Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7
USERS' SCORE
Good
Based on 9 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
Top Medical Research Studies
2
We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.
This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.
Read More
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
Most Useful Reviews
7.5
Fights depression effectively
50 people found this helpful
EXCELLENT RESULT! If you consume little fresh greens and spinach, this supplement is essential. The folic acid here is vital for women’s health, supporting all organs, revitalising the cardiovascular system, and aiding in youthfulness. Vitamin B12, combined with folic acid, is effective against depression, fatigue, and irritability. These vitamins are interconnected, so it's best to take them together. I highly recommend this product! Thank you very much for your recommendation!
Read More
9
Revitalises overall health
11 people found this helpful
Recommended for cardiovascular issues, sleep disturbances, and depression, this health formula, comprising vitamins B12 and B9, is invaluable. Just one capsule daily can rejuvenate the body. These vitamins are essential for various body functions, including blood production and sleep regulation, and folate notably contributes to serotonin production, hence serving as a potential antidepressant.
Read More
9
Effective depression support
I read a research publication stating that a daily intake of 400mg of folate significantly alleviates depression. This product is perfect for that purpose and is also very easy to take, as it dissolves quickly in the mouth.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7
- All Researches
9.5
We explored the impact of vitamin B12 supplementation on patients experiencing symptoms like depression, fatigue, and neuropathic pain—often linked with rheumatic diseases. Through our review of three case studies, we found that when these patients received vitamin B12 treatment, many of their depressive symptoms significantly improved.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
The findings suggest that vitamin B12 may play a crucial role in alleviating not just physical discomfort, but also mental health issues like depression, which can accompany rheumatic conditions. Despite the patients initially presenting normal vitamin B12 levels in lab tests, the supplementation showed almost complete resolution of their symptoms, highlighting that clinical evaluations should not solely depend on blood test results.
In summary, we recommend that healthcare professionals consider assessing vitamin B12 levels early on when diagnosing rheumatic diseases and think about supplementation even if serum levels appear adequate. This approach might offer a straightforward and effective option for improving patients' quality of life.
Read More
9
This research delves into the question of how vitamin B12 impacts stress resilience and depression. Utilizing a chronic variable stress mouse model, we identified changing gene activity linked to stress resilience after vitamin B12 treatment. By employing advanced techniques like RNA sequencing, we found that vitamin B12 plays a role in altering the way certain genes, particularly one called Ttr, are expressed under stress.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
We specifically observed that Ttr, or transthyretin, is influenced by vitamin B12 in a way that appears distinct for different sexes. Our findings indicated that postmortem samples from male patients with depression showed elevated levels of TTR in their brains, while no similar difference was noted in females. Further experimentation demonstrated that manipulating Ttr in the brains of stressed mice led to changes in behavior associated with stress and depression, along with alterations in brain structure and the expression of other related genes.
Notably, when stressed mice received vitamin B12, it appeared to reduce DNA methylation (a chemical modification that can regulate gene activity) in the region controlling Ttr. This led us to establish a clear connection between Ttr’s regulation and behaviors associated with chronic stress. Overall, our work suggests that vitamin B12 supplementation may stimulate mechanisms tied to stress resilience, sparking interest in dietary interventions as a means to combat mood disorders.
Read More
9
We explored the relationship between vitamin B12 levels and major depressive disorder (MDD) by examining serum vitamin B12, homocysteine (Hcy), and blood profiles in 59 patients diagnosed with MDD. The severity of depression was evaluated using the HAM-D scale, which allows for a clear understanding of how vitamin B12 might be linked to depressive symptoms.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Our findings revealed that vitamin B12 was deficient or depleted in all patients. The average level of serum vitamin B12 was significantly lower in those experiencing severe depression. Furthermore, we observed that the mean Hcy level was high among the participants, compared to normal reference ranges. Interestingly, we noted that patients who included non-vegetarian foods in their diet had higher median levels of vitamin B12.
Overall, our results indicate that there’s a notable correlation between vitamin B12 deficiency and the severity of MDD. Hcy levels were also elevated in these patients. Importantly, the study highlighted that depressive symptoms might appear before the more recognized blood-related manifestations of vitamin B12 deficiency. Thus, our observations suggest that addressing vitamin B12 status could be relevant in managing depressive disorders.
Read More
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Read More
8
We explored how a combination of chlorzoxazone, a medication that activates potassium channels, and folic acid affects anxiety and depression in a mouse model of spinocerebellar ataxia type 3 (SCA3). Specifically, we investigated whether this combination could improve mood and cognitive function in SCA3-84Q mice, which are known to exhibit symptoms linked to cerebellar cognitive affective syndrome.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Our results indicated that both chlorzoxazone and the combination with folic acid positively influenced motor coordination and cerebellar function. However, it was only the combination treatment that significantly alleviated anxiety and depressive symptoms, while also enhancing recognition memory in these mice. This suggests that while chlorzoxazone alone has benefits, the added folic acid plays a crucial role in addressing mood-related issues.
Overall, our findings underline the importance of combining therapies to target both motor and non-motor symptoms in complex conditions like SCA3. This combination approach could be beneficial for developing future treatments that address the full spectrum of the disease's impact on individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Fights depression effectively
50 people found this helpful
EXCELLENT RESULT! If you consume little fresh greens and spinach, this supplement is essential. The folic acid here is vital for women’s health, supporting all organs, revitalising the cardiovascular system, and aiding in youthfulness. Vitamin B12, combined with folic acid, is effective against depression, fatigue, and irritability. These vitamins are interconnected, so it's best to take them together. I highly recommend this product! Thank you very much for your recommendation!
Read More
9
Revitalises overall health
11 people found this helpful
Recommended for cardiovascular issues, sleep disturbances, and depression, this health formula, comprising vitamins B12 and B9, is invaluable. Just one capsule daily can rejuvenate the body. These vitamins are essential for various body functions, including blood production and sleep regulation, and folate notably contributes to serotonin production, hence serving as a potential antidepressant.
Read More
9
Effective depression support
I read a research publication stating that a daily intake of 400mg of folate significantly alleviates depression. This product is perfect for that purpose and is also very easy to take, as it dissolves quickly in the mouth.
Read More
7.5
Improves mental health
1 people found this helpful
I regularly consume folic acid, this time with vitamin B12. The brand's quality is excellent; small capsules containing clinically studied forms of both vitamins yield noticeable results. Vitamin B12 effectively combats depression and fatigue, while folic acid supports women's longevity.
Read More
9
Stops pain effectively
Vitamin B12 is vital for pain management and prevents pernicious anemia, heart attack, and stroke. It aids in treating nervous disorders, anemia, depression, and hypertension. The quality is superb, and ingredients are natural, making this supplement highly beneficial.
Read More
Frequently Asked Questions
9
Revitalises overall health
11 people found this helpful
Recommended for cardiovascular issues, sleep disturbances, and depression, this health formula, comprising vitamins B12 and B9, is invaluable. Just one capsule daily can rejuvenate the body. These vitamins are essential for various body functions, including blood production and sleep regulation, and folate notably contributes to serotonin production, hence serving as a potential antidepressant.
9
Effective depression support
I read a research publication stating that a daily intake of 400mg of folate significantly alleviates depression. This product is perfect for that purpose and is also very easy to take, as it dissolves quickly in the mouth.
8
Optimises brain function
The B9 and B12 vitamins are crucial for enhancing brain, nerve, and circulatory health. Vitamin B12 aids in reducing fatigue, optimises memory, and is involved in neurotransmitter production vital for preventing depression. Folate helps with cell processes and red blood cell maturation, making these vitamins essential for overall wellness.
7.5
Fights depression effectively
50 people found this helpful
EXCELLENT RESULT! If you consume little fresh greens and spinach, this supplement is essential. The folic acid here is vital for women’s health, supporting all organs, revitalising the cardiovascular system, and aiding in youthfulness. Vitamin B12, combined with folic acid, is effective against depression, fatigue, and irritability. These vitamins are interconnected, so it's best to take them together. I highly recommend this product! Thank you very much for your recommendation!
6
Essential for women
1 people found this helpful
Vitamin B9, or folic acid, is critical for women's health and preserving youthfulness. This combination with vitamin B12 effectively combats depression, fatigue, and irritability. These B vitamins work together, which simplifies their intake. I strongly recommend them.
7.5
Improves mental health
1 people found this helpful
I regularly consume folic acid, this time with vitamin B12. The brand's quality is excellent; small capsules containing clinically studied forms of both vitamins yield noticeable results. Vitamin B12 effectively combats depression and fatigue, while folic acid supports women's longevity.
7
We explored how different levels of depressive symptoms could influence folate levels in the body, focusing on findings from the NHANES database collected between 2017 and 2020. Our analysis involved nearly 5,000 participants and examined their serum and erythrocyte folate levels in relation to the severity of their depressive symptoms.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
Through linear regression models and logistic regression validation, we observed a clear connection between depression and reduced folate levels. Individuals with moderate depression were found to have significantly lower serum folate levels, while those with major depression showed decreased erythrocyte folate levels.
This highlights an important aspect of managing depression; we need to pay attention to the nutritional intake of those affected. As these patients often struggle with dietary habits, providing folic acid supplements could be valuable, particularly for those experiencing moderate to severe depression. This approach may contribute positively to their overall mental health care.
7
We conducted a study aiming to explore how low-dose methylfolate could improve treatment outcomes for patients struggling with depressive disorder when paired with standard antidepressants. In our open-label clinical trial, we involved 44 participants who received one of several evidence-based antidepressant treatments over four weeks.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
Those in the experimental group also received 800 µg of methylfolate daily. Throughout the study, we measured improvements in depressive symptoms using the Patient Health Questionnaire-9 at various intervals. This approach allowed us to gauge changes in their scores over time, as well as remission rates and other important factors.
The results indicated that combining methylfolate with antidepressants could be a promising and safe strategy for treating depression. We noticed improvements, suggesting that this combination might help enhance the effectiveness of traditional antidepressants. However, it's essential to remember that as we continued our research, we couldn't isolate the effects of methylfolate alone, making it hard to draw definitive conclusions about its standalone benefits.
8
We conducted an umbrella meta-analysis to explore how folate affects depression. By sifting through various studies up to October 2023 from multiple databases like PubMed and Scopus, we wanted to find a clear answer regarding folate supplementation's role in alleviating depressive symptoms.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
Our analysis included 11 relevant studies, out of which 8 underwent a quantitative review. The findings were promising: folate supplementation showed a significant reduction in depressive symptoms, with results suggesting an effect size that indicates moderate improvement. Specifically, the standardized mean difference was -0.42, and the weighted mean difference was -3.20, demonstrating a notable benefit with very little variability between studies.
Additionally, we found that those with low folate levels had a 35% higher chance of experiencing depression compared to their counterparts with adequate levels. This suggests a strong link between folate insufficiency and depressive symptoms.
Overall, our findings support the idea that folate supplementation could be an effective adjunct treatment when combined with standard depression therapies, providing individuals with another tool to manage their mental health.
References
- Yang Y, Qi H, Zhang J, Jia J, Yang Y, et al. Evaluating the association of depressive symptoms on serum folate and erythrocyte folate levels based on the 2017-2020 NHANES database. Front Nutr. 2025;12:1505700. doi:10.3389/fnut.2025.1505700
- Siddique A, Khokhar MM, Waheed A, Naeem U, Aziz SA. Effect of combination therapy of methylfolate with antidepressants in patients with depressive disorder. BMC Pharmacol Toxicol. 2025;26:14. doi:10.1186/s40360-025-00846-x
- Guo Q, Wang Y, Guo L, Xu K, Shang S. Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study. Clin Nutr ESPEN. 2025;65:50. doi:10.1016/j.clnesp.2024.11.021
- Xiong Y, Zhou G, Zhou L, Guo M, Lu H. Serum molecules of the folate-driven one-carbon cycle as indicators of depressive tendencies in the elderly. Heliyon. 2024;10:e36980. doi:10.1016/j.heliyon.2024.e36980
- Liu M, Wang G, Jiang C. Independent and combined effect of serum copper and folate on depression: cross-sectional data from the NHANES 2011-2016. Front Nutr. 2024;11:1389480. doi:10.3389/fnut.2024.1389480
- Gao S, Khalid A, Amini-Salehi E, Radkhah N, Jamilian P, et al. Folate supplementation as a beneficial add-on treatment in relieving depressive symptoms: A meta-analysis of meta-analyses. Food Sci Nutr. 2024;12:3806. doi:10.1002/fsn3.4073
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. doi:10.1093/hmg/ddae079
- Lv P, Xiang F, Zhang S, Lei D, Zhou C, et al. Valeriana jatamansi jones improves depressive behavior in CUMS mice by modulating vitamin B12-related ileal homeostasis. J Ethnopharmacol. 2025;342:119392. doi:10.1016/j.jep.2025.119392
- Alzahrani H. Assessment of Vitamin B12 Efficacy on Cognitive Memory Function and Depressive Symptoms: A Systematic Review and Meta-Analysis. Cureus. 2024;16:e73350. doi:10.7759/cureus.73350
- Zhang J, Liao Q, Chen H, Liu F, Sun D, et al. Association of Vitamin B12 and Polymorphism of with Early-Onset Post-Stroke Depression. Neuropsychiatr Dis Treat. 2024;20:2289. doi:10.2147/NDT.S480417
- Stein G, Aly JS, Manzolillo A, Lange L, Riege K, et al. Transthyretin Orchestrates Vitamin B12-Induced Stress Resilience. Biol Psychiatry. 2025;97:54. doi:10.1016/j.biopsych.2024.07.009
- Hui J, Zhang N, Kang M, Gou Y, Liu C, et al. Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study. Nutrients. 2024;16. doi:10.3390/nu16132042
- Harikaran S, Basu S, Mukherjee MP, Kar R, Nair S, et al. Vitamin B12 and homocysteine in patients with major depressive disorder. J Family Med Prim Care. 2024;13:2049. doi:10.4103/jfmpc.jfmpc_1460_23
- Gao Y, Yang J, Sun H, Zhou H. Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial. BMC Oral Health. 2024;24:603. doi:10.1186/s12903-024-04318-2
- Cruz-Rodríguez J, Canals-Sans J, Hernández-Martínez C, Arija V. Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study. J Reprod Infant Psychol. 2024. doi:10.1080/02646838.2024.2324043
- Reis da Silva T. Can supplementing vitamin B12 improve mental health outcomes?: a literature review. Br J Community Nurs. 2024;29:137. doi:10.12968/bjcn.2024.29.3.137
- Dułak NA, Rytlewska M, Jaskólska M, Chmielewski M. A new perspective on vitamin B12 deficiency in rheumatology: a case-based review. Rheumatol Int. 2024;44:737. doi:10.1007/s00296-024-05539-y
- Tan Y, Zhou L, Gu K, Xie C, Wang Y, et al. Correlation between Vitamin B12 and Mental Health in Children and Adolescents: A Systematic Review and Meta-analysis. Clin Psychopharmacol Neurosci. 2023;21:617. doi:10.9758/cpn.22.1040
