' 
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Directly addresses anxiety treatment.
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
8
Folate shows potential in anxiety treatment
Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation.
Study focuses on folate's effects
This study investigated how folic acid (FA), a vitamin commonly recommended during pregnancy, can support mental health by reducing anxiety and depression symptoms. We looked at the effects of FA in a mouse model subjected to postnatal immune activation—an event known to increase the likelihood of developing neuropsychiatric disorders later in life.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
Read More
Most Useful Reviews
8.8
Memory improvement
I've found the one! My memory, anxiety, and energy levels have notably improved after only two days of taking this product. I look forward to seeing the results over a few weeks or months. Keep up the excellent work!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.3
- All Researches
8
Folic acid alleviates pain-induced anxiety
Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats.
Addresses folic acid for anxiety relevance
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Read More
8
Folic acid aids anxiety treatment
A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice.
Study shows combined therapy benefits
A recent study explored how a combination of chlorzoxazone and folic acid can influence anxiety and cognitive functions. The research focused on SCA3-84Q mice, which exhibit anxiety, memory decline, and signs of low mood due to a genetic condition known as spinocerebellar ataxia type 3.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
Read More
8
Folic acid eases withdrawal symptoms
Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats.
Moderate relevance due to treatment overlap
We explored the impact of folic acid (FA) on anxiety and depressive-like behaviors in adolescent male rats following nicotine withdrawal. In our study, we divided the rats into groups that received either a nicotine treatment or a vehicle control, then observed their behavior as they experienced withdrawal.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
Read More
8
Folate shows potential in anxiety treatment
Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation.
Study focuses on folate's effects
This study investigated how folic acid (FA), a vitamin commonly recommended during pregnancy, can support mental health by reducing anxiety and depression symptoms. We looked at the effects of FA in a mouse model subjected to postnatal immune activation—an event known to increase the likelihood of developing neuropsychiatric disorders later in life.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
Read More
8
Vitamin B12 may reduce anxiety
Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.
Directly addresses anxiety treatment.
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Memory improvement
I've found the one! My memory, anxiety, and energy levels have notably improved after only two days of taking this product. I look forward to seeing the results over a few weeks or months. Keep up the excellent work!
