Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 11 Reviews
8.3
Supplement Facts
Serving Size: 2 Gummies
Amount Per Serving
%DV
Calories
20
Total Carbohydrate
4 g
1%*
Total Sugars
3 g
**
Includes 3 g Added Sugars
6%*
Sodium
5 mg
<1%
Melatonin
10 mg
**
Top Medical Research Studies
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
Read More
Most Useful Reviews
10
Changed routine
I purchased these gummies for my son, diagnosed with autism, to help settle him at bedtime. They've transformed our routine; he sleeps so much better now, taking two at 6.30pm and going to bed at 8pm. He sleeps more deeply until woken at 7am, and his mood has improved significantly.
Read More
9
Improved sleep pattern
My child with autism struggled with irregular sleep patterns. After having one gummy before bed, he now sleeps all night and enjoys the taste, making it easy for him to take.
Read More
9
Highly recommended
We used it for a child with autism in the second grade, who had trouble sleeping. Now he finds it much easier to sleep, enjoys the flavour, and the gummy size is perfect. I highly recommend it for children on the spectrum.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
8
We examined the link between insomnia and Autism Spectrum Disorder (ASD), particularly how melatonin can help manage sleep issues in affected children. The analysis, conducted by a team of experts, emphasized the importance of understanding sleep challenges to improve treatment outcomes for both kids and their caregivers.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Read More
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Read More
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We conducted a detailed look into sleep-related rhythmic movement disorder (SR-RMD) in children, involving data from 66 patients at a UK hospital.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
Changed routine
I purchased these gummies for my son, diagnosed with autism, to help settle him at bedtime. They've transformed our routine; he sleeps so much better now, taking two at 6.30pm and going to bed at 8pm. He sleeps more deeply until woken at 7am, and his mood has improved significantly.
Read More
9
Improved sleep pattern
My child with autism struggled with irregular sleep patterns. After having one gummy before bed, he now sleeps all night and enjoys the taste, making it easy for him to take.
Read More
9
Highly recommended
We used it for a child with autism in the second grade, who had trouble sleeping. Now he finds it much easier to sleep, enjoys the flavour, and the gummy size is perfect. I highly recommend it for children on the spectrum.
Read More
9
Undisputed benefit
Excellent! These help me sleep easily and are a valuable ally for autism. I take one per dose, and the benefit combined with the flavour is undeniable.
Read More
9
Helps settle grandsons
Great! These really help settle both my grandsons who have autism. If only they were consistently available, as they were out of stock last month.
Read More
Frequently Asked Questions
7.5
Mixed results
I received these after a previous order went missing. I mainly bought them for my kids, who have difficulty sleeping, especially our oldest on the spectrum. Within days, I noticed results. Initially, they were hesitant to try something new, but since they enjoy gummy vitamins, it wasn't an issue. Our youngest falls asleep in about 30 minutes after just one. I also find myself getting sleepy within 30 minutes of taking them. However, our oldest often takes longer to fall asleep, possibly due to her autism.
10
Changed routine
I purchased these gummies for my son, diagnosed with autism, to help settle him at bedtime. They've transformed our routine; he sleeps so much better now, taking two at 6.30pm and going to bed at 8pm. He sleeps more deeply until woken at 7am, and his mood has improved significantly.
9
Improved sleep pattern
My child with autism struggled with irregular sleep patterns. After having one gummy before bed, he now sleeps all night and enjoys the taste, making it easy for him to take.
6
Effective sleep aid
Works well. I have children with autism, and instead of purchasing expensive mixed medications, my paediatrician recommended melatonin, which has the same effect. The children can switch off and fall asleep.
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
5
We explored the effects of melatonin supplements, physical exercise, and their combination on sleep quality in children with autism spectrum disorder (ASD). Sixty-two children participated, assigned to groups receiving cycling, melatonin, both, or a placebo.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
7
Melatonin improves liver function in autism
We explored a study that examined how melatonin might help alleviate liver issues in a mouse model of autism known as BTBR. The researchers looked at various liver-related problems, including oxidative stress and inflammation, comparing the BTBR mice to healthy controls.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
References
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. doi:10.1016/j.sleep.2024.05.046
- Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, et al. Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis. Int J Mol Sci. 2024;25. doi:10.3390/ijms25021086
- Zhang Q, Li F, Li T, Lin J, Jian J, et al. Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO Rep. 2024;25:570. doi:10.1038/s44319-023-00036-y
- Wang L, Xu M, Wang Y, Wang F, Deng J, et al. Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder. Neural Regen Res. 2024;19:1618. doi:10.4103/1673-5374.387973
- Tse ACY, Lee PH, Sit CHP, Poon ET, Sun F, et al. Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD. J Autism Dev Disord. 2024;54:4456. doi:10.1007/s10803-023-06172-7
- Sadeh H, Meiri G, Zigdon D, Ilan M, Faroy M, et al. Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances. Child Adolesc Psychiatry Ment Health. 2023;17:123. doi:10.1186/s13034-023-00669-w
- Joels H, Benny A, Sharpe A, Postigo B, Joseph B, et al. Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. Sleep Med. 2023;112:21. doi:10.1016/j.sleep.2023.09.020
- Dong S, Kifune T, Kato H, Wang L, Kong J, et al. Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder. Biochem Biophys Res Commun. 2023;681:7. doi:10.1016/j.bbrc.2023.09.050
- Bernardi K, Prono F, Bruni G, Panerai S, Ferri R, et al. Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. Sleep Med. 2023;110:220. doi:10.1016/j.sleep.2023.08.020
- Horsnell J, Mangar S, Dimitriou D, Halstead EJ. Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11121780
