Natrol Melatonin Fast Dissolve Tablets

Melatonin ineffective for CFS symptoms

Questionable

Based on 7 Researches

Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy.

Most Relevant Research

We evaluated whether melatonin and bright-light phototherapy could help alleviate symptoms of chronic fatigue syndrome (CFS). In a controlled study with thirty participants, we assessed the effectiveness of these treatments by measuring various symptoms over several weeks.

Unfortunately, we found that neither melatonin nor phototherapy led to significant improvements in the patients’ symptoms or overall health. Our findings suggest that these treatments shouldn't be promoted for CFS unless proven beneficial.

9.5

Effective sleep aid

Most Useful Review

Melatonin is a natural adaptogen that has worked wonderfully for me. One 3 mg tablet taken before bed helps me sleep deeply without side effects. I wake up refreshed, ready to take on the day. It's effective for managing chronic fatigue syndrome and I recommend it to everyone.

Fibromyalgia details

Improved sleep quality

This has been a lifesaver for me! I have chronic pain from osteoarthritis and fibromyalgia, which makes sleeping difficult. With a weak heart, being overtired leaves me feeling unwell. I previously received melatonin from a compounding pharmacist, but it was costly. I’m delighted to find it available here. It works well, allowing me eight hours of restful sleep, hence improving my health. I will try 3mg next and continue ordering melatonin, as it has greatly enhanced my quality of sleep and life.

Prostate Cancer details

Improved sleep quality

This helps me sleep through the night! My enlarged prostate causes frequent awakenings, but this allows me to remain asleep the entire night.

Stroke details

After purchasing this for my mother post-stroke, she feels much better. I now sleep soundly and fall asleep quickly, waking up cheerfully!

Cancer details

Safe for cancer recovery

I’ve been taking melatonin for years without fail, especially recommended after my breast cancer 20 years ago. It ensures I have a good night’s sleep and is safe without causing addiction.

High Cholesterol details

Reduces cholesterol levels

Melatonin does more than control sleep; it acts as an antioxidant, reducing oxidative damage while sleeping. It enhances enzyme functions related to active oxygen elimination and lipid metabolism, which is vital for women in their 40s and 50s facing lipid metabolism issues. Additionally, it suppresses insulin secretion, and irregular melatonin secretion in shift workers is linked to high cholesterol and obesity risks.

Menopause details

Melatonin aids perimenopausal relief

Based on 10 Researches

Influence of Melatonin Treatment on Emotion, Sleep, and Life Quality in Perimenopausal Women: A Clinical Study.

Most Relevant Research

We evaluated the effects of melatonin treatment on emotion, sleep, and quality of life in 100 healthy perimenopausal women. Participants were divided into two groups: one receiving melatonin and the other a placebo over three cycles.

After analyzing various hormonal levels and using questionnaires to assess perimenopausal symptoms, sleep quality, anxiety, and mood, we found that melatonin significantly alleviated climacteric symptoms.

Participants reported improved sleep, enhanced mood, and a better overall quality of life without serious side effects.

8.8

Effective sleep aid

Most Useful Review

I was taking benzodiazepines for insomnia during menopause, but they didn’t work and left me dazed in the morning. After hearing positive feedback, I tried this and was astonished by its effectiveness. I felt drowsy within 20 minutes and slept through the night. I found it a bit strong, so I plan to cut the dosage next time. The size is small and tasteless, making it easy to take. I believe it offers great value for money.

Obesity details

Improved obesity management

This supplement has been a lifesaver for me. I originally used melatonin to combat jet lag, but now I take it daily for better sleep. Over the past decade, I've noticed various benefits, particularly in managing my obesity and improving my work performance. I believe the antioxidant properties of melatonin contribute to keeping me youthful. It's a supplement I cannot imagine living without, and I highly recommend trying it before resorting to sleep medications.

Tinnitus details

Improved sleep quality

My husband has always struggled with tinnitus, making it hard for him to relax and sleep. This product has helped him achieve a sweet sleep, and he wakes up in good spirits and mood. No side effects were noted after taking it.

Anxiety details

Melatonin reduces pediatric anxiety, pain

Based on 7 Researches

The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial.

Most Relevant Research

We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.

The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.

While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.

9.5

Peaceful sleep

Most Useful Review

I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.

Sleep Apnea details

Melatonin improves sleep apnea outcomes

Based on 4 Researches

Effect of melatonin on insomnia and daytime sleepiness, in patients with obstructive sleep apnea and insomnia (COMISA): A randomized double-blinded placebo-controlled trial.

Most Relevant Research

We investigated how melatonin affects patients with obstructive sleep apnea and insomnia. In a double-blind trial, thirty patients received either 10 mg of melatonin or a placebo for a month.

The results were striking; those taking melatonin reported better sleep quality, less daytime sleepiness, and greater adherence to their PAP devices. Improvements were noted across several assessments: the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and Functional Outcomes of Sleep Questionnaire showed significant gains for the melatonin group.

Thus, melatonin appears to be a promising option to enhance sleep quality and treatment compliance in this challenging patient group.

9.5

Improves sleep quality

Most Useful Review

Excellent! It aids in improving sleep and helps me fall asleep faster.

Autoimmune Disorder details

Melatonin improves MS-related symptoms

Based on 16 Researches

12-week melatonin intake attenuates cardiac autonomic dysfunction and oxidative stress in multiple sclerosis patients: a randomized controlled trial.

Most Relevant Research

We explored the impact of melatonin on patients with multiple sclerosis (MS), aiming to improve heart function and sleep. In a randomized controlled trial, participants received either melatonin or a placebo for 12 weeks.

We observed significant improvements in heart rate variability and markers of oxidative stress, suggesting that melatonin could enhance heart health and lower stress in MS patients. Additionally, sleep quality and quantity also improved with melatonin use.

This study indicates that melatonin might be a beneficial treatment option for managing cardiac issues and sleep disturbances in MS.

9.5

Effective treatment

Most Useful Review

I’m currently in the hospital for a sleep disorder (insomnia). My doctor recommended melatonin, which makes me feel drowsy about an hour after taking it. The effect is remarkable!

Migraine details

Melatonin's mixed effects on migraine

Questionable

Based on 16 Researches

Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial.

Most Relevant Research

We explored the potential of melatonin as an acute treatment for migraines in children and adolescents aged 4 to 17 years. Our study involved a randomized trial where participants were given either a high or a low dose of melatonin to see which worked better to relieve migraine pain.

The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.

We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.

9.5

Effective treatment

Most Useful Review

This product is great; it significantly helps with my migraines and fibromyalgia.

Reflux details

Melatonin reduces reflux esophagitis damage

Based on 16 Researches

Melatonin protects against experimental reflux esophagitis.

Most Relevant Research

We explored how melatonin can protect the esophagus from reflux esophagitis (RE), a condition where stomach contents flow back into the esophagus, often causing painful inflammation. In our research with rats, we found that melatonin pretreatment resulted in significantly fewer bleeding lesions and lower levels of harmful lipid peroxidation typically caused by RE.

Additionally, melatonin helped replenish important antioxidants in the esophagus, suggesting its potential to neutralize free radicals that contribute to tissue damage. As we delved into the immune response, we observed that melatonin decreased the levels of certain pro-inflammatory cytokines, like TNF-alpha and IL-6, while keeping the levels of the anti-inflammatory cytokine IL-10 steady.

Interestingly, when we tested a melatonin receptor blocker, luzindole, we discovered that this approach did not hinder melatonin's protective effects. This indicates that melatonin works its magic in a receptor-independent way as well, not just through its antioxidant properties but also by modulating inflammation. Overall, we found that melatonin could be a beneficial ally for those suffering from reflux esophagitis, providing insights for future treatment strategies.

8.8

Improvement noted

Most Useful Review

I’m a fan of Natrol products and normally take 1 mg of melatonin for sleep. However, I read that 5 mg for 30 days can help with reflux, and I experienced significant improvement. I'd definitely recommend it, but I suggest researching it first.

Bone Pain details

This product has been a lifesaver for me! Due to chronic pain from osteoarthritis and fibromyalgia, sleeping is a challenge. A night without sleep exacerbates my bone pain. I was thrilled to find melatonin here; it offers me restful sleep for over eight hours, significantly enhancing my health. I plan to try a higher dose next.

Melatonin's impact on dizziness

Addressing Sleep Disorders in Psychiatry: Comparing the Use of Melatonin, Trazodone, and Doxepin.

Most Relevant Research

We assessed how melatonin affects dizziness in patients dealing with sleep disturbances tied to psychiatric conditions. In a study with 175 participants, we found that melatonin was slightly less effective than trazodone and doxepin in improving overall sleep quality. However, it stood out for having a low incidence of adverse effects. Specifically, the rates of dizziness associated with melatonin use were measured, showing a relatively low occurrence.

While it did not provide the most substantial improvement in sleep quality, melatonin showed promise in enhancing tolerability among users. Only 10% of participants reported dizziness, which indicates that melatonin might be a safer option for those worried about side effects from more potent medications. By choosing melatonin, patients can potentially find a balance between managing sleep disturbances while minimizing unwanted symptoms like dizziness.

Overall, we observed that for individuals focused on avoiding adverse effects, melatonin serves as a viable alternative within this treatment landscape. Its effectiveness in curbing dizziness contributes to discussions on how best to treat sleep disorders in psychiatric patients without compromising their comfort.

8.8

Helps with dizziness

Most Useful Review

I can sleep! Initially, I was sceptical, but it certainly helps me sleep better. If I take a higher dosage, I feel dizzy.

Nausea details

Melatonin linked to nausea management

Based on 2 Researches

Melatonin Immunoreactivity in Malignant Small Intestinal Neuroendocrine Tumours.

Most Relevant Research

We explored how melatonin could affect nausea in patients with small intestinal neuroendocrine tumors (SI-NETs). Our research involved studying tumor tissue from 26 patients, examining their primary tumors alongside metastases for the presence of melatonin and its receptors.

Interestingly, we found that higher melatonin levels in the body were linked to reported experiences of nausea. Specifically, patients with higher plasma melatonin levels at both time points indicated more frequent nausea occurrences. This underscores the potential role of melatonin in influencing nausea symptoms.

However, it's notable that in those cases where the disease was stable or improving, plasma levels of melatonin dropped after treatment, suggesting a complicated relationship between melatonin levels and treatment responses. These findings provide some valuable insights into the endocrine roles of melatonin in SI-NETs and signal a need for future studies to further dissect these relationships.

9.5

Natural sleep aid

Most Useful Review

I've ordered this three times, but it causes nausea unlike other types. After taking half a pill, I can fall asleep naturally as if I'm using sleeping pills.

Headache details