Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
USERS' SCORE
Good
Based on 9 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
590%
Calcium (from Calcium Carbonate)
63 mg
4%
Melatonin
3 mg
*
Top Medical Research Studies
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
Read More
Most Useful Reviews
9
Improves sleep quality
62 people found this helpful
Excellent analogue of the pharmacy Melaxen. I gave melatonin to my son who struggles to fall asleep, especially when he's overexcited in the evenings. He is 6 years old and has autism. Children like him often have low melatonin levels, leading to sleep issues. Doctors often prescribe antidepressants that can harm not just the body but the brain. I sought a less harmful alternative and was recommended this melatonin. It calms my child effectively, allowing him to go to bed quietly without pills. I give him a quarter of a tablet, and he wakes up cheerful without headaches, which often accompany other medications. The price is very reasonable—240 tablets here were much cheaper than 24 in Russia. I highly recommend it!
Read More
9
Melatonin for insomnia
As someone with Asperger's Syndrome, insomnia has plagued me for my entire life. I understand that those on the autism spectrum produce little or no melatonin naturally, hence the need for supplementation. I am very satisfied with NATROL brand melatonin and highly recommend it to mothers with children on the spectrum or adults in a similar situation.
Read More
9
Saves relationships
This product has been a lifesaver for me while raising my grandchild, who has autism, ADHD, and several other diagnoses. He often can't calm down without medication during the day or at night to help him sleep. Previously, I had to hold him tightly to stop his constant movement before he could sleep. Since starting melatonin, he has dinner, takes his tablets, and within half an hour, he eagerly says he’s ready for bed. It’s as if a switch has been flipped! Adjustments to dosage were necessary, but the most significant change has been enabling him to enter REM sleep, with a substantial improvement in his sleep duration—from just 4 hours a night to 8-10 hours on average. We're all much happier now.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.2
- All Researches
8
We examined the link between insomnia and Autism Spectrum Disorder (ASD), particularly how melatonin can help manage sleep issues in affected children. The analysis, conducted by a team of experts, emphasized the importance of understanding sleep challenges to improve treatment outcomes for both kids and their caregivers.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Encouragingly, melatonin has been found to be both effective and safe for managing insomnia associated with ASD, particularly in prolonged-release forms. Although promising, more research is needed to further validate these findings and improve sleep management strategies.
Read More
8
Melatonin helps autistic zebrafish models
We explored the impact of Nomo1 deficiency on behavior in zebrafish, which mimics aspects of neuropsychiatric disorders, including autism. The study demonstrated that these zebrafish exhibited abnormal brain development and various neuropsychiatric symptoms.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Notably, we found that treating these fish with melatonin not only restored normal locomotor activity but also reduced repetitive behaviors and addressed inflammation in the brain. This suggests that melatonin could be a promising therapeutic option for managing neuropsychiatric conditions linked to NOMO1 deficiency.
Read More
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Read More
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Read More
8
We conducted a detailed look into sleep-related rhythmic movement disorder (SR-RMD) in children, involving data from 66 patients at a UK hospital.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Our assessment included questionnaires to explore autism traits and behavioral impacts. Notably, families reported the burden of sleeplessness and concerns for their children's safety.
Intriguingly, many parents noted improvements in their children’s sleep after administering extended-release melatonin, suggesting this could be a viable treatment option in the future.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Improves sleep quality
62 people found this helpful
Excellent analogue of the pharmacy Melaxen. I gave melatonin to my son who struggles to fall asleep, especially when he's overexcited in the evenings. He is 6 years old and has autism. Children like him often have low melatonin levels, leading to sleep issues. Doctors often prescribe antidepressants that can harm not just the body but the brain. I sought a less harmful alternative and was recommended this melatonin. It calms my child effectively, allowing him to go to bed quietly without pills. I give him a quarter of a tablet, and he wakes up cheerful without headaches, which often accompany other medications. The price is very reasonable—240 tablets here were much cheaper than 24 in Russia. I highly recommend it!
Read More
9
Melatonin for insomnia
As someone with Asperger's Syndrome, insomnia has plagued me for my entire life. I understand that those on the autism spectrum produce little or no melatonin naturally, hence the need for supplementation. I am very satisfied with NATROL brand melatonin and highly recommend it to mothers with children on the spectrum or adults in a similar situation.
Read More
9
Saves relationships
This product has been a lifesaver for me while raising my grandchild, who has autism, ADHD, and several other diagnoses. He often can't calm down without medication during the day or at night to help him sleep. Previously, I had to hold him tightly to stop his constant movement before he could sleep. Since starting melatonin, he has dinner, takes his tablets, and within half an hour, he eagerly says he’s ready for bed. It’s as if a switch has been flipped! Adjustments to dosage were necessary, but the most significant change has been enabling him to enter REM sleep, with a substantial improvement in his sleep duration—from just 4 hours a night to 8-10 hours on average. We're all much happier now.
Read More
9
Quick sleep aid
My grandson was prescribed melatonin for his autism and ADHD by his specialist, and it has worked wonders. Within 30 minutes of taking one tablet, he is fast asleep, waking up in a much better mood without the usual fights with his sister, myself, or his mother. The specialist suggested purchasing them from the USA due to prescription issues here in Australia. The fast freight is impressive—we usually receive our order in just 4 days.
Read More
7.5
Replaces strong meds
1 people found this helpful
Great product! I use it for my sister who has Down syndrome and autism, along with a herbal remedy prescribed medically, replacing strong sleep medications that caused her to drool. Gradually, we reduced the dose of her previous medication while increasing melatonin. Although melatonin alone couldn't resolve all her issues, today she enjoys peaceful sleep, wakes up in good humour and no longer drools. She's now more active and sociable, and I am very pleased with the product. I just need to order it a month in advance since it takes time to arrive in Brazil, but it's still cheaper than buying locally.
Read More
Frequently Asked Questions
9
Quick sleep aid
My grandson was prescribed melatonin for his autism and ADHD by his specialist, and it has worked wonders. Within 30 minutes of taking one tablet, he is fast asleep, waking up in a much better mood without the usual fights with his sister, myself, or his mother. The specialist suggested purchasing them from the USA due to prescription issues here in Australia. The fast freight is impressive—we usually receive our order in just 4 days.
9
Saves relationships
This product has been a lifesaver for me while raising my grandchild, who has autism, ADHD, and several other diagnoses. He often can't calm down without medication during the day or at night to help him sleep. Previously, I had to hold him tightly to stop his constant movement before he could sleep. Since starting melatonin, he has dinner, takes his tablets, and within half an hour, he eagerly says he’s ready for bed. It’s as if a switch has been flipped! Adjustments to dosage were necessary, but the most significant change has been enabling him to enter REM sleep, with a substantial improvement in his sleep duration—from just 4 hours a night to 8-10 hours on average. We're all much happier now.
7.5
Replaces strong meds
1 people found this helpful
Great product! I use it for my sister who has Down syndrome and autism, along with a herbal remedy prescribed medically, replacing strong sleep medications that caused her to drool. Gradually, we reduced the dose of her previous medication while increasing melatonin. Although melatonin alone couldn't resolve all her issues, today she enjoys peaceful sleep, wakes up in good humour and no longer drools. She's now more active and sociable, and I am very pleased with the product. I just need to order it a month in advance since it takes time to arrive in Brazil, but it's still cheaper than buying locally.
8
Calms for sleep
I love this product! My son, who is 11 years old and has autism and ADHD, has always struggled with sleep. This melatonin has significantly helped him calm down and fall asleep more easily.
9
Improves sleep quality
62 people found this helpful
Excellent analogue of the pharmacy Melaxen. I gave melatonin to my son who struggles to fall asleep, especially when he's overexcited in the evenings. He is 6 years old and has autism. Children like him often have low melatonin levels, leading to sleep issues. Doctors often prescribe antidepressants that can harm not just the body but the brain. I sought a less harmful alternative and was recommended this melatonin. It calms my child effectively, allowing him to go to bed quietly without pills. I give him a quarter of a tablet, and he wakes up cheerful without headaches, which often accompany other medications. The price is very reasonable—240 tablets here were much cheaper than 24 in Russia. I highly recommend it!
7
Effective for sleep
4 people found this helpful
I sleep well. The melatonin from this manufacturer comes in various doses; 1 mg didn't work unless I took several. However, 5 mg was effective, and 3 mg was just right. It operates like a light sleep inducer, albeit overdosing can lead to lingering effects the next day. It has been beneficial for my children with autism and even my nearly 90-year-old mother who has dementia, as it helps them calm and sleep with just one tablet during times of excitement. The results are similar to other brands.
8
Melatonin shows positive effects on sleep
We explored the impact of melatonin on sleep disturbances in children with autism spectrum disorder (ASD) through a retrospective study, using parent surveys for insights.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
Interestingly, about 8% of children in the study received melatonin, especially those with more severe symptoms. The results showed high adherence, with around 86% experiencing better sleep onset.
Additionally, over a quarter reported improved daytime behaviors. Despite some mild side effects, parents generally viewed melatonin as a safe and effective option for their children's sleep issues.
5
We explored the effects of melatonin supplements, physical exercise, and their combination on sleep quality in children with autism spectrum disorder (ASD). Sixty-two children participated, assigned to groups receiving cycling, melatonin, both, or a placebo.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
Results showed improvements in sleep efficiency and duration for all intervention groups, while the placebo did not yield significant changes. However, when comparing the groups, we found no notable differences between the effectiveness of melatonin and exercise, indicating both interventions could help alike.
8
We investigated the role of melatonin in enhancing synaptic development in mouse models of autism. Through long-term oral administration over 28 days, melatonin improved social interactions and dendritic spine density in genetically modified mice.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
Importantly, we found that melatonin's benefits are linked to the activation of a specific signaling pathway in the brain. However, when this pathway was blocked, the positive effects of melatonin on synaptic function were diminished. Overall, our findings highlight melatonin's promise for addressing certain autism-related challenges.
7
Melatonin improves liver function in autism
We explored a study that examined how melatonin might help alleviate liver issues in a mouse model of autism known as BTBR. The researchers looked at various liver-related problems, including oxidative stress and inflammation, comparing the BTBR mice to healthy controls.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
They found that BTBR mice had significant liver development issues and an increase in harmful markers. After administering melatonin, there were notable improvements in liver structure and function in the autistic mice. This suggests that melatonin could have beneficial effects on managing some health complications associated with autism.
8
We explored melatonin's potential to impact neurodevelopment in autism by using stem cells from children with autism. In our study, we differentiated these cells into dopaminergic neurons and tested the effects of melatonin on their growth and function. We discovered that, without melatonin, these neurons showed reduced growth and mitochondrial dysfunction.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
However, when melatonin was added, we observed significant improvements in neuron growth and mitochondrial health. Melatonin appears to enhance calcium signaling crucial for development. Nevertheless, further research is needed to confirm these findings and their practical applications for autism treatment.
References
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. doi:10.1016/j.sleep.2024.05.046
- Rezzani R, Gianò M, Pinto D, Rinaldi F, van Noorden CJF, et al. Hepatic Alterations in a BTBR T + Itpr3tf/J Mouse Model of Autism and Improvement Using Melatonin via Mitigation Oxidative Stress, Inflammation and Ferroptosis. Int J Mol Sci. 2024;25. doi:10.3390/ijms25021086
- Zhang Q, Li F, Li T, Lin J, Jian J, et al. Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO Rep. 2024;25:570. doi:10.1038/s44319-023-00036-y
- Wang L, Xu M, Wang Y, Wang F, Deng J, et al. Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder. Neural Regen Res. 2024;19:1618. doi:10.4103/1673-5374.387973
- Tse ACY, Lee PH, Sit CHP, Poon ET, Sun F, et al. Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD. J Autism Dev Disord. 2024;54:4456. doi:10.1007/s10803-023-06172-7
- Sadeh H, Meiri G, Zigdon D, Ilan M, Faroy M, et al. Adherence to treatment and parents' perspective about effectiveness of melatonin in children with autism spectrum disorder and sleep disturbances. Child Adolesc Psychiatry Ment Health. 2023;17:123. doi:10.1186/s13034-023-00669-w
- Joels H, Benny A, Sharpe A, Postigo B, Joseph B, et al. Sleep related rhythmic movement disorder: phenotypic characteristics and treatment response in a paediatric cohort. Sleep Med. 2023;112:21. doi:10.1016/j.sleep.2023.09.020
- Dong S, Kifune T, Kato H, Wang L, Kong J, et al. Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder. Biochem Biophys Res Commun. 2023;681:7. doi:10.1016/j.bbrc.2023.09.050
- Bernardi K, Prono F, Bruni G, Panerai S, Ferri R, et al. Sleep disturbances in subjects with autism spectrum disorder: A parental perspective. Sleep Med. 2023;110:220. doi:10.1016/j.sleep.2023.08.020
- Horsnell J, Mangar S, Dimitriou D, Halstead EJ. Parental Experiences of Melatonin Administration to Manage Sleep Disturbances in Autistic Children and Adolescent in the UK. Healthcare (Basel). 2023;11. doi:10.3390/healthcare11121780
