption.
Read More
9
Mitigates menopause effects
Thanks to this supplement, I feel nearly free from menopause symptoms.
Read More
7.5
Boosts menopause relief
Everyone needs zinc ⚡ to strengthen the immune system, skin, hair, and nails, while also improving mood 👍🏻 My zinc level has increased according to tests! It enhances testosterone and sperm count in men and alleviates symptoms of PMS and early menopause in women. This supplement contains zinc in a special chelated form, monomethionine and citrate, which are well absorbed by the body, unlike other preparations. The capsules are of medium size, not the smallest I've encountered, but certainly not the largest, soft, filled with white powder.
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
Read More
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
Read More
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
Read More
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
Read More
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
Zinc is vital for women during menopause. It regulates hormone production, combats viruses, and restores muscle function, making a significant difference for me. It's crucial to take it correctly—preferably in the morning after a meal—and ideally alongside vitamin D for better absorption.
Read More
9
Mitigates menopause effects
Thanks to this supplement, I feel nearly free from menopause symptoms.
Read More
7.5
Boosts menopause relief
Everyone needs zinc ⚡ to strengthen the immune system, skin, hair, and nails, while also improving mood 👍🏻 My zinc level has increased according to tests! It enhances testosterone and sperm count in men and alleviates symptoms of PMS and early menopause in women. This supplement contains zinc in a special chelated form, monomethionine and citrate, which are well absorbed by the body, unlike other preparations. The capsules are of medium size, not the smallest I've encountered, but certainly not the largest, soft, filled with white powder.
Read More
7.5
Helps with menopause
I switched from a zinc supplement by another company, intending to combat hair loss caused by menopause. I plan to continue using it for an extended period as I believe I won’t understand its effects until I give it time.
Read More
4
Menopause and hair loss
Zinc increases testosterone and sperm count in men while reducing symptoms of PMS and early menopause in women. Many suffer hair loss, loss of smell post-Covid, skin diseases, or poor immunity—all of which can be linked to zinc deficiency.
Read More
Frequently Asked Questions
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Zinc is a versatile metal known for its various applications in industry and health. It is a bluish-white metallic element represented by the symbol Zn and atomic number 30 on the periodic table. Zinc is primarily used for galvanizing steel to prevent rusting, in the manufacturing of alloys, and as a component in batteries. Additionally, zinc plays a crucial role in biological processes, making it an essential trace element in the human diet. It is involved in immune function, protein synthesis, wound healing, and DNA synthesis, highlighting its importance in maintaining overall health and well-being.
Zinc may play a supportive role during menopause, as it is known for its importance in numerous bodily functions, including immune response and hormone regulation. Some studies suggest that adequate zinc levels might help alleviate certain menopausal symptoms, such as mood swings, sleep disturbances, and fatigue. Additionally, zinc contributes to bone health, which is particularly important during menopause, as the decline in estrogen levels can lead to increased bone density loss.
However, it's worth noting that while zinc can contribute to overall health, it should not be viewed as a primary treatment for menopause-related symptoms. Women experiencing significant discomfort or health changes during menopause should consult a healthcare provider for personalized advice and treatment options. Supplementation of zinc should be approached with caution, as excessive intake can lead to adverse health effects. In summary, while zinc may offer some benefits during menopause, more research is needed to fully understand its impact and effectiveness.
Based on user reviews, the timeline for seeing results from a zinc supplement during menopause can vary significantly. Some users report feeling nearly free from menopause symptoms shortly after starting the supplement, which indicates that some may experience relatively quick relief (Read Review). However, others emphasize the importance of patience, noting that they plan to continue using the supplement for an extended period to fully understand its effects, suggesting that it may take longer for certain benefits to manifest (Read Review).
Overall, while some users notice improvements almost immediately, others may need to be more patient as they await the full benefits of supplementation. It seems that consistent use over time—sometimes recommended to correlate with extended use—is essential for achieving the desired results, particularly for managing symptoms related to hair loss and hormonal balance during menopause.
Recent studies suggest that zinc supplementation may be beneficial for postmenopausal women, particularly regarding antioxidant status, hormonal balance, and the alleviation of certain menopausal symptoms. For instance, a randomized trial showed that after eight weeks of zinc supplementation, participants experienced improved antioxidant capacity, which is crucial given the hormonal changes that accompany menopause [2]. Moreover, another study indicated that zinc plays a significant role in improving vitamin D levels, which are often linked to overall health during menopause [4].
Additionally, zinc appears to have a positive impact on symptoms associated with genitourinary syndrome of menopause (GSM). A trial involving a zinc-containing vaginal moisturizer gel demonstrated significant improvements in vaginal health, including reduced dryness and pain [7]. However, while these findings are promising, more extensive research with larger sample sizes is necessary to solidify these conclusions and fully understand the implications of zinc supplementation for menopausal health.
Users have reported a range of improvements in symptoms related to menopause after incorporating zinc supplements into their routines. Some individuals have experienced a notable reduction in menopause symptoms, with one user stating, "Thanks to this supplement, I feel nearly free from menopause symptoms" (Read Review). Additionally, others have highlighted the holistic benefits of zinc, such as enhanced mood, strengthened immune system, and improvements in skin, hair, and nails. For example, one reviewer mentioned feeling significant differences in muscle function and hormone regulation after starting the supplement, particularly when taken in the morning with vitamin D to aid absorption (Read Review).
While many users report positive changes, experiences can vary widely; some believe that consistent use is crucial to achieving the full benefits. A user who switched supplements to address hair loss indicated they plan to continue their regimen for a longer duration to properly assess the effects, emphasizing that time might be necessary for all benefits to reveal themselves (Read Review). Overall, while anecdotal experiences suggest potential for symptom relief, individual results may differ, making it essential for users to monitor their personal responses to supplementation.
Users report favorable outcomes when combining zinc supplements with other vitamins, particularly vitamin D, to manage menopause symptoms. One user highlighted the importance of taking zinc preferably in the morning after a meal and noted that when taken alongside vitamin D, it promotes better absorption, thereby enhancing its effectiveness in regulating hormone production and improving overall well-being during menopause (Read Review).
Additionally, some reviewers emphasize the general benefits of zinc in improving mood, immune function, and alleviating menopause symptoms. One user expressed that after starting zinc, they felt "nearly free from menopause symptoms," indicating a potential synergistic effect when combined with other health supplements. Another user transitioning from a different zinc supplement noted the necessity of giving the new supplement time to evaluate its effects, suggesting that a thoughtful approach to combining supplements could be beneficial in addressing specific issues like hair loss and hormonal imbalances during menopause (Read Review).
When it comes to zinc supplementation for postmenopausal women, research suggests that a dose of 50 mg per day may offer notable benefits. A study involving 51 participants indicated that this specific dosage over an eight-week period improved several health markers, including folate levels and the reduction of homocysteine levels, which is crucial for cardiovascular health [3]. Additionally, another study highlighted that the same dosage positively impacted vitamin D status and leptin levels, factors that can significantly influence overall well-being during menopause [4].
Furthermore, zinc supplementation is associated with enhanced antioxidant capacity, crucial for combating oxidative stress that may arise due to hormonal changes during menopause [2]. While the optimal dose appears to center around 50 mg daily, it's essential for individuals to consult healthcare providers before starting any supplementation regimen, as excessive zinc can lead to adverse effects, particularly linked to weight gain and hormonal imbalances [1]. Overall, zinc supplementation at this level can be a promising ally for managing various menopausal symptoms and supporting nutrient levels.
9
Mitigates menopause effects
Thanks to this supplement, I feel nearly free from menopause symptoms.
7.5
Helps with menopause
I switched from a zinc supplement by another company, intending to combat hair loss caused by menopause. I plan to continue using it for an extended period as I believe I won’t understand its effects until I give it time.
9
Essential for menopause
Zinc is vital for women during menopause. It regulates hormone production, combats viruses, and restores muscle function, making a significant difference for me. It's crucial to take it correctly—preferably in the morning after a meal—and ideally alongside vitamin D for better absorption.
8
Zinc enhances antioxidant protection
Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial.
We assessed how zinc (Zn) supplementation can impact the health of postmenopausal women, particularly regarding their antioxidant status. In this study, fifty-one women participating were split into two groups: one receiving a placebo treatment and the other receiving zinc supplements. This double-blind randomized trial lasted for eight weeks and focused on measuring changes in mineral status along with different antioxidant markers in the blood.
Before the intervention, we noticed that many participants had low zinc levels, which can lead to weakened antioxidant defenses—especially critical for postmenopausal women due to hormonal changes. After eight weeks of zinc supplementation, we saw a marked improvement in zinc levels among the women receiving the supplements. There were also significant positive correlations between zinc levels and overall antioxidant capacity, as well as specific antioxidant enzymes like glutathione peroxidase.
From our findings, it seems clear that zinc supplementation is a promising way to address deficiencies and bolster antioxidant defenses in postmenopausal women. This could not only support their nutritional health but might also contribute positively to their overall well-being during this transitional life stage.
9
Zinc enhances vitamin D in menopause
Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial.
We set out to understand how zinc supplementation could affect vitamin D status and leptin levels in postmenopausal women. The study involved 51 healthy postmenopausal women aged between 44 and 76 from Granada, Spain. They were divided into two groups: one receiving a zinc supplement of 50 mg daily for eight weeks and the other receiving a placebo.
Our findings revealed that zinc supplementation significantly improved vitamin D status in these women. Particularly, those who had reached menopause at a younger age saw a notable increase in their vitamin D levels after taking zinc.
Additionally, we discovered a connection between zinc and leptin levels, a hormone that regulates energy balance. Both dietary zinc intake and its plasma levels were found to be inversely related to serum leptin levels—meaning as zinc levels increased, leptin levels tended to decrease.
Overall, these results suggest that zinc supplementation may play a beneficial role during menopause by enhancing vitamin D levels and influencing leptin balance among postmenopausal women.
9
Zinc gel improves menopausal symptoms
Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study.
We evaluated the impact of a zinc-containing vaginal moisturizer gel on postmenopausal women experiencing genitourinary symptoms of menopause (GSM). Some women hesitate to use hormonal treatments like vaginal estrogen, which can be highly effective. To explore an alternative, we asked 37 participants to apply the gel daily for two weeks while tracking their symptoms.
Throughout the study, we used various methods to assess improvement. The Vaginal Health Index, which measures vaginal health, showed significant improvement after treatment. We also noted that participants reported reduced levels of vaginal pain and dryness on a visual analog scale, with the most notable benefit occurring for vaginal dryness. Additionally, the vulvovaginal symptom questionnaire indicated a substantial decrease in overall symptoms. Notably, side effects were minor and infrequent, which is encouraging for those considering this option.
In summary, our findings suggest that a novel zinc-containing vaginal moisturizer gel can effectively alleviate postmenopausal vulvovaginal symptoms without serious side effects, providing a viable solution for women who prefer non-hormonal treatments.
8
Zinc improves nutritional markers post-menopause
Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population.
In our study, we examined how zinc supplementation could affect menopausal women, particularly focusing on markers like homocysteine, vitamin B, and folate levels. We worked with 51 postmenopausal women aged between 44 and 76 years, dividing them into two groups: one received a placebo, while the other was given 50 mg of zinc daily for eight weeks.
After analyzing the results, we found that those who took zinc showed significantly higher folate levels compared to their baseline measurements. Additionally, we observed a noteworthy decrease in homocysteine levels when comparing the two groups after the intervention. Interestingly, we also noted a strong correlation between higher folate and vitamin B levels with lower homocysteine levels in the zinc group.
These findings suggest that zinc supplementation can have positive effects on certain nutritional markers in menopausal women. However, we emphasize the need for further research with larger sample sizes and refined dosing to validate and expand upon our results.
7
Zinc impacts postmenopausal obesity
Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity.
We investigated the effects of dietary zinc on obesity related to menopause, particularly in female mice that underwent ovariectomy (Ovx). Our findings revealed that excess zinc led to significant weight gain and symptoms resembling Cushing's syndrome, even though these mice did not consume more food.
The accumulation of zinc in the adrenal glands played a crucial role by interfering with steroid production. This is particularly important since, in Ovx mice, adrenal steroids are the only source of estrogen. The lack of estrogen triggered adrenal hyperplasia and an increase in glucocorticoids, which contributed to the development of Cushing's-like symptoms.
Interestingly, our results showed that supplementing with adrenal steroids could counteract the negative impacts of excess zinc. We also found a positive correlation between plasma zinc levels and cortisol while noting a negative correlation with adrenal steroids and estrogen levels in overweight postmenopausal women.
These insights suggest that it may be beneficial for postmenopausal women to avoid high dietary zinc and consider adrenal steroid supplementation to help manage obesity effectively.
References
Zhao Y, Wang Y, Hu L, Chen H, Xiao X, et al. Excess dietary zinc drives a Cushing's-like syndrome in ovariectomized mice - Implications for postmenopausal obesity. Biochem Biophys Res Commun. 2022;630:101. doi:10.1016/j.bbrc.2022.09.042
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, Quintero-Osso B, et al. Erythrocyte Zn concentration and antioxidant response after supplementation with Zn in a postmenopausal population. A double-blind randomized trial. Exp Gerontol. 2022;162:111766. doi:10.1016/j.exger.2022.111766
Vázquez-Lorente H, Herrera-Quintana L, Molina-López J, Gamarra Y, Planells E. Effect of zinc supplementation on circulating concentrations of homocysteine, vitamin B, and folate in a postmenopausal population. J Trace Elem Med Biol. 2022;71:126942. doi:10.1016/j.jtemb.2022.126942
Vázquez-Lorente H, Molina-López J, Herrera-Quintana L, Gamarra-Morales Y, López-González B, et al. Effectiveness of eight-week zinc supplementation on vitamin D status and leptin levels in a population of postmenopausal women: a double-blind randomized trial. J Trace Elem Med Biol. 2021;65:126730. doi:10.1016/j.jtemb.2021.126730
Csikós A, Kozma B, Pór Á, Kovács I, Lampé R, et al. Zinc Transporter 9 (SLC30A9) Expression Is Decreased in the Vaginal Tissues of Menopausal Women. Biol Trace Elem Res. 2021;199:4011. doi:10.1007/s12011-020-02525-w
Damjanovich P, Sipos AG, Larson K, Cunningham TD, Takacs P, et al. Cervicovaginal lavage fluid zinc level as a marker of vaginal atrophy. Menopause. 2020;27:776. doi:10.1097/GME.0000000000001536
Takacs P, Kozma B, Erdodi B, Jakab A, Larson K, et al. Zinc-containing Vaginal Moisturizer Gel Improves Postmenopausal Vulvovaginal Symptoms: A Pilot Study. J Menopausal Med. 2019;25:63. doi:10.6118/jmm.2019.25.1.63