To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
8
Vitamin K2 may support bone health
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
Read More
9
MK-4 enhances bone health
Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling.
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
Most Useful Reviews
9
Promotes bone health
333 people found this helpful
Crucial vitamin for heart and bone health. MK-7 (Menaquinone-7) is an enhanced form of Vitamin K2 that promotes bone health and helps prevent osteoporosis without side effects. I prefer this brand as Jarrow is highly reputable. The suggested intake is one softgel daily, either with food or on an empty stomach. MK-7 helps the body build bone naturally.
Read More
9
Essential for osteoporosis
55 people found this helpful
It’s crucial to take Vitamin K2 alongside high doses of D3, especially over 5000 IU. K2 improves calcium absorption and helps prevent conditions like osteoporosis. I recommend taking one capsule with breakfast.
Read More
9
Increased bone density
18 people found this helpful
This product, combined with others like Vitamin D3, has effectively supported my osteoporosis management. My recent DEXA scan indicated increased bone density, showing that I’m building bone rather than losing it.
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
Read More
9
MK-4 enhances bone health
Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling.
We explored the effects of menaquinone-4 (MK-4), a form of vitamin K, on osteoporosis in ovariectomized mice. In this study, groups of female mice received various treatments for 12 weeks, including MK-4 at different doses.
Our findings revealed that MK-4 significantly boosted bone mineral density and improved bone structure compared to untreated mice. It also promoted bone formation while reducing bone resorption.
Overall, this research highlights the potential of MK-4 as a promising treatment option for osteoporosis.
Read More
9
Vitamin K2 enhances osteoporosis treatment
Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis.
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
Read More
9
UBIAD1 crucial for bone growth
Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice.
We explored the role of UBIAD1, an enzyme crucial for converting dietary vitamin K into its active form, MK-4, in the context of bone health and osteoporosis. The study involved a special mouse model where UBIAD1 was intentionally disabled from the first week of life. This allowed us to observe the effects of reduced UBIAD1 activity on bone development.
Our findings revealed that mice lacking UBIAD1 had significantly shorter femurs and lower bone mineral density, indicating a detrimental effect on bone formation. Additionally, we noticed that the production of important proteins involved in forming both bone and cartilage was markedly decreased in these mice. Further experiments on cultured chondrocytes—the cells responsible for cartilage—showed that their differentiation was also impaired without UBIAD1.
These results suggest that UBIAD1 is vital for promoting healthy bone and cartilage growth, underscoring its potential importance in treating osteoporosis. While the study focuses on the enzyme's role, it highlights how vitamin K2 may support bone health through its influence on UBIAD1 activity.
Read More
9
Vitamin K2 promotes bone health
Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells.
We aimed to investigate how vitamin K2 (VK2), a small but powerful nutrient, can enhance osteogenic differentiation, which is crucial for bone health and may help counteract osteoporosis. Using C3H10 T1/2 clone 8 cells, we examined the effects of VK2 on various markers associated with bone generation.
Our results showed that VK2 significantly boosted alkaline phosphatase activity and increased levels of key osteogenic indicators such as osteocalcin and RUNX2. We also conducted RNA sequencing to identify how VK2 triggers these changes, uncovering numerous genes that were impacted by its administration.
Notably, we found that VK2 not only elevated signals associated with bone formation but also influenced specific signaling pathways. It seemed to work by reducing the expression of STAT1 through the Bcl-6 and IL-6/JAK signaling pathways. This means that VK2 may enhance bone growth by modulating the intricate network of biological signals involved in bone development.
Overall, our findings suggest that vitamin K2 could play a beneficial role in promoting bone health through its action on crucial biological pathways, hinting at its potential as a supportive treatment for osteoporosis.
Crucial vitamin for heart and bone health. MK-7 (Menaquinone-7) is an enhanced form of Vitamin K2 that promotes bone health and helps prevent osteoporosis without side effects. I prefer this brand as Jarrow is highly reputable. The suggested intake is one softgel daily, either with food or on an empty stomach. MK-7 helps the body build bone naturally.
Read More
9
Essential for osteoporosis
55 people found this helpful
It’s crucial to take Vitamin K2 alongside high doses of D3, especially over 5000 IU. K2 improves calcium absorption and helps prevent conditions like osteoporosis. I recommend taking one capsule with breakfast.
Read More
9
Increased bone density
18 people found this helpful
This product, combined with others like Vitamin D3, has effectively supported my osteoporosis management. My recent DEXA scan indicated increased bone density, showing that I’m building bone rather than losing it.
Read More
9
Support for osteoporosis
13 people found this helpful
This is an excellent product for osteoporosis. My healthcare provider recommends it for me and my mother, and I feel that this MK-7 formula significantly aids my condition.
Read More
9
Excellent results
10 people found this helpful
Works well. I have osteoporosis and take this to ensure calcium accumulates in my bones rather than elsewhere. The results have been excellent thus far. Prescription medications prevent bone loss but hinder new bone growth, leading to spontaneous breaks, as happened to my mother. I sought an alternative.
Osteoporosis is a medical condition characterized by weakened bones, making them fragile and more prone to fractures. This condition occurs when the body loses too much bone mass, doesn't make enough bone, or a combination of both. As bones lose density, they can break more easily, often as a result of minor falls or injury. Osteoporosis is often referred to as a "silent disease" because bone loss occurs without any symptoms until a fracture occurs, often in the hip, spine, or wrist.
Risk factors for developing osteoporosis include age, gender (it’s more common in women), family history, low body weight, and certain medical conditions and medications. Lifestyle choices such as smoking, excessive alcohol consumption, and a diet low in calcium and vitamin D can also contribute to bone loss. Regular weight-bearing exercise, ensuring adequate nutrition, and, in some cases, medications can help prevent or manage osteoporosis. If you believe you may be at risk, it is important to consult with a healthcare professional for appropriate screening and intervention options.
Vitamin K is a fat-soluble vitamin crucial for various bodily functions, particularly in the clotting process of blood. It exists in two primary forms: K1 (phylloquinone), which is primarily found in leafy green vegetables like spinach and kale, and K2 (menaquinone), which is found in fermented foods and certain animal products. Vitamin K plays a significant role in the synthesis of proteins that regulate blood coagulation and is also essential for bone metabolism, assisting in the binding of calcium to bones and other tissues.
Deficiencies in vitamin K can lead to increased bleeding and bruising, and in severe cases, it may contribute to bone weakness. While most people can obtain adequate amounts of vitamin K through a balanced diet rich in vegetables and fermented foods, those with certain medical conditions or who are on specific medications may require monitoring and supplementation. Incorporating a variety of nutrient-dense foods into your diet is the best way to ensure you get enough vitamin K for optimal health.
Vitamin K has garnered attention for its potential role in bone health, particularly in relation to osteoporosis. Research suggests that vitamin K can help in the regulation of calcium in the bones, which is essential for maintaining bone density. Several studies indicate that adequate intake of vitamin K may support bone mineralization and reduce the risk of fractures in individuals with osteoporosis. However, while some evidence supports its benefits, more extensive clinical trials are needed to establish a definitive causal relationship and determine the optimal dosage.
If you’re considering adding a vitamin K supplement to your osteoporosis management plan, it’s crucial to discuss this with your healthcare provider. They can provide personalized advice based on your health status, dietary needs, and any other medications you might be taking, particularly anticoagulants, as vitamin K can interact with blood-thinning medications. Overall, while vitamin K appears to play a supportive role in bone health, it should be viewed as part of a comprehensive approach that includes a balanced diet, regular weight-bearing exercise, and, when necessary, prescribed medications to effectively manage osteoporosis.
Based on user reviews, the timeline for seeing results from using Vitamin K2, particularly MK-7, for osteoporosis can vary significantly. Some users report improvement in bone density after a year of consistent use of the supplement in combination with Vitamin D3 and other treatments. For instance, one user mentioned that after a year of taking Jarrow MK-7 alongside Prolia, their bone density improved, which surprised their doctors Read Review. Others, however, talk about noticing benefits related to calcium absorption and overall bone health in a shorter period, sometimes just weeks to months, highlighting that every individual's response may differ depending on their specific health conditions and adherence to the regimen Read Review.
Overall, most users advocate for the combination of MK-7 with Vitamin D3 to enhance its effectiveness in addressing osteoporosis. Many share that maintaining a regular intake will lead to gradual improvements, and in some cases, users have reported significant changes within a few months of starting the supplement Read Review. Therefore, while a timeframe can be suggested, results will depend on individual factors such as lifestyle, other medications, and overall health.
Research indicates that vitamin K, particularly in its K2 forms like MK-4 and MK-7, shows promise in supporting bone health and potentially managing osteoporosis. Several studies have highlighted vitamin K2's role in improving bone mineral density and reducing fracture risks in postmenopausal women. For instance, a comprehensive review of studies involving over 6,400 participants found that vitamin K2 supplementation positively influences lumbar spine bone density, suggesting its effectiveness as a nutritional supplement for osteoporosis management [10]. Additionally, combining vitamin K2 with other treatments like teriparatide has been shown to further enhance bone density and overall bone health outcomes [17].
However, while studies report various benefits associated with vitamin K2, the effects can vary based on individual health conditions and the combination with other therapies. For example, a study on postmenopausal women indicated only modest improvements in bone structure when vitamin K2 was added to existing osteoporosis treatments [4]. Thus, while vitamin K2 has potential efficacy for bone health, more extensive research is required to fully understand its long-term benefits and optimal use in osteoporosis management. In summary, vitamin K2 supplementation seems to be a beneficial option worth considering, particularly for those at risk of or currently managing osteoporosis [11].
Users report a variety of improvements in their osteoporosis symptoms after incorporating Vitamin K2 (MK-7) into their supplement regimen. Many have noted significant enhancements in bone density, with one user sharing that their DEXA scan results confirmed increased bone density and the transition from bone loss to bone building Read Review. Others have experienced better calcium absorption, which helps to target osteoporosis more effectively while preventing unnecessary calcium build-up Read Review. Additionally, some users reported reduced pain and discomfort in joints and a general improvement in their bone health after a few weeks of consistent use Read Review.
Users also emphasize the importance of combining MK-7 with Vitamin D3 to maximize its benefits. Several reviews highlight how the supplement supports not just bone health but also overall well-being, including improved mood and energy levels Read Review. Users have expressed trust in their healthcare providers’ recommendations to prioritize MK-7 for osteoporosis management, and some advocate for its long-term use as a reliable preventative measure Read Review. However, results can vary based on individual health conditions and consistency in taking the supplement, underscoring the need for a personalized approach to supplementation.
Users report significant benefits from combining Vitamin K2 (MK-7) with other supplements, particularly Vitamin D3, to manage osteoporosis effectively. Many reviews highlight that the synergy between K2 and D3 enhances calcium absorption, thereby improving bone density and reducing the risk of osteoporosis-related fractures Read Review. For example, one user mentions that after adding MK-7 to their regimen alongside D3, their recent DEXA scan showed an increase in bone density, indicating positive outcomes in osteoporosis management Read Review. Others have also noted that a combination of these supplements has led to improvements in joint comfort and overall bone health, reinforcing the value of a tailored supplementation approach Read Review.
Additionally, users have reported taking MK-7 with calcium and magnesium for optimal bone health synergy, which underscores the significance of adding multiple supportive nutrients to their supplementation routine Read Review. The emphasis on taking these vitamins together, especially at higher doses of D3, suggests that users perceive this combination as crucial in targeting osteoporosis and ensuring effective calcium utilization within the bones Read Review. Overall, the user insights point to a well-rounded approach to osteoporosis supplementation that should be personalized and could yield promising results.
Based on user reviews, it appears that the right dose of Vitamin K2, specifically in the form of MK-7, for treating osteoporosis typically falls around 90 micrograms. Users like those who have shared their experiences with Jarrow MK-7 emphasize that this dosage is effective for improving calcium absorption and overall bone health, particularly when combined with Vitamin D3. For instance, one user noted that they take 90 mcg of MK-7 alongside high doses of D3 (5000 IU or more) to support osteoporosis prevention effectively Read Review.
Several reviewers also highlighted their success with this combination, reporting improved bone density and reduced osteoporosis symptoms after incorporating this dosage into their routine Read Review. Additionally, testimonials emphasized the importance of having Vitamin K2 to facilitate calcium's movement to the bones and teeth, thereby enhancing its therapeutic efficacy against osteoporosis Read Review. This synergy between MK-7 and Vitamin D not only boosts calcium absorption but also seems crucial for users managing their bone health.
9
Stable bone density
8 people found this helpful
Vitamin K2 has been beneficial for my osteoporosis. Despite doctors suggesting various treatments with poor results, I started taking Jarrow MK-7 alongside Prolia. After a year, my bone density improved, surprising my doctors. I believe natto has helped.
9
Enhanced calcium absorption
5 people found this helpful
This product has greatly improved my calcium absorption, which was previously inefficient. With MK-7, I am now targeting osteoporosis more effectively, preventing unnecessary calcium build-up.
9
Increased bone density
18 people found this helpful
This product, combined with others like Vitamin D3, has effectively supported my osteoporosis management. My recent DEXA scan indicated increased bone density, showing that I’m building bone rather than losing it.
7.5
Reduced back pain
15 people found this helpful
I've been taking Vitamin K2 in cycles for osteoporosis prevention. I've experienced less back pain and joint discomfort since starting this supplement, which I will continue to use.
9
High bioavailability
1 people found this helpful
Wonderful! Gold Vitamin K2 MK-7 is an active, highly bioavailable form. This fat-soluble vitamin is essential for protein synthesis, bone, and connective tissue strength, calcium absorption, and ensuring the interaction between calcium and vitamin D3. I've raised my vitamin D3 levels significantly, experiencing improved mood and energy. I highly recommend this supplement!
9
Essential vitamin support
1 people found this helpful
Excellent! This essential vitamin should be taken with vitamin D. It helps prevent osteoporosis and fractures while reducing inflammation risk. Vitamin K2 improves bone health, particularly in postmenopausal women.
9
Essential for osteoporosis
55 people found this helpful
It’s crucial to take Vitamin K2 alongside high doses of D3, especially over 5000 IU. K2 improves calcium absorption and helps prevent conditions like osteoporosis. I recommend taking one capsule with breakfast.
6
Supports osteoporosis treatment
1 people found this helpful
The benefits of vitamin K2 include assisting in building strong bones, facilitating calcium's movement to bones and teeth, and reducing the risk of osteoporosis. MK-7 has a significantly higher absorption rate than K1 from spinach, aiding specific bone protein carboxylation. I combine it with 90mcg K2 mk7, 2mg k2 mk4, 5000-10000IU Vitamin D3, 300mg Magnesium, and 3mg Boron for bone health synergy. However, the bovine gelatin softgel is unsuitable for vegetarians. After a few days, I noticed skin acne, likely due to the gelatin.
9
Vascular benefits noted
Excellent! Taking high doses of vitamin D3 above 5000 IU and MK-7 vitamin K2 is vital as a preventive measure against osteoporosis. It enhances vascular elasticity, aids blood clotting, and improves calcium absorption.
7.5
Good osteoporosis insurance
1 people found this helpful
I started using Jarrow MK-7 years ago for its benefits for bone health. MK-7 is a quality ingredient, and being post-menopausal with a family history of osteoporosis, I consider a combination of fat-soluble vitamins, calcium, and exercise as good protection. The price for Jarrow’s product is reasonable, especially from iHerb.
8
Vitamin K2 may support bone health
Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials.
We delved into the effects of vitamin K2 on postmenopausal osteoporosis by reviewing data from 16 randomized controlled trials with over 6,400 participants.
Our analysis revealed that vitamin K2 supplementation positively influences bone mineral density, particularly in the lumbar spine, and can potentially lower fracture rates.
However, while we noted improvements in bone density, the overall difference in fracture incidence was not consistently significant. Importantly, vitamin K2 seems to reduce certain serum markers without increasing adverse reactions, making it a promising option for maintaining bone health in postmenopausal women.
9
Vitamin K2 enhances osteoporosis treatment
Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis.
We aimed to understand how vitamin K2 influences osteoporosis, especially when combined with another treatment known as recombinant human parathyroid hormone 1-34 (rhPTH (1-34)).
In this study, 77 postmenopausal women with osteoporosis were divided into two groups. One group received vitamin K2 alone, while the other group was treated with a combination of rhPTH (1-34) and vitamin K2. Over the course of the treatment, we looked closely at changes in bone mineral density (BMD), pain levels, and various markers related to bone metabolism, as well as any potential side effects.
Both treatments were effective in improving key parameters like BMD and pain scores. However, the combination therapy significantly outperformed vitamin K2 alone in enhancing BMD and other important markers. Importantly, we found no significant increase in adverse reactions with the combined treatment, which suggests that it is a safe option.
Ultimately, our findings indicate that while vitamin K2 has a positive effect, its benefits were notably enhanced when used alongside rhPTH (1-34). This synergy may offer a promising pathway for more effective osteoporosis management.
4
Vitamin K shows modest hip geometry effects
The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.
We evaluated how vitamin K supplementation could impact fracture risk in post-menopausal women with osteoporosis, particularly when paired with bisphosphonates, calcium, and vitamin D. Although our study involved 105 women and used rigorous methods, we found no significant improvements in bone density or turnover.
Interestingly, vitamin K did show a modest effect on hip geometry, suggesting some potential benefits in this area. However, to truly understand its effectiveness, further studies are necessary to confirm these findings.
9
Vitamin K2 supports BMD in osteoporosis
Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review.
To explore vitamin K2's effect on osteoporosis, we conducted a thorough analysis of nine studies involving 6,853 participants.
The findings suggest that vitamin K2 significantly improves bone mineral density (BMD) and reduces certain bone markers.
While there were increased adverse reactions, they were not serious. Overall, this suggests that vitamin K2 can be a beneficial and safe option for postmenopausal women managing osteoporosis.
References
Ding F, Zhang W, Liu T, Rong X, Cui Y, et al. MK-4 Ameliorates Diabetic Osteoporosis in Angiogenesis-Dependent Bone Formation by Promoting Mitophagy in Endothelial Cells. Drug Des Devel Ther. 2025;19:2173. doi:10.2147/DDDT.S503930
Wang Q, Yu H, Kong Y. Association of vitamins with bone mineral density and osteoporosis measured by dual-energy x-ray absorptiometry: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:69. doi:10.1186/s12891-024-07173-y
Öz İ, Kochai A, Avan YL, Keskin D, Çınar BM, et al. The effect of pharmacological treatment in combination with vitamin K on healing in an experimental rat model of osteoporosis. Jt Dis Relat Surg. 2023;34:356. doi:10.52312/jdrs.2023.911
Moore AE, Dulnoan D, Voong K, Ayis S, Mangelis A, et al. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Arch Osteoporos. 2023;18:83. doi:10.1007/s11657-023-01288-w
Li C, Liang C, Kong Z, Su Y, Ren W, et al. Determination of Vitamin K1, MK-4, MK-7, and D Levels in Human Serum of Postmenopausal Osteoporosis Women Based on High Stability LC-MS/MS: MK-7 May Be a New Marker of Bone Metabolism. Ann Nutr Metab. 2023;79:334. doi:10.1159/000531065
Giordani C, Matacchione G, Giuliani A, Valli D, Scarpa ES, et al. Pro-Osteogenic and Anti-Inflammatory Synergistic Effect of Orthosilicic Acid, Vitamin K2, Curcumin, Polydatin and Quercetin Combination in Young and Senescent Bone Marrow-Derived Mesenchymal Stromal Cells. Int J Mol Sci. 2023;24. doi:10.3390/ijms24108820
Lee AS, Sung MJ, Son SJ, Han AR, Hong SM, et al. Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor B Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss. J Med Food. 2023;26:128. doi:10.1089/jmf.2022.K.0078
Jin C, Tan K, Yao Z, Lin BH, Zhang DP, et al. A Novel Anti-Osteoporosis Mechanism of VK2: Interfering with Ferroptosis via AMPK/SIRT1 Pathway in Type 2 Diabetic Osteoporosis. J Agric Food Chem. 2023;71:2745. doi:10.1021/acs.jafc.2c05632
Tao X, Xu T, Liu L, Lin X, Zhang Z, et al. Case report: Clinical characteristics and treatment of secondary osteoporosis induced by X-linked congenital adrenal dysplasia. Front Endocrinol (Lausanne). 2022;13:961322. doi:10.3389/fendo.2022.961322
Ma ML, Ma ZJ, He YL, Sun H, Yang B, et al. Efficacy of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: A systematic review and meta-analysis of randomized controlled trials. Front Public Health. 2022;10:979649. doi:10.3389/fpubh.2022.979649
Zhou M, Han S, Zhang W, Wu D. Efficacy and safety of vitamin K2 for postmenopausal women with osteoporosis at a long-term follow-up: meta-analysis and systematic review. J Bone Miner Metab. 2022;40:763. doi:10.1007/s00774-022-01342-6
Zhang W, Li L, Zhou X, Li K, Liu C, et al. Concurrent Treatment with Vitamin K2 and D3 on Spine Fusion in Patients with Osteoporosis-Associated Lumbar Degenerative Disorders. Spine (Phila Pa 1976). 2022;47:352. doi:10.1097/BRS.0000000000004309
Mandatori D, Penolazzi L, Pelusi L, Lambertini E, Michelucci F, et al. Three-Dimensional Co-Culture System of Human Osteoblasts and Osteoclast Precursors from Osteoporotic Patients as an Innovative Model to Study the Role of Nutrients: Focus on Vitamin K2. Nutrients. 2021;13. doi:10.3390/nu13082823
Wang H, Zhang N, Li L, Yang P, Ma Y. Menaquinone 4 Reduces Bone Loss in Ovariectomized Mice through Dual Regulation of Bone Remodeling. Nutrients. 2021;13. doi:10.3390/nu13082570
Wang B, Tang J, Weng S, Chen L, Wu Z, et al. Is vitamin K a treatment choice for atypical femoral fractures in patients with secondary osteoporosis?. J Int Med Res. 2021;49:3000605211001643. doi:10.1177/03000605211001643
Solmaz I, Ozdemir MA, Unal E, Abdurrezzak U, Muhtaroglu S, et al. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study. J Pediatr Endocrinol Metab. 2021;34:441. doi:10.1515/jpem-2020-0637
Zhang Z, Xia K, Gong W, Mai R, Liu P, et al. Efficacy of Recombinant Human Parathyroid Hormone 1-34 and Vitamin K2 Combination Therapy in Postmenopausal Osteoporosis. Horm Metab Res. 2025;57:33. doi:10.1055/a-2371-1642
Hirashima S, Kiyooka Y, Kaetsu S, Nakagawa K. Vitamin K converting enzyme UBIAD1 plays an important role in osteogenesis and chondrogenesis in mice. Biochem Biophys Res Commun. 2024;702:149635. doi:10.1016/j.bbrc.2024.149635
Kong M, Gao C, Luan X, Fan C, Hao M, et al. Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis. BMC Musculoskelet Disord. 2024;25:109. doi:10.1186/s12891-024-07227-1
Skalny AV, Aschner M, Tsatsakis A, Rocha JBT, Santamaria A, et al. Role of vitamins beyond vitamin D in bone health and osteoporosis (Review). Int J Mol Med. 2024;53. doi:10.3892/ijmm.2023.5333
Cui Y, Zhang W, Yang P, Zhu S, Luo S, et al. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Free Radic Biol Med. 2023;206:33. doi:10.1016/j.freeradbiomed.2023.06.022
Wang H, Li L, Zhang N, Ma Y. Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6 and IL-6/JAK in C3H10 T1/2 Clone 8 Cells. Nutrients. 2022;14. doi:10.3390/nu14142934
Jadhav N, Ajgaonkar S, Saha P, Gurav P, Pandey A, et al. Molecular Pathways and Roles for Vitamin K2-7 as a Health-Beneficial Nutraceutical: Challenges and Opportunities. Front Pharmacol. 2022;13:896920. doi:10.3389/fphar.2022.896920
Hu L, Ji J, Li D, Meng J, Yu B. The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials. J Orthop Surg Res. 2021;16:592. doi:10.1186/s13018-021-02728-4