Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Good
Based on 9 Reviews
8.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D (as cholecalciferol)
125 mcg
625%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
9.5
We looked into the growing concern of iodine deficiency hypothyroidism among children in the United States. This condition, which can lead to cognitive and physical impairments, was thought to be largely eliminated thanks to universal salt iodization started in the 1920s. However, recent trends suggest that iodine deficiency could be reappearing due to increased use of noniodized salts, lower iodine levels in dairy, and dietary restrictions like veganism or food allergies.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
Read More
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
Vitamin D aids hypothyroid complications
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
Most Useful Reviews
7.5
Increased energy levels
14 people found this helpful
I switched to a simpler iodine with vitamin K and appreciate the capsule size, which is easy to swallow. The vegetable iodine dosage is high, but not fully absorbed due to my hypothyroidism. My endocrinologist approved its use, and I take it alongside selenium for better absorption. After three months, I feel increased energy and recommend it.
Read More
9
Preventing deficiencies
1 people found this helpful
Elena Kornilova recommends this Live Extension product. It contains a good dosage of D3 and iodine, crucial for pregnant women to prevent hypothyroidism. Deficiency can lead to severe health issues. Iodine comes from various sources, and the recommended daily dose varies.
Read More
7.5
Improved vitality
1 people found this helpful
This vitamin D and iodine supplement, recommended by my nutritionist, comes in small capsules that I find easy to swallow. The dosage is appropriate for my hypothyroidism, and I've felt a significant increase in efficiency and vitality while taking it. I strongly recommend it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9.5
We looked into the growing concern of iodine deficiency hypothyroidism among children in the United States. This condition, which can lead to cognitive and physical impairments, was thought to be largely eliminated thanks to universal salt iodization started in the 1920s. However, recent trends suggest that iodine deficiency could be reappearing due to increased use of noniodized salts, lower iodine levels in dairy, and dietary restrictions like veganism or food allergies.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
Over an 18-month period, we documented a series of cases where three children were diagnosed with iodine deficiency hypothyroidism despite having no underlying thyroid dysfunction. Their clinical presentations varied significantly—some had large goiters while others showed mild or no goiter at all. The results of their biochemical tests also highlighted a range of thyroid-stimulating hormone elevations.
Importantly, all patients returned to normal thyroid function following iodine supplementation. We propose that measuring spot urine iodine levels alongside elevated serum thyroglobulin could serve as a simpler and effective diagnostic approach, moving away from the more complex 24-hour urinary iodine tests. Our findings shine a light on the necessity of addressing iodine deficiency in today’s dietary landscape.
Read More
9.5
We explored the impact of iodine treatment on hypothyroidism, particularly focusing on a unique case involving a patient who had undergone total entero-colectomy. In this situation, standard methods of administering iodine, such as oral supplements, proved ineffective due to absorption challenges. Our approach utilized ethiodized oil, an iodine-rich contrast agent, which we injected intramuscularly.
We observed that this method not only addressed the patient's goiter but also sustained normal thyroid function for more than five years. The long half-life of ethiodized oil made it an ideal option for patients reliant on parenteral nutrition, who often struggle with iodine deficiency.
This study highlights a promising alternative for individuals facing similar nutritional challenges due to severe digestive issues. Overall, our findings suggest that tailored iodine administration could offer a viable solution for hypothyroidism linked to dietary deficiencies.
We observed that this method not only addressed the patient's goiter but also sustained normal thyroid function for more than five years. The long half-life of ethiodized oil made it an ideal option for patients reliant on parenteral nutrition, who often struggle with iodine deficiency.
This study highlights a promising alternative for individuals facing similar nutritional challenges due to severe digestive issues. Overall, our findings suggest that tailored iodine administration could offer a viable solution for hypothyroidism linked to dietary deficiencies.
Read More
9
Vitamin D aids hypothyroid complications
We investigated how vitamin D supplementation affects hypothyroidism, focusing on its impact on heart and kidney health. In our study, we used forty male Wistar rats, dividing them into four groups: control, hypothyroid, and hypothyroid treated with two doses of vitamin D. After six weeks, we examined various biochemical markers and evaluated fibrosis in the heart and kidneys.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Our findings revealed that hypothyroidism led to an increase in markers of kidney damage, like creatinine and urea, alongside elevated levels of oxidative stress markers in both heart and kidney tissues. Interestingly, we noticed that vitamin D treatment significantly reduced these harmful effects. The administration of vitamin D improved oxidative stress levels and decreased fibrosis in the heart and kidneys.
In conclusion, our study underlines the potential of vitamin D as a beneficial therapeutic option for alleviating some complications associated with hypothyroidism, particularly concerning tissue fibrosis and oxidative stress. This reinforces the idea that vitamin D could play a vital role in managing health issues related to thyroid hormone deficits.
Read More
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
Read More
9
We aimed to investigate the effects of Vitamin D supplements on women recently diagnosed with Hashimoto's Thyroiditis (HT), a condition that can lead to hypothyroidism. This study was carefully structured as a randomized clinical trial that included a control group for comparison, allowing us to draw clearer conclusions about the effectiveness of Vitamin D.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Increased energy levels
14 people found this helpful
I switched to a simpler iodine with vitamin K and appreciate the capsule size, which is easy to swallow. The vegetable iodine dosage is high, but not fully absorbed due to my hypothyroidism. My endocrinologist approved its use, and I take it alongside selenium for better absorption. After three months, I feel increased energy and recommend it.
Read More
9
Preventing deficiencies
1 people found this helpful
Elena Kornilova recommends this Live Extension product. It contains a good dosage of D3 and iodine, crucial for pregnant women to prevent hypothyroidism. Deficiency can lead to severe health issues. Iodine comes from various sources, and the recommended daily dose varies.
Read More
7.5
Improved vitality
1 people found this helpful
This vitamin D and iodine supplement, recommended by my nutritionist, comes in small capsules that I find easy to swallow. The dosage is appropriate for my hypothyroidism, and I've felt a significant increase in efficiency and vitality while taking it. I strongly recommend it.
Read More
9
Effective assimilation
This vitamin is excellent for my needs. It is well absorbed, and my deficiency is improving. With hypothyroidism, the added iodine is beneficial.
Read More
6
Essential for thyroid
1 people found this helpful
I appreciate the iodine content, as it is vital for my thyroid gland due to my hypothyroidism.
Read More
Frequently Asked Questions
7.5
Increased energy levels
14 people found this helpful
I switched to a simpler iodine with vitamin K and appreciate the capsule size, which is easy to swallow. The vegetable iodine dosage is high, but not fully absorbed due to my hypothyroidism. My endocrinologist approved its use, and I take it alongside selenium for better absorption. After three months, I feel increased energy and recommend it.
7.5
Health improvement
After suffering from severe vitamin D deficiency, I noticed substantial health and mood improvements since taking D3 from Life Extension, which includes iodine. This compound supports my thyroid function, essential for my hypothyroidism.
9
Effective assimilation
This vitamin is excellent for my needs. It is well absorbed, and my deficiency is improving. With hypothyroidism, the added iodine is beneficial.
9
Stable thyroid levels
Despite differing opinions, I take this with autoimmune thyroiditis and hypothyroidism. My TSH levels remain stable, and I’ve raised my vitamin D levels significantly after years of taking other supplements.
7.5
Improved vitality
1 people found this helpful
This vitamin D and iodine supplement, recommended by my nutritionist, comes in small capsules that I find easy to swallow. The dosage is appropriate for my hypothyroidism, and I've felt a significant increase in efficiency and vitality while taking it. I strongly recommend it.
9
Preventing deficiencies
1 people found this helpful
Elena Kornilova recommends this Live Extension product. It contains a good dosage of D3 and iodine, crucial for pregnant women to prevent hypothyroidism. Deficiency can lead to severe health issues. Iodine comes from various sources, and the recommended daily dose varies.
7
Vitamin D and hypothyroidism explored
We conducted a thoughtful exploration into how vitamin D and other micronutrients might influence hypothyroidism, particularly looking at thyroid function, metabolism, and quality of life. In this double-blind, randomized controlled trial, we involved 104 patients who were already receiving levothyroxine for their hypothyroidism. They were split into two groups; one received a combination of micronutrients, including vitamin D, while the other group received a placebo.
After eight weeks, we observed some impacts on insulin resistance and quality of life among those receiving the micronutrient supplement, suggesting that these nutrients could play a role in improving overall well-being in hypothyroid patients. However, while vitamin D is part of the treatment, we found it challenging to isolate its direct effect due to its combination with other nutrients.
Ultimately, while our findings indicate potential benefits, they also emphasize the need for further clinical trials to confirm these results and better understand the role of vitamin D in managing hypothyroidism.
After eight weeks, we observed some impacts on insulin resistance and quality of life among those receiving the micronutrient supplement, suggesting that these nutrients could play a role in improving overall well-being in hypothyroid patients. However, while vitamin D is part of the treatment, we found it challenging to isolate its direct effect due to its combination with other nutrients.
Ultimately, while our findings indicate potential benefits, they also emphasize the need for further clinical trials to confirm these results and better understand the role of vitamin D in managing hypothyroidism.
8
We aimed to understand how vitamin D, specifically measured as 25(OH)D, correlates with hypothyroidism in adolescents. Our study involved 180 participants from West Kazakhstan, and we carefully analyzed their blood samples for key indicators, including thyroid-stimulating hormone (TSH) and free thyroxine (T4).
The results were quite striking. We found that adolescents with low levels of vitamin D had significantly higher TSH levels and lower free T4 levels compared to those with normal vitamin D levels. Our data indicated that those who were vitamin D deficient were more likely to have both subclinical and clinical hypothyroidism.
Additionally, there was a noteworthy negative correlation between vitamin D levels and TSH, meaning as vitamin D decreased, TSH increased. Conversely, a positive correlation between vitamin D and free T4 suggested that higher vitamin D levels are associated with better thyroid function.
While this study shows a definite link between vitamin D deficiency and hypothyroidism in adolescents, it does not directly establish vitamin D treatment as a solution. The findings highlight the importance of maintaining adequate vitamin D levels for potential thyroid health, yet further research is needed to explore treatment effectiveness.
The results were quite striking. We found that adolescents with low levels of vitamin D had significantly higher TSH levels and lower free T4 levels compared to those with normal vitamin D levels. Our data indicated that those who were vitamin D deficient were more likely to have both subclinical and clinical hypothyroidism.
Additionally, there was a noteworthy negative correlation between vitamin D levels and TSH, meaning as vitamin D decreased, TSH increased. Conversely, a positive correlation between vitamin D and free T4 suggested that higher vitamin D levels are associated with better thyroid function.
While this study shows a definite link between vitamin D deficiency and hypothyroidism in adolescents, it does not directly establish vitamin D treatment as a solution. The findings highlight the importance of maintaining adequate vitamin D levels for potential thyroid health, yet further research is needed to explore treatment effectiveness.
5
We conducted a case-control study to understand how vitamin D levels relate to hypothyroidism. This involved 90 participants from Baghdad, split into two groups. One group included 60 people with hypothyroidism, while the other had 30 healthy individuals for comparison.
We measured the serum levels of vitamin D, TSH, T3, T4, and anti-TPO using advanced testing methods. Our findings revealed that patients with hypothyroidism had significantly lower levels of vitamin D, T3, and T4 compared to the healthy group. In contrast, their TSH and anti-TPO levels were much higher.
Interestingly, we discovered a notable negative correlation between vitamin D and T3 levels, while TSH showed a significant positive correlation with vitamin D. However, the relationship between vitamin D and T4, as well as anti-TPO, was weak and not statistically significant.
Overall, our study suggests that low vitamin D levels might play a role in hypothyroidism among the Iraqi population we examined. While this sheds light on the importance of vitamin D, more research is needed to determine if increasing vitamin D could effectively treat hypothyroidism.
We measured the serum levels of vitamin D, TSH, T3, T4, and anti-TPO using advanced testing methods. Our findings revealed that patients with hypothyroidism had significantly lower levels of vitamin D, T3, and T4 compared to the healthy group. In contrast, their TSH and anti-TPO levels were much higher.
Interestingly, we discovered a notable negative correlation between vitamin D and T3 levels, while TSH showed a significant positive correlation with vitamin D. However, the relationship between vitamin D and T4, as well as anti-TPO, was weak and not statistically significant.
Overall, our study suggests that low vitamin D levels might play a role in hypothyroidism among the Iraqi population we examined. While this sheds light on the importance of vitamin D, more research is needed to determine if increasing vitamin D could effectively treat hypothyroidism.
9
We conducted a thorough exploration of how vitamin D supplementation can affect hypothyroidism, particularly in patients with Hashimoto's thyroiditis (HT). Our findings draw from a meta-analysis of twelve randomized controlled trials, involving a total of 862 participants. These studies compared the effects of vitamin D against placebo or no treatment, focusing on various thyroid function indicators and autoantibodies.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
The results were promising. We found that vitamin D supplementation significantly reduced the levels of anti-thyroid antibodies, specifically thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin antibodies (TG-Ab). Additionally, it appeared to enhance thyroid function by lowering thyroid-stimulating hormone (TSH) levels and increasing free triiodothyronine (FT3) and free thyroxine (FT4) levels.
Notably, we observed that active forms of vitamin D, like calcitriol, were more effective in reducing TPO-Ab compared to the more common D2 and D3 forms. We also noted that longer treatment durations, particularly those exceeding 12 weeks, led to greater improvements in thyroid hormone levels and antibody reductions.
Overall, our study suggests that vitamin D may play a beneficial role in managing Hashimoto’s thyroiditis, potentially helping to modulate immune responses and improve thyroid function.
9
We aimed to investigate the effects of Vitamin D supplements on women recently diagnosed with Hashimoto's Thyroiditis (HT), a condition that can lead to hypothyroidism. This study was carefully structured as a randomized clinical trial that included a control group for comparison, allowing us to draw clearer conclusions about the effectiveness of Vitamin D.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
Over six months, we observed that women receiving Vitamin D experienced significant health benefits. Specifically, those treated saw a notable decrease in Thyroid Peroxidase Antibody (TPOAb) levels, which is a marker of thyroid inflammation. Additionally, markers of thyroid function, such as Free Triiodothyronine (FT3) and Free Thyroxine (FT4), increased, while Thyroid-Stimulating Hormone (TSH) levels decreased. This combination of changes suggests that Vitamin D can help slow the progression of hypothyroidism and enhance thyroid function.
Overall, these findings indicate that Vitamin D supplementation can be a useful adjunct in managing Hashimoto's Thyroiditis, potentially leading to improved health outcomes for patients with this condition.
References
- Nikkhah M, Vafa M, Abiri B, Golgiri F, Sarbakhsh P, et al. The Effect of Some Micronutrients Multi-Supplementation on Thyroid Function, Metabolic Features and Quality of Life in Patients Treating With Levothyroxine and Vitamin D: A Double-blind, Randomized Controlled Trial. Med J Islam Repub Iran. 2024;38:133. 10.47176/mjiri.38.133
- Rastegar-Moghaddam SH, Akbarian M, Rajabian A, Alipour F, Hojjati Shargh A, et al. Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat. Naunyn Schmiedebergs Arch Pharmacol. 2024. 10.1007/s00210-024-03593-8
- Krysiak R, Kowalcze K, Szkróbka W, Okopień B. The Association between Vitamin D Status and the Impact of Metformin on Hypothalamic-Pituitary-Thyroid Axis Activity in Women with Subclinical Hypothyroidism. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16081093
- Maneewan S, Manosroi W, Jesadaporn P, Phimphilai M, Tipduangta P. Effect of Vitamin D Supplementation on Muscle Function in Patients With I131-Induced Hypothyroidism: A Pilot Randomized Trial. J Endocr Soc. 2024;8:bvae072. 10.1210/jendso/bvae072
- Donayeva A, Kulzhanova D, Amanzholkyzy A, Abdelazim IA, Abilov T, et al. Relationship between vitamin D and adolescents' hypothyroidism - a cross-sectional study. Prz Menopauzalny. 2023;22:186. 10.5114/pm.2023.133280
- Abdulateef M, Hilal N, Abdul-Aziz M. EVALUATION OF VITAMIN D SERUM LEVELS AND THYROID FUNCTION TEST IN HYPOTHYROIDISM IRAQI PATIENTS. Georgian Med News. 2023.
- Tang J, Shan S, Li F, Yun P. Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis. Medicine (Baltimore). 2023;102:e36759. 10.1097/MD.0000000000036759
- Kuroda K, Horikawa T, Moriyama A, Ojiro Y, Takamizawa S, et al. Therapeutic efficacy of the optimization of thyroid function, thrombophilia, immunity and uterine milieu (OPTIMUM) treatment strategy on pregnancy outcomes after single euploid blastocyst transfer in advanced age women with recurrent reproductive failure. Reprod Med Biol. 2023;22:e12554. 10.1002/rmb2.12554
- Jiang X, Huang Y, Li Y, Xia Y, Liu L, et al. Therapeutic effect of vitamin D in Hashimoto's thyroiditis: a prospective, randomized and controlled clinical trial in China. Am J Transl Res. 2023;15:6234.
- Waśniowska J, Piątkowska E, Pawlicki P, Smoleń S, Kopeć A, et al. Comparative Analysis of Iodine Levels, Biochemical Responses, and Thyroid Gene Expression in Rats Fed Diets with Kale Biofortified with 5,7-Diiodo-8-Quinolinol. Int J Mol Sci. 2025;26. 10.3390/ijms26020822
- Cox SE, Wakeling J, Hall T, Williams TL. Survival of radioiodine treated hyperthyroid cats that are euthyroid and hypothyroid after treatment, and effect of levothyroxine supplementation on survival time of cats with iatrogenic hypothyroidism. J Vet Intern Med. 2025;39:e17295. 10.1111/jvim.17295
- He J, Dong Y, Chen X, Wang S, Shen Z, et al. Hypothyroidism induced by excessive-iodine is associated in humans with altered hsa-miR-199a-5p/HIF-1α axis and thyroglobulin. J Nutr Biochem. 2025;138:109841. 10.1016/j.jnutbio.2025.109841
- Seetharaman S, Sasidharan Pillai S, Ganta A, Millington K, Quintos JB, et al. Iodine Deficiency Hypothyroidism Among Children in the United States - 21st Century Resurgence?. AACE Clin Case Rep. 2024;10:236. 10.1016/j.aace.2024.08.003
- Chielens L, Nauwynck E, Bourgeois S, Staels W, Vanbesien J, et al. A Belgian single centre outcome study of radioiodine treatment in adolescents with Graves' disease. Sci Rep. 2024;14:31063. 10.1038/s41598-024-82052-z
- Belaid S, Raghu V, Alissa F, Rudolph J. Long lasting effect of intramuscular iodine injection in the treatment of goiter in an intestinal failure patient with complete entero-colectomy. JPGN Rep. 2024;5:561. 10.1002/jpr3.12117
