' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.6
USERS' SCORE
Very Good
Based on 4 Reviews
7.1
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
5
Melatonin's mixed effects on migraine
Melatonin for Acute Treatment of Migraine in Children and Adolescents: A Pilot Randomized Trial.
Directly addresses melatonin effectiveness
We explored the potential of melatonin as an acute treatment for migraines in children and adolescents aged 4 to 17 years. Our study involved a randomized trial where participants were given either a high or a low dose of melatonin to see which worked better to relieve migraine pain.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
The results revealed that both dosages led to some level of pain reduction, though the difference wasn't significant. The high-dose group saw an average pain reduction of 2.7 cm on a scale, while the low-dose group reported a 2.3 cm reduction, a difference that wasn't statistically meaningful.
We also observed a fairly high dropout rate from the study, which could impact our findings on effectiveness. Interestingly, we found that taking a higher dose of melatonin and napping afterward seemed to correlate with better migraine relief. Overall, while melatonin shows promise as a treatment, we must continue our investigation to establish clearer benefits.
Read More
9
Melatonin beneficial for migraine prevention
Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis.
Directly examines melatonin's effects
We explored the role of melatonin in preventing migraines in adults through a detailed analysis of three relevant studies. By comparing melatonin against a placebo and standard treatments like amitriptyline and valproate, we aimed to assess its effectiveness and safety for those suffering from migraines.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Read More
8
Melatonin reduces migraine frequency
Efficacy of Melatonin as a Promising Intervention for Migraine Prevention: A Systematic Review of Randomized Control Trials.
Direct focus on melatonin use
We explored how melatonin can help in preventing migraines through a systematic review of randomized controlled trials. By analyzing seven studies that involved 1,283 participants, we compared the effects of melatonin to standard migraine treatments and placebo groups.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Read More
Most Useful Reviews
9.5
Effective treatment
This product is great; it significantly helps with my migraines and fibromyalgia.
Read More
8.8
Improved sleep quality
Countermeasures against nightmares with migraine: I often experience nightmares due to my migraines. My doctor mentioned this as a symptom. I tried melatonin, which seemed effective; my sleep deepened, and I noticed fewer nightmares.
Read More
8.8
Helps me rest
They are excellent and help me rest while reducing my migraines.
Read More
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6.6
9
Melatonin effective for migraine relief
Efficacy of Melatonin Administration in Reducing Headaches in Children with Migraines without Sleep Disorders.
Moderate relevance due to control use
We conducted a study to explore how melatonin can help reduce migraine headaches in children who do not have sleep disorders. In our clinical trial, we included 55 children aged between five to 15 years. The participants were divided into two groups: one group received propranolol only, while the other was treated with propranolol plus melatonin for three months.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
After evaluating the results, we observed that the children taking melatonin alongside propranolol experienced a notable decrease in headache frequency compared to those who only took propranolol. About three months into the treatment, there was a significant difference in how well the two groups responded—many more children in the melatonin group reported positive effects from the treatment. Additionally, parents of these children were more satisfied with the results than those in the control group.
Importantly, we found no significant side effects from either treatment group, and the intensity of disability caused by the headaches remained similar between the two groups. Overall, it appears that adding melatonin could be a useful strategy for managing migraine headaches in children without sleep issues.
Read More
9
Melatonin reduces migraine frequency
The Effect of Melatonin on Reducing the Frequency and Severity of Migraine Attacks: A Double-Blind, Randomized Clinical Trial.
Treatment includes propranolol influence
We conducted a randomized, double-blind clinical trial to examine the effects of melatonin on migraine attacks. In this study, 60 patients experiencing episodic migraines were divided into two groups. One group received 3 mg of melatonin, while the other received a placebo, both along with a standard treatment of propranolol over two months.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
Throughout the follow-up period, we assessed the frequency, duration, and severity of migraine attacks. We found that those taking melatonin experienced a notable reduction in both the frequency and duration of their migraine events compared to the placebo group. While the severity of pain did not show a significant difference between the two groups, the overall impact on attack frequency and duration was promising.
Importantly, both treatments were similarly safe, with only a slight incidence of side effects observed. This suggests that melatonin could serve as an effective preventive option for adults suffering from episodic migraines when used alongside other standard therapies.
Read More
9
Melatonin beneficial for migraine prevention
Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis.
Directly examines melatonin's effects
We explored the role of melatonin in preventing migraines in adults through a detailed analysis of three relevant studies. By comparing melatonin against a placebo and standard treatments like amitriptyline and valproate, we aimed to assess its effectiveness and safety for those suffering from migraines.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Our findings revealed that melatonin provided significant benefits compared to a placebo. Specifically, we observed a higher rate of responders, meaning more people experienced relief from their migraines when using melatonin. The therapy significantly reduced the frequency and duration of migraine attacks, lessened the severity of headaches, and decreased the need for pain-relief medication.
However, melatonin didn’t show a significant advantage over established migraine treatments like amitriptyline or valproate. Importantly, common side effects such as drowsiness and fatigue did not occur more frequently in those taking melatonin compared to other groups. Overall, melatonin appears to be a promising option for migraine prevention, particularly for those looking for alternatives to traditional medications.
Read More
8
Melatonin reduces migraine frequency
Efficacy of Melatonin as a Promising Intervention for Migraine Prevention: A Systematic Review of Randomized Control Trials.
Direct focus on melatonin use
We explored how melatonin can help in preventing migraines through a systematic review of randomized controlled trials. By analyzing seven studies that involved 1,283 participants, we compared the effects of melatonin to standard migraine treatments and placebo groups.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Our findings suggest that melatonin can significantly reduce both the frequency and severity of migraine attacks. However, the effectiveness seemed to depend on the dosage, and there are still questions about the best approach to take.
Beyond migraine relief, we also noted intriguing hints that melatonin might assist with weight control, indicating further avenues for research. As melatonin continues to gain popularity for various uses, including sleep disorders, its potential as a migraine preventative is a significant development worth considering.
Read More
8
Melatonin's migraine relief mechanisms
Proposed receptor-mediated mechanisms of melatonin in nitroglycerin-induced migraine-like hyperalgesic conditions in rats.
Study directly explores melatonin's efficacy
We investigated how melatonin might alleviate migraine symptoms by looking at the biological processes involved. Our study specifically examined the effects of melatonin in rats experiencing migraine-like pain stimulated by nitroglycerin.
To understand its mechanisms, we used various antagonists—blocking specific melatonin receptors in the process. This approach allowed us to observe changes in pain behavior, levels of certain pain-related substances, and the activation of mast cells linked to migraines.
Our findings revealed that melatonin significantly reduced mechanical pain sensitivity and decreased the levels of CGRP, a protein associated with migraine pain. It also seemed to calm the activation of mast cells in the meninges, which play a role in headache conditions. Notably, these effects were largely cancelled when we used specific receptor blockers, indicating that its benefits primarily stem from the MT2 receptor, while there may still be a role for the MT1 receptor.
Overall, this research sheds light on melatonin's potential as a therapeutic option for migraines, highlighting its influence on pain pathways and mast cell activity.
To understand its mechanisms, we used various antagonists—blocking specific melatonin receptors in the process. This approach allowed us to observe changes in pain behavior, levels of certain pain-related substances, and the activation of mast cells linked to migraines.
Our findings revealed that melatonin significantly reduced mechanical pain sensitivity and decreased the levels of CGRP, a protein associated with migraine pain. It also seemed to calm the activation of mast cells in the meninges, which play a role in headache conditions. Notably, these effects were largely cancelled when we used specific receptor blockers, indicating that its benefits primarily stem from the MT2 receptor, while there may still be a role for the MT1 receptor.
Overall, this research sheds light on melatonin's potential as a therapeutic option for migraines, highlighting its influence on pain pathways and mast cell activity.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 4 Reviews
7.1
9.5
Effective treatment
This product is great; it significantly helps with my migraines and fibromyalgia.
8.8
Improved sleep quality
Countermeasures against nightmares with migraine: I often experience nightmares due to my migraines. My doctor mentioned this as a symptom. I tried melatonin, which seemed effective; my sleep deepened, and I noticed fewer nightmares.
8.8
Helps me rest
They are excellent and help me rest while reducing my migraines.
2.3
Side effects noted
I can sleep well, even if I take a quarter dose. I liked it and continued using it. However, I always wake up with a headache, which is disappointing. I think it varies by individual, especially for those prone to migraines.
