Last update
5/19/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.4
USERS' SCORE
Good
Based on 4 Reviews
8.8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
8
Vitamin E reduces hot flash severity and frequency significantly
We tested whether vitamin E could help menopausal women experiencing hot flashes. In a double-blind, placebo-controlled trial with 51 women, participants first received placebo for 4 weeks, then vitamin E (400 IU daily) for another 4 weeks, with their hot flashes tracked throughout.
Vitamin E proved significantly more effective than placebo. Women taking vitamin E experienced a notable reduction in hot flash severity and how often they occurred each day. These improvements were statistically significant and suggest vitamin E may be a worthwhile option for women seeking non-hormonal relief from hot flashes.
Vitamin E proved significantly more effective than placebo. Women taking vitamin E experienced a notable reduction in hot flash severity and how often they occurred each day. These improvements were statistically significant and suggest vitamin E may be a worthwhile option for women seeking non-hormonal relief from hot flashes.
Read More
2
We examined 16 randomized controlled trials testing non-hormonal approaches to ease hot flashes in women with a history of breast cancer. The review included studies on various treatments ranging from medications like SSRIs and gabapentin to lifestyle interventions like relaxation therapy and acupuncture.
When it came to vitamin E specifically, one study found it did not provide any measurable benefit for reducing hot flashes. Among the treatments evaluated, three medications—SSRIs, SNRIs, clonidine, and gabapentin—showed mild to moderate effectiveness. Relaxation therapy showed promise in some cases, while other non-drug approaches had no significant effect. Overall, the research suggests that while some non-hormonal options exist for breast cancer survivors experiencing hot flashes, choices are limited and effects are modest.
When it came to vitamin E specifically, one study found it did not provide any measurable benefit for reducing hot flashes. Among the treatments evaluated, three medications—SSRIs, SNRIs, clonidine, and gabapentin—showed mild to moderate effectiveness. Relaxation therapy showed promise in some cases, while other non-drug approaches had no significant effect. Overall, the research suggests that while some non-hormonal options exist for breast cancer survivors experiencing hot flashes, choices are limited and effects are modest.
Read More
2
We examined the evidence on vitamins, minerals, and trace elements for postmenopausal women's health, including hot flashes. Our review of clinical studies, systematic reviews, and meta-analyses from major databases identified vitamin E as the only supplement studied specifically for vasomotor symptoms—the medical term for hot flashes.
Unfortunately, the evidence did not support vitamin E's effectiveness for this purpose. While vitamins C, D, K and calcium showed promise for bone health in postmenopausal women, vitamin E lacked the clinical support needed to recommend it for managing hot flashes. We concluded that supplementation in healthy postmenopausal women generally cannot be recommended unless they have documented deficiencies or absorption problems.
Unfortunately, the evidence did not support vitamin E's effectiveness for this purpose. While vitamins C, D, K and calcium showed promise for bone health in postmenopausal women, vitamin E lacked the clinical support needed to recommend it for managing hot flashes. We concluded that supplementation in healthy postmenopausal women generally cannot be recommended unless they have documented deficiencies or absorption problems.
Read More
Most Useful Reviews
10
Symptoms alleviated
195 people found this helpful
I purchased selenium from iHerb based on a friend's recommendation due to the high levels of healthy minerals found in centenarians, especially selenium. Our Selenium Super Complex offers three forms of selenium and vitamin E for health and longevity, which is essential for me at my age, dealing with menopause and hot flashes. Since using this complex, symptoms like hot flashes, weakness, and dizziness have disappeared. I realised this complex assists the body in combating oxidative damage. You only need to take it once a day; there are 100 capsules in a jar, sufficient for three months.
Read More
9
Hot flashes reduced
3 people found this helpful
I have been eager to try this product. At 58 years old, I've experienced menopause for eight years, suffering very severe hot flashes every three hours. Although I take medications, they don’t help much. After adding this complex with vitamin E, I nearly eliminated hot flashes. My health has improved significantly; I no longer wake at night and feel much calmer.
Read More
0
Dosage concern
3 people found this helpful
After two weeks of taking this selenium, I started to experience hot flashes like those during menopause, which initially frightened me. A nutritionist advised that the dosage might be too high and suggested taking selenium without vitamin E. Once I stopped taking this selenium, the hot flashes ceased.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 16 Researches
4.4
- All Researches
We conducted a study with eighty-four postmenopausal women to see how vitamin E affects hot flashes, among other health markers. The participants were divided into three groups and received either Vitamin E, Curcumin, or a placebo for eight weeks.
Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.
Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.
Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.
Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.
Read More
8
Vitamin E effectively reduces hot flashes in postmenopausal women
A triple-blind randomized controlled trial enrolled 93 postmenopausal women to test whether curcumin and vitamin E could ease hot flashes and other menopause symptoms. Women received either curcumin (500 mg), vitamin E (200 IU/day), or placebo twice daily for eight weeks. Both curcumin and vitamin E significantly reduced hot flashes compared to placebo.
However, neither supplement improved anxiety, sexual function, or overall menopausal symptoms. The findings suggest these supplements have a focused benefit—specifically targeting hot flashes—rather than offering broad relief across menopause-related concerns.
However, neither supplement improved anxiety, sexual function, or overall menopausal symptoms. The findings suggest these supplements have a focused benefit—specifically targeting hot flashes—rather than offering broad relief across menopause-related concerns.
Read More
8
Vitamin E reduces hot flash severity and frequency significantly
We tested whether vitamin E could help menopausal women experiencing hot flashes. In a double-blind, placebo-controlled trial with 51 women, participants first received placebo for 4 weeks, then vitamin E (400 IU daily) for another 4 weeks, with their hot flashes tracked throughout.
Vitamin E proved significantly more effective than placebo. Women taking vitamin E experienced a notable reduction in hot flash severity and how often they occurred each day. These improvements were statistically significant and suggest vitamin E may be a worthwhile option for women seeking non-hormonal relief from hot flashes.
Vitamin E proved significantly more effective than placebo. Women taking vitamin E experienced a notable reduction in hot flash severity and how often they occurred each day. These improvements were statistically significant and suggest vitamin E may be a worthwhile option for women seeking non-hormonal relief from hot flashes.
Read More
7
We explored the role of vitamin E in alleviating hot flashes among postmenopausal women, focusing on its potential effectiveness in managing this common symptom. The accumulated studies in our review cleverly grouped the findings into three areas: the physical changes related to menopause, the specific warm sensations known as hot flashes, and how vitamin E might interact with vascular health.
Our analysis included a thorough examination of 16 studies, which suggested that vitamin E does have an influence on hot flashes and other menopause-related symptoms. While we found that vitamin E may help ease some of the discomfort associated with menopause, it is essential to note that estrogen therapy generally shows more significant results.
Interestingly, vitamin E could provide a complementary approach for women who cannot use estrogen due to various contraindications. However, further research is needed to solidify these findings and enhance our understanding of how effective vitamin E may be as a standalone treatment.
Our analysis included a thorough examination of 16 studies, which suggested that vitamin E does have an influence on hot flashes and other menopause-related symptoms. While we found that vitamin E may help ease some of the discomfort associated with menopause, it is essential to note that estrogen therapy generally shows more significant results.
Interestingly, vitamin E could provide a complementary approach for women who cannot use estrogen due to various contraindications. However, further research is needed to solidify these findings and enhance our understanding of how effective vitamin E may be as a standalone treatment.
Read More
7
Phytoestrogens show symptom relief
We explored how a combination of phytoestrogens, vitamin E, and grapeseed extract can help alleviate menopausal symptoms like hot flashes. This five-month study significantly observed improvements in various symptoms when the subjects followed the treatment protocol crafted from soy germ extracts.
Although we noted a decrease in discomfort such as irritability, anxiety, and hot flashes, it’s essential to point out that the impact of vitamin E alone remains unclear. The dramatic positive changes were particularly evident in premenopausal women.
Overall, the original formula—including vitamin E and phytoestrogens—seems to show promise in supporting women's health during premenopause and surgically induced menopause. As we reflect on the results, it becomes apparent that further investigation is needed to understand vitamin E’s standalone role in managing menopausal symptoms.
Although we noted a decrease in discomfort such as irritability, anxiety, and hot flashes, it’s essential to point out that the impact of vitamin E alone remains unclear. The dramatic positive changes were particularly evident in premenopausal women.
Overall, the original formula—including vitamin E and phytoestrogens—seems to show promise in supporting women's health during premenopause and surgically induced menopause. As we reflect on the results, it becomes apparent that further investigation is needed to understand vitamin E’s standalone role in managing menopausal symptoms.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Symptoms alleviated
195 people found this helpful
I purchased selenium from iHerb based on a friend's recommendation due to the high levels of healthy minerals found in centenarians, especially selenium. Our Selenium Super Complex offers three forms of selenium and vitamin E for health and longevity, which is essential for me at my age, dealing with menopause and hot flashes. Since using this complex, symptoms like hot flashes, weakness, and dizziness have disappeared. I realised this complex assists the body in combating oxidative damage. You only need to take it once a day; there are 100 capsules in a jar, sufficient for three months.
Read More
9
Hot flashes reduced
3 people found this helpful
I have been eager to try this product. At 58 years old, I've experienced menopause for eight years, suffering very severe hot flashes every three hours. Although I take medications, they don’t help much. After adding this complex with vitamin E, I nearly eliminated hot flashes. My health has improved significantly; I no longer wake at night and feel much calmer.
Read More
0
Dosage concern
3 people found this helpful
After two weeks of taking this selenium, I started to experience hot flashes like those during menopause, which initially frightened me. A nutritionist advised that the dosage might be too high and suggested taking selenium without vitamin E. Once I stopped taking this selenium, the hot flashes ceased.
Read More
7.5
Intensities decreased
Selenium with vitamin E serves as a powerful antioxidant. I have thyroid issues, which are accompanied by hot flashes. After starting selenium, I noticed the hot flashes became less frequent, and their intensity decreased significantly.
Read More
Frequently Asked Questions
9
Hot flashes reduced
3 people found this helpful
I have been eager to try this product. At 58 years old, I've experienced menopause for eight years, suffering very severe hot flashes every three hours. Although I take medications, they don’t help much. After adding this complex with vitamin E, I nearly eliminated hot flashes. My health has improved significantly; I no longer wake at night and feel much calmer.
0
Dosage concern
3 people found this helpful
After two weeks of taking this selenium, I started to experience hot flashes like those during menopause, which initially frightened me. A nutritionist advised that the dosage might be too high and suggested taking selenium without vitamin E. Once I stopped taking this selenium, the hot flashes ceased.
7.5
Intensities decreased
Selenium with vitamin E serves as a powerful antioxidant. I have thyroid issues, which are accompanied by hot flashes. After starting selenium, I noticed the hot flashes became less frequent, and their intensity decreased significantly.
10
Symptoms alleviated
195 people found this helpful
I purchased selenium from iHerb based on a friend's recommendation due to the high levels of healthy minerals found in centenarians, especially selenium. Our Selenium Super Complex offers three forms of selenium and vitamin E for health and longevity, which is essential for me at my age, dealing with menopause and hot flashes. Since using this complex, symptoms like hot flashes, weakness, and dizziness have disappeared. I realised this complex assists the body in combating oxidative damage. You only need to take it once a day; there are 100 capsules in a jar, sufficient for three months.
We conducted a study with eighty-four postmenopausal women to see how vitamin E affects hot flashes, among other health markers. The participants were divided into three groups and received either Vitamin E, Curcumin, or a placebo for eight weeks.
Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.
Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.
Our findings revealed that vitamin E significantly reduced the frequency of hot flashes by nearly one-third compared to those taking the placebo. This reduction was accompanied by improvements in several health indicators, including lower serum triglyceride levels and enhanced high-density lipoprotein (HDL) cholesterol.
Furthermore, vitamin E also showed positive effects on liver health markers. Overall, it appears that vitamin E is effective not only in alleviating hot flashes but also in improving some aspects of the lipid profile in postmenopausal women, without adverse effects on liver or kidney function.
4
We investigated how vitamin E impacts the frequency and intensity of hot flashes experienced by menopausal women. The research included a systematic review of multiple studies, focusing on vitamin E and its potential benefits when used alone or alongside omega-3 supplements.
After carefully analyzing data from ten different studies with a total of 1,100 participants, we discovered some interesting insights. Although combining vitamin E with omega-3 showed a significant reduction in the intensity of hot flashes compared to a placebo, vitamin E used alone did not result in notable improvements.
The frequency and intensity of hot flashes in the groups using omega-3 or vitamin E did not differ significantly from those taking a placebo. It's worth mentioning that no serious side effects were noted in any of the studies. However, given the limited number of randomized controlled trials, we believe more research with larger sample sizes is necessary to better understand the isolated effects of vitamin E on hot flashes.
After carefully analyzing data from ten different studies with a total of 1,100 participants, we discovered some interesting insights. Although combining vitamin E with omega-3 showed a significant reduction in the intensity of hot flashes compared to a placebo, vitamin E used alone did not result in notable improvements.
The frequency and intensity of hot flashes in the groups using omega-3 or vitamin E did not differ significantly from those taking a placebo. It's worth mentioning that no serious side effects were noted in any of the studies. However, given the limited number of randomized controlled trials, we believe more research with larger sample sizes is necessary to better understand the isolated effects of vitamin E on hot flashes.
7
We explored the role of vitamin E in alleviating hot flashes among postmenopausal women, focusing on its potential effectiveness in managing this common symptom. The accumulated studies in our review cleverly grouped the findings into three areas: the physical changes related to menopause, the specific warm sensations known as hot flashes, and how vitamin E might interact with vascular health.
Our analysis included a thorough examination of 16 studies, which suggested that vitamin E does have an influence on hot flashes and other menopause-related symptoms. While we found that vitamin E may help ease some of the discomfort associated with menopause, it is essential to note that estrogen therapy generally shows more significant results.
Interestingly, vitamin E could provide a complementary approach for women who cannot use estrogen due to various contraindications. However, further research is needed to solidify these findings and enhance our understanding of how effective vitamin E may be as a standalone treatment.
Our analysis included a thorough examination of 16 studies, which suggested that vitamin E does have an influence on hot flashes and other menopause-related symptoms. While we found that vitamin E may help ease some of the discomfort associated with menopause, it is essential to note that estrogen therapy generally shows more significant results.
Interestingly, vitamin E could provide a complementary approach for women who cannot use estrogen due to various contraindications. However, further research is needed to solidify these findings and enhance our understanding of how effective vitamin E may be as a standalone treatment.
7
Phytoestrogens show symptom relief
We explored how a combination of phytoestrogens, vitamin E, and grapeseed extract can help alleviate menopausal symptoms like hot flashes. This five-month study significantly observed improvements in various symptoms when the subjects followed the treatment protocol crafted from soy germ extracts.
Although we noted a decrease in discomfort such as irritability, anxiety, and hot flashes, it’s essential to point out that the impact of vitamin E alone remains unclear. The dramatic positive changes were particularly evident in premenopausal women.
Overall, the original formula—including vitamin E and phytoestrogens—seems to show promise in supporting women's health during premenopause and surgically induced menopause. As we reflect on the results, it becomes apparent that further investigation is needed to understand vitamin E’s standalone role in managing menopausal symptoms.
Although we noted a decrease in discomfort such as irritability, anxiety, and hot flashes, it’s essential to point out that the impact of vitamin E alone remains unclear. The dramatic positive changes were particularly evident in premenopausal women.
Overall, the original formula—including vitamin E and phytoestrogens—seems to show promise in supporting women's health during premenopause and surgically induced menopause. As we reflect on the results, it becomes apparent that further investigation is needed to understand vitamin E’s standalone role in managing menopausal symptoms.
References
- Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, et al. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022;15. 10.3390/nu15010160
- Yousefi-Nodeh H, Farshbaf-Khalili A, Sadeghzadeh Oskouei B, Jafarilar-Aghdam N, Kazemi-Zanjani N, et al. Curcumin and vitamin E improve hot flashes, lipid profile, and fasting blood glucose without any detrimental effect on the liver and renal function in postmenopausal women: A triple-blind placebo-controlled clinical trial. Health Care Women Int. 2024;45:1184. 10.1080/07399332.2022.2117815
- Maghalian M, Hasanzadeh R, Mirghafourvand M. The effect of oral vitamin E and omega-3 alone and in combination on menopausal hot flushes: A systematic review and meta-analysis. Post Reprod Health. 2022;28:93. 10.1177/20533691221083196
- Anastasiu D, Gluhovschi A, Iordache O, Anderca R, Popescu V, et al. Aspects Regarding the Value of the Treatment of Surgically Induced Menopause with Phytoestrogens - a Postmarketing Surveillance Study (PMSS). Maedica (Bucur). 2021;16:663. 10.26574/maedica.2021.16.4.663
- Bolgova O, Shypilova I, Mavrych V. Natural strategies to optimize estrogen levels in aging women: mini review. Front Aging. 2025;6:1706117. 10.3389/fragi.2025.1706117
- Raccah-Tebeka B, Boutet G, Plu-Bureau G. [Non-hormonal alternatives for the management of menopausal hot flushes. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines]. Gynecol Obstet Fertil Senol. 2021;49:373. 10.1016/j.gofs.2021.03.020
- Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M. The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complement Ther Med. 2020;48:102267. 10.1016/j.ctim.2019.102267
- Rada G, Capurro D, Pantoja T, Corbalán J, Moreno G, et al. Non-hormonal interventions for hot flushes in women with a history of breast cancer. Cochrane Database Syst Rev. 2010. 10.1002/14651858.CD004923.pub2
- Dennehy C, Tsourounis C. A review of select vitamins and minerals used by postmenopausal women. Maturitas. 2010;66:370. 10.1016/j.maturitas.2010.06.003
- Muenstedt K, El-Safadi S. Nutritive Supplements - Help or Harm for Breast Cancer Patients?. Breast Care (Basel). 2010;5:383. PubMed
- Biglia N, Sgandurra P, Peano E, Marenco D, Moggio G, et al. Non-hormonal treatment of hot flushes in breast cancer survivors: gabapentin vs. vitamin E. Climacteric. 2009;12:310. 10.1080/13697130902736921
- Li JJ, Pan AZ, Yi WM. [The effect of gengnianningshentang on treating 72 patients with female climacteric syndrome of fever due to yin-deficiency]. Zhong Yao Cai. 2008;31:628. PubMed
- Loprinzi CL, Barton DL, Sloan JA, Novotny PJ, Dakhil SR, et al. Mayo Clinic and North Central Cancer Treatment Group hot flash studies: a 20-year experience. Menopause. 2008;15:655. 10.1097/gme.0b013e3181679150
- Ziaei S, Kazemnejad A, Zareai M. The effect of vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest. 2007;64:204. PubMed
- Cheema D, Coomarasamy A, El-Toukhy T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. Arch Gynecol Obstet. 2007;276:463. PubMed
- Gold EB, Flatt SW, Pierce JP, Bardwell WA, Hajek RA, et al. Dietary factors and vasomotor symptoms in breast cancer survivors: the WHEL Study. Menopause. 2006;13:423. PubMed
