Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.6
Supplement Facts
Serving Size: Serving Size 1 Capsule
Amount Per Serving
%DV
Dehydroepiandrosterone (DHEA)
25 mg
**
Top Medical Research Studies
8
We systematically reviewed studies about nonestrogen therapies for treating genitourinary syndrome of menopause (GSM).
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
Read More
8
We explored the impact of DHEA supplementation on estradiol levels in women through a thorough meta-analysis of randomized clinical trials. Our findings show that DHEA significantly raises estradiol concentrations, especially in postmenopausal women and those aged 60 and older, with a notable increase after 26 weeks of supplementation.
The analysis indicated that a daily dosage of 50 mg of DHEA leads to a marked improvement in estradiol levels. However, while results are promising, they suggest further investigation is needed.
The analysis indicated that a daily dosage of 50 mg of DHEA leads to a marked improvement in estradiol levels. However, while results are promising, they suggest further investigation is needed.
Read More
8
We explored the effects of vaginal DHEA on stress urinary incontinence (SUI) and pelvic floor muscle (PFM) function in postmenopausal women dealing with vulvovaginal atrophy. Our observational study included 34 participants who used 6.5 mg of DHEA daily for 12 weeks.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
Read More
Most Useful Reviews
9
Eases menopause symptoms
6 people found this helpful
I recommend DHEA for those experiencing menopause. Its effects have been substantial for me; I feel more energetic and youthful. With better skin texture and improved mood, I've noticed a distinct change compared to before starting DHEA. It has alleviated my symptoms associated with menopause and vulvovaginal atrophy. More research into its benefits would be worthwhile, as I consider it an extraordinary supplement that has improved my quality of life.
Read More
7.5
Restores menstrual cycle
5 people found this helpful
An excellent supplement for those at the onset of menopause, it has prolonged youthfulness and improved egg quality for IVF preparations, making it a great asset to women's health during this transition.
Read More
9
Boosts mood and energy
4 people found this helpful
At 44, since experiencing premature ovarian failure, DHEA has significantly improved my menopausal symptoms. I feel revitalised, more active, and my skin looks better than ever. It has truly felt like an elixir of youth, restoring my confidence and overall well-being. The ease of taking this supplement combined with its quality has made a positive difference in my life.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
8
We explored the effects of vaginal DHEA on stress urinary incontinence (SUI) and pelvic floor muscle (PFM) function in postmenopausal women dealing with vulvovaginal atrophy. Our observational study included 34 participants who used 6.5 mg of DHEA daily for 12 weeks.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
Read More
8
We delved into current strategies for managing genitourinary syndrome of menopause (GSM), a condition that significantly impacts women's quality of life but often goes untreated. Our review highlighted that GSM stems from reduced estrogen levels and causes issues like vulvovaginal atrophy and urinary concerns.
We found that while lubricants and moisturizers offer short-term relief, hormonal treatments like dehydroepiandrosterone (DHEA) and selective estrogen receptor modulators can provide benefits for more severe symptoms. However, there's still a pressing need for more rigorous studies to evaluate these options further, especially concerning safety and efficacy.
We found that while lubricants and moisturizers offer short-term relief, hormonal treatments like dehydroepiandrosterone (DHEA) and selective estrogen receptor modulators can provide benefits for more severe symptoms. However, there's still a pressing need for more rigorous studies to evaluate these options further, especially concerning safety and efficacy.
Read More
8
We systematically reviewed studies about nonestrogen therapies for treating genitourinary syndrome of menopause (GSM).
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
Read More
8
We conducted a pilot study involving 10 breast cancer survivors experiencing severe symptoms of menopause, specifically genitourinary syndrome. Each participant was given vaginal DHEA ovules for six months while being monitored for changes in symptoms and hormone levels.
Remarkably, we observed significant improvements in sexual health and vaginal wellness—dyspareunia scores dropped notably, and both the Vaginal Health Index and Female Sexual Function Index showed increased scores. Importantly, serum estradiol levels remained low, suggesting that DHEA could be a safe and effective treatment option for women in this situation.
Remarkably, we observed significant improvements in sexual health and vaginal wellness—dyspareunia scores dropped notably, and both the Vaginal Health Index and Female Sexual Function Index showed increased scores. Importantly, serum estradiol levels remained low, suggesting that DHEA could be a safe and effective treatment option for women in this situation.
Read More
8
We explored how dehydroepiandrosterone (DHEA) affects cardiovascular health in postmenopausal women. This review highlights that postmenopausal women are more prone to atherosclerosis due to changes in blood lipid levels, oxidative stress, and other factors.
DHEA shows promise in combating these issues by improving lipid profiles and protecting blood vessels. It helps counteract inflammation, oxidative damage, and promotes healthy blood vessel function. Overall, DHEA presents a meaningful approach for supporting heart health in women during and after menopause.
DHEA shows promise in combating these issues by improving lipid profiles and protecting blood vessels. It helps counteract inflammation, oxidative damage, and promotes healthy blood vessel function. Overall, DHEA presents a meaningful approach for supporting heart health in women during and after menopause.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Eases menopause symptoms
6 people found this helpful
I recommend DHEA for those experiencing menopause. Its effects have been substantial for me; I feel more energetic and youthful. With better skin texture and improved mood, I've noticed a distinct change compared to before starting DHEA. It has alleviated my symptoms associated with menopause and vulvovaginal atrophy. More research into its benefits would be worthwhile, as I consider it an extraordinary supplement that has improved my quality of life.
Read More
7.5
Restores menstrual cycle
5 people found this helpful
An excellent supplement for those at the onset of menopause, it has prolonged youthfulness and improved egg quality for IVF preparations, making it a great asset to women's health during this transition.
Read More
9
Boosts mood and energy
4 people found this helpful
At 44, since experiencing premature ovarian failure, DHEA has significantly improved my menopausal symptoms. I feel revitalised, more active, and my skin looks better than ever. It has truly felt like an elixir of youth, restoring my confidence and overall well-being. The ease of taking this supplement combined with its quality has made a positive difference in my life.
Read More
9
Improves skin elasticity
3 people found this helpful
I've noticed substantial improvements in my wife's skin and mucous membranes post-menopause thanks to DHEA. The improvements in elasticity and moisture retention are remarkable, validating its effectiveness and quality. We highly recommend this ingredient for anyone facing similar issues.
Read More
9
Increased energy
2 people found this helpful
Excellent purchase! Unfortunately, as we age, our bodies need assistance to maintain normal hormone levels. I began taking it during menopause as my doctor prescribed to stabilise my hormonal levels and emotional state. Judging by the effect, I can say that the quality is excellent. I’ve experienced increased energy and a noticeable improvement in my skin and hair.
Read More
Frequently Asked Questions
9
Better sleep
1 people found this helpful
I’m using this alongside Genisoy to regulate sleep issues due to menopause. In just under a week, I've noticed a significant improvement for the better.
6
Stabilises mood and energy
Life Extension’s DHEA 25 mg capsules support hormonal balance and overall wellbeing. After several weeks of use, I've felt an uplift in energy and mood, alongside improved fitness and recovery after workouts. The convenient dosage and reliable brand offer reassurance in its quality. However, it’s crucial to consider potential side effects and consult a doctor before beginning supplementation.
9
Increased energy
2 people found this helpful
Excellent purchase! Unfortunately, as we age, our bodies need assistance to maintain normal hormone levels. I began taking it during menopause as my doctor prescribed to stabilise my hormonal levels and emotional state. Judging by the effect, I can say that the quality is excellent. I’ve experienced increased energy and a noticeable improvement in my skin and hair.
9
Energy boost
1 people found this helpful
An excellent drug! I have been taking it for two months. It's a fantastic option for women in menopause, requiring just one tablet daily. My energy levels have shot up, alongside my intake of vitamin D, Omega 3, and iron.
9
Eases menopause symptoms
6 people found this helpful
I recommend DHEA for those experiencing menopause. Its effects have been substantial for me; I feel more energetic and youthful. With better skin texture and improved mood, I've noticed a distinct change compared to before starting DHEA. It has alleviated my symptoms associated with menopause and vulvovaginal atrophy. More research into its benefits would be worthwhile, as I consider it an extraordinary supplement that has improved my quality of life.
9
Boosts mood and energy
4 people found this helpful
At 44, since experiencing premature ovarian failure, DHEA has significantly improved my menopausal symptoms. I feel revitalised, more active, and my skin looks better than ever. It has truly felt like an elixir of youth, restoring my confidence and overall well-being. The ease of taking this supplement combined with its quality has made a positive difference in my life.
9
Relieved symptoms
Excellent for menopausal women to alleviate dry eyes and endocrine dysfunctions.
9
Balanced hormones
My doctor prescribed this product to balance my hormones due to menopause, resulting in improved sleep, increased energy, and a newfound desire to exercise—something I had greatly lacked. I feel more alert and less unfocused.
7.5
Quality product, effective
2 people found this helpful
Since starting DHEA during menopause, I’ve stabilised my hormonal levels and emotional state. The quality of the tablets is evident in the positive effects I’ve experienced. Consulting a doctor before starting is advisable, but I can attest to its effectiveness.
8
We conducted a pilot study involving 10 breast cancer survivors experiencing severe symptoms of menopause, specifically genitourinary syndrome. Each participant was given vaginal DHEA ovules for six months while being monitored for changes in symptoms and hormone levels.
Remarkably, we observed significant improvements in sexual health and vaginal wellness—dyspareunia scores dropped notably, and both the Vaginal Health Index and Female Sexual Function Index showed increased scores. Importantly, serum estradiol levels remained low, suggesting that DHEA could be a safe and effective treatment option for women in this situation.
Remarkably, we observed significant improvements in sexual health and vaginal wellness—dyspareunia scores dropped notably, and both the Vaginal Health Index and Female Sexual Function Index showed increased scores. Importantly, serum estradiol levels remained low, suggesting that DHEA could be a safe and effective treatment option for women in this situation.
8
We delved into current strategies for managing genitourinary syndrome of menopause (GSM), a condition that significantly impacts women's quality of life but often goes untreated. Our review highlighted that GSM stems from reduced estrogen levels and causes issues like vulvovaginal atrophy and urinary concerns.
We found that while lubricants and moisturizers offer short-term relief, hormonal treatments like dehydroepiandrosterone (DHEA) and selective estrogen receptor modulators can provide benefits for more severe symptoms. However, there's still a pressing need for more rigorous studies to evaluate these options further, especially concerning safety and efficacy.
We found that while lubricants and moisturizers offer short-term relief, hormonal treatments like dehydroepiandrosterone (DHEA) and selective estrogen receptor modulators can provide benefits for more severe symptoms. However, there's still a pressing need for more rigorous studies to evaluate these options further, especially concerning safety and efficacy.
8
We explored the effects of vaginal DHEA on stress urinary incontinence (SUI) and pelvic floor muscle (PFM) function in postmenopausal women dealing with vulvovaginal atrophy. Our observational study included 34 participants who used 6.5 mg of DHEA daily for 12 weeks.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
The results were promising—after treatment, SUI episodes significantly decreased, and participants reported improved PFM strength. Overall, vaginal DHEA appears to enhance quality of life for women experiencing these symptoms. Further research is essential to confirm the benefits and explore additional applications for androgen therapy.
8
We systematically reviewed studies about nonestrogen therapies for treating genitourinary syndrome of menopause (GSM).
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
Our search included over 9,000 abstracts, leading to 136 studies that fit our criteria.
We found that vaginal DHEA, among other treatments, showed effectiveness in improving menopause-related symptoms like vaginal atrophy and sexual function.
While several options exist, there isn't strong data to directly compare these nonestrogen therapies with each other.
8
We explored the impact of DHEA supplementation on estradiol levels in women through a thorough meta-analysis of randomized clinical trials. Our findings show that DHEA significantly raises estradiol concentrations, especially in postmenopausal women and those aged 60 and older, with a notable increase after 26 weeks of supplementation.
The analysis indicated that a daily dosage of 50 mg of DHEA leads to a marked improvement in estradiol levels. However, while results are promising, they suggest further investigation is needed.
The analysis indicated that a daily dosage of 50 mg of DHEA leads to a marked improvement in estradiol levels. However, while results are promising, they suggest further investigation is needed.
References
- Misasi G, Russo E, Montt Guevara MM, Tomatis V, Fidecicchi T, et al. Effects of vaginal DHEA on stress urinary incontinence in postmenopausal women with vulvovaginal atrophy. Maturitas. 2025;196:108232. doi:10.1016/j.maturitas.2025.108232
- Pennacchini E, Dall'Alba R, Iapaolo S, Marinelli M, Palazzetti PL, et al. Treatment of Genitourinary Syndrome of Menopause in Breast Cancer and Gynecologic Cancer Survivors: Retrospective Analysis of Efficacy and Safety of Vaginal Estriol, Vaginal Dehydroepiandrosterone and Ospemifene. J Menopausal Med. 2024;30:170. doi:10.6118/jmm.24011
- Cuccu I, Golia D'Augè T, Firulli I, De Angelis E, Buzzaccarini G, et al. Update on Genitourinary Syndrome of Menopause: A Scoping Review of a Tailored Treatment-Based Approach. Life (Basel). 2024;14. doi:10.3390/life14111504
- Danan ER, Sowerby C, Ullman KE, Ensrud K, Forte ML, et al. Hormonal Treatments and Vaginal Moisturizers for Genitourinary Syndrome of Menopause : A Systematic Review. Ann Intern Med. 2024;177:1400. doi:10.7326/ANNALS-24-00610
- Casiano Evans EA, Hobson DTG, Aschkenazi SO, Alas AN, Balgobin S, et al. Nonestrogen Therapies for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review. Obstet Gynecol. 2023;142:555. doi:10.1097/AOG.0000000000005288
- Mension E, Alonso I, Cebrecos I, Castrejon N, Tortajada M, et al. Safety of prasterone in breast cancer survivors treated with aromatase inhibitors: the VIBRA pilot study. Climacteric. 2022;25:476. doi:10.1080/13697137.2022.2050208
- Tang J, Chen LR, Chen KH. The Utilization of Dehydroepiandrosterone as a Sexual Hormone Precursor in Premenopausal and Postmenopausal Women: An Overview. Pharmaceuticals (Basel). 2021;15. doi:10.3390/ph15010046
- Zhang S, Zhou J, Li L, Pan X, Lin J, et al. Effect of dehydroepiandrosterone on atherosclerosis in postmenopausal women. Biosci Trends. 2022;15:353. doi:10.5582/bst.2021.01320
- Zhu Y, Qiu L, Jiang F, Găman MA, Abudoraehem OS, et al. The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials. Steroids. 2021;173:108889. doi:10.1016/j.steroids.2021.108889
