Life Extension CoQ10

We explored the effects of selenium supplementation in patients suffering from Hashimoto thyroiditis (HT), a leading cause of hypothyroidism. By analyzing multiple randomized controlled trials, we aimed to see how selenium might impact thyroid function, particularly focusing on thyroid-stimulating hormone (TSH) levels and thyroid antibodies.

Our analysis included results from 35 studies, where we observed that selenium supplementation led to a notable decrease in TSH levels among patients not undergoing thyroid hormone replacement therapy. This suggests that selenium may help manage thyroid function in specific populations.

Additionally, we found that selenium also reduced levels of thyroid peroxidase antibodies (TPOAb) and malondialdehyde (MDA), which indicates improved thyroid health and reduced oxidative stress. Interestingly, we observed that these benefits occurred irrespective of whether patients were receiving thyroid hormone therapy.

However, we did not find significant changes in other thyroid hormones or immune markers, indicating that while selenium can be effective in some areas, its benefits may not extend across all measures of thyroid health. Overall, our findings support the safe use of selenium in lowering TSH and certain antibodies in HT patients not on hormone therapy.

9.5

Reduced illness frequency

Most Useful Review

Very good for those suffering from Hashimoto's disease or hypothyroidism. I was frequently unwell, but after using selenium, my health improved remarkably, leading to weight loss without needing thyroxine. This product truly made a difference for me.

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Most Relevant Research

We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.

The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.

Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.

8.8

Defence against cancer

Most Useful Review

Selenium is indispensable for maintaining health, based on its role in protecting against cancer through its antioxidant activity. A daily intake has notably increased my immune response and offers protection against harmful metals.

Cardiovascular Disease details

Excellent strength, price, and quality! It helps combat viral diseases and strengthens the immune system. Highly recommended!

Chronic Fatigue Syndrome details

After tests revealed low levels of selenium and iodine, I began taking selenium. Within two weeks, my overall wellbeing improved significantly, and fatigue decreased. It also reduced heavy metal levels in my body, and I felt revitalised.

Liver Disease details

I use selenium for treating endocrine ophthalmopathy, and currently, in Russia, there are no pure selenium products available. This selenium combines three forms, and I alternate it with another brand. Endocrinologists recommend its use for mild cases. After four months, I can attest to its effectiveness; my symptoms have significantly improved, including the regression of eye issues related to thyroid disease.

Bone Pain details

This product was recommended on a thyroid forum. Although it's too early to determine its benefits, I believe I may have experienced some. A week ago, I suffered terrible pain from a fallen arch in my right foot. I took this supplement as this condition can relate to low thyroid function. After two days of wearing supportive shoes and taking selenium, the excruciating pain vanished! I was amazed to have NO pain at all just two days later. I hope the selenium played a part in this swift recovery.

Brain Tumor details

Supports thyroid function

Most Useful Review

The best selenium! As part of the Super Selenium complex, it contains three forms of selenium along with vitamin E. Selenium helps maintain normal thyroid gland function and boosts immunity. It also enhances heart and brain functioning.

Leg Cramps details

Vitamin E's potential in leg cramps

Are there alternatives to the use of quinine to treat nocturnal leg cramps?

Most Relevant Research

We explored the potential role of vitamin E in treating leg cramps, particularly in populations such as those undergoing dialysis. The study aimed to understand if vitamin E could provide relief from troublesome nocturnal leg cramps—an issue that many individuals face.

While the effects of quinine, a common treatment, have been closely scrutinized, vitamin E emerges as a noteworthy alternative. Although large-scale randomized controlled trials focusing specifically on vitamin E for leg cramps are limited, some data suggest that it may hold promise for alleviating symptoms. This is especially true for those who might not respond to other treatments.

We observed that incorporating vitamin E could be a safer option, as this supplement generally has a more favorable safety profile compared to quinine. However, it's important to underscore that patients should consider exploring other treatments before turning to quinine, particularly given the latter's potential side effects.

9.5

Prevents convulsions

Most Useful Review

I used to wake up with painful leg cramps, but after taking selenium, I've forgotten what those convulsions feel like. I will continue this for prevention purposes; it's truly made a difference for me.

Sleep Apnea details

Enhanced energy levels

Most Useful Review

This complex is an effective dietary supplement for my age-related thyroid issues. It supports the thyroid gland, leading to healing and rejuvenation. I categorically abstain from hormones and rely on natural complexes. My sleep has normalised, which feels like a gift during menopause. The uncontrolled appetite has subsided, and I have noticed a significant improvement in my overall mood—both physical and mental. I am very satisfied and highly recommend it to older women.

Psoriasis details

Perfectly! This supplement helps me heal psoriasis spots on my skin more rapidly. Personally, I noticed the effect within a week; the itching diminished and the condition of my spots improved. Additionally, I've felt much more cheerful overall. I plan to purchase it again.

Yeast Infection details

Supports yeast prevention

Most Useful Review

Great Complex Selena! Life Extension selenium comprises three organic forms: selenomethionine, selenite, and selenocysteine, supplemented with vitamin E to enhance its action. This selenium complex is vital for individuals prone to candidiasis. The small capsules have a distinctive smell, but as a medicine, it is tolerable for health. Selenium is an essential antioxidant, aiding the removal of free radicals and offering protection against cancer cells. It is indispensable for treating and preventing thyroid hypofunction and thyroiditis. I always consult a doctor when taking any medicines or vitamins. I take one capsule every evening after meals. I am confident this complex benefits my body! I plan to continue this annually in spring and autumn. I wish everyone good health!

Autoimmune Disorder details

SCIENTIFIC SCORE

Questionable

Based on 16 Researches

Selenium aids Graves' orbitopathy treatment

The efficacy and safety of selenium supplementation versus placebo in the treatment of Graves' orbitopathy: A systematic review and meta-analysis of randomised controlled trials.

Most Relevant Research

We explored how selenium supplementation might help individuals suffering from Graves' orbitopathy, an autoimmune disorder linked to thyroid dysfunction. Our approach involved a systematic review and meta-analysis that assessed results from four randomized controlled trials.

The findings revealed that selenium supplementation had a significant positive impact on various aspects of Graves' orbitopathy. Over a period of six months, patients taking selenium showed a notable reduction in clinical activity scores, which reflect the severity of eye symptoms. Furthermore, their quality of life also improved significantly.

We observed improvements not only in the overall quality of life specific to eye conditions, but also in visual and psychological functioning scores. Additionally, selenium appeared to reduce the width of the eyelids, providing further benefits for eye-related symptoms. However, we found no significant changes in other areas, such as eye bulging or muscle movement abilities.

Importantly, selenium supplementation was deemed safe with minor side effects reported, suggesting it could be a viable option for managing Graves' orbitopathy. While our results are promising, we believe further research is needed to thoroughly validate the long-term effectiveness and safety of selenium treatment for this condition.

9.5

Improved skin health

Most Useful Review

Great supplement! I’m currently on my second jar, as advised by a nutritionist based on test results. After a short time, she observed that my skin became incredibly smooth, with cracks and dryness disappearing. My chronic runny nose and congestion have also resolved, leading to an overall improvement in my condition. Selenium is advised to take in courses for those with thyroid issues. I will order more!

Breast Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Selenium compounds may fight breast cancer

Di- and Triselenoesters-Promising Drug Candidates for the Future Therapy of Triple-Negative Breast Cancer.

Most Relevant Research

We set out to explore the effects of selenium-containing compounds on breast cancer cells, particularly focusing on their potential as treatments. Our research involved testing several novel selenoesters on two breast cancer cell lines, MCF-7 and MDA-MB-231, to understand how these compounds can impact cell growth and survival.

What we found was quite promising. The selenoesters showed significant cytotoxic effects, meaning they can kill cancer cells effectively, even at very low doses. We observed that these compounds triggered important processes that lead to cell death, specifically by activating pathways that make cells undergo apoptosis, or programmed cell death.

The mechanisms at play include both the extrinsic and intrinsic apoptosis pathways, which means they are working from multiple angles to combat cancer. Additionally, these compounds also activate autophagy, a process that helps clear out damaged cells and contributes to the overall effectiveness of the treatment.

In summary, our findings suggest that these selenium-based compounds could be valuable candidates for future breast cancer therapies, worth considering in the ongoing fight against this disease.

9.5

Effective skin remedy

Most Useful Review

This brand and dosage are fantastic! After a period of late nights and sleep deprivation, I had a flare-up of skin issues. Upon taking a blend of vitamins and this selenium supplement, I noticed significant improvement. The swollen, itchy skin reduced drastically within two days. It's far more effective than Western antiviral medicines! Now, it's a staple in my home for daily intake. If you have hepatitis B, I recommend combining selenium with natural vitamin E and silymarin to protect your liver and lower the risk of liver cancer.

Heart Attack details

SCIENTIFIC SCORE

Possibly Effective

Based on 14 Researches

Selenium nanoparticles for heart health

A Self-Sustaining Antioxidant Strategy for Effective Treatment of Myocardial Infarction.

Most Relevant Research

We examined the role of selenium in treating myocardial infarction (MI), a major cause of death worldwide that can lead to serious heart problems. The study focused on how this antioxidant works across different phases of a heart attack, where harmful reactive oxygen species (ROS) play a significant role in worsening the condition.

Our findings highlighted a new approach using selenium-embedded nanoparticles, which are specially designed to act as antioxidants at various stages of MI. This innovative method allows for selective ROS elimination when it's most needed, leading to impressive recovery outcomes for the heart.

Throughout the research, it became clear that these nanoparticles help protect vital functions in heart cells by reducing cell death, inflammation, and scar tissue, while also encouraging new blood vessel growth. Overall, this self-sustaining antioxidant strategy shows great potential, not just for treating heart attacks but also inspiring therapies for other ischemic conditions.

9.5

Improved energy levels

Most Useful Review

The complex is effective! I began taking it on the advice of a nutritionist to restore my thyroid function, addressing fatigue, muscle weakness, and heart issues. Almost immediately, I felt better; my energy increased, hair loss decreased, and my heartbeat was more stable. I recommend this essential vitamin for optimal body performance. Please like if you find this helpful.

Lung Cancer details

The king of anti-cancer must be consumed; I've already had three bottles.

Prostate Cancer details

SCIENTIFIC SCORE

Possibly Effective

Based on 16 Researches

Selenium nanoparticles show promise

Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.

Most Relevant Research

We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.

By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.

This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.

Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.

9.5

Overall health

Most Useful Review

This excellent supplement prevents cancer, boosts immunity, and improves the circulatory system. Selenium protects against free radicals and is essential for thyroid hormone production.