Overview
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The results showed that this treatment improved cognitive abilities, as evidenced by better performance in behavioral tests and prevented the increase of acetylcholinesterase activity.
Overall, diphenyl diselenide appears to hold promise in mitigating cognitive decline linked to menopause.
While both curcumin and vitamin E were found to significantly reduce hot flashes, they didn’t show any notable benefits for anxiety, sexual function, or other menopausal symptoms. This suggests that vitamin E may be helpful for hot flashes but not for a broader range of menopause-related challenges.
We saw improvements in vaginal health measures in the vitamin E group, suggesting it could be a helpful option for those who prefer to avoid hormone therapy.
However, further research is essential to fully understand its effectiveness.
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After 20 days of treatment, we observed a significant reduction in symptoms such as pain and dryness, with pain incidence decreasing from 16.7% to 11.8% and dryness dropping from 85.5% to 53.8%.
Although Ozoile demonstrated effectiveness in addressing these symptoms, more research is necessary to understand how it compares to other treatments for this condition.
After conducting a comprehensive study, we found that the SEDDS formulation significantly boosted the levels of delta-tocotrienol and was effective in promoting bone strength and health.
While both SEDDS-formulated and unformulated tocotrienol improved bone structure, the SEDDS offered superior results in certain areas, such as trabecular microstructure.
Overall, this suggests a promising path for human trials to further investigate tocotrienol's impact on postmenopausal bone health.
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
The findings suggest that it has positive effects on hot flashes, mood swings, and joint pain, thanks to its anti-inflammatory properties and rich nutrient content, including vitamins, minerals, and selenium.
Importantly, E-MHK-0103 appears to enhance bone health and provides antioxidants, making it an interesting option for women seeking natural relief during menopause.
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Frequently Asked Questions
Menopause is a natural biological process that marks the end of a woman's reproductive years, characterized by the cessation of menstruation and a decline in hormonal levels, particularly estrogen and progesterone. Typically occurring between the ages of 45 and 55, menopause can bring a variety of physical and emotional changes. Common symptoms may include hot flashes, night sweats, mood swings, and changes in sleep patterns. It is important to note that menopause is a gradual process and often begins with perimenopause, where women may experience irregular periods and increased symptoms for several years before periods stop completely.
While menopause is a natural phase of life, it can have significant impacts on a woman's health and well-being. This transition can increase the risk of certain health issues, such as osteoporosis and cardiovascular disease, due in part to lowered hormone levels. Therefore, it is advisable for women to consult with healthcare providers to discuss potential management strategies and lifestyle adjustments during this time. These may include hormone replacement therapy, dietary changes, regular physical activity, and alternative therapies, all aimed at alleviating symptoms and promoting overall health during and after menopause.
Selenium is a powerful and widely used open-source tool designed for automating web applications for testing purposes. It enables developers and testers to write code in various programming languages such as Java, Python, C#, and Ruby to simulate user interactions with a web browser. Selenium's flexibility allows users to create complex test scenarios that mimic real-world user behaviors, making it an essential tool for ensuring web application functionality and performance.
In addition to its core functionalities, Selenium consists of several components, including Selenium WebDriver for automating browsers, Selenium Grid for running tests across multiple machines and environments in parallel, and Selenium IDE for record-and-playback test creation. Its compatibility with multiple browser types—such as Chrome, Firefox, Safari, and Edge—makes it a versatile choice for automated testing, catering to a wide range of projects and team needs. For anyone involved in web development or quality assurance, understanding and utilizing Selenium can significantly improve testing efficiency and reliability.
Based on user reviews, most individuals taking the Selenium Super Complex for menopause report noticeable improvements in symptoms such as hot flashes, mood swings, and overall well-being within a few weeks to a couple of months. For instance, one user mentioned that after a few weeks of taking the supplement, they felt more energetic and stronger (Read Review). Another user experienced a significant reduction in hot flashes after integrating it into their regimen (Read Review).
However, the timeline for results can vary, as some users may find relief more quickly than others. One review highlighted that after switching to this complex alongside other supplements, the individual saw gradual improvements in their symptoms (Read Review). It appears that regular use, along with adherence to recommendations, is key to optimizing benefits from this supplement.
Scientific research does lend support to several supplements indicated for alleviating menopause symptoms. One notable example is E-MHK-0103, which has shown promise in reducing hot flashes, mood swings, and joint pain while also enhancing bone health due to its rich nutrient profile and anti-inflammatory properties [21]. This natural nutraceutical derived from Mytilus galloprovincialis could be a valuable option for women seeking relief from menopausal discomfort.
Additionally, selenium has been connected to improved bone health in postmenopausal women, with findings suggesting that higher dietary intake can lead to better bone mineral density and potentially reduce the risk of osteoporosis [1]. Other studies have also explored various forms of vitamin E, suggesting that it may help with some menopausal symptoms, although not as effectively as traditional hormone therapies [10]. Overall, while some supplements show scientific promise, it's crucial for women to consult healthcare professionals before starting any new supplement regimen to ensure safety and appropriateness for individual health needs.
Users who have tried the Selenium Super Complex report a range of improvements in menopause-related symptoms, particularly regarding hot flashes and mood fluctuations. Many users, such as those with recurrent severe hot flashes, have noted a dramatic reduction or even complete elimination of these discomforts after integrating the complex into their routine (Read Review). Additionally, individuals have found that their overall well-being enhances, leading to a calmer mindset and improved energy levels (Read Review).
Besides hormonal balance, users have also mentioned benefits for skin health and thyroid support, which are crucial during this stage of life. For instance, one user noted a significant improvement in dry skin associated with perimenopause (Read Review). However, it's important to note that results can vary by individual; factors such as dosage adherence and concurrent use of other supplements may influence the effectiveness of the Selenium Super Complex (Read Review). As with any supplement, it’s advisable to consult with a healthcare provider to determine personal suitability and dosage.
Based on user reviews, many individuals taking the Selenium Super Complex alongside other supplements report notable improvements in managing menopause symptoms. One user specifically mentioned integrating selenium with magnesium, omega 3, and biotin, stating that they experienced undeniable benefits for both their hair and overall well-being (Read Review). Others mentioned that the combination of selenium with vitamin E truly enhances their metabolic health and thyroid function, further alleviating symptoms like anxiety and hormonal imbalances (Read Review).
Users seem to find that these combinations not only support the effectiveness of the Selenium Super Complex for hot flashes and mood stabilization but also contribute positively to occasions like weight management and skin health during menopause (Read Review). The overall consensus is that integrating this supplement with others can lead to a more comprehensive approach to tackling menopause-related issues, thus enhancing individual experiences and satisfaction with their health regimen.
Based on user reviews, it appears that there is a consensus on the effective dosage for Selenium when treating menopause symptoms. Several users specifically recommend taking one capsule of a Selenium Super Complex containing three forms of selenium along with vitamin E once daily. This dosage is convenient and is said to provide significant relief from menopause-related symptoms such as hot flashes, anxiety, and hormonal imbalances. For instance, one review mentions that after incorporating this supplement into their routine, they experienced a notable reduction in nighttime waking and an overall improvement in calmness ((Read Review); (Read Review)).
Moreover, the Selenium complex is noted for its antioxidant properties and contributions to thyroid function, which many users find beneficial during menopause. One user highlighted the importance of regular intake, stating that consistent use helped normalize their hormone levels and significantly improve their overall well-being ((Read Review); (Read Review)). Ultimately, this daily dose seems to resonate with users as a manageable and effective approach to alleviating menopause symptoms.
E-MHK-0103’s beneficial properties stem from its high content of vitamins, including vitamin E, and its anti-inflammatory effects. Overall, the findings suggest that this natural treatment may serve as a valuable addition to clinical practice for managing menopause symptoms effectively.
Those who consumed more selenium were less likely to have osteoporosis compared to those with lower intake. This study suggests that increasing selenium in our diet could play a role in preventing osteoporosis as we age.
While vitamin E did show some beneficial effects, such as reducing hot flashes and improving vascular profiles, it was found to be less effective than estrogen. We noted that it could be a supportive option for those unable to use hormones. However, more rigorous research is needed before we make definitive conclusions.
References
- Grili PPDF, Vidigal CV, da Cruz GF, Albergaria BH, Marques-Rocha JL, et al. Dietary consumption of selenium inversely associated with osteoporosis in postmenopausal women. Front Nutr. 2022;9:997414. doi:10.3389/fnut.2022.997414
- Corzo L, Rodriguez S, Alejo R, Fernandez-Novoa L, Aliev G, et al. E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions. Curr Drug Metab. 2017;18:39. doi:10.2174/1389200217666161014151341
- Adriani M, Diarry VI, Abdulah R, Wirjatmadi B. Selenium Intake in Hypertensive and Normotensive Post-Menopausal Indonesian Women. J Nutr Sci Vitaminol (Tokyo). 2015;61:322. doi:10.3177/jnsv.61.322
- da Rocha JT, Pinton S, Mazzanti A, Mazzanti CM, Beckemann DV, et al. Diphenyl diselenide ameliorates cognitive deficits induced by a model of menopause in rats. Behav Pharmacol. 2012;23:98. doi:10.1097/FBP.0b013e32834ed849
- Ha EJ, Smith AM. Selenium-dependent glutathione peroxidase activity is increased in healthy post-menopausal women. Biol Trace Elem Res. 2009;131:90. doi:10.1007/s12011-009-8346-5
- Venditti N, Petronio Petronio G, Guarnieri A, Pietrangelo L, Spicciato A, et al. Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women. Diseases. 2024;12. doi:10.3390/diseases12100237
- Liang G, Kow ASF, Lee YZ, Yusof R, Tham CL, et al. Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice. Biochem Biophys Res Commun. 2024;734:150443. doi:10.1016/j.bbrc.2024.150443
- Ronsini C, Iavarone I, Lacerenza N, Andreoli G, Vastarella MG, et al. Stable Ozonides plus Vitamin E Acetate (Ozoile) for Treatment of Genitourinary Syndrome. Medicina (Kaunas). 2024;60. doi:10.3390/medicina60060880
- Na Takuathung M, Klinjan P, Sakuludomkan W, Dukaew N, Inpan R, et al. Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Clin Med. 2023;12. doi:10.3390/jcm12041326
- Feduniw S, Korczyńska L, Górski K, Zgliczyńska M, Bączkowska M, et al. The Effect of Vitamin E Supplementation in Postmenopausal Women-A Systematic Review. Nutrients. 2022;15. doi:10.3390/nu15010160
- Farshbaf-Khalili A, Ostadrahimi A, Mirghafourvand M, Ataei-Almanghadim K, Dousti S, et al. Clinical Efficacy of Curcumin and Vitamin E on Inflammatory-Oxidative Stress Biomarkers and Primary Symptoms of Menopause in Healthy Postmenopausal Women: A Triple-Blind Randomized Controlled Trial. J Nutr Metab. 2022;2022:6339715. doi:10.1155/2022/6339715
- Porterfield L, Wur N, Delgado ZS, Syed F, Song A, et al. Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials. J Menopausal Med. 2022;28:9. doi:10.6118/jmm.21028
- Mohamad NV, Ima-Nirwana S, Chin KY. Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio. Int J Med Sci. 2021;18:3665. doi:10.7150/ijms.64045
- Mohamad NV, Ima-Nirwana S, Chin KY. Therapeutic potential of annatto tocotrienol with self-emulsifying drug delivery system in a rat model of postmenopausal bone loss. Biomed Pharmacother. 2021;137:111368. doi:10.1016/j.biopha.2021.111368
- Ataei-Almanghadim K, Farshbaf-Khalili A, Ostadrahimi AR, Shaseb E, Mirghafourvand M. The effect of oral capsule of curcumin and vitamin E on the hot flashes and anxiety in postmenopausal women: A triple blind randomised controlled trial. Complement Ther Med. 2020;48:102267. doi:10.1016/j.ctim.2019.102267
- Fait T, Sailer M, Regidor PA. Prospective observational study to evaluate the efficacy and safety of the pollen extract Sérélys in the management of women with menopausal symptoms. Gynecol Endocrinol. 2019;35:360. doi:10.1080/09513590.2018.1538347
- Golmakani N, Parnan Emamverdikhan A, Zarifian A, Sajadi Tabassi SA, Hassanzadeh M. Vitamin E as alternative local treatment in genitourinary syndrome of menopause: a randomized controlled trial. Int Urogynecol J. 2019;30:831. doi:10.1007/s00192-018-3698-z
- Pourafshar S, Johnson SA, Keshavarz B, Feresin RG, Khalil DA, et al. The effects of supplemental vitamin E on hematological parameters in a rat model of ovarian hormone deficiency. Menopause. 2018;25:336. doi:10.1097/GME.0000000000001003
- Parnan Emamverdikhan A, Golmakani N, Tabassi SA, Hassanzadeh M, Sharifi N, et al. A survey of the therapeutic effects of Vitamin E suppositories on vaginal atrophy in postmenopausal women. Iran J Nurs Midwifery Res. 2016;21:475.
- Radzinskii VE, Kuznetsova IV, Uspenskaya YB, Repina NB, Gusak YK, et al. Treatment of climacteric symptoms with an ammonium succinate-based dietary supplement: a randomized, double-blind, placebo-controlled trial. Gynecol Endocrinol. 2016;32:64.
- Corzo L, Rodriguez S, Alejo R, Fernandez-Novoa L, Aliev G, et al. E-MHK-0103 (Mineraxin™): A Novel Nutraceutical with Biological Properties in Menopausal Conditions. Curr Drug Metab. 2017;18:39. doi:10.2174/1389200217666161014151341
