Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
Vitamin D aids hypothyroid complications
Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat.
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
Most Useful Reviews
9
Increased energy
Excellent D3, preferable to other brands. I felt a surge of energy, particularly beneficial for my hypothyroidism. The quality and dosage are great if larger amounts are needed.
Read More
9
Fatigue relief
Vitamin D3 acts almost like a hormone and is vital, especially where sunlight is scarce. I trust Life Extension and find it effective for my hypothyroidism. I take 5000 IU monthly and a maintenance dose of 2000 IU. It greatly reduces my fatigue. Vitamin D is fat-soluble, so I take it with fatty foods.
Read More
7.5
Beneficial dosage
Good dosage and composition. I take it consistently as part of my treatment for hypothyroidism.
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
9
Vitamin D improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
Vitamin D aids Hashimoto's outcomes
Therapeutic effect of vitamin D in Hashimoto's thyroiditis: a prospective, randomized and controlled clinical trial in China.
We aimed to investigate the effects of Vitamin D supplements on women recently diagnosed with Hashimoto's Thyroiditis (HT), a condition that can lead to hypothyroidism. This study was carefully structured as a randomized clinical trial that included a control group for comparison, allowing us to draw clearer conclusions about the effectiveness of Vitamin D.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Read More
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
9
Vitamin D3 and iodine benefits
Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats.
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Excellent D3, preferable to other brands. I felt a surge of energy, particularly beneficial for my hypothyroidism. The quality and dosage are great if larger amounts are needed.
Read More
9
Fatigue relief
Vitamin D3 acts almost like a hormone and is vital, especially where sunlight is scarce. I trust Life Extension and find it effective for my hypothyroidism. I take 5000 IU monthly and a maintenance dose of 2000 IU. It greatly reduces my fatigue. Vitamin D is fat-soluble, so I take it with fatty foods.
Read More
7.5
Beneficial dosage
Good dosage and composition. I take it consistently as part of my treatment for hypothyroidism.
Read More
7.5
No side effects
A good vitamin D that is fish-free, which suits my hypothyroidism condition. It does not lead to swelling or drowsiness.
Read More
7.5
Health benefits
The quality and ingredients are excellent, providing health benefits. It's particularly good for hypothyroidism.
Read More
Frequently Asked Questions
Hypothyroidism is a medical condition that occurs when the thyroid gland, a small butterfly-shaped gland located at the base of the neck, does not produce enough thyroid hormones. These hormones, mainly thyroxine (T4) and triiodothyronine (T3), play a critical role in regulating various bodily functions, including metabolism, energy production, and overall growth and development. When hormone levels drop, it can lead to a slow metabolism, weight gain, fatigue, depression, and a host of other symptoms that can significantly affect quality of life.
The condition can be caused by a variety of factors, including autoimmune diseases like Hashimoto's thyroiditis, certain medications, radiation treatment, or iodine deficiency. Diagnosis typically involves blood tests to check levels of thyroid-stimulating hormone (TSH) and thyroid hormones. Treatment primarily includes hormone replacement therapy, with synthetic thyroid hormones such as levothyroxine being the most common form of treatment. With proper management, individuals with hypothyroidism can lead normal, healthy lives by ensuring they receive the necessary hormones their bodies need to function optimally.
Vitamin D is a fat-soluble vitamin that's essential for maintaining healthy bones and teeth, supporting immune system function, and facilitating normal cell growth and development. It plays a crucial role in calcium absorption in the gut, which is vital for bone health. Unlike most vitamins, our bodies can produce Vitamin D when exposed to sunlight, specifically UVB rays, which is why it’s often referred to as the "sunshine vitamin." However, depending on your geographical location, lifestyle, and skin type, getting sufficient Vitamin D from the sun alone can be challenging, particularly during the winter months.
In addition to sunlight, Vitamin D can be obtained from certain foods such as fatty fish (like salmon and mackerel), fish liver oils, and fortified foods like milk and cereals. Some individuals may also consider supplements, especially if they're at risk for deficiency. Insufficient vitamin D levels are linked to various health issues, including rickets in children, osteomalacia in adults, and even an increased risk of chronic diseases. Regularly checking your vitamin D levels and consulting with a healthcare professional can help ensure you're meeting your needs for optimal health.
While vitamin D is essential for overall health and plays a crucial role in immune function, its direct link to hypothyroidism is still a subject of research. Some studies suggest that there may be a correlation between low vitamin D levels and an increased risk of thyroid problems, including hypothyroidism. This has led some experts to propose that maintaining adequate vitamin D levels could potentially support thyroid function and help in managing the condition, especially since vitamin D is involved in regulating the immune system, which is particularly significant for those with autoimmune thyroid disorders like Hashimoto's thyroiditis.
However, it is important to note that vitamin D supplementation alone is not a treatment for hypothyroidism. If you suspect you have hypothyroidism or are already diagnosed, it’s vital to follow your healthcare provider’s recommendations, which typically include thyroid hormone replacement therapy. Additionally, if you are considering vitamin D supplementation, consult with your healthcare provider to determine the appropriate dosage and ensure it doesn't interfere with any other medications or treatments you may be undergoing.
Based on user reviews, individuals taking Vitamin D3 supplements for hypothyroidism report varying timelines for observing results. Some users suggest that they experienced noticeable improvements in energy levels almost immediately after starting the supplement. For instance, one review highlights a "surge of energy" shortly after beginning the regimen, which suggests results can be felt quickly, especially when managing symptoms like fatigue associated with hypothyroidism Read Review.
Other users have indicated that consistent use is key to reaping the full benefits, advocating for a regular dosage as part of a comprehensive treatment plan. One review notes that after maintaining a specific dosage, individuals found a significant reduction in fatigue Read Review. Therefore, while some might feel an impact in a few days, achieving optimal benefits may take several weeks of consistent intake.
Recent studies suggest that vitamin D supplementation may offer benefits for individuals with hypothyroidism, particularly in those with Hashimoto's thyroiditis. A comprehensive meta-analysis including twelve randomized controlled trials found that vitamin D supplementation can lead to significant reductions in thyroid autoantibodies while enhancing thyroid function, shown by lower TSH levels and higher levels of T3 and T4 [7]. Moreover, clinical trials indicate that vitamin D's effects can be particularly pronounced when treatment duration exceeds 12 weeks [10]. Additionally, research has shown that individuals with hypothyroidism often have lower levels of vitamin D and that maintaining adequate levels may contribute to better thyroid health [6].
However, it's essential to note that despite the promising findings, some studies have reported no significant protective effect of vitamin D against the development of hypothyroidism overall [10]. While vitamin D may be beneficial for thyroid function, particularly in those with deficiencies, more research is warranted to fully understand its role and effectiveness as a treatment for hypothyroidism. Current evidence does not definitively support vitamin D as a standalone treatment but suggests it could be a valuable adjunct in managing hypothyroid-related conditions [2].
Users have reported a range of improvements in symptoms related to their hypothyroidism after incorporating Vitamin D3 into their routine. Many individuals mention a notable increase in energy levels, with one reviewer experiencing an immediate "surge of energy" upon starting the supplement Read Review. Consistent intake is highlighted by several users as essential for maximizing the benefits, with another user stating they found a "greatly reduced" fatigue level after taking regular doses Read Review.
In addition to increased energy, users appreciate the formulation of the supplements, with reports of no adverse effects such as swelling or drowsiness, which can sometimes accompany vitamin supplementation Read Review. Overall, while anecdotal experiences vary, many users feel that Vitamin D3 significantly enhances their quality of life by alleviating specific hypothyroidism-related symptoms.
Users report positive experiences when combining this Vitamin D3 supplement with other treatments for hypothyroidism. One review highlights that the supplement acts almost like a hormone and is vital for individuals, especially those with limited sunlight exposure. A user noted that they take 5000 IU monthly along with a maintenance dose of 2000 IU, which has significantly reduced their fatigue and improved their overall well-being Read Review. Additionally, some individuals integrate the supplement into their broader treatment plan, indicating that consistent intake is essential for optimal results Read Review.
There's also mention of the supplement's compatibility with dietary practices, as users recommend taking it with fatty foods due to its fat-soluble nature. Notably, users have found that using this Vitamin D3 does not lead to adverse effects like swelling or drowsiness, which can be a concern with other vitamin supplements Read Review. Overall, anecdotal reports suggest that combining this Vitamin D3 with other treatments for hypothyroidism can enhance energy levels and improve quality of life.
Users report varying dosages of Vitamin D for managing hypothyroidism, with some finding success at higher doses. One user specifically mentioned taking a higher dose of 5000 IU per month alongside a maintenance dose of 2000 IU, attributing significant reductions in fatigue to this regimen Read Review. Another user emphasized the importance of quality and dosage, noting that larger amounts may be necessary for effective treatment Read Review.
Consistency in taking Vitamin D appears to be a common theme among those reviewing its effects on hypothyroidism, with one user confirming they take their supplementation regularly as part of their treatment Read Review. Overall, users appreciate the health benefits of Vitamin D, particularly in connection with thyroid health, leading to improved energy levels without adverse effects Read Review. However, the optimal dose may vary from person to person depending on individual health status and needs.
9
Increased energy
Excellent D3, preferable to other brands. I felt a surge of energy, particularly beneficial for my hypothyroidism. The quality and dosage are great if larger amounts are needed.
9
Fatigue relief
Vitamin D3 acts almost like a hormone and is vital, especially where sunlight is scarce. I trust Life Extension and find it effective for my hypothyroidism. I take 5000 IU monthly and a maintenance dose of 2000 IU. It greatly reduces my fatigue. Vitamin D is fat-soluble, so I take it with fatty foods.
7.5
No side effects
A good vitamin D that is fish-free, which suits my hypothyroidism condition. It does not lead to swelling or drowsiness.
7.5
Beneficial dosage
Good dosage and composition. I take it consistently as part of my treatment for hypothyroidism.
9
Vitamin D improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
4
Vitamin D shows no significant impact
The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial.
We explored the relationship between vitamin D supplementation and hypothyroidism through the D-Health Trial, a well-structured study involving over 21,000 Australian participants aged 60 and older. This trial randomly assigned participants to receive either a monthly dose of 60,000 international units of vitamin D or a placebo, allowing us to effectively assess any potential benefits of vitamin D on thyroid function.
Our analysis revealed that, during an average follow-up of 4.1 years, 293 participants developed hypothyroidism. Interestingly, the rates were similar between the groups, with 1.5% of those taking vitamin D and 1.7% of those on placebo developing the condition. Overall, vitamin D supplementation did not significantly lower the risk of hypothyroidism, as shown by the hazard ratio of 0.89.
However, we did notice a slight difference when analyzing the data by gender. While there was some evidence suggesting a potential benefit for females (with a hazard ratio of 0.78), no such effect was observed in males. Given the findings, it seems that vitamin D supplementation does not provide a clear protective effect against hypothyroidism overall, although the intriguing trend observed in females deserves further research to better understand its implications.
5
Vitamin D's role in hypothyroidism
EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS.
We conducted a case-control study to understand how vitamin D levels relate to hypothyroidism. This involved 90 participants from Baghdad, split into two groups. One group included 60 people with hypothyroidism, while the other had 30 healthy individuals for comparison.
We measured the serum levels of vitamin D, TSH, T3, T4, and anti-TPO using advanced testing methods. Our findings revealed that patients with hypothyroidism had significantly lower levels of vitamin D, T3, and T4 compared to the healthy group. In contrast, their TSH and anti-TPO levels were much higher.
Interestingly, we discovered a notable negative correlation between vitamin D and T3 levels, while TSH showed a significant positive correlation with vitamin D. However, the relationship between vitamin D and T4, as well as anti-TPO, was weak and not statistically significant.
Overall, our study suggests that low vitamin D levels might play a role in hypothyroidism among the Iraqi population we examined. While this sheds light on the importance of vitamin D, more research is needed to determine if increasing vitamin D could effectively treat hypothyroidism.
9
Vitamin D aids hypothyroid complications
Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat.
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
References
Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
Rastegar-Moghaddam SH, Akbarian M, Rajabian A, Alipour F, Hojjati Shargh A, et al. Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat. Naunyn Schmiedebergs Arch Pharmacol. 2024. 10.1007/s00210-024-03593-8
Krysiak R, Kowalcze K, Szkróbka W, Okopień B. The Association between Vitamin D Status and the Impact of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Subclinical Hypothyroidism. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16081093
Maneewan S, Manosroi W, Jesadaporn P, Phimphilai M, Tipduangta P. Effect of Vitamin D Supplementation on Muscle Function in Patients With I131-Induced Hypothyroidism: A Pilot Randomized Trial. J Endocr Soc. 2024;8:bvae072. 10.1210/jendso/bvae072
Donayeva A, Kulzhanova D, Amanzholkyzy A, Abdelazim IA, Abilov T, et al. Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study. Prz Menopauzalny. 2023;22:186. 10.5114/pm.2023.133280
Abdulateef M, Hilal N, Abdul-Aziz M. EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS. Georgian Med News. 2023.
Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. 10.1097/MD.0000000000036759
Kuroda K, Horikawa T, Moriyama A, Ojiro Y, Takamizawa S, et al. Therapeutic efficacy of the optimization of thyroid function, thrombophilia, immunity and uterine milieu (OPTIMUM) treatment strategy on pregnancy outcomes after single euploid blastocyst transfer in advanced age women with recurrent reproductive failure. Reprod Med Biol. 2023;22:e12554. 10.1002/rmb2.12554
Jiang X, Huang Y, Li Y, Xia Y, Liu L, et al. Therapeutic effect of vitamin D in Hashimoto's thyroiditis: a prospective, randomized and controlled clinical trial in China. Am J Transl Res. 2023;15:6234.
Waterhouse M, Pham H, Rahman ST, Baxter C, Duarte Romero B, et al. The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial. Thyroid. 2023;33:1302. 10.1089/thy.2023.0317
Bhakat B, Pal J, Das S, Charaborty SK, SircarMedical NR. A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis. J Assoc Physicians India. 2023;71:1.
Liu Q, Zhang Y, Zhao H, Yao X. Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats. Front Physiol. 2021;12:669652. 10.3389/fphys.2021.669652
ElRawi HA, Ghanem NS, ElSayed NM, Ali HM, Rashed LA, et al. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. J Thyroid Res. 2019;2019:3583250. 10.1155/2019/3583250
Ucan B, Sahin M, Sayki Arslan M, Colak Bozkurt N, Kizilgul M, et al. Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism. Int J Vitam Nutr Res. 2016;86:9. 10.1024/0300-9831/a000269
Anaraki PV, Aminorroaya A, Amini M, Feizi A, Iraj B, et al. Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. J Res Med Sci. 2017;22:5. 10.4103/1735-1995.199090
Mansournia N, Mansournia MA, Saeedi S, Dehghan J. The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis. J Endocrinol Invest. 2014;37:473. 10.1007/s40618-014-0064-y
Kemmochi S, Fujimoto H, Woo GH, Hirose M, Nishikawa A, et al. Preventive effects of calcitriol on the development of capsular invasive carcinomas in a rat two-stage thyroid carcinogenesis model. J Vet Med Sci. 2011;73:655.